Anthony Kossiakoff to Humans
This is a "connection" page, showing publications Anthony Kossiakoff has written about Humans.
Connection Strength
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Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2424679122.
Score: 0.030
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Engineered protein G variants for multifunctional antibody-based assemblies. Protein Sci. 2025 Feb; 34(2):e70019.
Score: 0.029
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Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins. J Mol Biol. 2022 06 30; 434(12):167602.
Score: 0.024
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Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun. 2020 03 27; 11(1):1598.
Score: 0.021
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An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Protein Sci. 2020 01; 29(1):141-156.
Score: 0.020
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Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure. 2019 12 03; 27(12):1862-1874.e7.
Score: 0.020
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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol. 2018 02 02; 430(3):337-347.
Score: 0.018
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Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody. Sci Rep. 2017 04 03; 7(1):556.
Score: 0.017
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Generating Conformation and Complex-Specific Synthetic Antibodies. Methods Mol Biol. 2017; 1575:93-119.
Score: 0.017
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A polar ring endows improved specificity to an antibody fragment. Protein Sci. 2016 07; 25(7):1290-8.
Score: 0.016
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A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction. J Mol Biol. 2015 Aug 14; 427(16):2707-25.
Score: 0.015
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Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J Mol Biol. 2015 Jul 31; 427(15):2532-2547.
Score: 0.015
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Phage display selections for affinity reagents to membrane proteins in nanodiscs. Methods Enzymol. 2015; 557:219-45.
Score: 0.015
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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal. 2015 Jan 15; 13:1.
Score: 0.015
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Cell biology. New tricks for an old dimer. Science. 2014 May 16; 344(6185):703-4.
Score: 0.014
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Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjug Chem. 2012 Jan 18; 23(1):42-6.
Score: 0.012
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An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11011-5.
Score: 0.010
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The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry. 2006 Jul 18; 45(28):8488-98.
Score: 0.008
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Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 05; 358(3):773-84.
Score: 0.008
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Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor. Nature. 2025 Jul; 643(8070):280-287.
Score: 0.007
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Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem. 2005 Jul 08; 280(27):25524-32.
Score: 0.007
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Structural basis for nucleolin recognition of MYC promoter G-quadruplex. Science. 2025 04 18; 388(6744):eadr1752.
Score: 0.007
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Mapping the extracellular molecular architecture of the pAg-signaling complex with a-Butyrophilin antibodies. Sci Rep. 2025 Apr 09; 15(1):12162.
Score: 0.007
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Structural basis of BAK sequestration by MCL-1 in apoptosis. Mol Cell. 2025 Apr 17; 85(8):1606-1623.e10.
Score: 0.007
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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function. Nat Commun. 2024 12 04; 15(1):10545.
Score: 0.007
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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17078-83.
Score: 0.007
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Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure. 2024 11 07; 32(11):1936-1951.e5.
Score: 0.007
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Structural insights into translocation and tailored synthesis of hyaluronan. Nat Struct Mol Biol. 2025 Jan; 32(1):161-171.
Score: 0.007
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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol. 2024 06 17; 7(1):733.
Score: 0.007
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Development of Luminescent Biosensors for Calprotectin. ACS Chem Biol. 2024 06 21; 19(6):1250-1259.
Score: 0.007
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Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries. Biochemistry. 2004 May 25; 43(20):6076-84.
Score: 0.007
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Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature. 2024 May; 629(8012):704-709.
Score: 0.007
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Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nat Commun. 2024 Mar 20; 15(1):2476.
Score: 0.007
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The Molecular Basis of Human ALKBH3 Mediated RNA N1 -methyladenosine (m1 A) Demethylation. Angew Chem Int Ed Engl. 2024 02 12; 63(7):e202313900.
Score: 0.007
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Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci. 2024 Jan; 33(1):e4824.
Score: 0.007
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The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Adv Protein Chem. 2004; 68:147-69.
Score: 0.007
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Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun. 2023 09 18; 14(1):5774.
Score: 0.007
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Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci. 2003 Sep; 12(9):1960-70.
Score: 0.007
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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry. Nat Commun. 2023 07 20; 14(1):4368.
Score: 0.007
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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):952-7.
Score: 0.006
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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat Chem Biol. 2023 05; 19(5):575-584.
Score: 0.006
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Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J Biol Chem. 2022 09; 298(9):102357.
Score: 0.006
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A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Nature. 2022 07; 607(7918):374-380.
Score: 0.006
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Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res. 2022 08; 32(8):773-776.
Score: 0.006
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Architecture of the cytoplasmic face of the nuclear pore. Science. 2022 06 10; 376(6598):eabm9129.
Score: 0.006
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Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites. J Mol Biol. 2002 Feb 15; 316(2):277-89.
Score: 0.006
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Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest. 2022 02 15; 132(4).
Score: 0.006
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Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).
Score: 0.006
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Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021 07 23; 373(6553):413-419.
Score: 0.006
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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol. 2021 08; 17(8):896-905.
Score: 0.006
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Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on av Integrins. J Mol Biol. 2021 07 23; 433(15):167090.
Score: 0.006
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A T cell redirection platform for co-targeting dual antigens on solid tumors. MAbs. 2021 Jan-Dec; 13(1):1933690.
Score: 0.005
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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat Struct Biol. 2000 Sep; 7(9):808-15.
Score: 0.005
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Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife. 2020 08 07; 9.
Score: 0.005
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The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallogr D Biol Crystallogr. 2000 Jan; 56(Pt 1):14-24.
Score: 0.005
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Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin. Biochemistry. 2019 07 09; 58(27):2996-3004.
Score: 0.005
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The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab. Acta Crystallogr D Struct Biol. 2018 07 01; 74(Pt 7):681-689.
Score: 0.005
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. 2018 06; 558(7711):553-558.
Score: 0.005
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Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor. Protein Sci. 1998 Apr; 7(4):1057-60.
Score: 0.005
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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife. 2018 03 29; 7.
Score: 0.005
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Structural basis for cytokine hormone-receptor recognition and receptor activation. Adv Protein Chem. 1998; 52:67-108.
Score: 0.004
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Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity. Cancer Res. 2017 04 01; 77(7):1684-1696.
Score: 0.004
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Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PLoS One. 2015; 10(10):e0139695.
Score: 0.004
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Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nat Methods. 2015 Aug; 12(8):725-31.
Score: 0.004
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Structure of the growth hormone-receptor complex and mechanism of receptor signaling. J Nucl Med. 1995 Jun; 36(6 Suppl):14S-16S.
Score: 0.004
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Nuclear pores. Architecture of the nuclear pore complex coat. Science. 2015 Mar 06; 347(6226):1148-52.
Score: 0.004
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Scalable high throughput selection from phage-displayed synthetic antibody libraries. J Vis Exp. 2015 Jan 17; (95):51492.
Score: 0.004
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The X-ray structure of a growth hormone-prolactin receptor complex. Nature. 1994 Dec 01; 372(6505):478-81.
Score: 0.004
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Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors. Protein Sci. 1994 Oct; 3(10):1697-705.
Score: 0.004
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Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies. J Virol. 2014 Oct; 88(20):11713-25.
Score: 0.004
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Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell Rep. 2014 Jul 10; 8(1):297-310.
Score: 0.003
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Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol. 2014 Mar; 21(3):244-52.
Score: 0.003
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Molecular recognition in biological systems: from activation to inhibition. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):614-8.
Score: 0.003
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Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41.
Score: 0.003
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X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J Mol Biol. 1993 Feb 20; 229(4):969-95.
Score: 0.003
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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992 Jan 17; 255(5042):306-12.
Score: 0.003
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Crystals of the complex between human growth hormone and the extracellular domain of its receptor. J Mol Biol. 1991 Dec 20; 222(4):865-8.
Score: 0.003
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X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. J Mol Biol. 1991 Sep 05; 221(1):15-21.
Score: 0.003
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X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry. 1990 Oct 30; 29(43):10018-22.
Score: 0.003
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High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol. 2007 Nov 02; 373(4):924-40.
Score: 0.002
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Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. J Biol Chem. 2006 Aug 04; 281(31):22378-22385.
Score: 0.002
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Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat Chem Biol. 2006 Mar; 2(3):139-43.
Score: 0.002
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Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angew Chem Int Ed Engl. 2005 Jun 20; 44(25):3852-6.
Score: 0.002
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Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. J Mol Biol. 2005 Apr 01; 347(3):489-94.
Score: 0.002
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The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol. 2003 Sep 05; 332(1):195-204.
Score: 0.002
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Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones. Mol Biol Evol. 2002 Jul; 19(7):1083-92.
Score: 0.002
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The crystal structure of affinity-matured human growth hormone at 2 A resolution. J Mol Biol. 1994 Feb 11; 236(1):286-99.
Score: 0.001