LucyGodley22VmD60QeczMknJtY0fp/Cv/+94=Lucy Godley41.78927490000000-87.601250000000001017Godley, LucyProfessorplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1006961Authorship 1011086Authorship 1007451Authorship 1013955Authorship 10106816Authorship 101341227497531Rojek K, Nickels E, Neistadt B, Marquez R, Wickrema A, Artz A, van Besien K, Larson RA, Lee MK, Segal JP, King MC, Walsh T, Shimamura A, Keel SB, Churpek JE, Godley LABiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationIdentifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy. Biol Blood Marrow Transplant. 2016 11; 22(11):2100-2103.Biol Blood Marrow Transplant2016-08-04T00:00:002016Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.27899193Feurstein S, Drazer MW, Godley LASeminars in oncologyGenetic predisposition to leukemia and other hematologic malignancies. Semin Oncol. 2016 Oct; 43(5):598-608.Semin Oncol2016-10-25T00:00:002016Genetic predisposition to leukemia and other hematologic malignancies.27950013Godley LA, Steensma DP, Baer MR, Slack JL, Buckstein R, Larsen JS, Arora S, Cullen MT, Kantarjian HMJournal of clinical oncology : official journal of the American Society of Clinical OncologyCytogenetic responses to a 5-day dosing schedule of decitabine in patients (Pts) with myelodysplastic syndromes (MDS). J Clin Oncol. 2008 May 20; 26(15_suppl):7030.J Clin Oncol2008-05-20T00:00:002008Cytogenetic responses to a 5-day dosing schedule of decitabine in patients (Pts) with myelodysplastic syndromes (MDS).27950008Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA, Larsen JS, Arora S, Cullen MT, Kantarjian HMJournal of clinical oncology : official journal of the American Society of Clinical OncologyA multicenter phase II trial of the decitabine alternative 5-day dosing regimen: Analysis of efficacy in various subgroups of patients with myelodysplastic syndromes (MDS). J Clin Oncol. 2008 May 20; 26(15_suppl):7032.J Clin Oncol2008-05-20T00:00:002008A multicenter phase II trial of the decitabine alternative 5-day dosing regimen: Analysis of efficacy in various subgroups of patients with myelodysplastic syndromes (MDS).27471235University of Chicago Hematopoietic Malignancies Cancer Risk TeamBloodHow I diagnose and manage individuals at risk for inherited myeloid malignancies. Blood. 2016 10 06; 128(14):1800-1813.Blood2016-07-28T00:00:002016How I diagnose and manage individuals at risk for inherited myeloid malignancies.28278716Khan N, Hantel A, Knoebel RW, Artz A, Larson RA, Godley LA, Thirman MJ, Liu H, Churpek JE, King D, Odenike O, Stock WLeukemia & lymphomaEfficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia. Leuk Lymphoma. 2017 09; 58(9):1-7.Leuk Lymphoma2017-02-20T00:00:002017Efficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia.Authorship 101840128302692Godley LABloodDNAJC21: the new kid on the SDS block. Blood. 2017 03 16; 129(11):1413-1414.Blood2017-03-16T00:00:002017DNAJC21: the new kid on the SDS block.Authorship 104492228555414Feurstein S, Godley LAInternational journal of hematologyGermline ETV6 mutations and predisposition to hematological malignancies. Int J Hematol. 2017 Aug; 106(2):189-195.Int J Hematol2017-05-29T00:00:002017Germline ETV6 mutations and predisposition to hematological malignancies.Authorship 104669128600339Godley LA, Shimamura ABloodGenetic predisposition to hematologic malignancies: management and surveillance. Blood. 2017 07 27; 130(4):424-432.Blood2017-06-09T00:00:002017Genetic predisposition to hematologic malignancies: management and surveillance.Authorship 105621428637618Brown AL, Churpek JE, Malcovati L, Döhner H, Godley LASeminars in hematologyRecognition of familial myeloid neoplasia in adults. Semin Hematol. 2017 04; 54(2):60-68.Semin Hematol2017-04-18T00:00:002017Recognition of familial myeloid neoplasia in adults.28835720McNerney ME, Godley LA, Le Beau MMNature reviews. CancerTherapy-related myeloid neoplasms: when genetics and environment collide. Nat Rev Cancer. 2017 08 24; 17(9):513-527.Nat Rev Cancer2017-08-24T00:00:002017Therapy-related myeloid neoplasms: when genetics and environment collide.Authorship 107121229769727Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri BNatureMicrobial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584.Nature2018-05-16T00:00:002018Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.Authorship 10990226Authorship 1122578Authorship 11485230Authorship 11594316Authorship 11228010Authorship 1166213Authorship 1169161Authorship 1187594Authorship 1205276Authorship 11778315Authorship 1179401Authorship 1244652Authorship 123205429365323Drazer MW, Kadri S, Sukhanova M, Patil SA, West AH, Feurstein S, Calderon DA, Jones MF, Weipert CM, Daugherty CK, Ceballos-López AA, Raca G, Lingen MW, Li Z, Segal JP, Churpek JE, Godley LABlood advancesPrognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies. Blood Adv. 2018 01 23; 2(2):146-150.Blood Adv2018-01-23T00:00:002018Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.29270394Desai AV, Perpich M, Godley LAFrontiers in pediatricsClinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience. Front Pediatr. 2017; 5:252.Front Pediatr2017-12-06T00:00:002017Clinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience.29559475Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip J, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SMCancer researchGermline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018 05 15; 78(10):2747-2759.Cancer Res2018-03-20T00:00:002018Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.30259338Akpan IJ, Osman AEG, Drazer MW, Godley LACurrent hematologic malignancy reportsHereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies. Curr Hematol Malig Rep. 2018 12; 13(6):426-434.Curr Hematol Malig Rep2018-12-01T00:00:002018Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies.30423270Osman AEG, Anderson J, Churpek JE, Christ TN, Curran E, Godley LA, Liu H, Thirman MJ, Odenike T, Stock W, Larson RAJournal of oncology practiceTreatment of Acute Promyelocytic Leukemia in Adults. J Oncol Pract. 2018 11; 14(11):649-657.J Oncol Pract2018-11-01T00:00:002018Treatment of Acute Promyelocytic Leukemia in Adults.30287469Busque L, Godley LABloodMBD4: guardian of the epigenetic galaxy. Blood. 2018 10 04; 132(14):1468-1469.Blood2018-10-04T00:00:002018MBD4: guardian of the epigenetic galaxy.29288821Tsai SB, Rhodes J, Liu H, Shore T, Bishop M, Cushing MM, Gergis U, Godley L, Kline J, Larson RA, Mayer S, Odenike O, Stock W, Wickrema A, van Besien K, Artz ASBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationReduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults. Biol Blood Marrow Transplant. 2018 05; 24(5):997-1004.Biol Blood Marrow Transplant2017-12-27T00:00:002017Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults.30466750Obrochta E, Godley LABest practice & research. Clinical haematologyIdentifying patients with genetic predisposition to acute myeloid leukemia. Best Pract Res Clin Haematol. 2018 12; 31(4):373-378.Best Pract Res Clin Haematol2018-09-25T00:00:002018Identifying patients with genetic predisposition to acute myeloid leukemia.29304833Wang AY, Weiner H, Green M, Chang H, Fulton N, Larson RA, Odenike O, Artz AS, Bishop MR, Godley LA, Thirman MJ, Kosuri S, Churpek JE, Curran E, Pettit K, Stock W, Liu HJournal of hematology & oncologyA phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia. J Hematol Oncol. 2018 01 05; 11(1):4.J Hematol Oncol2018-01-05T00:00:002018A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia.29146818Godley LABloodMutant RUNX1 and histone tales. Blood. 2017 11 16; 130(20):2156-2157.Blood2017-11-16T00:00:002017Mutant RUNX1 and histone tales.28986391Bhattacharyya S, Pradhan K, Campbell N, Mazdo J, Vasantkumar A, Maqbool S, Bhagat TD, Gupta S, Suzuki M, Yu Y, Greally JM, Steidl U, Bradner J, Dawlaty M, Godley L, Maitra A, Verma AGenome researchAltered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways. Genome Res. 2017 11; 27(11):1830-1842.Genome Res2017-10-06T00:00:002017Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.30070150D'Angelo CR, Novitsky B, Mee Lee S, Godley LA, Kline J, Larson RA, Liu H, Odenike O, Stock W, Bishop MR, Artz ASLeukemia & lymphomaCharacterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation. Leuk Lymphoma. 2019 03; 60(3):629-638.Leuk Lymphoma2018-08-02T00:00:002018Characterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation.Authorship 126521730622841Fan Y, Artz AS, van Besien K, Stock W, Larson RA, Odenike O, Godley LA, Kline J, Cunningham JM, LaBelle JL, Bishop MR, Liu HExperimental hematology & oncologyOutcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant. Exp Hematol Oncol. 2019; 8:1.Exp Hematol Oncol2019-01-03T00:00:002019Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant.Authorship 127822Authorship 128244730819616Moshfegh CM, Collins CW, Gunda V, Vasanthakumar A, Cao JZ, Singh PK, Godley LA, Case AJRedox biologyMitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes. Redox Biol. 2019 10; 27:101141.Redox Biol2019-02-21T00:00:002019Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes.Authorship 126151Authorship 1288131930944118Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema ACancer discoveryCytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Cancer Discov. 2019 06; 9(6):778-795.Cancer Discov2019-04-03T00:00:002019Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.Authorship 181992Authorship 174534Authorship 184392Authorship 129631431101556Trottier AM, Cavalcante de Andrade Silva M, Li Z, Godley LACancer geneticsSomatic mutation panels: Time to clear their names. Cancer Genet. 2019 06; 235-236:84-92.Cancer Genet2019-04-26T00:00:002019Somatic mutation panels: Time to clear their names.Authorship 16452131179414Applebaum MA, Barr EK, Karpus J, Nie J, Zhang Z, Armstrong AE, Uppal S, Sukhanova M, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman R, Godley LA, Stranger BE, He C, Cohn SLJCO precision oncology5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype. JCO Precis Oncol. 2019; 3.JCO Precis Oncol2019-05-16T00:00:0020195-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype.Authorship 13002315Authorship 130174131221794Godley LABloodFouNdER mutations confer risk for leukemias. Blood. 2019 06 20; 133(25):2636-2638.Blood2019-06-20T00:00:002019FouNdER mutations confer risk for leukemias.Authorship 215023D009190Disorders543450.762141Myelodysplastic SyndromesAuthorship 274576Authorship 132797131506287Godley LABlood advancesInherited predisposition to myeloid malignancies. Blood Adv. 2019 09 10; 3(17):2688.Blood Adv2019-09-10T00:00:002019Inherited predisposition to myeloid malignancies.Authorship 329042Authorship 331821Authorship 329076Authorship 343529Authorship 286856Authorship 350434Authorship 1336924Authorship 1337183231647332Brown AL, Hahn C, Hiwase D, Godley LA, Scott HSLeukemia & lymphomaCorrect application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis. Leuk Lymphoma. 2020 01; 61(1):246-247.Leuk Lymphoma2019-10-24T00:00:002019Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis.31648317Luo X, Feurstein S, Mohan S, Porter CC, Jackson SA, Keel S, Chicka M, Brown AL, Kesserwan C, Agarwal A, Luo M, Li Z, Ross JE, Baliakas P, Pineda-Alvarez D, DiNardo CD, Bertuch AA, Mehta N, Vulliamy T, Wang Y, Nichols KE, Malcovati L, Walsh MF, Rawlings LH, McWeeney SK, Soulier J, Raimbault A, Routbort MJ, Zhang L, Ryan G, Speck NA, Plon SE, Wu D, Godley LABlood advancesClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants. Blood Adv. 2019 10 22; 3(20):2962-2979.Blood Adv2019-10-22T00:00:002019ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.Authorship 359977Authorship 363854Authorship 415771Authorship 329725Authorship 432952Authorship 433136Authorship 1348211531852832Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Oliva M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman RL, Godley LA, Stranger BE, He C, Cohn SLClinical cancer research : an official journal of the American Association for Cancer Research5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 03 15; 26(6):1309-1317.Clin Cancer Res2019-12-18T00:00:0020195-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.Authorship 4551013Authorship 4583316Authorship 348619Authorship 478591Authorship 469247Authorship 4695616Authorship 479091Authorship 348019Authorship 381433Authorship 383865Authorship 4903618Authorship 382511Authorship 454728Authorship 4609311Authorship 135939932074275Cahill KE, Karimi YH, Karrison TG, Jain N, Green M, Weiner H, Fulton N, Kadri S, Godley LA, Artz AS, Liu H, Thirman MJ, Le Beau MM, McNerney ME, Segal J, Larson RA, Stock W, Odenike OBlood advancesA phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia. Blood Adv. 2020 02 25; 4(4):599-606.Blood Adv2020-02-25T00:00:002020A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.Authorship 136035932101699Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCTCell chemical biologyMYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Cell Chem Biol. 2020 05 21; 27(5):538-550.e7.Cell Chem Biol2020-02-25T00:00:002020MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.Authorship 370876Authorship 418423Authorship 136319732165484Wu D, Luo X, Feurstein S, Kesserwan C, Mohan S, Pineda-Alvarez DE, Godley LA, collaborative group of the American Society of Hematology - Clinical Genome Resource Myeloid MalignaHaematologicaHow I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies. Haematologica. 2020 04; 105(4):870-887.Haematologica2020-03-12T00:00:002020How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies.Authorship 4952417Authorship 1364495132208489Brown AL, Arts P, Carmichael CL, Babic M, Dobbins J, Chong CE, Schreiber AW, Feng J, Phillips K, Wang PPS, Ha T, Homan CC, King-Smith SL, Rawlings L, Vakulin C, Dubowsky A, Burdett J, Moore S, McKavanagh G, Henry D, Wells A, Mercorella B, Nicola M, Suttle J, Wilkins E, Li XC, Michaud J, Brautigan P, Cannon P, Altree M, Jaensch L, Fine M, Butcher C, D'Andrea RJ, Lewis ID, Hiwase DK, Papaemmanuil E, Horwitz MS, Natsoulis G, Rienhoff HY, Patton N, Mapp S, Susman R, Morgan S, Cooney J, Currie M, Popat U, Bochtler T, Izraeli S, Bradstock K, Godley LA, Krämer A, Fröhling S, Wei AH, Forsyth C, Mar Fan H, Poplawski NK, Hahn CN, Scott HSBlood advancesRUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Adv. 2020 03 24; 4(6):1131-1144.Blood Adv2020-03-24T00:00:002020RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.Authorship 410641Authorship 4173215Authorship 394165Authorship 443651Authorship 137030432286542Cavalcante de Andrade Silva M, Katsumura KR, Mehta C, Velloso EDRP, Bresnick EH, Godley LALeukemiaBreaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome. Leukemia. 2021 01; 35(1):264-268.Leukemia2020-04-14T00:00:002020Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome.Authorship 423954Authorship 425126Authorship 427037Authorship 443574Authorship 4328420Authorship 4336915Authorship 4373113Authorship 438519Authorship 463603Authorship 4785110Authorship 441341Authorship 4547022Authorship 493671Authorship 138818332618208Kewan T, Noss R, Godley LA, Rogers HJ, Carraway HEJournal of investigative medicine high impact case reportsInherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620938941.J Investig Med High Impact Case Rep2020-01-01T00:00:002020Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome.Authorship 139051432634239Cao JZ, Liu H, Wickrema A, Godley LABlood advancesHIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. Blood Adv. 2020 07 14; 4(13):3053-3062.Blood Adv2020-07-14T00:00:002020HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia.Authorship 483333Authorship 121352Authorship 140178232807974Roloff GW, Godley LA, Drazer MWGenetics in medicine : official journal of the American College of Medical GeneticsAssessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies. Genet Med. 2021 01; 23(1):211-214.Genet Med2020-08-18T00:00:002020Assessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies.Authorship 302619Authorship 316796Authorship 357881Authorship 367702Authorship 416107Authorship 467875Authorship 140660532916696Toubiana S, Larom G, Smoom R, Duszynski RJ, Godley LA, Francastel C, Velasco G, Selig SHuman molecular geneticsRegulation of telomeric function by DNA methylation differs between humans and mice. Hum Mol Genet. 2020 11 25; 29(19):3197-3210.Hum Mol Genet2020-11-25T00:00:002020Regulation of telomeric function by DNA methylation differs between humans and mice.Authorship 47271138895979Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HEProgress in clinical and biological researchThe role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Prog Clin Biol Res. 1996; 395:1-11.Prog Clin Biol Res1996-01-01T00:00:001996The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.Authorship 1414041233035329Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, West DePersia AH, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME, Churpek JEBlood advancesTelomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Adv. 2020 10 13; 4(19):4873-4886.Blood Adv2020-10-13T00:00:002020Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations.D018095Physiology1123290.804045Germ-Line Mutation10486214Godley LA, Lai F, Liu J, Zhao N, Le Beau MMGenomicsTTID: A novel gene at 5q31 encoding a protein with titin-like features. Genomics. 1999 Sep 01; 60(2):226-33.Genomics1999-09-01T00:00:001999TTID: A novel gene at 5q31 encoding a protein with titin-like features.KoenVan BesienKoen Van Besien0.000000000000000.000000000000002944Van Besien, KoenPROFESSORAuthorship 1417111033108454Trottier AM, Druhan LJ, Kraft IL, Lance A, Feurstein S, Helgeson M, Segal JP, Das S, Avalos BR, Godley LABlood advancesHeterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies. Blood Adv. 2020 10 27; 4(20):5269-5284.Blood Adv2020-10-27T00:00:002020Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies.Authorship 142219233236764Kraft IL, Godley LABloodIdentifying potential germline variants from sequencing hematopoietic malignancies. Blood. 2020 11 26; 136(22):2498-2506.Blood2020-11-26T00:00:002020Identifying potential germline variants from sequencing hematopoietic malignancies.10843806Lai F, Orelli BJ, Till BG, Godley LA, Fernald AA, Pamintuan L, Le Beau MMGenomicsMolecular characterization of KLHL3, a human homologue of the Drosophila kelch gene. Genomics. 2000 May 15; 66(1):65-75.Genomics2000-05-15T00:00:002000Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.11087669Lai F, Godley LA, Fernald AA, Orelli BJ, Pamintuan L, Zhao N, Le Beau MMGenomicscDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Genomics. 2000 Nov 15; 70(1):123-30.Genomics2000-11-15T00:00:002000cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins.12417757Qian Z, Fernald AA, Godley LA, Larson RA, Le Beau MMProceedings of the National Academy of Sciences of the United States of AmericaExpression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14925-30.Proc Natl Acad Sci U S A2002-11-04T00:00:002002Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.Authorship 142474233275754Kraft IL, Godley LAHematology. American Society of Hematology. Education ProgramIdentifying potential germline variants from sequencing hematopoietic malignancies. 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Epigenetics. 2012 Feb; 7(2):201-7.Epigenetics2012-02-01T00:00:002012Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.Authorship 148153234298596Saygin C, Godley LACancersGenetics of Myelodysplastic Syndromes. Cancers (Basel). 2021 Jul 06; 13(14).Cancers (Basel)2021-07-06T00:00:002021Genetics of Myelodysplastic Syndromes.21421111Godley LA, Cunningham J, Dolan ME, Huang RS, Gurbuxani S, McNerney ME, Larson RA, Leong H, Lussier Y, Onel K, Odenike O, Stock W, White KP, Le Beau MMSeminars in oncologyAn integrated genomic approach to the assessment and treatment of acute myeloid leukemia. Semin Oncol. 2011 Apr; 38(2):215-24.Semin Oncol2011-04-01T00:00:002011An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.22138693Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MANature geneticsDnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 04; 44(1):23-31.Nat Genet2011-12-04T00:00:002011Dnmt3a is essential for hematopoietic stem cell differentiation.22232674Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaEpigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20.Proc Natl Acad Sci U S A2012-01-09T00:00:002012Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.20846103Churpek JE, Garcia JS, Madzo J, Jackson SA, Onel K, Godley LALeukemia & lymphomaIdentification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder. Leuk Lymphoma. 2010 Oct; 51(10):1931-5.Leuk Lymphoma2010-10-01T00:00:002010Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.Authorship 148910134405775Godley LALeukemia & lymphomaAnticipation in hematopoietic malignancies: biology, bias, or both? Leuk Lymphoma. 2021 12; 62(13):3070-3072.Leuk Lymphoma2021-08-18T00:00:002021Anticipation in hematopoietic malignancies: biology, bias, or both?Authorship 149031434435481Cao JZ, Bigelow K, Wickrema A, Godley LAHaematologicaBET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines. Haematologica. 2021 12 01; 106(12):3223-3227.Haematologica2021-12-01T00:00:002021BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines.Authorship 149668534492705Patel AA, Rojek AE, Drazer MW, Weiner H, Godley LA, Le Beau MM, Larson RABlood advancesTherapy-related myeloid neoplasms in 109 patients after radiation monotherapy. Blood Adv. 2021 10 26; 5(20):4140-4148.Blood Adv2021-10-26T00:00:002021Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy.17917958Godley LALeukemia & lymphomaHMGA2 levels in CML: reflective of miRNA gene regulation in a hematopoietic tumor? Leuk Lymphoma. 2007 Oct; 48(10):1898-9.Leuk Lymphoma2007-10-01T00:00:002007HMGA2 levels in CML: reflective of miRNA gene regulation in a hematopoietic tumor?19528372Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA, Garcia-Manero G, Albitar M, Larsen JS, Arora S, Cullen MT, Kantarjian HJournal of clinical oncology : official journal of the American Society of Clinical OncologyMulticenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol. 2009 Aug 10; 27(23):3842-8.J Clin Oncol2009-06-15T00:00:002009Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial.8668193Broccoli D, Godley LA, Donehower LA, Varmus HE, de Lange TMolecular and cellular biologyTelomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol. 1996 Jul; 16(7):3765-72.Mol Cell Biol1996-07-01T00:00:001996Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.22037496Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, Jin PNature neuroscience5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci. 2011 Oct 30; 14(12):1607-16.Nat Neurosci2011-10-30T00:00:0020115-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.22417205Godley LAThe New England journal of medicineProfiles in leukemia. N Engl J Med. 2012 Mar 22; 366(12):1152-3.N Engl J Med2012-03-14T00:00:002012Profiles in leukemia.8846920Godley LA, Kopp JB, Eckhaus M, Paglino JJ, Owens J, Varmus HEGenes & developmentWild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes Dev. 1996 Apr 01; 10(7):836-50.Genes Dev1996-04-01T00:00:001996Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.16009946van Besien K, Artz A, Smith S, Cao D, Rich S, Godley L, Jones D, Del Cerro P, Bennett D, Casey B, Odenike O, Thirman M, Daugherty C, Wickrema A, Zimmerman T, Larson RA, Stock WJournal of clinical oncology : official journal of the American Society of Clinical OncologyFludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol. 2005 Aug 20; 23(24):5728-38.J Clin Oncol2005-07-11T00:00:002005Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome.18425419Stock W, Undevia SD, Bivins C, Ravandi F, Odenike O, Faderl S, Rich E, Borthakur G, Godley L, Verstovsek S, Artz A, Wierda W, Larson RA, Zhang Y, Cortes J, Ratain MJ, Giles FJInvestigational new drugsA phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia. Invest New Drugs. 2008 Aug; 26(4):331-8.Invest New Drugs2008-04-19T00:00:002008A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia.18473998Mattison RJ, Ostler KR, Locke FL, Godley LAReviews on recent clinical trialsImplications of FLT3 mutations in the therapy of acute myeloid leukemia. Rev Recent Clin Trials. 2007 May; 2(2):135-41.Rev Recent Clin Trials2007-05-01T00:00:002007Implications of FLT3 mutations in the therapy of acute myeloid leukemia.18766971Ozer O, Zhao YD, Ostler KR, Akin C, Anastasi J, Vardiman JW, Godley LALeukemia & lymphomaThe identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells. Leuk Lymphoma. 2008 Aug; 49(8):1567-77.Leuk Lymphoma2008-08-01T00:00:002008The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells.20587527Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LACancer researchDNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 2010 Jul 15; 70(14):5840-50.Cancer Res2010-06-29T00:00:002010DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.20616953Garcia JS, Jain N, Godley LAOncoTargets and therapyAn update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes. Onco Targets Ther. 2010 Jun 24; 3:1-13.Onco Targets Ther2010-06-24T00:00:002010An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes.21133735Larson SM, Godley LALeukemia & lymphomaGetting to the root of the stem cell in mutated chronic myeloid leukemia. Leuk Lymphoma. 2010 Dec; 51(12):2147-8.Leuk Lymphoma2010-12-01T00:00:002010Getting to the root of the stem cell in mutated chronic myeloid leukemia.21142785Kenkre VP, Horowitz S, Artz AS, Liao C, Cohen KS, Godley LA, Kline JP, Smith SM, Stock W, van Besien KLeukemia & lymphomaT-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. Predictors for survival after transplant relapse. Leuk Lymphoma. 2011 Feb; 52(2):214-22.Leuk Lymphoma2010-12-10T00:00:002010T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. Predictors for survival after transplant relapse.22548695Richa EM, Kunnavakkam R, Godley LA, Kline J, Odenike O, Larson RA, Nguyen V, Stock W, Wickrema A, Van Besien K, Artz ASCytotherapyInfluence of related donor age on outcomes after peripheral blood stem cell transplantation. Cytotherapy. 2012 Jul; 14(6):707-15.Cytotherapy2012-05-02T00:00:002012Influence of related donor age on outcomes after peripheral blood stem cell transplantation.23001125Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RLNature geneticsRecurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012 Nov; 44(11):1179-81.Nat Genet2012-09-23T00:00:002012Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.Authorship 15179226Authorship 151880334994594Roloff GW, Drazer MW, Godley LAJCO precision oncologyInherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology. JCO Precis Oncol. 2021 11; 5:107-122.JCO Precis Oncol2021-11-01T00:00:002021Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology.34753908Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher PNature communicationsThe chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021 11 09; 12(1):6468.Nat Commun2021-11-09T00:00:002021The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.Authorship 152287435063349Feurstein S, Hahn CN, Mehta N, Godley LAGenetics in medicine : official journal of the American College of Medical GeneticsA practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias. Genet Med. 2022 04; 24(4):931-954.Genet Med2022-01-19T00:00:002022A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias.Authorship 1542041235419889DeRoin L, Cavalcante de Andrade Silva M, Petras K, Arndt K, Phillips N, Wanjari P, Subramanian HP, Montes D, McElherne J, Theissen M, Briese R, Das S, Godley LA, Segal J, Del Gaudio D, Fitzpatrick C, Churpek JEHuman mutationFeasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders. Hum Mutat. 2022 07; 43(7):950-962.Hum Mutat2022-04-14T00:00:002022Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders.Authorship 1547322335537115Drazer MW, Homan CC, Yu K, Cavalcante de Andrade Silva M, McNeely KE, Pozsgai MJ, Acevedo-Mendez MG, Segal JP, Wang P, Feng J, King-Smith SL, Kim E, Korotev S, Lawrence DM, Schreiber AW, Hahn CN, Scott HS, Sood R, NISC Comparative Sequencing Program, Velloso EDRP, Brown AL, Liu PP, Godley LABlood advancesClonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations. Blood Adv. 2022 08 09; 6(15):4357-4359.Blood Adv2022-08-09T00:00:002022Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.Authorship 155261335674998Stubbins RJ, Korotev S, Godley LACurrent hematologic malignancy reportsGermline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies. Curr Hematol Malig Rep. 2022 08; 17(4):94-104.Curr Hematol Malig Rep2022-06-08T00:00:002022Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.Authorship 15580320Authorship 155801735764482Feurstein S, Luo X, Shah M, Walker T, Mehta N, Wu D, Godley LABlood advancesRevision of RUNX1 variant curation rules. Blood Adv. 2022 08 23; 6(16):4726-4730.Blood Adv2022-08-23T00:00:002022Revision of RUNX1 variant curation rules.35767897Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Branford S, Bueso-Ramos CE, Cortes JE, Dal Cin P, DiNardo CD, Dombret H, Duncavage EJ, Ebert BL, Estey EH, Facchetti F, Foucar K, Gangat N, Gianelli U, Godley LA, Gökbuget N, Gotlib J, Hellström-Lindberg E, Hobbs GS, Hoffman R, Jabbour EJ, Kiladjian JJ, Larson RA, Le Beau MM, Loh ML, Löwenberg B, Macintyre E, Malcovati L, Mullighan CG, Niemeyer C, Odenike OM, Ogawa S, Orfao A, Papaemmanuil E, Passamonti F, Porkka K, Pui CH, Radich JP, Reiter A, Rozman M, Rudelius M, Savona MR, Schiffer CA, Schmitt-Graeff A, Shimamura A, Sierra J, Stock WA, Stone RM, Tallman MS, Thiele J, Tien HF, Tzankov A, Vannucchi AM, Vyas P, Wei AH, Weinberg OK, Wierzbowska A, Cazzola M, Döhner H, Tefferi ABloodInternational Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022 09 15; 140(11):1200-1228.Blood2022-09-15T00:00:002022International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.Authorship 155874635797463Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg BBloodDiagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022 09 22; 140(12):1345-1377.Blood2022-09-22T00:00:002022Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.35844676Patel AA, Heng J, Dworkin E, Monick S, Derman BA, DuVall AS, Gurbuxani S, Kosuri S, Liu H, Thirman M, Godley LA, Odenike O, Larson RA, Stock WEJHaemEfficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults. EJHaem. 2021 Aug; 2(3):413-420.EJHaem2021-06-22T00:00:002021Efficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults.Authorship 15614711D019337Disorders953290.754473Hematologic Neoplasms36655425Roloff GW, Wen F, Ramsland A, Artz AS, Kosuri S, Stock W, Odenike O, Larson RA, Liu H, Godley LA, Thirman MJ, Patel AA, Daugherty CK, DuVall AS, Nawas MT, Dworkin E, Wool GD, Gurbuxani S, Fitzpatrick C, Segal JP, Wang P, Drazer MWHaematologicaClinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors. Haematologica. 2023 08 01; 108(8):2234-2239.Haematologica2023-08-01T00:00:002023Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors.35942521Hains AE, Uppal S, Cao JZ, Salwen HR, Applebaum MA, Cohn SL, Godley LAEpigeneticsMYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia. Epigenetics. 2022 12; 17(13):2056-2074.Epigenetics2022-08-08T00:00:002022MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.24373966Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LACell reportsHydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. Cell Rep. 2014 Jan 16; 6(1):231-244.Cell Rep2013-12-27T00:00:002013Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.24835990Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LACell reportsTET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014 Jun 12; 7(5):1343-1352.Cell Rep2014-05-15T00:00:002014TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.Authorship 1582577Authorship 15837120Authorship 15859222Authorship 1587065Authorship 15918320Authorship 1602483Authorship 15924115Authorship 15947314Authorship 15989910Authorship 1599247Authorship 1602854836322930Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Müller-Tidow C, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa SBloodGerm line DDX41 mutations define a unique subtype of myeloid neoplasms. Blood. 2023 02 02; 141(5):534-549.Blood2023-02-02T00:00:002023Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.36453641Osman AEG, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai M, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LABlood advancesPaired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv. 2023 05 09; 7(9):1910-1914.Blood Adv2023-05-09T00:00:002023Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones.36138229Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Gaiti F, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DANature geneticsSingle-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 10; 54(10):1514-1526.Nat Genet2022-09-22T00:00:002022Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.35969835Feurstein S, Trottier AM, Estrada-Merly N, Pozsgai M, McNeely K, Drazer MW, Ruhle B, Sadera K, Koppayi AL, Scott BL, Oran B, Nishihori T, Agrawal V, Saad A, Lindsley RC, Nakamura R, Kim S, Hu Z, Sobecks R, Spellman S, Saber W, Godley LABloodGerm line predisposition variants occur in myelodysplastic syndrome patients of all ages. Blood. 2022 12 15; 140(24):2533-2548.Blood2022-12-15T00:00:002022Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages.36001442Saygin C, Roloff G, Hahn CN, Chhetri R, Gill S, Elmariah H, Talati C, Nunley E, Gao G, Kim A, Bishop M, Kosuri S, Das S, Singhal D, Venugopal P, Homan CC, Brown A, Scott HS, Hiwase D, Godley LABlood advancesAllogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies. Blood Adv. 2023 02 28; 7(4):549-554.Blood Adv2023-02-28T00:00:002023Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies.36455200Makishima H, Bowman TV, Godley LABloodDDX41-associated susceptibility to myeloid neoplasms. Blood. 2023 03 30; 141(13):1544-1552.Blood2023-03-30T00:00:002023DDX41-associated susceptibility to myeloid neoplasms.36130297Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola MBloodGenomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Blood. 2022 11 24; 140(21):2228-2247.Blood2022-11-24T00:00:002022Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.36266327Kubota Y, Zawit M, Durrani J, Shen W, Bahaj W, Kewan T, Ponvilawan B, Mori M, Meggendorfer M, Gurnari C, LaFramboise T, Feurstein S, Sekeres MA, Visconte V, Godley LA, Haferlach T, Maciejewski JPLeukemiaSignificance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia. Leukemia. 2022 12; 36(12):2827-2834.Leukemia2022-10-20T00:00:002022Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia.36271151Niemeyer CM, Rudelius M, Shimamura A, Flotho C, Hasle H, Stieglitz E, Strahm B, Godley LA, Weinberg OK, Orazi A, Calvo KRLeukemiaClassification of rare pediatric myeloid neoplasia-Quo vadis? Leukemia. 2022 12; 36(12):2947-2948.Leukemia2022-10-21T00:00:002022Classification of rare pediatric myeloid neoplasia-Quo vadis?Authorship 160952136793609Godley LAFrontiers in oncologyPrioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies. Front Oncol. 2023; 13:1084736.Front Oncol2023-01-30T00:00:002023Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies.Authorship 1611541636809258Jung MM, Shen S, Botten GA, Olender T, Katsumura KR, Johnson KD, Soukup AA, Liu P, Zhang Q, Jensvold ZD, Lewis PW, Beagrie RA, Low JK, Yang L, Mackay JP, Godley LA, Brand M, Xu J, Keles S, Bresnick EHThe Journal of clinical investigationPathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. J Clin Invest. 2023 04 03; 133(7).J Clin Invest2023-04-03T00:00:002023Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.Authorship 1612661636847506Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JACancer discovery(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers. Cancer Discov. 2023 06 02; 13(6):1478-1497.Cancer Discov2023-06-02T00:00:002023(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.https://cgh.uchicago.edu/page/leadershipGlobal Healthhttps://www.uchicagomedicine.org/find-a-physician/physician/olufunmilayo-i-olopadeUChicago Medicinehttps://cancerbio.uchicago.edu/program/faculty/olufunmilayo-olopadeCancer Biologyhttps://www.uchicagomedicine.org/conditions-services/cancer/cancer-risk-preventionCancer Risk and Prevention2024-03-31NIHGODLEY, LUCY ANN ;WU, DAVID2021-04-20Myeloid Malignancy Variant Curation Expert PanelU24CA2581182025-05-31NIHAGARWAL, ANUPRIYA2021-07-01Hematopoiesis in germline RUNX1mutation carriers: impact of inflammation and the bone marrow nicheR01HL1554262013-02-28NIHGODLEY, LUCY ANN2008-04-01The Role of DNMT3B in the DNA Methylation of Cancer CellsR01CA1298312011-03-31NIHGODLEY, LUCY ANN2009-04-01A chemical crosslinking strategy to determine DNA methylating protein complexesR21CA1383102015-05-31NIHZHANG, WEI2011-08-01Epigenetic and Genetic Dissection of Drug ResponseR21HG006367Co-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal Investigatorhttps://www.thedrazergroup.org/Drazer Group WebsiteTwitter michaelwd Solving Mystery of a Rare Blood Cancer Leads to a Cure Solving the Mystery of a Blood Cancer Leads to a CureAuthorship 163175637139596Stubbins RJ, Asom AS, Wang P, Lager AM, Gary A, Godley LAHaematologicaGermline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies. Haematologica. 2024 Jan 01; 109(1):351-356.Haematologica2024-01-01T00:00:002024Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies.CanerSayginCaner Saygin41.7886000000000087.598699999999994321Saygin, CanerAssistant ProfessorD020022Physiology39922670.521997Genetic Predisposition to DiseaseAuthorship 1639302Authorship 1639514Authorship 1641166437405177Saheb Kashaf S, Godley LA, Chadha A, Waldinger JBJAAD case reportsSystemic mastocytosis, in the context of a deleterious germline SDHC variant, treated with ripretinib. JAAD Case Rep. 2023 Jul; 37:119-122.JAAD Case Rep2023-04-24T00:00:002023Systemic mastocytosis, in the context of a deleterious germline SDHC variant, treated with ripretinib.37406166Homan CC, Drazer MW, Yu K, Lawrence DM, Feng J, Arriola-Martinez L, Pozsgai MJ, McNeely KE, Ha T, Venugopal P, Arts P, King-Smith SL, Cheah J, Armstrong M, Wang P, Bödör C, Cantor AB, Cazzola M, Degelman E, DiNardo CD, Duployez N, Favier R, Fröhling S, Rio-Machin A, Klco JM, Krämer A, Kurokawa M, Lee J, Malcovati L, Morgan NV, Natsoulis G, Owen C, Patel KP, Preudhomme C, Raslova H, Rienhoff H, Ripperger T, Schulte R, Tawana K, Velloso E, Yan B, Kim E, Sood R, Hsu AP, Holland SM, Phillips K, Poplawski NK, Babic M, Wei AH, Forsyth C, Mar Fan H, Lewis ID, Cooney J, Susman R, Fox LC, Blombery P, Singhal D, Hiwase D, Phipson B, Schreiber AW, Hahn CN, Scott HS, Liu P, Godley LA, Brown AL, NISC Comparative Sequencing ProgramBlood advancesSomatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107.Blood Adv2023-10-24T00:00:002023Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.37421681Liu J, Osman AEG, Bolton K, Godley LALeukemia researchGermline predisposition to clonal hematopoiesis. Leuk Res. 2023 09; 132:107344.Leuk Res2023-06-19T00:00:002023Germline predisposition to clonal hematopoiesis.MedicinePathologyUniversity of Chicago11.47980.00691571707research areas2.644650.024545682coauthor of289.03736.896860similar to11225selected publicationsRichard A.LarsonRichard A. Larson41.78927490000000-87.601250000000001169Larson, Richard A.Professor37590029Godley LABloodGerm line risk variants: beyond cancer. Blood. 2023 08 17; 142(7):616-617.Blood2023-08-17T00:00:002023Germ line risk variants: beyond cancer.Authorship 1660571YonglanZhengYonglan Zheng41.78927490000000-87.601250000000001374Zheng, YonglanResearch Associate ProfessorWendyStockwHF9BKIeOfnamXNnYUHhvWD+6g==Wendy Stock41.78927490000000-87.601250000000001502Stock, WendyProfessorRitaNandaxWxoBaUUOfnamXNnYUHhvWD+6g==Rita Nanda41.78927490000000-87.601250000000001717Nanda, RitaAssociate ProfessorOlufunmilayoOlopade321vBIF1GuTQkntjbwjr93A=Olufunmilayo Olopade41.78927490000000-87.601250000000001960Olopade, OlufunmilayoProfessorHarvey M.GolombHarvey M. Golomb41.78927490000000-87.601250000000002105Golomb, Harvey M.ProfessorHedyKindler32lgBaUZHP75hHlsaUXv9Gq0+s+oHedy Kindler41.78927490000000-87.601250000000002499Kindler, HedyProfessorPeter H.O'DonnellPeter H. O'Donnell41.78927490000000-87.60125000000000537O'Donnell, Peter H.Associate ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorAuthorship 1676993Authorship 1678181637913908Williams LS, Williams KM, Gillis N, Bolton K, Damm F, Deuitch NT, Farhadfar N, Gergis U, Keel SB, Michelis FV, Panch SR, Porter CC, Sucheston-Campbell L, Tamari R, Stefanski HE, Godley LA, Lai CTransplantation and cellular therapyDonor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation. Transplant Cell Ther. 2024 Mar; 30(3):255-267.Transplant Cell Ther2023-10-31T00:00:002023Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation.37898151Gurnari C, Robin M, Godley LA, Drozd-Sokolowska J, Wlodarski MW, Raj K, Onida F, Worel N, Ciceri F, Carbacioglu S, Kenyon M, Aljurf M, Bonfim C, Makishima H, Niemeyer C, Fenaux P, Zebisch A, Hamad N, Chalandon Y, Hellström-Lindberg E, Voso MT, Mecucci C, Duarte FB, Sebert M, Sicre de Fontbrune F, Soulier J, Shimamura A, Lindsley RC, Maciejewski JP, Calado RT, Yakoub-Agha I, McLornan DPThe Lancet. HaematologyGermline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT. Lancet Haematol. 2023 Dec; 10(12):e994-e1005.Lancet Haematol2023-10-25T00:00:002023Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.Authorship 1685752438054407Kraft IL, Basdag H, Koppayi A, Rodgers CV, Saygin C, Haribabu Y, Wanjari P, Niu N, Das S, de Jong JLO, Segal J, Godley LAGenetics in medicine : official journal of the American College of Medical GeneticsSequential tumor molecular profiling identifies likely germline variants. Genet Med. 2024 Mar; 26(3):101037.Genet Med2023-12-03T00:00:002023Sequential tumor molecular profiling identifies likely germline variants.38150184Saygin C, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, Luskin MR, Knepper TC, Wanjari P, Wang P, Lager AM, Fitzpatrick C, Segal JP, Gharghabi M, Gurbuxani S, Venkataraman G, Cheng JX, Eisfelder BJ, Bohorquez O, Patel AA, Umesh Nagalakshmi S, Jayaram S, Odenike OM, Larson RA, Godley LA, Arber DA, Gibson CJ, Munshi NC, Marcucci G, Ebert BL, Greally JM, Steidl U, Lapalombella R, Shah BD, Stock WBlood cancer discoveryAcute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis. Blood Cancer Discov. 2023 Dec 27.Blood Cancer Discov2023-12-27T00:00:002023Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.Authorship 1692062538205536Feng Q, Xu K, Shah M, Li S, Leavitt AD, Godley LA, De Smith AJ, Wiemels JLHaematologicaEvaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population. Haematologica. 2024 Jan 11.Haematologica2024-01-11T00:00:002024Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population.Authorship 1694106https://voices.uchicago.edu/sayginlab/Saygin LabAuthorship 170681238426560Cobaleda C, Godley LA, Nichols KE, Wlodarski MW, Sanchez-Garcia ICancer discoveryInsights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions. Cancer Discov. 2024 Mar 01; 14(3):396-405.Cancer Discov2024-03-01T00:00:002024Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.Authorship 170923338490765Trottier AM, Feurstein S, Godley LABest practice & research. Clinical haematologyGermline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders. Best Pract Res Clin Haematol. 2024 Mar; 37(1):101537.Best Pract Res Clin Haematol2024-02-01T00:00:002024Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.true1PROFESSORPROFESSORtrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 6567318Authorship 669662Authorship 6591129Authorship 674196Authorship 683515Authorship 689706Authorship 686637Authorship 6961924Authorship 7007316Authorship 701529Authorship 724732Authorship 734798Authorship 744125Authorship 725651Authorship 765304Authorship 7753913Authorship 7720817Authorship 782973Authorship 773662Authorship 7768111Authorship 789677Authorship 791985Authorship 7854824Authorship 667664Authorship 672813Authorship 6862412Authorship 784062218818802Carbonaro A, Mohanty SK, Huang H, Godley LA, Sohn LLLab on a chipCell characterization using a protein-functionalized pore. Lab Chip. 2008 Sep; 8(9):1478-85.Lab Chip2008-07-25T00:00:002008Cell characterization using a protein-functionalized pore.23861445Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, Bhagat TD, Nischal S, Christopeit M, Parekh S, Steidl U, Godley L, Maitra A, Greally JM, Verma ANucleic acids researchGenome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. Nucleic Acids Res. 2013 Sep; 41(16):e157.Nucleic Acids Res2013-07-16T00:00:002013Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.23771005Locke F, Agarwal R, Kunnavakkam R, van Besien K, Larson RA, Odenike O, Godley LA, Liu H, Le Beau MM, Gurbuxani S, Thirman MJ, Sipkins D, White C, Artz A, Stock WBone marrow transplantationA novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes. Bone Marrow Transplant. 2013 Nov; 48(11):1437-43.Bone Marrow Transplant2013-06-17T00:00:002013A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.25154823Ustun C, Reiter A, Scott BL, Nakamura R, Damaj G, Kreil S, Shanley R, Hogan WJ, Perales MA, Shore T, Baurmann H, Stuart R, Gruhn B, Doubek M, Hsu JW, Tholouli E, Gromke T, Godley LA, Pagano L, Gilman A, Wagner EM, Shwayder T, Bornhäuser M, Papadopoulos EB, Böhm A, Vercellotti G, Van Lint MT, Schmid C, Rabitsch W, Pullarkat V, Legrand F, Yakoub-Agha I, Saber W, Barrett J, Hermine O, Hagglund H, Sperr WR, Popat U, Alyea EP, Devine S, Deeg HJ, Weisdorf D, Akin C, Valent PJournal of clinical oncology : official journal of the American Society of Clinical OncologyHematopoietic stem-cell transplantation for advanced systemic mastocytosis. J Clin Oncol. 2014 Oct 10; 32(29):3264-74.J Clin Oncol2014-08-25T00:00:002014Hematopoietic stem-cell transplantation for advanced systemic mastocytosis.23955273Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden KL, Inghirami G, Leonard JP, Melnick A, Cerchietti LCancer discoveryMechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov. 2013 Sep; 3(9):1002-19.Cancer Discov2013-08-16T00:00:002013Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.25510270Moen EL, Mariani CJ, Zullow H, Jeff-Eke M, Litwin E, Nikitas JN, Godley LAImmunological reviewsNew themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine. Immunol Rev. 2015 Jan; 263(1):36-49.Immunol Rev2015-01-01T00:00:002015New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.25625182Balakrishnan KR, Whang JC, Hwang R, Hack JH, Godley LA, Sohn LLAnalytical chemistryNode-pore sensing enables label-free surface-marker profiling of single cells. Anal Chem. 2015 Mar 03; 87(5):2988-95.Anal Chem2015-02-12T00:00:002015Node-pore sensing enables label-free surface-marker profiling of single cells.25311743Godley LASeminars in hematologyInherited predisposition to acute myeloid leukemia. Semin Hematol. 2014 Oct; 51(4):306-21.Semin Hematol2014-08-12T00:00:002014Inherited predisposition to acute myeloid leukemia.25482556Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RLCell reportsDNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 2014 Dec 11; 9(5):1841-1855.Cell Rep2014-12-04T00:00:002014DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.25920683Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Müller-Tidow C, Maciejewski JPCancer cellInherited and Somatic Defects in DDX41 in Myeloid Neoplasms. Cancer Cell. 2015 May 11; 27(5):658-70.Cancer Cell2015-04-23T00:00:002015Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.23926458Nickels EM, Soodalter J, Churpek JE, Godley LATherapeutic advances in hematologyRecognizing familial myeloid leukemia in adults. Ther Adv Hematol. 2013 Aug; 4(4):254-69.Ther Adv Hematol2013-08-01T00:00:002013Recognizing familial myeloid leukemia in adults.25581430Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura ANature geneticsGermline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015 Feb; 47(2):180-5.Nat Genet2015-01-12T00:00:002015Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.25483416Odenike O, Halpern A, Godley LA, Madzo J, Karrison T, Green M, Fulton N, Mattison RJ, Yee KW, Bennett M, Koval G, Malnassy G, Larson RA, Ratain MJ, Stock WInvestigational new drugsA phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia. Invest New Drugs. 2015 Apr; 33(2):371-9.Invest New Drugs2014-12-09T00:00:002014A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.24202321Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LACancersAlterations of 5-hydroxymethylcytosine in human cancers. Cancers (Basel). 2013 Jun 25; 5(3):786-814.Cancers (Basel)2013-06-25T00:00:002013Alterations of 5-hydroxymethylcytosine in human cancers.24270360Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MANature geneticsLarge conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23.Nat Genet2013-11-24T00:00:002013Large conserved domains of low DNA methylation maintained by Dnmt3a.25607950Brambert PR, Kelpsch DJ, Hameed R, Desai CV, Calafiore G, Godley LA, Raimondi SLPloS oneDNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells. PLoS One. 2015; 10(1):e0117310.PLoS One2015-01-21T00:00:002015DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells.24568970Moen EL, Stark AL, Zhang W, Dolan ME, Godley LAMolecular cancer therapeuticsThe role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide. Mol Cancer Ther. 2014 May; 13(5):1334-44.Mol Cancer Ther2014-02-25T00:00:002014The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.24385541Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich RBloodVariability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood. 2014 Mar 13; 123(11):1699-708.Blood2014-01-02T00:00:002014Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.24628296Marquez R, Hantel A, Lorenz R, Neistadt B, Wong J, Churpek JE, Mardini NA, Shaukat I, Gurbuxani S, Miller JL, Godley LALeukemia & lymphomaA new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies. Leuk Lymphoma. 2014 Dec; 55(12):2945-6.Leuk Lymphoma2014-04-22T00:00:002014A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.24467820West AH, Godley LA, Churpek JEAnnals of the New York Academy of SciencesFamilial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations. Ann N Y Acad Sci. 2014 Mar; 1310:111-8.Ann N Y Acad Sci2014-01-27T00:00:002014Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.24702991Vasanthakumar A, Godley LACell stem cellOn the origin of leukemic species. Cell Stem Cell. 2014 Apr 03; 14(4):421-2.Cell Stem Cell2014-04-03T00:00:002014On the origin of leukemic species.24816237Muffly LS, Kocherginsky M, Stock W, Chu Q, Bishop MR, Godley LA, Kline J, Liu H, Odenike OM, Larson RA, van Besien K, Artz ASHaematologicaGeriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients. Haematologica. 2014 Aug; 99(8):1373-9.Haematologica2014-05-09T00:00:002014Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients.23199206Moen EL, Godley LA, Zhang W, Dolan MEGenome medicinePharmacogenomics of chemotherapeutic susceptibility and toxicity. Genome Med. 2012; 4(11):90.Genome Med2012-11-30T00:00:002012Pharmacogenomics of chemotherapeutic susceptibility and toxicity.24913729Jasielec J, Saloura V, Godley LALeukemiaThe mechanistic role of DNA methylation in myeloid leukemogenesis. Leukemia. 2014 Sep; 28(9):1765-73.Leukemia2014-05-20T00:00:002014The mechanistic role of DNA methylation in myeloid leukemogenesis.24943591Zhang X, Moen EL, Liu C, Mu W, Gamazon ER, Delaney SM, Wing C, Godley LA, Dolan ME, Zhang WHuman molecular geneticsLinking the genetic architecture of cytosine modifications with human complex traits. Hum Mol Genet. 2014 Nov 15; 23(22):5893-905.Hum Mol Genet2014-06-18T00:00:002014Linking the genetic architecture of cytosine modifications with human complex traits.1010Chicago60637ILAuthorship 806541525972343Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JPCancer researchTET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res. 2015 Jul 15; 75(14):2833-43.Cancer Res2015-05-13T00:00:002015TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.Authorship 81185225892122Vasanthakumar A, Godley LACancer genetics5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy. Cancer Genet. 2015 May; 208(5):167-77.Cancer Genet2015-03-03T00:00:0020155-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.Authorship 81421726178744Moen EL, Litwin E, Arnovitz S, Zhang X, Zhang W, Dolan ME, Godley LAEpigeneticsCharacterization of CpG sites that escape methylation on the inactive human X-chromosome. Epigenetics. 2015; 10(9):810-8.Epigenetics2015-07-15T00:00:002015Characterization of CpG sites that escape methylation on the inactive human X-chromosome.Authorship 831001126365193Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich RCell reportsDNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID. Cell Rep. 2015 Sep 29; 12(12):2086-98.Cell Rep2015-09-10T00:00:002015DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.Authorship 845512626492932Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TABloodGenomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. 2015 Nov 26; 126(22):2484-90.Blood2015-10-22T00:00:002015Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.Authorship 847951026631571Chapman CG, Mariani CJ, Wu F, Meckel K, Butun F, Chuang A, Madzo J, Bissonnette MB, Kwon JH, Godley LAScientific reportsTET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. Sci Rep. 2015 Dec 03; 5:17568.Sci Rep2015-12-03T00:00:002015TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.Authorship 85313526478096Churpek JE, Artz A, Bishop M, Liu H, Godley LABiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationCorrespondence Regarding the Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues. Biol Blood Marrow Transplant. 2016 Jan; 22(1):183-4.Biol Blood Marrow Transplant2015-10-22T00:00:002015Correspondence Regarding the Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues.Authorship 8554410Authorship 8542513Authorship 85499826641009Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RACancerInherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. 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