D053455Chemicals & DrugsD08.811.277.656.262.500.126.550.910D08.811.277.656.300.200.126.550.910D12.644.360.075.405.550.910D12.776.476.075.405.550.910450.996112Caspase 10plugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonDavidChangDavid Chang0.000000000000000.000000000000002852Chang, DavidProfessor9852092Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJThe Journal of biological chemistryGranzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83.J Biol Chem1998-12-18T00:00:001998Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.9765224Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GSThe Journal of biological chemistryPro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90.J Biol Chem1998-10-16T00:00:001998Pro-caspase-3 is a major physiologic target of caspase-8.Medicine-Hematology and OncologyPediatrics-Hematology and OncologySurgery-Plastic and Reconstructive0.5597660.0214664research area of0.561950.04284195subject area forhttp://www.uchospitals.edu/physicians/samuel-volchenboum.htmlClinical Pagehttps://voices.uchicago.edu/volchenboum/Sam Volchenboumhttps://ome.bsd.uchicago.eduOffice of Master's Educationhttp://commons.cri.uchicago.eduPediatric Cancer Data CommonsSamVolchenboumUniversity of ChicagoChristopherFroelichChristopher Froelich41.78927490000000-87.601250000000001210Froelich, ChristopherAndrzejJakubowiak1mhjCqp1G+POmHtvQFPt+2z5/syyp7BaZQ==Andrzej Jakubowiak41.78927490000000-87.601250000000002384Jakubowiak, AndrzejProfessorSamuel L.VolchenboumxG5/K7QWEeXakH1rLkPq5g==Samuel L. Volchenboum41.78927490000000-87.6012500000000063Volchenboum, Samuel L.Professortrue1true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor12221529Farrokh-Siar L, Rezai KA, Palmer EM, van Seventer J, Hamann KJ, Rajadurai H, Patel SC, Ernest JT, van Seventer GACurrent eye researchHuman fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL. Curr Eye Res. 2002 Mar; 24(3):206-13.Curr Eye Res2002-03-01T00:00:002002Human fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL.12637514Chang DW, Ditsworth D, Liu H, Srinivasula SM, Alnemri ES, Yang XThe Journal of biological chemistryOligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. J Biol Chem. 2003 May 09; 278(19):16466-9.J Biol Chem2003-03-13T00:00:002003Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.26637366Rosebeck S, Alonge MM, Kandarpa M, Mayampurath A, Volchenboum SL, Jasielec J, Dytfeld D, Maxwell SP, Kraftson SJ, McCauley D, Shacham S, Kauffman M, Jakubowiak AJMolecular cancer therapeuticsSynergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor. Mol Cancer Ther. 2016 Jan; 15(1):60-71.Mol Cancer Ther2015-12-04T00:00:002015Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.