D051376Chemicals & DrugsD05.750.078.730.246D12.776.220.525.2468200.985924Actin-Related Protein 2-3 Complexprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonPhysicsMargaretGardelMargaret L. Gardel41.7886000000000087.598699999999993493Gardel, MargaretProfessor29535305Nekrasova O, Harmon RM, Broussard JA, Koetsier JL, Godsel LM, Fitz GN, Gardel ML, Green KJNature communicationsDesmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. Nat Commun. 2018 03 13; 9(1):1053.Nat Commun2018-03-13T00:00:002018Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.24967897Beckham Y, Vasquez RJ, Stricker J, Sayegh K, Campillo C, Gardel MLPloS oneArp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. PLoS One. 2014; 9(6):e100943.PLoS One2014-06-26T00:00:002014Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.Molecular Genetics and Cell Biology30013181Schaffer AE, Breuss MW, Caglayan AO, Al-Sanaa N, Al-Abdulwahed HY, Kaymakçalan H, Yilmaz C, Zaki MS, Rosti RO, Copeland B, Baek ST, Musaev D, Scott EC, Ben-Omran T, Kariminejad A, Kayserili H, Mojahedi F, Kara M, Cai N, Silhavy JL, Elsharif S, Fenercioglu E, Barshop BA, Kara B, Wang R, Stanley V, James KN, Nachnani R, Kalur A, Megahed H, Incecik F, Danda S, Alanay Y, Faqeih E, Melikishvili G, Mansour L, Miller I, Sukhudyan B, Chelly J, Dobyns WB, Bilguvar K, Jamra RA, Gunel M, Gleeson JGNature geneticsBiallelic loss of human CTNNA2, encoding aN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nat Genet. 2018 08; 50(8):1093-1101.Nat Genet2018-07-16T00:00:002018Biallelic loss of human CTNNA2, encoding aN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration.CristianSuarez AtiasCristian Suarez Atias0.000000000000000.000000000000002962Suarez Atias, CristianPost Doctoral ScholarWilliamDobynsWilliam B. Dobyns0.000000000000000.000000000000002964Dobyns, WilliamPROFESSOR 1.80380.02538558research area of0.6747590.07353816subject area forhttps://munrolab.uchicago.edu/Munro Labhttps://voices.uchicago.edu/kovarlab/Kovar Lab WebsiteHuman GeneticsMol Gen/Cell BioUniversity of ChicagoEdwin M.MunroEdwin M. Munro41.78927490000000-87.601250000000001929Munro, Edwin M.ProfessorDavid R.Kovar02lmHaAHOe7KlTRxY07n8GT98IW47aA=David R. Kovar41.78927490000000-87.60125000000000402Kovar, David R.Professortrue1PROFESSOR PROFESSOR true1Post Doctoral ScholarPost Doctoral Scholartrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor25543281Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JEDevelopmental cellProfilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell. 2015 Jan 12; 32(1):54-67.Dev Cell2014-12-24T00:00:002014Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.25543282Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DRDevelopmental cellProfilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell. 2015 Jan 12; 32(1):43-53.Dev Cell2014-12-24T00:00:002014Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.