Christopher Froelich to Granzymes
This is a "connection" page, showing publications Christopher Froelich has written about Granzymes.
Connection Strength
3.679
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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. Cell Death Differ. 2015 Jan; 22(1):74-85.
Score: 0.494
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Granule-associated serine proteases: granzymes might not just be killer proteases. Trends Immunol. 2009 Mar; 30(3):117-23.
Score: 0.337
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Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity. 2008 Nov 14; 29(5):720-33.
Score: 0.330
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Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. Arthritis Rheumatol. 2017 Feb; 69(2):320-334.
Score: 0.146
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Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
Score: 0.127
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Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis. Cell Rep. 2014 Jul 24; 8(2):420-9.
Score: 0.122
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Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. PLoS Pathog. 2013 Jan; 9(1):e1003119.
Score: 0.110
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Perforin activity at membranes leads to invaginations and vesicle formation. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21016-21.
Score: 0.102
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Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One. 2011; 6(9):e24286.
Score: 0.101
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Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011 Jul; 18(7):1112-9.
Score: 0.097
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Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem. 2010 Jun 11; 285(24):18918-27.
Score: 0.091
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Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem. 2010 Jul 16; 285(29):22461-72.
Score: 0.091
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Granzyme A is a proinflammatory protease. Blood. 2009 Oct 29; 114(18):3968; author reply 3969-70.
Score: 0.088
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The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr; 11(4):452-9.
Score: 0.084
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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol. 2008 Jun 15; 180(12):8184-91.
Score: 0.080
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Granzyme B translocates across the lipid membrane only in the presence of lytic agents. Biochem Biophys Res Commun. 2008 Jul 04; 371(3):391-4.
Score: 0.080
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Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol. 2008 Mar 15; 180(6):3766-74.
Score: 0.079
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Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1. J Biol Chem. 2007 Jan 26; 282(4):2305-13.
Score: 0.072
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Human neutrophils lack granzyme A, granzyme B, and perforin. Blood. 2004 Aug 01; 104(3):905-6; author reply 907-8.
Score: 0.061
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Granzyme B-mediated apoptosis--the elephant and the blind men? Cell Death Differ. 2004 Apr; 11(4):369-71.
Score: 0.060
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Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 2003 Oct; 15(5):528-32.
Score: 0.058
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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 2003 Mar 17; 160(6):875-85.
Score: 0.056
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Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem. 2002 Dec 20; 277(51):49523-30.
Score: 0.054
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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar; 16(3):417-28.
Score: 0.052
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Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999 May 01; 162(9):5345-50.
Score: 0.043
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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today. 1998 Jan; 19(1):30-6.
Score: 0.039
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Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med. 1997 Oct 20; 186(8):1323-31.
Score: 0.038
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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 1996 Nov 15; 271(46):29073-9.
Score: 0.036
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Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.
Score: 0.036
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Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell Immunol. 1996 Jul 10; 171(1):159-63.
Score: 0.035
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Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol. 1993 Dec 15; 151(12):7161-71.
Score: 0.029
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Rapid purification of cationic granule proteases: application to human granzymes. Protein Expr Purif. 1993 Oct; 4(5):398-404.
Score: 0.029
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Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 01; 3(9):e3102.
Score: 0.020
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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem. 2005 Jun 24; 280(25):23549-58.
Score: 0.016
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A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. J Biol Chem. 2005 May 27; 280(21):20752-61.
Score: 0.016
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SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood. 2005 Feb 01; 105(3):1153-61.
Score: 0.016
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A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis. J Immunol. 2004 Sep 15; 173(6):3801-9.
Score: 0.016
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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events. J Biol Chem. 2004 May 21; 279(21):22020-9.
Score: 0.015
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Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem. 2004 May 07; 279(19):20200-10.
Score: 0.015
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The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins. J Virol. 2003 Apr; 77(8):4539-45.
Score: 0.014
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Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules. Blood. 2003 Jul 01; 102(1):180-3.
Score: 0.014
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003 Jan 20; 160(2):223-33.
Score: 0.014
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Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol. 2002 Oct; 72(4):668-76.
Score: 0.014
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HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J Immunol. 2001 Oct 01; 167(7):3928-35.
Score: 0.013
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The T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin Cancer Res. 2001 Oct; 7(10):3276-81.
Score: 0.013
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Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother. 2001 Jun; 50(4):212-7.
Score: 0.012
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Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. Rheumatology (Oxford). 2001 Jan; 40(1):55-61.
Score: 0.012
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HIV virions and HIV infection in vitro are unaffected by human granzymes A and B. AIDS Res Hum Retroviruses. 2000 Mar 01; 16(4):367-72.
Score: 0.011
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Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood. 2000 Feb 15; 95(4):1465-72.
Score: 0.011
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Purification and use of granzyme B. Methods Enzymol. 2000; 322:125-43.
Score: 0.011
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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 1999 Dec; 19(12):8604-15.
Score: 0.011
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The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol. 1999 May; 116(2):366-70.
Score: 0.011
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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem. 1999 Feb 12; 274(7):3953-61.
Score: 0.011
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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83.
Score: 0.010
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Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90.
Score: 0.010
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FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 1998 Oct 15; 161(8):3936-42.
Score: 0.010
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Nuclear targeting of the serine protease granzyme A (fragmentin-1). J Cell Sci. 1998 Sep; 111 ( Pt 17):2645-54.
Score: 0.010
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Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998 Aug 01; 92(3):1044-54.
Score: 0.010
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Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase. J Med Chem. 1998 Jun 18; 41(13):2289-301.
Score: 0.010
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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ. 1998 Jun; 5(6):488-96.
Score: 0.010
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Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol. 1998 Apr 01; 160(7):3610-6.
Score: 0.010
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The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells. Immunology. 1998 Mar; 93(3):383-9.
Score: 0.010
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
Score: 0.010
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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12; 271(28):16720-4.
Score: 0.009
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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol. 1996 Jul 01; 6(7):897-9.
Score: 0.009
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Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol. 1996 Apr 01; 156(7):2585-90.
Score: 0.009
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Human granzyme B is essential for DNA fragmentation of susceptible target cells. Eur J Immunol. 1994 Sep; 24(9):2073-80.
Score: 0.008