D039302Chemicals & DrugsD12.776.395.550.625.439D12.776.543.550.625.439D12.776.543.750.705.408.460.870.500D12.776.543.750.705.675.54112170.990476Integrin alphaVbeta3prns:emailEncryptedemail addressFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonJeffreyHubbell3Wp8CaMQFeD5hHlsaUXv9Gq0+s+oJeffrey Hubbell41.7886000000000087.598699999999993473Hubbell, JeffreyBarry L. MacLean ProfessorSurgery-Surgical Res.Pritzker Institute for Molecular EngineeringObstetrics and Gynecology-Gynecologic OncologyObstetrics and Gynecology-Maternal Fetal MedicineObstetrics and Gynecology-Urogynecology20844080Moyano JV, Greciano PG, Buschmann MM, Koch M, Matlin KSMolecular biology of the cellAutocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 2010 Nov 01; 21(21):3654-68.Mol Biol Cell2010-09-15T00:00:002010Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.19808644Kaur S, Kenny HA, Jagadeeswaran S, Zillhardt MR, Montag AG, Kistner E, Yamada SD, Mitra AK, Lengyel EThe American journal of pathology{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol. 2009 Nov; 175(5):2184-96.Am J Pathol2009-10-01T00:00:002009{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.https://obgyn.uchicago.edu/page/section-gynecologic-oncologyGynecologic Oncology Section - Univ. of Chicagohttps://obgyn.uchicago.edu/Univ. of Chicago OB&GYNhttp://obg.bsd.uchicago.edu/FacultyResearch/lengyellab.htmOvarian Cancer Laboratory in Chicagohttps://www.uchicagomedicine.org/find-a-physician/physician/ernst-lengyelClinical Profilehttps://www.uchicagomedicine.org/conditions-services/obgyn/specialtyOB&GYN Clinical Patient informationMargaretMuellerMargaret Mueller41.7886000000000087.598699999999994299Mueller, MargaretAssociate Professor0.5306780.015591112research area of0.4917660.062535614subject area forUniversity of ChicagoErnst RobertLengyel0m5sBaYMHOD5hHlsaUXv9Gq0+s+oErnst Robert Lengyel41.78927490000000-87.601250000000001942Lengyel, Ernst RobertProfessorKarlMatlinKarl S. Matlin41.78927490000000-87.601250000000002502Matlin, KarlEmeritus/Emerita, Professor17308094Zhang C, Jugold M, Woenne EC, Lammers T, Morgenstern B, Mueller MM, Zentgraf H, Bock M, Eisenhut M, Semmler W, Kiessling FCancer researchSpecific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer Res. 2007 Feb 15; 67(4):1555-62.Cancer Res2007-02-15T00:00:002007Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner.19789239Kiessling F, Huppert J, Zhang C, Jayapaul J, Zwick S, Woenne EC, Mueller MM, Zentgraf H, Eisenhut M, Addadi Y, Neeman M, Semmler WRadiologyRGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment. Radiology. 2009 Nov; 253(2):462-9.Radiology2009-09-29T00:00:002009RGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment.true1ProfessorProfessortrue1Clinical ProfessorClinical Professortrue1Associate ProfessorAssociate Professortrue1Barry L. MacLean ProfessorBarry L. MacLean Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professor1010JacquesAbramowiczJacques Abramowicz0.000000000000000.000000000000003287Abramowicz, JacquesClinical Professor24304684Barua A, Yellapa A, Bahr JM, Machado SA, Bitterman P, Basu S, Sharma S, Abramowicz JSInternational journal of gynecological cancer : official journal of the International Gynecological Cancer SocietyEnhancement of ovarian tumor detection with avß3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer. Int J Gynecol Cancer. 2014 Jan; 24(1):19-28.Int J Gynecol Cancer2014-01-01T00:00:002014Enhancement of ovarian tumor detection with avß3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer.