D048748Chemicals & DrugsD08.811.913.696.620.682.700.559.300D12.644.360.400.300D12.776.476.400.3006120.995492MAP Kinase Kinase Kinase 3prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonSurgery-General SurgeryRomualdGirardRomuald Girard41.7886000000000087.598699999999993817Girard, RomualdResearch Assistant Professor31917316Koskimäki J, Zhang D, Carrión-Penagos J, Girard R, Piedad K, Polster SP, Lyne S, Stadnik A, Awad IAWorld neurosurgerySymptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature. World Neurosurg. 2020 Apr; 136:7-11.World Neurosurg2020-01-07T00:00:002020Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.31968585Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen LInternational journal of molecular sciencesCerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2).Int J Mol Sci2020-01-20T00:00:002020Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation.33910229Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn MLNaturePIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021 06; 594(7862):271-276.Nature2021-04-28T00:00:002021PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.Neurological SurgerySeanPolsterSean Polster41.7886000000000087.598699999999994144Polster, Sean0000-0002-3229-5021Assistant Professor0.2868080.0465486research area of0.5745670.1310115subject area for25414119Luke JJ, Ott PA, Shapiro GIDrugsThe biology and clinical development of MEK inhibitors for cancer. Drugs. 2014 Dec; 74(18):2111-28.Drugs2014-12-01T00:00:002014The biology and clinical development of MEK inhibitors for cancer.http://surgeryresearch.uchicago.edu/robert-shenkarRobert Shenkar, PhDUniversity of ChicagoLeShenLe Shen41.78927490000000-87.60125000000000411Shen, LeResearch Associate ProfessorIssamAwad3mN+CqU1DO/RmHllZ0mg9mHvIssam Awad41.78927490000000-87.60125000000000867Awad, IssamProfessorRobertShenkarRobert Shenkar41.78927490000000-87.60125000000000963Shenkar, RobertResearch Associate Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1Research Assistant ProfessorResearch Assistant Professortrue1Assistant ProfessorAssistant Professortrue1Research Associate ProfessorResearch Associate Professor27027284Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn MLNatureCerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016 Apr 07; 532(7597):122-6.Nature2016-03-30T00:00:002016Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.