Christopher Froelich to Perforin
This is a "connection" page, showing publications Christopher Froelich has written about Perforin.
Connection Strength
2.564
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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. Cell Death Differ. 2015 Jan; 22(1):74-85.
Score: 0.497
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Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One. 2011; 6(9):e24286.
Score: 0.405
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Granule-associated serine proteases: granzymes might not just be killer proteases. Trends Immunol. 2009 Mar; 30(3):117-23.
Score: 0.339
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Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity. 2008 Nov 14; 29(5):720-33.
Score: 0.331
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Effects of MACPF/CDC proteins on lipid membranes. Cell Mol Life Sci. 2013 Jun; 70(12):2083-98.
Score: 0.109
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Perforin activity at membranes leads to invaginations and vesicle formation. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21016-21.
Score: 0.103
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Human perforin employs different avenues to damage membranes. J Biol Chem. 2011 Jan 28; 286(4):2946-55.
Score: 0.095
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Detection of functional cell surface perforin by flow cytometry. J Immunol Methods. 2005 Apr; 299(1-2):117-27.
Score: 0.065
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Human neutrophils lack granzyme A, granzyme B, and perforin. Blood. 2004 Aug 01; 104(3):905-6; author reply 907-8.
Score: 0.062
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Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 2003 Oct; 15(5):528-32.
Score: 0.058
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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar; 16(3):417-28.
Score: 0.052
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Flow cytometry cannot assess surface binding of perforin to target cells. Blood. 2001 Apr 01; 97(7):2181-3.
Score: 0.049
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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today. 1998 Jan; 19(1):30-6.
Score: 0.039
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Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays. Biochem Biophys Res Commun. 1996 Dec 04; 229(1):44-9.
Score: 0.036
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Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.
Score: 0.036
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Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH. Mol Immunol. 2010 Sep; 47(15):2492-504.
Score: 0.023
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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol. 2008 Jun 15; 180(12):8184-91.
Score: 0.020
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Granzyme B translocates across the lipid membrane only in the presence of lytic agents. Biochem Biophys Res Commun. 2008 Jul 04; 371(3):391-4.
Score: 0.020
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Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol. 2008 Mar 15; 180(6):3766-74.
Score: 0.020
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Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells. J Immunol Methods. 2005 Jul; 302(1-2):13-25.
Score: 0.016
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Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. Clin Cancer Res. 2004 Nov 01; 10(21):7402-12.
Score: 0.016
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The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins. J Virol. 2003 Apr; 77(8):4539-45.
Score: 0.014
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003 Jan 20; 160(2):223-33.
Score: 0.014
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Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol. 2002 Oct; 72(4):668-76.
Score: 0.014
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The T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin Cancer Res. 2001 Oct; 7(10):3276-81.
Score: 0.013
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Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother. 2001 Jun; 50(4):212-7.
Score: 0.012
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P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins. J Biol Chem. 2001 May 18; 276(20):16667-73.
Score: 0.012
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Purification and use of granzyme B. Methods Enzymol. 2000; 322:125-43.
Score: 0.011
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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 1999 Dec; 19(12):8604-15.
Score: 0.011
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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem. 1999 Feb 12; 274(7):3953-61.
Score: 0.011
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FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 1998 Oct 15; 161(8):3936-42.
Score: 0.010
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An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 02; 282(5386):121-5.
Score: 0.010
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Nuclear targeting of the serine protease granzyme A (fragmentin-1). J Cell Sci. 1998 Sep; 111 ( Pt 17):2645-54.
Score: 0.010
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Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998 Aug 01; 92(3):1044-54.
Score: 0.010
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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ. 1998 Jun; 5(6):488-96.
Score: 0.010
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
Score: 0.010