Froelich, Christopher
first name: Christopher
last name: Froelich
coauthor of: Sprague, Stuart
coauthor of: Franzoso, Guido
coauthor of: Leikin, Jerrold
full name: Christopher Froelich
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selected publications: Authorship 99423
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selected publications: Authorship 43922
selected publications: Authorship 42696
selected publications: Authorship 41704
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selected publications: Authorship 37458
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selected publications: Authorship 36012
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selected publications: Authorship 34913
selected publications: Authorship 34448
selected publications: Authorship 30964
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selected publications: Authorship 26950
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selected publications: Authorship 25966
selected publications: Authorship 25676
selected publications: Authorship 25530
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selected publications: Authorship 24164
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selected publications: Authorship 24477
selected publications: Authorship 24390
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selected publications: Authorship 21412
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selected publications: Authorship 19503
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Authorship 100322
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.
PubMed Identifier: 14960210
author list: Vermijlen D, Luo D, Froelich CJ, Medema JP, Kummer JA, Willems E, Braet F, Wisse E
published in: Comparative hepatology
information resource reference: Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S58.
journal title abbreviation: Comp Hepatol
publication date: 2004-01-14T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Doi, Kunio
first name: Kunio
last name: Doi
full name: Kunio Doi
latitude: 41.78860000000000
longitude: 87.59869999999999
Person ID: 3668
person in primary position: Ralph W. Gerard Professor of Biological Sciences, Emeritus
type: Agent
type: Person
preferred title: Ralph W. Gerard Professor of Biological Sciences, Emeritus

Biochemistry and Molecular Biology
type: Department
type: Organization

Radiation and Cellular Oncology
type: Department
type: Organization

Authorship 10394
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Human granzyme B is essential for DNA fragmentation of susceptible target cells.

Authorship 10057
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.

Authorship 10855
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.

Authorship 12816
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.

Authorship 12118
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.

Authorship 12350
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines.

Authorship 12494
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.

Authorship 12119
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.

Authorship 12744
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.

Authorship 12449
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.

Authorship 14792
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.

Authorship 13897
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.

Authorship 15267
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.

Authorship 15650
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.

Authorship 12934
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.

Authorship 13599
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis.

Authorship 15481
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

Authorship 13940
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

Authorship 14500
type: Authorship
author rank in publication: 10
linked author: Froelich, Christopher
linked information resource: Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.

Authorship 15018
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Nuclear targeting of the serine protease granzyme A (fragmentin-1).

Authorship 14840
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells.

Authorship 15200
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: An antimicrobial activity of cytolytic T cells mediated by granulysin.

Authorship 15225
type: Authorship
author rank in publication: 12
linked author: Froelich, Christopher
linked information resource: Pro-caspase-3 is a major physiologic target of caspase-8.

Authorship 14950
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

Authorship 16678
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.

Authorship 16993
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.

Authorship 17072
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis.

Authorship 18416
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.

Authorship 17279
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Cell death-associated translocation of plasma membrane components induced by CTL.

Authorship 17134
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.

Authorship 18752
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.

Authorship 14327
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.

Authorship 17653
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Purification and use of granzyme B.

Authorship 21375
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.

Authorship 19229
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.

Authorship 22350
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.

Authorship 19503
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.

Authorship 15897
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.

Authorship 15955
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.

Authorship 16025
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).

Authorship 18774
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Flow cytometry cannot assess surface binding of perforin to target cells.

Authorship 1657
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice.

Authorship 22209
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.

Authorship 19573
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: The T cell death knell: immune-mediated tumor death in renal cell carcinoma.

Authorship 21412
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

Authorship 20364
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

Authorship 2059
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Agarose/polyacrylamide minislab gel electrophoresis of intact cartilage proteoglycans and their proteolytic degradation products.

Authorship 21910
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.

Authorship 22307
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules.

Authorship 2396
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Detection of anticardiolipin antibody in patients with cocaine abuse.

Authorship 23483
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.

Authorship 25249
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Human neutrophils lack granzyme A, granzyme B, and perforin.

Authorship 19120
type: Authorship
author rank in publication: 11
linked author: Froelich, Christopher
linked information resource: A distinct pathway of cell-mediated apoptosis initiated by granulysin.

Authorship 27169
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Detection of functional cell surface perforin by flow cytometry.

Authorship 24164
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Granzyme B-mediated apoptosis--the elephant and the blind men?

Authorship 24241
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Right place, right time.

Authorship 24390
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.

Authorship 24477
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.

Authorship 24544
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.

Authorship 25676
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.

Authorship 23541
type: Authorship
author rank in publication: 11
linked author: Froelich, Christopher
linked information resource: NF-kappaB protects from the lysosomal pathway of cell death.

Authorship 2748
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB).

Authorship 35235
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.

Authorship 25966
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.

Authorship 26757
type: Authorship
author rank in publication: 10
linked author: Froelich, Christopher
linked information resource: A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.

Authorship 27439
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.

Authorship 34913
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Granzyme B translocates across the lipid membrane only in the presence of lytic agents.

Authorship 36012
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells.

Authorship 39610
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Granzyme A is a proinflammatory protease.

Authorship 41063
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.

Authorship 4195
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus.

Authorship 34448
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.

Authorship 42696
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Human perforin employs different avenues to damage membranes.

Authorship 4270
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Modulation of the autologous mixed lymphocyte reaction by beta-endorphin.

Authorship 30964
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: https://profiles.uchicago.edu/profiles/profile/238941

Authorship 45386
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Intracellular trafficking of perforin: to thwart a killer.

Authorship 47067
type: Authorship
author rank in publication: 10
linked author: Froelich, Christopher
linked information resource: Perforin activity at membranes leads to invaginations and vesicle formation.

Authorship 3667
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies.

Authorship 36429
type: Authorship
author rank in publication: 11
linked author: Froelich, Christopher
linked information resource: Human and mouse granzyme A induce a proinflammatory cytokine response.

Authorship 37350
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Granule-associated serine proteases: granzymes might not just be killer proteases.

Authorship 37458
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation.

Authorship 7032
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: The effect of beta-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity.

Authorship 7417
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Enhancement of natural cytotoxicity by beta-endorphin.

Authorship 5488
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Natural killer cells do not lyse resting or mitogen-stimulated B cells.

Authorship 41078
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.

Authorship 8180
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid arthritis and normal controls.

Authorship 4273
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Lysis of human T cell leukemia virus infected T and B lymphoid cells by interleukin 2-activated killer cells.

Authorship 7527
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG.

Authorship 7596
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: High anion gap acidosis during intravenous infusion of protein hydrolysate.

Authorship 8629
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: A case of Guillain-Barré syndrome with immunologic abnormalities.

Authorship 8064
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Natural killing and antibody-dependent cellular cytotoxicity: characterization of effector cells by E-rosetting and monoclonal antibodies.

Authorship 9089
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.

Authorship 426
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Telltale mouth flora: a clue to the diagnosis of factitious recurrent thigh abscesses.

Authorship 41704
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.

Authorship 43922
type: Authorship
author rank in publication: 8
linked author: Froelich, Christopher
linked information resource: Mouse granzyme K has pro-inflammatory potential.

Authorship 5466
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Induction of lymphokine activated killer cells in serum-free medium.

Authorship 463
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: D-penicillamine-induced myasthenia gravis in rheumatoid arthritis.

Authorship 7063
type: Authorship
author rank in publication: 4
linked author: Froelich, Christopher
linked information resource: Lymphocytotoxic antibodies in Guillain-Barré syndrome.

Authorship 7222
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry.

Authorship 7629
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease?

Authorship 8093
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors.

Authorship 48659
type: Authorship
author rank in publication: 3
linked author: Froelich, Christopher
linked information resource: Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.

Authorship 7524
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Enrichment of natural killer cells by negative selection: comparison to Percoll gradient separation method.

Authorship 7801
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors.

Authorship 8324
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Human E-rosette-positive cells which bind monomeric IgG mediate natural cytotoxicity.

Authorship 5099
type: Authorship
author rank in publication: 1
linked author: Froelich, Christopher
linked information resource: Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.

Authorship 7887
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Interferon-alpha regulation of lymphocyte function in systemic lupus erythematosus.

Authorship 8181
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera.

Authorship 10836
type: Authorship
author rank in publication: 6
linked author: Froelich, Christopher
linked information resource: Rapid purification of cationic granule proteases: application to human granzymes.

Authorship 18520
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.

Authorship 25530
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.

Authorship 26950
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

Authorship 46185
type: Authorship
author rank in publication: 7
linked author: Froelich, Christopher
linked information resource: Perforin rapidly induces plasma membrane phospholipid flip-flop.

Authorship 4869
type: Authorship
author rank in publication: 5
linked author: Froelich, Christopher
linked information resource: Antiphospholipid antibodies associated with retinal vascular disease.

Authorship 5994
type: Authorship
author rank in publication: 2
linked author: Froelich, Christopher
linked information resource: Salmonella typhimurium mitogen induces proliferation of human B lymphocytes.

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
PubMed Identifier: 8663294
author list: Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM
published in: The Journal of biological chemistry
information resource reference: ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12; 271(28):16720-4.
journal title abbreviation: J Biol Chem
publication date: 1996-07-12T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines.
PubMed Identifier: 8754861
author list: Sower LE, Klimpel GR, Hanna W, Froelich CJ
published in: Cellular immunology
information resource reference: Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell Immunol. 1996 Jul 10; 171(1):159-63.
journal title abbreviation: Cell Immunol
publication date: 1996-07-10T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
PubMed Identifier: 8663580
author list: Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM
published in: The Journal of biological chemistry
information resource reference: The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem. 1996 Jul 12; 271(28):16443-6.
journal title abbreviation: J Biol Chem
publication date: 1996-07-12T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis.
PubMed Identifier: 9195506
author list: Swedler W, Wallman J, Froelich CJ, Teodorescu M
published in: The Journal of rheumatology
information resource reference: Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis. J Rheumatol. 1997 Jun; 24(6):1037-44.
journal title abbreviation: J Rheumatol
publication date: 1997-06-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells.
PubMed Identifier: 9640249
author list: Wever PC, Van Der Vliet HJ, Spaeny LH, Wolbink AM, Van Diepen FN, Froelich CJ, Hack CE, ten Berge IJ
published in: Immunology
information resource reference: The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells. Immunology. 1998 Mar; 93(3):383-9.
journal title abbreviation: Immunology
publication date: 1998-03-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
PubMed Identifier: 8910561
author list: Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W
published in: The Journal of biological chemistry
information resource reference: New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 1996 Nov 15; 271(46):29073-9.
journal title abbreviation: J Biol Chem
publication date: 1996-11-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
PubMed Identifier: 9465486
author list: Froelich CJ, Dixit VM, Yang X
published in: Immunology today
information resource reference: Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today. 1998 Jan; 19(1):30-6.
journal title abbreviation: Immunol Today
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
PubMed Identifier: 9632362
author list: Jackson DS, Fraser SA, Ni LM, Kam CM, Winkler U, Johnson DA, Froelich CJ, Hudig D, Powers JC
published in: Journal of medicinal chemistry
information resource reference: Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase. J Med Chem. 1998 Jun 18; 41(13):2289-301.
journal title abbreviation: J Med Chem
publication date: 1998-06-18T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

An antimicrobial activity of cytolytic T cells mediated by granulysin.
PubMed Identifier: 9756476
author list: Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL
published in: Science (New York, N.Y.)
information resource reference: An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 02; 282(5386):121-5.
journal title abbreviation: Science
publication date: 1998-10-02T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
PubMed Identifier: 9316633
author list: Hommel-Berrey GA, Bochan MR, Montel AH, Goebel WS, Froelich CJ, Brahmi Z
published in: Cellular immunology
information resource reference: Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
journal title abbreviation: Cell Immunol
publication date: 1997-08-25T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
PubMed Identifier: 9852092
author list: Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ
published in: The Journal of biological chemistry
information resource reference: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83.
journal title abbreviation: J Biol Chem
publication date: 1998-12-18T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.
PubMed Identifier: 8805307
author list: Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM
published in: Current biology : CB
information resource reference: Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol. 1996 Jul 01; 6(7):897-9.
journal title abbreviation: Curr Biol
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
PubMed Identifier: 8885990
author list: Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM
published in: Biochemical and biophysical research communications
information resource reference: Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1996-10-23T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
PubMed Identifier: 8954081
author list: Froelich CJ, Turbov J, Hanna W
published in: Biochemical and biophysical research communications
information resource reference: Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays. Biochem Biophys Res Commun. 1996 Dec 04; 229(1):44-9.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1996-12-04T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Nuclear targeting of the serine protease granzyme A (fragmentin-1).
PubMed Identifier: 9701563
author list: Jans DA, Briggs LJ, Jans P, Froelich CJ, Parasivam G, Kumar S, Sutton VR, Trapani JA
published in: Journal of cell science
information resource reference: Nuclear targeting of the serine protease granzyme A (fragmentin-1). J Cell Sci. 1998 Sep; 111 ( Pt 17):2645-54.
journal title abbreviation: J Cell Sci
publication date: 1998-09-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
PubMed Identifier: 9933585
author list: Jans DA, Sutton VR, Jans P, Froelich CJ, Trapani JA
published in: The Journal of biological chemistry
information resource reference: BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem. 1999 Feb 12; 274(7):3953-61.
journal title abbreviation: J Biol Chem
publication date: 1999-02-12T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).
PubMed Identifier: 10337032
author list: Tak PP, Spaeny-Dekking L, Kraan MC, Breedveld FC, Froelich CJ, Hack CE
published in: Clinical and experimental immunology
information resource reference: The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol. 1999 May; 116(2):366-70.
journal title abbreviation: Clin Exp Immunol
publication date: 1999-05-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
PubMed Identifier: 11278745
author list: Johnstone RW, Tainton KM, Ruefli AA, Froelich CJ, Cerruti L, Jane SM, Smyth MJ
published in: The Journal of biological chemistry
information resource reference: P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins. J Biol Chem. 2001 May 18; 276(20):16667-73.
journal title abbreviation: J Biol Chem
publication date: 2001-02-20T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
PubMed Identifier: 10666226
author list: Spaeny-Dekking EH, Kamp AM, Froelich CJ, Hack CE
published in: Blood
information resource reference: Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood. 2000 Feb 15; 95(4):1465-72.
journal title abbreviation: Blood
publication date: 2000-02-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Purification and use of granzyme B.
PubMed Identifier: 10914010
author list: Shi L, Yang X, Froelich CJ, Greenberg AH
published in: Methods in enzymology
information resource reference: Purification and use of granzyme B. Methods Enzymol. 2000; 322:125-43.
journal title abbreviation: Methods Enzymol
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
PubMed Identifier: 9680374
author list: Pinkoski MJ, Hobman M, Heibein JA, Tomaselli K, Li F, Seth P, Froelich CJ, Bleackley RC
published in: Blood
information resource reference: Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998 Aug 01; 92(3):1044-54.
journal title abbreviation: Blood
publication date: 1998-08-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Pro-caspase-3 is a major physiologic target of caspase-8.
PubMed Identifier: 9765224
author list: Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS
published in: The Journal of biological chemistry
information resource reference: Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90.
journal title abbreviation: J Biol Chem
publication date: 1998-10-16T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
PubMed Identifier: 10200500
author list: Trapani JA, Jans P, Smyth MJ, Froelich CJ, Williams EA, Sutton VR, Jans DA
published in: Cell death and differentiation
information resource reference: Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ. 1998 Jun; 5(6):488-96.
journal title abbreviation: Cell Death Differ
publication date: 1998-06-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.
PubMed Identifier: 9531325
author list: Spaeny-Dekking EH, Hanna WL, Wolbink AM, Wever PC, Kummer JA, Kummer AJ, Swaak AJ, Middeldorp JM, Huisman HG, Froelich CJ, Hack CE
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol. 1998 Apr 01; 160(7):3610-6.
journal title abbreviation: J Immunol
publication date: 1998-04-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.
PubMed Identifier: 11564811
author list: Jerome KR, Chen Z, Lang R, Torres MR, Hofmeister J, Smith S, Fox R, Froelich CJ, Corey L
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J Immunol. 2001 Oct 01; 167(7):3928-35.
journal title abbreviation: J Immunol
publication date: 2001-10-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis.
PubMed Identifier: 10694431
author list: Pink JJ, Wuerzberger-Davis S, Tagliarino C, Planchon SM, Yang X, Froelich CJ, Boothman DA
published in: Experimental cell research
information resource reference: Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res. 2000 Mar 15; 255(2):144-55.
journal title abbreviation: Exp Cell Res
publication date: 2000-03-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
PubMed Identifier: 11911826
author list: Metkar SS, Wang B, Aguilar-Santelises M, Raja SM, Uhlin-Hansen L, Podack E, Trapani JA, Froelich CJ
published in: Immunity
information resource reference: Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar; 16(3):417-28.
journal title abbreviation: Immunity
publication date: 2002-03-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
PubMed Identifier: 10567584
author list: Browne KA, Blink E, Sutton VR, Froelich CJ, Jans DA, Trapani JA
published in: Molecular and cellular biology
information resource reference: Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 1999 Dec; 19(12):8604-15.
journal title abbreviation: Mol Cell Biol
publication date: 1999-12-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell death-associated translocation of plasma membrane components induced by CTL.
PubMed Identifier: 10779768
author list: Kawasaki Y, Saito T, Shirota-Someya Y, Ikegami Y, Komano H, Lee MH, Froelich CJ, Shinohara N, Takayama H
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Cell death-associated translocation of plasma membrane components induced by CTL. J Immunol. 2000 May 01; 164(9):4641-8.
journal title abbreviation: J Immunol
publication date: 2000-05-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
PubMed Identifier: 10716374
author list: Mackewicz CE, Lieberman J, Froelich C, Levy JA
published in: AIDS research and human retroviruses
information resource reference: HIV virions and HIV infection in vitro are unaffected by human granzymes A and B. AIDS Res Hum Retroviruses. 2000 Mar 01; 16(4):367-72.
journal title abbreviation: AIDS Res Hum Retroviruses
publication date: 2000-03-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice.
PubMed Identifier: 1614979
author list: Johnston TP, Punjabi MA, Froelich CJ
published in: Pharmaceutical research
information resource reference: Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice. Pharm Res. 1992 Mar; 9(3):425-34.
journal title abbreviation: Pharm Res
publication date: 1992-03-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Flow cytometry cannot assess surface binding of perforin to target cells.
PubMed Identifier: 11286222
author list: Metkar SS, Aguilar-Santelises M, Wang B, Froelich CJ
published in: Blood
information resource reference: Flow cytometry cannot assess surface binding of perforin to target cells. Blood. 2001 Apr 01; 97(7):2181-3.
journal title abbreviation: Blood
publication date: 2001-04-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

A distinct pathway of cell-mediated apoptosis initiated by granulysin.
PubMed Identifier: 11418670
author list: Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE, Froelich CJ, Thompson CB, Newmeyer DD, Anel A, Clayberger C, Krensky AM
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol. 2001 Jul 01; 167(1):350-6.
journal title abbreviation: J Immunol
publication date: 2001-07-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.
PubMed Identifier: 11196185
author list: Yang XH, Sladek TL, Liu X, Butler BR, Froelich CJ, Thor AD
published in: Cancer research
information resource reference: Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res. 2001 Jan 01; 61(1):348-54.
journal title abbreviation: Cancer Res
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

NF-kappaB protects from the lysosomal pathway of cell death.
PubMed Identifier: 14517268
author list: Liu N, Raja SM, Zazzeroni F, Metkar SS, Shah R, Zhang M, Wang Y, Brömme D, Russin WA, Lee JC, Peter ME, Froelich CJ, Franzoso G, Ashton-Rickardt PG
published in: The EMBO journal
information resource reference: NF-kappaB protects from the lysosomal pathway of cell death. EMBO J. 2003 Oct 01; 22(19):5313-22.
journal title abbreviation: EMBO J
publication date: 2003-10-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
PubMed Identifier: 12388539
author list: Raja SM, Wang B, Dantuluri M, Desai UR, Demeler B, Spiegel K, Metkar SS, Froelich CJ
published in: The Journal of biological chemistry
information resource reference: Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem. 2002 Dec 20; 277(51):49523-30.
journal title abbreviation: J Biol Chem
publication date: 2002-10-17T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Agarose/polyacrylamide minislab gel electrophoresis of intact cartilage proteoglycans and their proteolytic degradation products.
PubMed Identifier: 1785694
author list: Varelas JB, Zenarosa NR, Froelich CJ
published in: Analytical biochemistry
information resource reference: Agarose/polyacrylamide minislab gel electrophoresis of intact cartilage proteoglycans and their proteolytic degradation products. Anal Biochem. 1991 Sep 02; 197(2):396-400.
journal title abbreviation: Anal Biochem
publication date: 1991-09-02T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules.
PubMed Identifier: 12649153
author list: Mackewicz CE, Wang B, Metkar S, Richey M, Froelich CJ, Levy JA
published in: Blood
information resource reference: Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules. Blood. 2003 Jul 01; 102(1):180-3.
journal title abbreviation: Blood
publication date: 2003-03-20T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
PubMed Identifier: 12663760
author list: Odeberg J, Browne H, Metkar S, Froelich CJ, Brandén L, Cosman D, Söderberg-Nauclér C
published in: Journal of virology
information resource reference: The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins. J Virol. 2003 Apr; 77(8):4539-45.
journal title abbreviation: J Virol
publication date: 2003-04-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B-mediated apoptosis--the elephant and the blind men?
PubMed Identifier: 14726962
author list: Froelich CJ, Metkar SS, Raja SM
published in: Cell death and differentiation
information resource reference: Granzyme B-mediated apoptosis--the elephant and the blind men? Cell Death Differ. 2004 Apr; 11(4):369-71.
journal title abbreviation: Cell Death Differ
publication date: 2004-04-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
PubMed Identifier: 15041704
author list: Lee YJ, Froelich CJ, Fujita N, Tsuruo T, Kim JH
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage. Clin Cancer Res. 2004 Mar 15; 10(6):1894-900.
journal title abbreviation: Clin Cancer Res
publication date: 2004-03-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
PubMed Identifier: 11459173
author list: Vermijlen D, Froelich CJ, Luo D, Suarez-Huerta N, Robaye B, Wisse E
published in: Cancer immunology, immunotherapy : CII
information resource reference: Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother. 2001 Jun; 50(4):212-7.
journal title abbreviation: Cancer Immunol Immunother
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.
PubMed Identifier: 15454490
author list: Bots M, Kolfschoten IG, Bres SA, Rademaker MT, de Roo GM, Krüse M, Franken KL, Hahne M, Froelich CJ, Melief CJ, Offringa R, Medema JP
published in: Blood
information resource reference: SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood. 2005 Feb 01; 105(3):1153-61.
journal title abbreviation: Blood
publication date: 2004-09-28T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
PubMed Identifier: 11595725
author list: Uzzo RG, Kolenko V, Froelich CJ, Tannenbaum C, Molto L, Novick AC, Bander NH, Bukowski R, Finke JH
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: The T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin Cancer Res. 2001 Oct; 7(10):3276-81.
journal title abbreviation: Clin Cancer Res
publication date: 2001-10-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
PubMed Identifier: 15356127
author list: Phillips T, Opferman JT, Shah R, Liu N, Froelich CJ, Ashton-Rickardt PG
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis. J Immunol. 2004 Sep 15; 173(6):3801-9.
journal title abbreviation: J Immunol
publication date: 2004-09-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
PubMed Identifier: 15534117
author list: Azuma T, Otsuki T, Kuzushima K, Froelich CJ, Fujita S, Yasukawa M
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. Clin Cancer Res. 2004 Nov 01; 10(21):7402-12.
journal title abbreviation: Clin Cancer Res
publication date: 2004-11-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Human neutrophils lack granzyme A, granzyme B, and perforin.
PubMed Identifier: 15265799
author list: Metkar SS, Froelich CJ
published in: Blood
information resource reference: Human neutrophils lack granzyme A, granzyme B, and perforin. Blood. 2004 Aug 01; 104(3):905-6; author reply 907-8.
journal title abbreviation: Blood
publication date: 2004-08-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
PubMed Identifier: 12538642
author list: Trapani JA, Sutton VR, Thia KY, Li YQ, Froelich CJ, Jans DA, Sandrin MS, Browne KA
published in: The Journal of cell biology
information resource reference: A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003 Jan 20; 160(2):223-33.
journal title abbreviation: J Cell Biol
publication date: 2003-01-20T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
PubMed Identifier: 12629051
author list: Metkar SS, Wang B, Ebbs ML, Kim JH, Lee YJ, Raja SM, Froelich CJ
published in: The Journal of cell biology
information resource reference: Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 2003 Mar 17; 160(6):875-85.
journal title abbreviation: J Cell Biol
publication date: 2003-03-10T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Ben May Department of Cancer Research
type: Department
type: Organization

Detection of functional cell surface perforin by flow cytometry.
PubMed Identifier: 15914196
author list: Metkar SS, Wang B, Froelich CJ
published in: Journal of immunological methods
information resource reference: Detection of functional cell surface perforin by flow cytometry. J Immunol Methods. 2005 Apr; 299(1-2):117-27.
journal title abbreviation: J Immunol Methods
publication date: 2005-03-17T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
PubMed Identifier: 18439904
author list: Besenicar MP, Metkar S, Wang B, Froelich CJ, Anderluh G
published in: Biochemical and biophysical research communications
information resource reference: Granzyme B translocates across the lipid membrane only in the presence of lytic agents. Biochem Biophys Res Commun. 2008 Jul 04; 371(3):391-4.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2008-04-24T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
PubMed Identifier: 14985351
author list: Dressel R, Raja SM, Höning S, Seidler T, Froelich CJ, von Figura K, Günther E
published in: The Journal of biological chemistry
information resource reference: Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem. 2004 May 07; 279(19):20200-10.
journal title abbreviation: J Biol Chem
publication date: 2004-02-25T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Granule-associated serine proteases: granzymes might not just be killer proteases.
PubMed Identifier: 19217825
author list: Froelich CJ, Pardo J, Simon MM
published in: Trends in immunology
information resource reference: Granule-associated serine proteases: granzymes might not just be killer proteases. Trends Immunol. 2009 Mar; 30(3):117-23.
journal title abbreviation: Trends Immunol
publication date: 2009-02-13T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.
PubMed Identifier: 15843372
author list: Buzza MS, Zamurs L, Sun J, Bird CH, Smith AI, Trapani JA, Froelich CJ, Nice EC, Bird PI
published in: The Journal of biological chemistry
information resource reference: Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem. 2005 Jun 24; 280(25):23549-58.
journal title abbreviation: J Biol Chem
publication date: 2005-04-19T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB).
PubMed Identifier: 2108246
author list: Froelich CJ, Wallman J, Skosey JL, Teodorescu M
published in: The Journal of rheumatology
information resource reference: Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB). J Rheumatol. 1990 Feb; 17(2):192-200.
journal title abbreviation: J Rheumatol
publication date: 1990-02-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies.
PubMed Identifier: 2511302
author list: Heckerling PS, Froelich CJ, Schade SG
published in: The Journal of rheumatology
information resource reference: Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies. J Rheumatol. 1989 Aug; 16(8):1144-6.
journal title abbreviation: J Rheumatol
publication date: 1989-08-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme A is a proinflammatory protease.
PubMed Identifier: 19875524
author list: Pardo J, Simon MM, Froelich CJ
published in: Blood
information resource reference: Granzyme A is a proinflammatory protease. Blood. 2009 Oct 29; 114(18):3968; author reply 3969-70.
journal title abbreviation: Blood
publication date: 2009-10-29T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse granzyme K has pro-inflammatory potential.
PubMed Identifier: 21311565
author list: Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM
published in: Cell death and differentiation
information resource reference: Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011 Jul; 18(7):1112-9.
journal title abbreviation: Cell Death Differ
publication date: 2011-02-11T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Intracellular trafficking of perforin: to thwart a killer.
PubMed Identifier: 21703535
author list: Froelich C, Metkar S
published in: Immunity
information resource reference: Intracellular trafficking of perforin: to thwart a killer. Immunity. 2011 Jun 24; 34(6):823-5.
journal title abbreviation: Immunity
publication date: 2011-06-24T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
PubMed Identifier: 18523284
author list: Bovenschen N, de Koning PJ, Quadir R, Broekhuizen R, Damen JM, Froelich CJ, Slijper M, Kummer JA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol. 2008 Jun 15; 180(12):8184-91.
journal title abbreviation: J Immunol
publication date: 2008-06-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Lysis of human T cell leukemia virus infected T and B lymphoid cells by interleukin 2-activated killer cells.
PubMed Identifier: 2824611
author list: Froelich CJ, Guiffaut S
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Lysis of human T cell leukemia virus infected T and B lymphoid cells by interleukin 2-activated killer cells. J Immunol. 1987 Dec 01; 139(11):3637-43.
journal title abbreviation: J Immunol
publication date: 1987-12-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.
PubMed Identifier: 22674984
author list: Joeckel LT, Wallich R, Metkar SS, Froelich CJ, Simon MM, Borner C
published in: Journal of virology
information resource reference: Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. J Virol. 2012 Aug; 86(16):8713-9.
journal title abbreviation: J Virol
publication date: 2012-06-06T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin activity at membranes leads to invaginations and vesicle formation.
PubMed Identifier: 22173634
author list: Praper T, Sonnen AF, Kladnik A, Andrighetti AO, Viero G, Morris KJ, Volpi E, Lunelli L, Dalla Serra M, Froelich CJ, Gilbert RJ, Anderluh G
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Perforin activity at membranes leads to invaginations and vesicle formation. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21016-21.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2011-12-15T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of the autologous mixed lymphocyte reaction by beta-endorphin.
PubMed Identifier: 2824556
author list: Froelich CJ
published in: Journal of neuroimmunology
information resource reference: Modulation of the autologous mixed lymphocyte reaction by beta-endorphin. J Neuroimmunol. 1987 Dec; 17(1):1-10.
journal title abbreviation: J Neuroimmunol
publication date: 1987-12-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
PubMed Identifier: 18322182
author list: Hallermalm K, Seki K, De Geer A, Motyka B, Bleackley RC, Jager MJ, Froelich CJ, Kiessling R, Levitsky V, Levitskaya J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol. 2008 Mar 15; 180(6):3766-74.
journal title abbreviation: J Immunol
publication date: 2008-03-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Natural killer cells do not lyse resting or mitogen-stimulated B cells.
PubMed Identifier: 3494907
author list: Froelich CJ, Guiffaut S
published in: Natural immunity and cell growth regulation
information resource reference: Natural killer cells do not lyse resting or mitogen-stimulated B cells. Nat Immun Cell Growth Regul. 1987; 6(1):12-8.
journal title abbreviation: Nat Immun Cell Growth Regul
publication date: 1987-01-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
PubMed Identifier: 15788411
author list: Raja SM, Metkar SS, Höning S, Wang B, Russin WA, Pipalia NH, Menaa C, Belting M, Cao X, Dressel R, Froelich CJ
published in: The Journal of biological chemistry
information resource reference: A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. J Biol Chem. 2005 May 27; 280(21):20752-61.
journal title abbreviation: J Biol Chem
publication date: 2005-03-23T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.
PubMed Identifier: 16005014
author list: Zuber B, Levitsky V, Jönsson G, Paulie S, Samarina A, Grundström S, Metkar S, Norell H, Callender GG, Froelich C, Ahlborg N
published in: Journal of immunological methods
information resource reference: Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells. J Immunol Methods. 2005 Jul; 302(1-2):13-25.
journal title abbreviation: J Immunol Methods
publication date: 2005-07-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Human and mouse granzyme A induce a proinflammatory cytokine response.
PubMed Identifier: 18951048
author list: Metkar SS, Menaa C, Pardo J, Wang B, Wallich R, Freudenberg M, Kim S, Raja SM, Shi L, Simon MM, Froelich CJ
published in: Immunity
information resource reference: Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity. 2008 Nov 14; 29(5):720-33.
journal title abbreviation: Immunity
publication date: 2008-10-23T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The effect of beta-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity.
PubMed Identifier: 6087056
author list: Froelich CJ, Bankhurst AD
published in: Life sciences
information resource reference: The effect of beta-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity. Life Sci. 1984 Jul 16; 35(3):261-5.
journal title abbreviation: Life Sci
publication date: 1984-07-16T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

High anion gap acidosis during intravenous infusion of protein hydrolysate.
PubMed Identifier: 6426065
author list: Tzamaloukas AH, Froelich CJ, Jeffery WH
published in: Southern medical journal
information resource reference: High anion gap acidosis during intravenous infusion of protein hydrolysate. South Med J. 1984 May; 77(5):661-3.
journal title abbreviation: South Med J
publication date: 1984-05-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Interferon-alpha regulation of lymphocyte function in systemic lupus erythematosus.
PubMed Identifier: 6733982
author list: Sibbitt WL, Froelich CJ, Bankhurst AD
published in: Clinical immunology and immunopathology
information resource reference: Interferon-alpha regulation of lymphocyte function in systemic lupus erythematosus. Clin Immunol Immunopathol. 1984 Jul; 32(1):70-80.
journal title abbreviation: Clin Immunol Immunopathol
publication date: 1984-07-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors.
PubMed Identifier: 6883808
author list: Sibbitt WL, Froelich CJ, Bankhurst AD
published in: Clinical and experimental immunology
information resource reference: Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors. Clin Exp Immunol. 1983 Aug; 53(2):363-70.
journal title abbreviation: Clin Exp Immunol
publication date: 1983-08-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus.
PubMed Identifier: 2783399
author list: Froelich CJ, Guiffaut S, Sosenko M, Muth K
published in: Clinical immunology and immunopathology
information resource reference: Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1989 Jan; 50(1 Pt 1):132-45.
journal title abbreviation: Clin Immunol Immunopathol
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Apoptosis
MeSH DescriptorUI: D017209
MeSH semantic group name: Physiology
number of authors: 441
number of publications: 1760
uniqueness weight: 0.619708
type: Concept

Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
PubMed Identifier: 8258716
author list: Froelich CJ, Zhang X, Turbov J, Hudig D, Winkler U, Hanna WL
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol. 1993 Dec 15; 151(12):7161-71.
journal title abbreviation: J Immunol
publication date: 1993-12-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Salmonella typhimurium mitogen induces proliferation of human B lymphocytes.
PubMed Identifier: 3888415
author list: McChesney MB, Froelich CJ, Cantrell JL, Williams RC
published in: Cellular immunology
information resource reference: Salmonella typhimurium mitogen induces proliferation of human B lymphocytes. Cell Immunol. 1985 Jun; 93(1):83-90.
journal title abbreviation: Cell Immunol
publication date: 1985-06-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.
PubMed Identifier: 20580434
author list: Praper T, Besenicar MP, Istinic H, Podlesek Z, Metkar SS, Froelich CJ, Anderluh G
published in: Molecular immunology
information resource reference: Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH. Mol Immunol. 2010 Sep; 47(15):2492-504.
journal title abbreviation: Mol Immunol
publication date: 2010-06-26T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Enrichment of natural killer cells by negative selection: comparison to Percoll gradient separation method.
PubMed Identifier: 6366058
author list: Froelich CJ, Sibbitt WL, Bankhurst AD
published in: Journal of immunological methods
information resource reference: Enrichment of natural killer cells by negative selection: comparison to Percoll gradient separation method. J Immunol Methods. 1983 Nov 25; 64(3):327-33.
journal title abbreviation: J Immunol Methods
publication date: 1983-11-25T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors.
PubMed Identifier: 6651894
author list: Sibbitt WL, Froelich CJ, Bankhurst AD
published in: Arthritis and rheumatism
information resource reference: Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors. Arthritis Rheum. 1983 Dec; 26(12):1452-9.
journal title abbreviation: Arthritis Rheum
publication date: 1983-12-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Telltale mouth flora: a clue to the diagnosis of factitious recurrent thigh abscesses.
PubMed Identifier: 424800
author list: Selinger DS, Chongsiriwatana K, Froelich CJ, Vogel AV, Kisch AL
published in: Southern medical journal
information resource reference: Telltale mouth flora: a clue to the diagnosis of factitious recurrent thigh abscesses. South Med J. 1979 Feb; 72(2):225-6.
journal title abbreviation: South Med J
publication date: 1979-02-01T00:00:00
year: 1979
type: Academic Article
type: Article
type: Document
type: Information Resource

Human E-rosette-positive cells which bind monomeric IgG mediate natural cytotoxicity.
PubMed Identifier: 7083331
author list: Froelich CJ, Tai AS, Bankhurst AD, Warner NL
published in: Cellular immunology
information resource reference: Human E-rosette-positive cells which bind monomeric IgG mediate natural cytotoxicity. Cell Immunol. 1982 Jan 01; 66(1):190-4.
journal title abbreviation: Cell Immunol
publication date: 1982-01-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Antiphospholipid antibodies associated with retinal vascular disease.
PubMed Identifier: 3124231
author list: Pulido JS, Ward LM, Fishman GA, Goodwin JA, Froelich CJ, Sanghvi JP
published in: Retina (Philadelphia, Pa.)
information resource reference: Antiphospholipid antibodies associated with retinal vascular disease. Retina. 1987; 7(4):215-8.
journal title abbreviation: Retina
publication date: 1987-01-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.
PubMed Identifier: 7963538
author list: Hanna WL, Turbov JM, Jackman HL, Tan F, Froelich CJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein. J Immunol. 1994 Nov 15; 153(10):4663-72.
journal title abbreviation: J Immunol
publication date: 1994-11-15T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhancement of natural cytotoxicity by beta-endorphin.
PubMed Identifier: 6300232
author list: Mathews PM, Froelich CJ, Sibbitt WL, Bankhurst AD
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Enhancement of natural cytotoxicity by beta-endorphin. J Immunol. 1983 Apr; 130(4):1658-62.
journal title abbreviation: J Immunol
publication date: 1983-04-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry.
PubMed Identifier: 6214345
author list: Froelich CJ, Bankhurst AD, Warner NL
published in: Clinical immunology and immunopathology
information resource reference: Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry. Clin Immunol Immunopathol. 1982 Jan; 22(1):105-17.
journal title abbreviation: Clin Immunol Immunopathol
publication date: 1982-01-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin rapidly induces plasma membrane phospholipid flip-flop.
PubMed Identifier: 21931672
author list: Metkar SS, Wang B, Catalan E, Anderluh G, Gilbert RJ, Pardo J, Froelich CJ
published in: PloS one
information resource reference: Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One. 2011; 6(9):e24286.
journal title abbreviation: PLoS One
publication date: 2011-09-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG.
PubMed Identifier: 6368063
author list: Froelich CJ, Bankhurst AD
published in: Clinical and experimental immunology
information resource reference: Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG. Clin Exp Immunol. 1984 Mar; 55(3):664-70.
journal title abbreviation: Clin Exp Immunol
publication date: 1984-03-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Natural killing and antibody-dependent cellular cytotoxicity: characterization of effector cells by E-rosetting and monoclonal antibodies.
PubMed Identifier: 6850846
author list: Froelich CJ, Bankhurst AD
published in: Cellular immunology
information resource reference: Natural killing and antibody-dependent cellular cytotoxicity: characterization of effector cells by E-rosetting and monoclonal antibodies. Cell Immunol. 1983 May; 78(1):33-42.
journal title abbreviation: Cell Immunol
publication date: 1983-05-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera.
PubMed Identifier: 6971106
author list: Williams RC, Froelich CJ, Kilpatrick K, Crowe WE, Levinson JE
published in: Arthritis and rheumatism
information resource reference: T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera. Arthritis Rheum. 1981 Apr; 24(4):585-91.
journal title abbreviation: Arthritis Rheum
publication date: 1981-04-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

https://profiles.uchicago.edu/profiles/profile/238941
PubMed Identifier: 17142451
author list: Swanson R, Raghavendra MP, Zhang W, Froelich C, Gettins PG, Olson ST
published in: The Journal of biological chemistry
information resource reference: Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1. J Biol Chem. 2007 Jan 26; 282(4):2305-13.
journal title abbreviation: J Biol Chem
publication date: 2006-12-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1.

A case of Guillain-Barré syndrome with immunologic abnormalities.
PubMed Identifier: 7436188
author list: Froelich CJ, Searles RP, Davis LE, Goodwin JS
published in: Annals of internal medicine
information resource reference: A case of Guillain-Barré syndrome with immunologic abnormalities. Ann Intern Med. 1980 Oct; 93(4):563-5.
journal title abbreviation: Ann Intern Med
publication date: 1980-10-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Lymphocytotoxic antibodies in Guillain-Barré syndrome.
PubMed Identifier: 6109920
author list: Searles RP, Davis LE, Hermanson S, Froelich CJ
published in: Lancet (London, England)
information resource reference: Lymphocytotoxic antibodies in Guillain-Barré syndrome. Lancet. 1981 Jan 31; 1(8214):273.
journal title abbreviation: Lancet
publication date: 1981-01-31T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid arthritis and normal controls.
PubMed Identifier: 6971100
author list: Froelich CJ, Bankhurst AD, Crowe WE, Williams RC, Warner NL, Levinson JE
published in: Arthritis and rheumatism
information resource reference: Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid arthritis and normal controls. Arthritis Rheum. 1981 Mar; 24(3):457-63.
journal title abbreviation: Arthritis Rheum
publication date: 1981-03-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.
PubMed Identifier: 7608566
author list: Sower LE, Froelich CJ, Carney DH, Fenton JW, Klimpel GR
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. J Immunol. 1995 Jul 15; 155(2):895-901.
journal title abbreviation: J Immunol
publication date: 1995-07-15T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Human granzyme B is essential for DNA fragmentation of susceptible target cells.
PubMed Identifier: 8088328
author list: Su B, Bochan MR, Hanna WL, Froelich CJ, Brahmi Z
published in: European journal of immunology
information resource reference: Human granzyme B is essential for DNA fragmentation of susceptible target cells. Eur J Immunol. 1994 Sep; 24(9):2073-80.
journal title abbreviation: Eur J Immunol
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation.
PubMed Identifier: 19249384
author list: Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM
published in: Microbes and infection
information resource reference: The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr; 11(4):452-9.
journal title abbreviation: Microbes Infect
publication date: 2009-02-26T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
PubMed Identifier: 20395300
author list: Martin P, Pardo J, Schill N, Jöckel L, Berg M, Froelich CJ, Wallich R, Simon MM
published in: The Journal of biological chemistry
information resource reference: Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem. 2010 Jun 11; 285(24):18918-27.
journal title abbreviation: J Biol Chem
publication date: 2010-04-15T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
PubMed Identifier: 3264041
author list: Froelich CJ, Burkett JS, Guiffaut S, Kingsland R, Brauner D
published in: Life sciences
information resource reference: Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion. Life Sci. 1988; 43(20):1583-90.
journal title abbreviation: Life Sci
publication date: 1988-01-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease?
PubMed Identifier: 6448001
author list: Froelich CJ, Goodwin JS, Bankhurst AD, Williams RC
published in: The American journal of medicine
information resource reference: Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease? Am J Med. 1980 Sep; 69(3):329-31.
journal title abbreviation: Am J Med
publication date: 1980-09-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.
PubMed Identifier: 8786323
author list: Sower LE, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol. 1996 Apr 01; 156(7):2585-90.
journal title abbreviation: J Immunol
publication date: 1996-04-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
PubMed Identifier: 9334372
author list: Talanian RV, Yang X, Turbov J, Seth P, Ghayur T, Casiano CA, Orth K, Froelich CJ
published in: The Journal of experimental medicine
information resource reference: Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med. 1997 Oct 20; 186(8):1323-31.
journal title abbreviation: J Exp Med
publication date: 1997-10-20T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
PubMed Identifier: 9780161
author list: Kataoka T, Schröter M, Hahne M, Schneider P, Irmler M, Thome M, Froelich CJ, Tschopp J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 1998 Oct 15; 161(8):3936-42.
journal title abbreviation: J Immunol
publication date: 1998-10-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
PubMed Identifier: 10228010
author list: Galvin JP, Spaeny-Dekking LH, Wang B, Seth P, Hack CE, Froelich CJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999 May 01; 162(9):5345-50.
journal title abbreviation: J Immunol
publication date: 1999-05-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
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Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
PubMed Identifier: 11157142
author list: Ronday HK, van der Laan WH, Tak PP, de Roos JA, Bank RA, TeKoppele JM, Froelich CJ, Hack CE, Hogendoorn PC, Breedveld FC, Verheijen JH
published in: Rheumatology (Oxford, England)
information resource reference: Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. Rheumatology (Oxford). 2001 Jan; 40(1):55-61.
journal title abbreviation: Rheumatology (Oxford)
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
PubMed Identifier: 12377935
author list: Vermijlen D, Luo D, Froelich CJ, Medema JP, Kummer JA, Willems E, Braet F, Wisse E
published in: Journal of leukocyte biology
information resource reference: Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol. 2002 Oct; 72(4):668-76.
journal title abbreviation: J Leukoc Biol
publication date: 2002-10-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
PubMed Identifier: 14499261
author list: Raja SM, Metkar SS, Froelich CJ
published in: Current opinion in immunology
information resource reference: Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 2003 Oct; 15(5):528-32.
journal title abbreviation: Curr Opin Immunol
publication date: 2003-10-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Right place, right time.
PubMed Identifier: 14749780
author list: Froelich CJ
published in: Nature immunology
information resource reference: Right place, right time. Nat Immunol. 2004 Feb; 5(2):124-5.
journal title abbreviation: Nat Immunol
publication date: 2004-02-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
PubMed Identifier: 15014070
author list: Han J, Goldstein LA, Gastman BR, Froelich CJ, Yin XM, Rabinowich H
published in: The Journal of biological chemistry
information resource reference: Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events. J Biol Chem. 2004 May 21; 279(21):22020-9.
journal title abbreviation: J Biol Chem
publication date: 2004-03-10T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Detection of anticardiolipin antibody in patients with cocaine abuse.
PubMed Identifier: 1955680
author list: Fritsma GA, Leikin JB, Maturen AJ, Froelich CJ, Hryhorczuk DO
published in: The Journal of emergency medicine
information resource reference: Detection of anticardiolipin antibody in patients with cocaine abuse. J Emerg Med. 1991; 9 Suppl 1:37-43.
journal title abbreviation: J Emerg Med
publication date: 1991-01-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells.
PubMed Identifier: 18769617
author list: Rajalingam K, Sharma M, Lohmann C, Oswald M, Thieck O, Froelich CJ, Rudel T
published in: PloS one
information resource reference: Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 01; 3(9):e3102.
journal title abbreviation: PLoS One
publication date: 2008-09-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.
PubMed Identifier: 20388708
author list: Han J, Goldstein LA, Hou W, Froelich CJ, Watkins SC, Rabinowich H
published in: The Journal of biological chemistry
information resource reference: Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem. 2010 Jul 16; 285(29):22461-72.
journal title abbreviation: J Biol Chem
publication date: 2010-04-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Human perforin employs different avenues to damage membranes.
PubMed Identifier: 20889983
author list: Praper T, Sonnen A, Viero G, Kladnik A, Froelich CJ, Anderluh G, Dalla Serra M, Gilbert RJ
published in: The Journal of biological chemistry
information resource reference: Human perforin employs different avenues to damage membranes. J Biol Chem. 2011 Jan 28; 286(4):2946-55.
journal title abbreviation: J Biol Chem
publication date: 2010-10-02T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

D-penicillamine-induced myasthenia gravis in rheumatoid arthritis.
PubMed Identifier: 458795
author list: Froelich CJ, Hashimoto F, Searles RP, Bankhurst AD
published in: The Journal of rheumatology
information resource reference: D-penicillamine-induced myasthenia gravis in rheumatoid arthritis. J Rheumatol. 1979 Mar-Apr; 6(2):237-9.
journal title abbreviation: J Rheumatol
publication date: 1979-03-01T00:00:00
year: 1979
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of lymphokine activated killer cells in serum-free medium.
PubMed Identifier: 3484769
author list: Froelich CJ, Guiffaut S
published in: Journal of immunological methods
information resource reference: Induction of lymphokine activated killer cells in serum-free medium. J Immunol Methods. 1986 Feb 12; 86(2):205-11.
journal title abbreviation: J Immunol Methods
publication date: 1986-02-12T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapid purification of cationic granule proteases: application to human granzymes.
PubMed Identifier: 8251751
author list: Hanna WL, Zhang X, Turbov J, Winkler U, Hudig D, Froelich CJ
published in: Protein expression and purification
information resource reference: Rapid purification of cationic granule proteases: application to human granzymes. Protein Expr Purif. 1993 Oct; 4(5):398-404.
journal title abbreviation: Protein Expr Purif
publication date: 1993-10-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

T-Lymphocytes, Cytotoxic
MeSH DescriptorUI: D013602
MeSH semantic group name: Anatomy
number of authors: 83
number of publications: 320
uniqueness weight: 0.887053
type: Concept

Granzymes
MeSH DescriptorUI: D053804
MeSH semantic group name: Chemicals & Drugs
number of authors: 22
number of publications: 96
uniqueness weight: 0.972604
type: Concept

Perforin
MeSH DescriptorUI: D054353
MeSH semantic group name: Chemicals & Drugs
number of authors: 16
number of publications: 56
uniqueness weight: 0.977827
type: Concept

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Molecular Mechanism of Granule-mediated Apoptosis
end date: 2012-01-31
grant awarded by: NIH
principal investigator name: FROELICH, CHRISTOPHER JOHN
start date: 2000-06-01
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Principal Investigator
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researcher role of: Froelich, Christopher
contributes to: Molecular Mechanism of Granule-mediated Apoptosis

Serine Endopeptidases
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Medicine
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Pathology
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Pediatrics
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Radiology
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University of Chicago
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Authorship 71718
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linked information resource: Membrane pore formation at protein-lipid interfaces.

Authorship 72210
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linked information resource: Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

Authorship 76086
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linked information resource: Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.

Authorship 78160
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Authorship 78187
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linked information resource: Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.

Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.
PubMed Identifier: 25017060
author list: Arias MA, Jiménez de Bagües MP, Aguiló N, Menao S, Hervás-Stubbs S, de Martino A, Alcaraz A, Simon MM, Froelich CJ, Pardo J
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information resource reference: Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis. Cell Rep. 2014 Jul 24; 8(2):420-9.
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Membrane pore formation at protein-lipid interfaces.
PubMed Identifier: 25440714
author list: Gilbert RJ, Dalla Serra M, Froelich CJ, Wallace MI, Anderluh G
published in: Trends in biochemical sciences
information resource reference: Membrane pore formation at protein-lipid interfaces. Trends Biochem Sci. 2014 Nov; 39(11):510-6.
journal title abbreviation: Trends Biochem Sci
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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
PubMed Identifier: 25146929
author list: Metkar SS, Marchioretto M, Antonini V, Lunelli L, Wang B, Gilbert RJ, Anderluh G, Roth R, Pooga M, Pardo J, Heuser JE, Serra MD, Froelich CJ
published in: Cell death and differentiation
information resource reference: Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. Cell Death Differ. 2015 Jan; 22(1):74-85.
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Can foot orthoses prevent hallux valgus deformity in rheumatoid arthritis? A randomized clinical trial.
PubMed Identifier: 19078008
author list: Budiman-Mak E, Conrad KJ, Roach KE, Moore JW, Lertratanakul Y, Koch AE, Skosey JL, Froelich C, Joyce-Clark N
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information resource reference: Can foot orthoses prevent hallux valgus deformity in rheumatoid arthritis? A randomized clinical trial. J Clin Rheumatol. 1995 Dec; 1(6):313-22.
journal title abbreviation: J Clin Rheumatol
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Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
PubMed Identifier: 25605735
author list: Catalán E, Jaime-Sánchez P, Aguiló N, Simon MM, Froelich CJ, Pardo J
published in: The Journal of biological chemistry
information resource reference: Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
journal title abbreviation: J Biol Chem
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10
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Rathmell, Jeffrey
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linked information resource: Glomerulosclerosis in the sudden infant death syndrome.

Authorship 60290
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linked information resource: Effects of MACPF/CDC proteins on lipid membranes.

Authorship 61199
type: Authorship
author rank in publication: 11
linked author: Froelich, Christopher
linked information resource: Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.

Glomerulosclerosis in the sudden infant death syndrome.
PubMed Identifier: 2315230
author list: Valdes-Dapena M, Hoffman HJ, Froelich C, Requeira O
published in: Pediatric pathology
information resource reference: Glomerulosclerosis in the sudden infant death syndrome. Pediatr Pathol. 1990; 10(1-2):273-9.
journal title abbreviation: Pediatr Pathol
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Professor
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Professor
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Clinical Professor
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Emeritus/Emerita, Professor
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Clinical Professor
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Professor
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Professor-Clinical Dept
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Clinical Associate
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Professor
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Effects of MACPF/CDC proteins on lipid membranes.
PubMed Identifier: 22983385
author list: Gilbert RJ, Mikelj M, Dalla Serra M, Froelich CJ, Anderluh G
published in: Cellular and molecular life sciences : CMLS
information resource reference: Effects of MACPF/CDC proteins on lipid membranes. Cell Mol Life Sci. 2013 Jun; 70(12):2083-98.
journal title abbreviation: Cell Mol Life Sci
publication date: 2012-09-15T00:00:00
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Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.
PubMed Identifier: 23326234
author list: Spencer CT, Abate G, Sakala IG, Xia M, Truscott SM, Eickhoff CS, Linn R, Blazevic A, Metkar SS, Peng G, Froelich CJ, Hoft DF
published in: PLoS pathogens
information resource reference: Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. PLoS Pathog. 2013 Jan; 9(1):e1003119.
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Authorship 98755
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linked information resource: Granzymes A and K differentially potentiate LPS-induced cytokine response.

Granzymes A and K differentially potentiate LPS-induced cytokine response.
PubMed Identifier: 28028441
author list: Wensink AC, Kok HM, Meeldijk J, Fermie J, Froelich CJ, Hack CE, Bovenschen N
published in: Cell death discovery
information resource reference: Granzymes A and K differentially potentiate LPS-induced cytokine response. Cell Death Discov. 2016; 2:16084.
journal title abbreviation: Cell Death Discov
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Authorship 99423
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linked information resource: Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.

Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.
PubMed Identifier: 27598995
author list: Santiago L, Menaa C, Arias M, Martin P, Jaime-Sánchez P, Metkar S, Comas L, Erill N, Gonzalez-Rumayor V, Esser E, Galvez EM, Raja S, Simon MM, Sprague SM, Gabay C, Martinez-Lostao L, Pardo J, Froelich CJ
published in: Arthritis & rheumatology (Hoboken, N.J.)
information resource reference: Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. Arthritis Rheumatol. 2017 Feb; 69(2):320-334.
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