Nancy Jean Cox to Genetic Predisposition to Disease
This is a "connection" page, showing publications Nancy Jean Cox has written about Genetic Predisposition to Disease.
Connection Strength
5.935
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Gene and phenome-based analysis of the shared genetic architecture of eye diseases. Am J Hum Genet. 2025 Feb 06; 112(2):318-331.
Score: 0.469
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Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J. 2016 08; 16(4):388-92.
Score: 0.241
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A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. PLoS Genet. 2011 Feb 03; 7(2):e1001292.
Score: 0.178
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Interpreting P values in pharmacogenetic studies: a call for process and perspective. J Clin Oncol. 2007 Oct 10; 25(29):4513-5.
Score: 0.141
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Genetic epidemiology of diabetes. J Clin Invest. 2005 Jun; 115(6):1431-9.
Score: 0.120
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Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet. 2005 Jun; 76(6):967-86.
Score: 0.119
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EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma. Am J Hum Genet. 2025 May 01; 112(5):1199-1214.
Score: 0.119
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Basic Science and Pathogenesis. Alzheimers Dement. 2024 Dec; 20 Suppl 1:e093573.
Score: 0.116
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Clinical associations with a polygenic predisposition to benign lower white blood cell counts. Nat Commun. 2024 Apr 22; 15(1):3384.
Score: 0.111
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Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation. Cell Rep Med. 2024 02 20; 5(2):101430.
Score: 0.110
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Computational issues in mapping variation affecting susceptibility to complex disorders: the chicken and the egg. Theor Popul Biol. 2001 Nov; 60(3):221-5.
Score: 0.094
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A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk. Int J Cancer. 2022 01 01; 150(1):80-90.
Score: 0.093
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Discovery and implications of polygenicity of common diseases. Science. 2021 Sep 24; 373(6562):1468-1473.
Score: 0.093
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A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes. Genome Med. 2021 09 01; 13(1):141.
Score: 0.092
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Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am J Hum Genet. 2001 Oct; 69(4):820-30.
Score: 0.092
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Fate or coincidence: do COPD and major depression share genetic risk factors? Hum Mol Genet. 2021 05 12; 30(7):619-628.
Score: 0.091
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A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet. 2000 Nov; 67(5):1154-62.
Score: 0.087
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A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk. Cancer Res. 2020 10 15; 80(20):4346-4354.
Score: 0.086
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Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet. 2000 Feb; 66(2):517-26.
Score: 0.083
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data. Nat Commun. 2019 12 03; 10(1):5508.
Score: 0.082
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Genome-wide screen for atopy susceptibility alleles in the Hutterites. Clin Exp Allergy. 1999 Dec; 29 Suppl 4:11-5.
Score: 0.082
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APOE e4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. Neurobiol Aging. 2020 03; 87:18-25.
Score: 0.082
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Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019 09 01; 142(9):2581-2589.
Score: 0.081
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Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits. Nat Genet. 2019 06; 51(6):933-940.
Score: 0.079
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A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. Nat Neurosci. 2019 05; 22(5):691-699.
Score: 0.078
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Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet. 1999 Feb; 21(2):213-5.
Score: 0.077
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Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. Science. 2018 03 16; 359(6381):1233-1239.
Score: 0.073
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Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):379-384.
Score: 0.072
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Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma. PLoS One. 2017; 12(10):e0185730.
Score: 0.071
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Classification of common human diseases derived from shared genetic and environmental determinants. Nat Genet. 2017 Sep; 49(9):1319-1325.
Score: 0.070
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The genetic architecture of type 2 diabetes. Nature. 2016 08 04; 536(7614):41-47.
Score: 0.065
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet. 2016 05 15; 25(10):2070-2081.
Score: 0.063
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Poly-omic prediction of complex traits: OmicKriging. Genet Epidemiol. 2014 Jul; 38(5):402-15.
Score: 0.056
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Guidelines for investigating causality of sequence variants in human disease. Nature. 2014 Apr 24; 508(7497):469-76.
Score: 0.056
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A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013 Sep 26; 155(1):70-80.
Score: 0.053
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Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers. Carcinogenesis. 2013 Jul; 34(7):1520-8.
Score: 0.051
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SCAN: a systems biology approach to pharmacogenomic discovery. Methods Mol Biol. 2013; 1015:213-24.
Score: 0.051
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Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2013 Jul; 18(7):788-98.
Score: 0.049
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Genome-wide association study of Tourette's syndrome. Mol Psychiatry. 2013 Jun; 18(6):721-8.
Score: 0.049
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Power and sample size calculations for SNP association studies with censored time-to-event outcomes. Genet Epidemiol. 2012 Sep; 36(6):538-48.
Score: 0.049
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Replication analysis for severe diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Apr 30; 53(4):2377-81.
Score: 0.048
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Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry. Carcinogenesis. 2012 Apr; 33(4):835-40.
Score: 0.048
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Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry. Cancer Epidemiol Biomarkers Prev. 2012 Mar; 21(3):552-6.
Score: 0.047
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Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry. 2013 Mar; 18(3):340-6.
Score: 0.047
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Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia. 2011 Aug; 54(8):2047-55.
Score: 0.045
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Copy number polymorphisms and anticancer pharmacogenomics. Genome Biol. 2011; 12(5):R46.
Score: 0.045
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Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet. 2011 Jun 15; 20(12):2472-81.
Score: 0.045
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Finding the missing heritability of complex diseases. Nature. 2009 Oct 08; 461(7265):747-53.
Score: 0.041
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Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility. Blood. 2009 May 28; 113(22):5575-82.
Score: 0.039
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Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 05; 147B(7):1116-25.
Score: 0.038
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Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans. Breast Cancer Res Treat. 2008 Jul; 110(2):367-76.
Score: 0.035
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Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. Biol Psychiatry. 2007 Oct 15; 62(8):856-62.
Score: 0.034
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Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases? Eur J Hum Genet. 2007 Mar; 15(3):260-3.
Score: 0.033
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Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci. J Allergy Clin Immunol. 2006 Aug; 118(2):396-402.
Score: 0.032
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Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. Diabetologia. 2006 Jul; 49(7):1560-6.
Score: 0.032
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Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet. 2006 Feb; 78(2):315-33.
Score: 0.031
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Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease. Lupus Sci Med. 2025 Jun 12; 12(1).
Score: 0.030
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Haplotype structure and phylogenetic shadowing of a hypervariable region in the CAPN10 gene. Hum Genet. 2005 Jul; 117(2-3):258-66.
Score: 0.030
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Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 Feb; 76(2):349-57.
Score: 0.029
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Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes. 2004 Oct; 53(10):2676-83.
Score: 0.029
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Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry. 2004 Jul 01; 56(1):18-23.
Score: 0.028
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Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes. 2004 Jun; 53(6):1609-13.
Score: 0.028
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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nat Hum Behav. 2024 Jun; 8(6):1177-1193.
Score: 0.028
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Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI. Nat Commun. 2024 Feb 03; 15(1):1016.
Score: 0.027
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Linkage of calpain 10 to type 2 diabetes: the biological rationale. Diabetes. 2004 Feb; 53 Suppl 1:S19-25.
Score: 0.027
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APOL1 and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus. Lupus. 2023 May; 32(6):763-770.
Score: 0.026
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Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects. Diabetes. 2003 Jan; 52(1):209-13.
Score: 0.025
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Ancestry, ACKR1 and leucopenia in patients with systemic lupus erythematosus. Lupus Sci Med. 2022 11; 9(1).
Score: 0.025
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Genome-wide association analyses of common infections in a large practice-based biobank. BMC Genomics. 2022 Sep 27; 23(1):672.
Score: 0.025
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Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 07 29; 145(7):2541-2554.
Score: 0.025
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Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Jun; 87(6):2606-10.
Score: 0.024
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Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Apr; 87(4):1669-73.
Score: 0.024
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Calpain 10 and genetics of type 2 diabetes. Curr Diab Rep. 2002 Apr; 2(2):186-90.
Score: 0.024
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Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am J Hum Genet. 2002 May; 70(5):1096-106.
Score: 0.024
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Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. Genome Biol. 2022 01 13; 23(1):23.
Score: 0.024
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Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene. Hum Mol Genet. 2001 Oct 01; 10(20):2301-5.
Score: 0.023
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Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet. 2021 10 07; 108(10):1836-1851.
Score: 0.023
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Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies. J Hum Genet. 2022 Feb; 67(2):87-93.
Score: 0.023
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Recommendations for Statistical Reporting in Cardiovascular Medicine: A Special Report From the American Heart Association. Circulation. 2021 07 27; 144(4):e70-e91.
Score: 0.023
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Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis. Lupus. 2021 Jul; 30(8):1264-1272.
Score: 0.023
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Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet. 2001 Jun; 68(6):1437-46.
Score: 0.023
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Genome-wide approaches for identifying interacting susceptibility regions for asthma. Genet Epidemiol. 2001; 21 Suppl 1:S266-71.
Score: 0.022
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Introduction: interactions in asthma.. Genet Epidemiol. 2001; 21 Suppl 1:S264-5.
Score: 0.022
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000 Oct; 26(2):163-75.
Score: 0.022
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Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis. Arthritis Rheumatol. 2020 09; 72(9):1483-1492.
Score: 0.021
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Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716.
Score: 0.021
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Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease. Mol Psychiatry. 2021 08; 26(8):4254-4264.
Score: 0.020
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Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms. Clin Cancer Res. 2019 07 01; 25(13):4104-4116.
Score: 0.020
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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat Genet. 2019 04; 51(4):659-674.
Score: 0.020
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Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. Am J Psychiatry. 2019 03 01; 176(3):217-227.
Score: 0.019
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LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins. Circulation. 2018 10 23; 138(17):1839-1849.
Score: 0.019
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LNK deficiency promotes acute aortic dissection and rupture. JCI Insight. 2018 10 18; 3(20).
Score: 0.019
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The genetics of asthma. Mapping genes for complex traits in founder populations. Clin Exp Allergy. 1998 Apr; 28 Suppl 1:101-5; discussion 108-10.
Score: 0.018
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An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies. Genome Med. 2018 01 29; 10(1):7.
Score: 0.018
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Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 2017 Jun 21; 94(6):1101-1111.e7.
Score: 0.017
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Genetic resilience to amyloid related cognitive decline. Brain Imaging Behav. 2017 04; 11(2):401-409.
Score: 0.017
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017 07; 66(7):2019-2032.
Score: 0.017
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Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. Mol Autism. 2017; 8:14.
Score: 0.017
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Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. PLoS One. 2017; 12(2):e0172880.
Score: 0.017
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Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Hum Mol Genet. 2016 11 01; 25(21):4835-4846.
Score: 0.017
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A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. Nat Commun. 2016 Feb 12; 7:10635.
Score: 0.016
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A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015 Sep; 47(9):1091-8.
Score: 0.015
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Genome-wide interrogation of longitudinal FEV1 in children with asthma. Am J Respir Crit Care Med. 2014 Sep 15; 190(6):619-27.
Score: 0.014
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Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):910-9.
Score: 0.014
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Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5968-73.
Score: 0.014
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Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients. Clin Pharmacol Ther. 2014 Jun; 95(6):644-52.
Score: 0.014
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar; 46(3):234-44.
Score: 0.014
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A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69.
Score: 0.014
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A genome-wide integrative study of microRNAs in human liver. BMC Genomics. 2013 Jun 13; 14:395.
Score: 0.013
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Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival. J Natl Cancer Inst. 2013 Feb 20; 105(4):302-9.
Score: 0.013
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An exponential combination procedure for set-based association tests in sequencing studies. Am J Hum Genet. 2012 Dec 07; 91(6):977-86.
Score: 0.013
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Variants affecting exon skipping contribute to complex traits. PLoS Genet. 2012; 8(10):e1002998.
Score: 0.013
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A genome-wide association study of breast cancer in women of African ancestry. Hum Genet. 2013 Jan; 132(1):39-48.
Score: 0.012
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Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes. Genet Epidemiol. 2012 Dec; 36(8):820-8.
Score: 0.012
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The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy. PLoS One. 2012; 7(3):e32958.
Score: 0.012
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Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry. Breast Cancer Res Treat. 2012 Feb; 132(1):341-5.
Score: 0.012
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Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 2011 Aug 28; 43(10):1022-5.
Score: 0.012
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Factors that impact susceptibility to fiber-induced health effects. J Toxicol Environ Health B Crit Rev. 2011; 14(1-4):246-66.
Score: 0.011
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Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. Clin Pharmacol Ther. 2010 Aug; 88(2):191-6.
Score: 0.011
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Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60. Transl Res. 2010 Jul; 156(1):7-14.
Score: 0.011
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Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Mol Psychiatry. 2010 Sep; 15(9):928-37.
Score: 0.010
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Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 05; 147B(1):59-67.
Score: 0.009
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Gender-specific differences in expression in human lymphoblastoid cell lines. Pharmacogenet Genomics. 2007 Jun; 17(6):447-50.
Score: 0.009
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A German genome-wide linkage scan for type 2 diabetes supports the existence of a metabolic syndrome locus on chromosome 1p36.13 and a type 2 diabetes locus on chromosome 16p12.2. Diabetologia. 2007 Jul; 50(7):1418-22.
Score: 0.009
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Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium. Hum Hered. 2008; 66(1):35-49.
Score: 0.008
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Combined analysis of three whole genome linkage scans for Ankylosing Spondylitis. Rheumatology (Oxford). 2007 May; 46(5):763-71.
Score: 0.008
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Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry. 2006 Jul; 63(7):778-85.
Score: 0.008
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Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Mol Psychiatry. 2004 Jan; 9(1):87-92; image 5.
Score: 0.007
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Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol. 2003 Apr; 111(4):840-6.
Score: 0.006
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Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Diabetes. 2002 Dec; 51(12):3561-7.
Score: 0.006
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Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Sep; 87(9):4297-300.
Score: 0.006
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Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002 Feb; 87(2):650-4.
Score: 0.006
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A statistical method for identification of polymorphisms that explain a linkage result. Am J Hum Genet. 2002 Feb; 70(2):399-411.
Score: 0.006
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A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet. 1998 Jul; 19(3):292-6.
Score: 0.005
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A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet. 1996 Jun; 13(2):161-6.
Score: 0.004
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Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes. 1995 Aug; 44(8):999-1001.
Score: 0.004