Nancy B.SchwartzNancy B. Schwartz41.78927490000000-87.601250000000001432Schwartz, Nancy B.ChondrodystrophGenetic disordersCNS developmentThis program has evolved from the basic biochemistry and enzymology of glycoconjugate structure, function, and synthesis to the study of glycoconjugates in cartilage development, including the identification of gene defects in disorders of skeletal development and chondrodystrophies and the underlying pathophysiology of the matrix deficiencies.
A second major area of interest involves CNS development, and the role of gliogenesis and glial cell function in traumatic brain injury, infection and developmental disorders.Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonPediatrics-Kennedy CenterKunioDoiKunio Doi41.7886000000000087.598699999999993668Doi, KunioRalph W. Gerard Professor of Biological Sciences, Emeritus1971University of PittsburghPittsburgh, PAUniversity of Pittsburgh, BiochemistryPhDBiochemistry1971-74University of ChicagoChicago, ILUniversity of Chicago, BiochemistryPostdocBiochemistryArthritis Foundation FellowshipAmerican Heart Association Established Investigatorship Research Career Development Award NIH Merit AwardeeNPA Distinguished Service AwardAuthorship 1079086Authorship 1079091Authorship 107910Authorship 10791129513405Schwartz NB, Domowicz MSFEBS lettersProteoglycans in brain development and pathogenesis. FEBS Lett. 2018 12; 592(23):3791-3805.FEBS Lett2018-03-23T00:00:002018Proteoglycans in brain development and pathogenesis.Domowicz, M.S., Cortes, M., Schwartz, N.B. (2015)In "Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials" Royal Society of Chemistry Publishing Matrix Biology: Gradients and patterns within the extracellular matrix. In "Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials" Royal Society of Chemistry Publishing. (Chapter 2; pp 31-64).1900-01-01T00:00:001900Matrix Biology: Gradients and patterns within the extracellular matrixSchwartz, NB. and Domowicz M. (2017) Chapter 03764: Chondrodysplasias, 2018 in Reference Module in Biomedical Sciences, Ed. M.Kaplan, Elsevier Ltd., Oxford, UK.Chapter 03764: Chondrodysplasias, 2018 in Reference Module in Biomedical Sciences, Ed. M.Kaplan, Elsevier Ltd., Oxford, UK. 1900-01-01T00:00:001900Chapter 03764: Chondrodysplasias, 2018 in Reference Module in Biomedical Sciences, Ed. M.Kaplan, Elsevier Ltd., Oxford, UK29274879Domowicz M, Wadlington NL, Henry JG, Diaz K, Munoz MJ, Schwartz NBBrain researchGlial cell responses in a murine multifactorial perinatal brain injury model. Brain Res. 2018 02 15; 1681:52-63.Brain Res2017-12-21T00:00:002017Glial cell responses in a murine multifactorial perinatal brain injury model.NIH Mentor of Excellence Award Authorship 1257825Authorship 1258001529049023Hitchcock P, Mathur A, Bennett J, Cameron P, Chow C, Clifford P, Duvoisin R, Feig A, Finneran K, Klotz DM, McGee R, O'Riordan M, Pfund C, Pickett C, Schwartz N, Street NE, Watkins E, Wiest J, Engelke DeLifeThe future of graduate and postdoctoral training in the biosciences. Elife. 2017 10 19; 6.Elife2017-10-19T00:00:002017The future of graduate and postdoctoral training in the biosciences.30561332McConnell SC, Westerman EL, Pierre JF, Heckler EJ, Schwartz NBeLifeUnited States National Postdoc Survey results and the interaction of gender, career choice and mentor impact. Elife. 2018 12 18; 7.Elife2018-12-18T00:00:002018United States National Postdoc Survey results and the interaction of gender, career choice and mentor impact.Authorship 104631Authorship 106064Authorship 110963Authorship 102656Authorship 102645Authorship 102504Authorship 107682Authorship 106905Authorship 119123Authorship 119133Authorship 116716Authorship 1223Authorship 115643Authorship 133591Authorship 125956Authorship 149287Authorship 133415Authorship 145594Authorship 128970731003587Domowicz MS, Chan WC, Claudio-Vázquez P, Henry JG, Ware CB, Andrade J, Dawson G, Schwartz NBASN neuroGlobal Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model. ASN Neuro. 2019 Jan-Dec; 11:1759091419843393.ASN Neuro2019-01-01T00:00:002019Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.Authorship 17787Authorship 167803Authorship 158814Authorship 166503Authorship 181274Authorship 16213Authorship 175701Authorship 189214Authorship 18543Authorship 178623Authorship 1802Authorship 22844Authorship 165025Authorship 207231Authorship 214894Authorship 21552Authorship 218285Authorship 189543Authorship 2712Authorship 277037Authorship 2562Authorship 259001Authorship 229253Authorship 315541Authorship 33334Authorship 3414Authorship 378823Authorship 35112Authorship 402451Authorship 442926Authorship 32843D011509Chemicals & Drugs411210.936898ProteoglycansAuthorship 135324131969784Schwartz NB, Risner LE, Domowicz M, Freedman VHEthnicity & diseaseComparisons and Approaches of PREP Programs at Different Stages of Maturity: Challenges, Best Practices and Benefits. Ethn Dis. 2020; 30(1):55-64.Ethn Dis2020-01-16T00:00:002020Comparisons and Approaches of PREP Programs at Different Stages of Maturity: Challenges, Best Practices and Benefits.Authorship 36402Authorship 364102Authorship 375074Authorship 49842Authorship 135884432083237Jo SY, Domowicz MS, Henry JG, Schwartz NBJBMR plusThe Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone. JBMR Plus. 2020 Feb; 4(2):e10254.JBMR Plus2019-12-17T00:00:002019The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone.Authorship 57942Authorship 60383Authorship 61833Authorship 37485Authorship 7231Authorship 73692Authorship 83252Authorship 85404Authorship 87066Authorship 89166Authorship 941Authorship 83971Authorship 89695Authorship 96604Authorship 47084Authorship 477824Authorship 5352Authorship 5371Authorship 473634Authorship 47702Authorship 45262Authorship 75912Authorship 75982Authorship 8451Authorship 8591Authorship 9244Authorship 54632Authorship 6031Authorship 60803Authorship 75755Authorship 5431Authorship 60371Authorship 65151Authorship 49052Authorship 7621Authorship 63741Authorship 67141Authorship 71263Authorship 7641Authorship 991Authorship 115655Authorship 117982Authorship 120193Authorship 129854Authorship 144573Authorship 146361Authorship 156441Authorship 18524Authorship 140457732870930Risner LE, Morin XK, Erenrich ES, Clifford PS, Franke J, Hurley I, Schwartz NBPloS oneLeveraging a collaborative consortium model of mentee/mentor training to foster career progression of underrepresented postdoctoral researchers and promote institutional diversity and inclusion. PLoS One. 2020; 15(9):e0238518.PLoS One2020-09-01T00:00:002020Leveraging a collaborative consortium model of mentee/mentor training to foster career progression of underrepresented postdoctoral researchers and promote institutional diversity and inclusion.Authorship 340654Authorship 368584Authorship 1406511132909945Nandadasa S, Szafron JM, Pathak V, Murtada SI, Kraft CM, O'Donnell A, Norvik C, Hughes C, Caterson B, Domowicz MS, Schwartz NB, Tran-Lundmark K, Veigl M, Sedwick D, Philipson EH, Humphrey JD, Apte SSeLifeVascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. Elife. 2020 09 10; 9.Elife2020-09-10T00:00:002020Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.Authorship 54544Authorship 6731Authorship 73682Authorship 78803Authorship 844118619989Ozeran JD, Westley J, Schwartz NBBiochemistryIdentification and partial purification of PAPS translocase. Biochemistry. 1996 Mar 26; 35(12):3695-703.Biochemistry1996-03-26T00:00:001996Identification and partial purification of PAPS translocase.8536646Szabo M, Knox KL, Ringstrom SJ, Perlyn CA, Sutandi S, Schwartz NBEndocrinologyMechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology. 1996 Jan; 137(1):85-9.Endocrinology1996-01-01T00:00:001996Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge.8587132Li H, Schwartz NBJournal of molecular evolutionGene structure of chick cartilage chondroitin sulfate proteoglycan (aggrecan) core protein. J Mol Evol. 1995 Dec; 41(6):878-85.J Mol Evol1995-12-01T00:00:001995Gene structure of chick cartilage chondroitin sulfate proteoglycan (aggrecan) core protein.8496172Kearns AE, Vertel BM, Schwartz NBThe Journal of biological chemistryTopography of glycosylation and UDP-xylose production. J Biol Chem. 1993 May 25; 268(15):11097-104.J Biol Chem1993-05-25T00:00:001993Topography of glycosylation and UDP-xylose production.8496173Vertel BM, Walters LM, Flay N, Kearns AE, Schwartz NBThe Journal of biological chemistryXylosylation is an endoplasmic reticulum to Golgi event. J Biol Chem. 1993 May 25; 268(15):11105-12.J Biol Chem1993-05-25T00:00:001993Xylosylation is an endoplasmic reticulum to Golgi event.167013Galligani L, Hopwood J, Schwartz NB, Dorfman AThe Journal of biological chemistryStimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells. J Biol Chem. 1975 Jul 25; 250(14):5400-6.J Biol Chem1975-07-25T00:00:001975Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells.8965652Li H, Domowicz M, Hennig A, Schwartz NBBrain research. Molecular brain researchS103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene. Brain Res Mol Brain Res. 1996 Mar; 36(2):309-21.Brain Res Mol Brain Res1996-03-01T00:00:001996S103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene.8635512Pettway Z, Domowicz M, Schwartz NB, Bronner-Fraser MExperimental cell researchAge-dependent inhibition of neural crest migration by the notochord correlates with alterations in the S103L chondroitin sulfate proteoglycan. Exp Cell Res. 1996 May 25; 225(1):195-206.Exp Cell Res1996-05-25T00:00:001996Age-dependent inhibition of neural crest migration by the notochord correlates with alterations in the S103L chondroitin sulfate proteoglycan.8619988Ozeran JD, Westley J, Schwartz NBBiochemistryKinetics of PAPS translocase: evidence for an antiport mechanism. Biochemistry. 1996 Mar 26; 35(12):3685-94.Biochemistry1996-03-26T00:00:001996Kinetics of PAPS translocase: evidence for an antiport mechanism.9519833Immergluck LC, Domowicz MS, Schwartz NB, Herold BCThe Journal of general virologyViral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells. J Gen Virol. 1998 Mar; 79 ( Pt 3):549-59.J Gen Virol1998-03-01T00:00:001998Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells.8842798Domowicz M, Krueger RC, Li H, Mangoura D, Vertel BM, Schwartz NBInternational journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceThe nanomelic mutation in the aggrecan gene is expressed in chick chondrocytes and neurons. Int J Dev Neurosci. 1996 Jun; 14(3):191-201.Int J Dev Neurosci1996-06-01T00:00:001996The nanomelic mutation in the aggrecan gene is expressed in chick chondrocytes and neurons.10559207Kurima K, Singh B, Schwartz NBThe Journal of biological chemistryGenomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. J Biol Chem. 1999 Nov 19; 274(47):33306-12.J Biol Chem1999-11-19T00:00:001999Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2.9111072Pirok EW, Li H, Mensch JR, Henry J, Schwartz NBThe Journal of biological chemistryStructural and functional analysis of the chick chondroitin sulfate proteoglycan (aggrecan) promoter and enhancer region. J Biol Chem. 1997 Apr 25; 272(17):11566-74.J Biol Chem1997-04-25T00:00:001997Structural and functional analysis of the chick chondroitin sulfate proteoglycan (aggrecan) promoter and enhancer region.9566742Schwartz NB, Lyle S, Ozeran JD, Li H, Deyrup A, Ng K, Westley JChemico-biological interactionsSulfate activation and transport in mammals: system components and mechanisms. Chem Biol Interact. 1998 Feb 20; 109(1-3):143-51.Chem Biol Interact1998-02-20T00:00:001998Sulfate activation and transport in mammals: system components and mechanisms.9671738Kurima K, Warman ML, Krishnan S, Domowicz M, Krueger RC, Deyrup A, Schwartz NBProceedings of the National Academy of Sciences of the United States of AmericaA member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8681-5.Proc Natl Acad Sci U S A1998-07-21T00:00:001998A member of a family of sulfate-activating enzymes causes murine brachymorphism.10506138Deyrup AT, Singh B, Krishnan S, Lyle S, Schwartz NBThe Journal of biological chemistryChemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. J Biol Chem. 1999 Oct 08; 274(41):28929-36.J Biol Chem1999-10-08T00:00:001999Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase.10594233Krueger RC, Kurima K, Schwartz NBMammalian genome : official journal of the International Mammalian Genome SocietyCompletion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene. Mamm Genome. 1999 Dec; 10(12):1119-25.Mamm Genome1999-12-01T00:00:001999Completion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene.10877997Schwartz NFrontiers in bioscience : a journal and virtual libraryBiosynthesis and regulation of expression of proteoglycans. Front Biosci. 2000 Jul 01; 5:D649-55.Front Biosci2000-07-01T00:00:002000Biosynthesis and regulation of expression of proteoglycans.10196147Deyrup AT, Krishnan S, Singh B, Schwartz NBThe Journal of biological chemistryActivity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. J Biol Chem. 1999 Apr 16; 274(16):10751-7.J Biol Chem1999-04-16T00:00:001999Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase.9932455Schwartz NB, Pirok EW, Mensch JR, Domowicz MSProgress in nucleic acid research and molecular biologyDomain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family. Prog Nucleic Acid Res Mol Biol. 1999; 62:177-225.Prog Nucleic Acid Res Mol Biol1999-01-01T00:00:001999Domain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family.Authorship 1420361733166315Weber-Main AM, McGee R, Eide Boman K, Hemming J, Hall M, Unold T, Harwood EM, Risner LE, Smith A, Lawson K, Engler J, Steer CJ, Buchwald D, Jones HP, Manson SM, Ofili E, Schwartz NB, Vishwanatha JK, Okuyemi KSPloS oneGrant application outcomes for biomedical researchers who participated in the National Research Mentoring Network's Grant Writing Coaching Programs. PLoS One. 2020; 15(11):e0241851.PLoS One2020-11-09T00:00:002020Grant application outcomes for biomedical researchers who participated in the National Research Mentoring Network's Grant Writing Coaching Programs.1601881Krueger RC, Hennig AK, Schwartz NBThe Journal of biological chemistryTwo immunologically and developmentally distinct chondroitin sulfate proteolglycans in embryonic chick brain. J Biol Chem. 1992 Jun 15; 267(17):12149-61.J Biol Chem1992-06-15T00:00:001992Two immunologically and developmentally distinct chondroitin sulfate proteolglycans in embryonic chick brain.11063750Domowicz MS, Pirok EW, Novak TE, Schwartz NBThe Journal of biological chemistryRole of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors. J Biol Chem. 2000 Nov 10; 275(45):35098-105.J Biol Chem2000-11-10T00:00:002000Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors.1665019Ng K, D'Souza M, Callahan L, Geller DH, Kearns AE, Lyle S, Schwartz NBAnalytical biochemistrySynthesis and utilization of a nonhydrolyzable phosphoadenosine phosphosulfate analog. Anal Biochem. 1991 Oct; 198(1):60-7.Anal Biochem1991-10-01T00:00:001991Synthesis and utilization of a nonhydrolyzable phosphoadenosine phosphosulfate analog.1694853Krueger RC, Fields TA, Mensch JR, Schwartz NBThe Journal of biological chemistryChick cartilage chondroitin sulfate proteoglycan core protein. II. Nucleotide sequence of cDNA clone and localization of the S103L epitope. J Biol Chem. 1990 Jul 15; 265(20):12088-97.J Biol Chem1990-07-15T00:00:001990Chick cartilage chondroitin sulfate proteoglycan core protein. II. Nucleotide sequence of cDNA clone and localization of the S103L epitope.1694854Dennis JE, Carrino DA, Schwartz NB, Caplan AIThe Journal of biological chemistryUltrastructural characterization of embryonic chick cartilage proteoglycan core protein and the mapping of a monoclonal antibody epitope. J Biol Chem. 1990 Jul 15; 265(20):12098-103.J Biol Chem1990-07-15T00:00:001990Ultrastructural characterization of embryonic chick cartilage proteoglycan core protein and the mapping of a monoclonal antibody epitope.197101John KV, Schwartz NB, Ankel HThe Journal of biological chemistryUDP-glucuronate carboxy-lyase in cultured chondrocytes. J Biol Chem. 1977 Oct 10; 252(19):6707-10.J Biol Chem1977-10-10T00:00:001977UDP-glucuronate carboxy-lyase in cultured chondrocytes.11350977Pirok EW, Henry J, Schwartz NBThe Journal of biological chemistrycis elements that control the expression of chick aggrecan. J Biol Chem. 2001 May 18; 276(20):16894-903.J Biol Chem2001-05-18T00:00:002001cis elements that control the expression of chick aggrecan.12508223Domowicz MS, Mueller MM, Novak TE, Schwartz LE, Schwartz NBDevelopmental dynamics : an official publication of the American Association of AnatomistsDevelopmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis. Dev Dyn. 2003 Jan; 226(1):42-50.Dev Dyn2003-01-01T00:00:002003Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis.12855192Domowicz MS, Mangoura D, Schwartz NBBrain research. Developmental brain researchAggrecan regulates telencephalic neuronal aggregation in culture. Brain Res Dev Brain Res. 2003 Jul 12; 143(2):207-16.Brain Res Dev Brain Res2003-07-12T00:00:002003Aggrecan regulates telencephalic neuronal aggregation in culture.1842909Callahan L, Schwartz N, Ng KAnalytical biochemistryDibasic amines as competitive ions improve the resolution between polyanionic nucleotides. Anal Biochem. 1991 Aug 01; 196(2):229-33.Anal Biochem1991-08-01T00:00:001991Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides.D016326Chemicals & Drugs631230.937767Extracellular Matrix Proteins12042245Schwartz NB, Domowicz MGlycobiologyChondrodysplasias due to proteoglycan defects. Glycobiology. 2002 Apr; 12(4):57R-68R.Glycobiology2002-04-01T00:00:002002Chondrodysplasias due to proteoglycan defects.12414806Singh B, Schwartz NBThe Journal of biological chemistryIdentification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. J Biol Chem. 2003 Jan 03; 278(1):71-5.J Biol Chem2002-10-31T00:00:002002Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase.16100116Pirok EW, Domowicz MS, Henry J, Wang Y, Santore M, Mueller MM, Schwartz NBThe Journal of biological chemistryAPBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region. J Biol Chem. 2005 Oct 21; 280(42):35606-16.J Biol Chem2005-08-12T00:00:002005APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region.Orthopedic Surgery and Rehabilitation MedicineRadiology-Basic Sciences1906743Kearns AE, Campbell SC, Westley J, Schwartz NBBiochemistryInitiation of chondroitin sulfate biosynthesis: a kinetic analysis of UDP-D-xylose: core protein beta-D-xylosyltransferase. Biochemistry. 1991 Jul 30; 30(30):7477-83.Biochemistry1991-07-30T00:00:001991Initiation of chondroitin sulfate biosynthesis: a kinetic analysis of UDP-D-xylose: core protein beta-D-xylosyltransferase.18207138Domowicz MS, Sanders TA, Ragsdale CW, Schwartz NBDevelopmental biologyAggrecan is expressed by embryonic brain glia and regulates astrocyte development. Dev Biol. 2008 Mar 01; 315(1):114-24.Dev Biol2008-01-22T00:00:002008Aggrecan is expressed by embryonic brain glia and regulates astrocyte development.19067028Bradley ME, Rest JS, Li WH, Schwartz NBJournal of molecular evolutionSulfate activation enzymes: phylogeny and association with pyrophosphatase. J Mol Evol. 2009 Jan; 68(1):1-13.J Mol Evol2008-12-06T00:00:002008Sulfate activation enzymes: phylogeny and association with pyrophosphatase.15514481Schwartz NB, Domowicz MGlycoconjugate journalProteoglycans in brain development. Glycoconj J. 2004; 21(6):329-41.Glycoconj J2004-01-01T00:00:002004Proteoglycans in brain development.2340282Campbell SC, Krueger RC, Schwartz NBBiochemistryDeglycosylation of chondroitin sulfate proteoglycan and derived peptides. Biochemistry. 1990 Jan 30; 29(4):907-14.Biochemistry1990-01-30T00:00:001990Deglycosylation of chondroitin sulfate proteoglycan and derived peptides.19369399Cortes M, Baria AT, Schwartz NBDevelopment (Cambridge, England)Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development. 2009 May; 136(10):1697-706.Development2009-04-15T00:00:002009Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate.2450484Krueger RC, Schwartz NBAnalytical biochemistryAn improved method of sequential alcian blue and ammoniacal silver staining of chondroitin sulfate proteoglycan in polyacrylamide gels. Anal Biochem. 1987 Dec; 167(2):295-300.Anal Biochem1987-12-01T00:00:001987An improved method of sequential alcian blue and ammoniacal silver staining of chondroitin sulfate proteoglycan in polyacrylamide gels.20078284Schwartz NBUpsala journal of medical sciencesRegulation of synthesis of chondroitin sulfate proteoglycan. Ups J Med Sci. 1977; 82(2):76-7.Ups J Med Sci1977-01-01T00:00:001977Regulation of synthesis of chondroitin sulfate proteoglycan.2545117Callahan L, Ng K, Geller DH, Agarwal K, Schwartz NBAnalytical biochemistrySynthesis and properties of a nonhydrolyzable adenosine phosphosulfate analog. Anal Biochem. 1989 Feb 15; 177(1):67-71.Anal Biochem1989-02-15T00:00:001989Synthesis and properties of a nonhydrolyzable adenosine phosphosulfate analog.336902Campbell CS, Schwartz NBJournal of toxicology and environmental healthSteroid feedback regulation of luteinizing hormone and follicle-stimulating hormone secretion rates in male and female rats. J Toxicol Environ Health. 1977 Sep; 3(1-2):61-95.J Toxicol Environ Health1977-09-01T00:00:001977Steroid feedback regulation of luteinizing hormone and follicle-stimulating hormone secretion rates in male and female rats.17317565Schwartz NB, Cortes M, King LAChemistry & biologyGot sulfate? Luring axons this way and that. Chem Biol. 2007 Feb; 14(2):119-20.Chem Biol2007-02-01T00:00:002007Got sulfate? Luring axons this way and that.242267Stoolmiller AC, Schwartz NB, Dorfman AArchives of biochemistry and biophysicsBiosynthesis of chondroitin 4-sulfate-proteoglycan by a transplantable rat chondrosarcoma. Arch Biochem Biophys. 1975 Nov; 171(1):124-35.Arch Biochem Biophys1975-11-01T00:00:001975Biosynthesis of chondroitin 4-sulfate-proteoglycan by a transplantable rat chondrosarcoma.3034891Geller DH, Henry JG, Belch J, Schwartz NBThe Journal of biological chemistryCo-purification and characterization of ATP-sulfurylase and adenosine-5'-phosphosulfate kinase from rat chondrosarcoma. J Biol Chem. 1987 May 25; 262(15):7374-82.J Biol Chem1987-05-25T00:00:001987Co-purification and characterization of ATP-sulfurylase and adenosine-5'-phosphosulfate kinase from rat chondrosarcoma.3065768Melvin T, Schwartz NBPathology and immunopathology researchBiochemical correlations in animal models of chondrodysplasias. Pathol Immunopathol Res. 1988; 7(1-2):68-72.Pathol Immunopathol Res1988-01-01T00:00:001988Biochemical correlations in animal models of chondrodysplasias.558875Campbell CS, Schwartz NB, Firlit MGEndocrinologyThe role of adrenal and ovarian steroids in the control of serum LH and FSH. Endocrinology. 1977 Jul; 101(1):162-72.Endocrinology1977-07-01T00:00:001977The role of adrenal and ovarian steroids in the control of serum LH and FSH.3472204Bourdon MA, Krusius T, Campbell S, Schwartz NB, Ruoslahti EProceedings of the National Academy of Sciences of the United States of AmericaIdentification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins. Proc Natl Acad Sci U S A. 1987 May; 84(10):3194-8.Proc Natl Acad Sci U S A1987-05-01T00:00:001987Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins.3479956Vernillo AT, Schwartz NBArchives of oral biologyStimulation of collagen and glycosaminoglycan production by phenytoin 5,5-diphenylhydantoin in monolayer cultures of mesenchymal cells derived from embryonic chick sternae. Arch Oral Biol. 1986; 31(12):819-23.Arch Oral Biol1986-01-01T00:00:001986Stimulation of collagen and glycosaminoglycan production by phenytoin 5,5-diphenylhydantoin in monolayer cultures of mesenchymal cells derived from embryonic chick sternae.3917943Schwartz NB, Habib G, Campbell S, D'Elvlyn D, Gartner M, Krueger R, Olson C, Philipson LFederation proceedingsSynthesis and structure of proteoglycan core protein. Fed Proc. 1985 Feb; 44(2):369-72.Fed Proc1985-02-01T00:00:001985Synthesis and structure of proteoglycan core protein.3917944Rodén L, Koerner T, Olson C, Schwartz NBFederation proceedingsMechanisms of chain initiation in the biosynthesis of connective tissue polysaccharides. Fed Proc. 1985 Feb; 44(2):373-80.Fed Proc1985-02-01T00:00:001985Mechanisms of chain initiation in the biosynthesis of connective tissue polysaccharides.6425282Philipson LH, Schwartz NBThe Journal of biological chemistrySubcellular localization of hyaluronate synthetase in oligodendroglioma cells. J Biol Chem. 1984 Apr 25; 259(8):5017-23.J Biol Chem1984-04-25T00:00:001984Subcellular localization of hyaluronate synthetase in oligodendroglioma cells.942716Schwartz NBThe Journal of biological chemistryBiosynthesis of chondroitin sulfate. Role of phospholipids in the activity of UDP-D-galactose: D-xylose galactosyltransferase. J Biol Chem. 1976 Jan 25; 251(2):285-91.J Biol Chem1976-01-25T00:00:001976Biosynthesis of chondroitin sulfate. Role of phospholipids in the activity of UDP-D-galactose: D-xylose galactosyltransferase.945267Schwartz NBThe Journal of biological chemistryChondroitin sulfate glycosyltransferases in cultured chondrocytes. Turnover, oscillatory change during growth, and suppression by 5-bromodeoxyuridine. J Biol Chem. 1976 Jun 10; 251(11):3346-51.J Biol Chem1976-06-10T00:00:001976Chondroitin sulfate glycosyltransferases in cultured chondrocytes. Turnover, oscillatory change during growth, and suppression by 5-bromodeoxyuridine.7556944Domowicz M, Li H, Hennig A, Henry J, Vertel BM, Schwartz NBDevelopmental biologyThe biochemically and immunologically distinct CSPG of notochord is a product of the aggrecan gene. Dev Biol. 1995 Oct; 171(2):655-64.Dev Biol1995-10-01T00:00:001995The biochemically and immunologically distinct CSPG of notochord is a product of the aggrecan gene.8204616Lyle S, Ozeran JD, Stanczak J, Westley J, Schwartz NBBiochemistryIntermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcoma. Biochemistry. 1994 Jun 07; 33(22):6822-7.Biochemistry1994-06-07T00:00:001994Intermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcoma.8353936Hennig AK, Mangoura D, Schwartz NBBrain research. Developmental brain researchLarge chondroitin sulfate proteoglycans of developing chick CNS are expressed in cerebral hemisphere neuronal cultures. Brain Res Dev Brain Res. 1993 Jun 08; 73(2):261-72.Brain Res Dev Brain Res1993-06-08T00:00:001993Large chondroitin sulfate proteoglycans of developing chick CNS are expressed in cerebral hemisphere neuronal cultures.19268444Domowicz MS, Cortes M, Henry JG, Schwartz NBDevelopmental biologyAggrecan modulation of growth plate morphogenesis. Dev Biol. 2009 May 15; 329(2):242-57.Dev Biol2009-03-03T00:00:002009Aggrecan modulation of growth plate morphogenesis.230515Sugahara K, Schwartz NBProceedings of the National Academy of Sciences of the United States of AmericaDefect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6615-8.Proc Natl Acad Sci U S A1979-12-01T00:00:001979Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice.561070Schwartz NBThe Journal of biological chemistryRegulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein. J Biol Chem. 1977 Sep 25; 252(18):6316-21.J Biol Chem1977-09-25T00:00:001977Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein.7084318Conway WF, Schwartz NB, Dorfman AExperimental cell researchThe irreversible effect of bromodeoxyuridine on chick chondrocytes. Exp Cell Res. 1982 May; 139(1):79-86.Exp Cell Res1982-05-01T00:00:001982The irreversible effect of bromodeoxyuridine on chick chondrocytes.7356486Coudron C, Ellis K, Philipson L, Schwartz NBBiochemical and biophysical research communicationsPreliminary characterization of a xylose acceptor prepared by hydrogen fluoride treatment of proteoglycan core protein. Biochem Biophys Res Commun. 1980 Jan 29; 92(2):618-23.Biochem Biophys Res Commun1980-01-29T00:00:001980Preliminary characterization of a xylose acceptor prepared by hydrogen fluoride treatment of proteoglycan core protein.3178808Zaruba ME, Schwartz NB, Tennekoon GIBiochemical and biophysical research communicationsReconstitution of adenosine 3'-phosphate 5'-phosphosulfate transporter from rat brain. Biochem Biophys Res Commun. 1988 Sep 30; 155(3):1271-7.Biochem Biophys Res Commun1988-09-30T00:00:001988Reconstitution of adenosine 3'-phosphate 5'-phosphosulfate transporter from rat brain.7827052Lyle S, Stanczak JD, Westley J, Schwartz NBBiochemistrySulfate-activating enzymes in normal and brachymorphic mice: evidence for a channeling defect. Biochemistry. 1995 Jan 24; 34(3):940-5.Biochemistry1995-01-24T00:00:001995Sulfate-activating enzymes in normal and brachymorphic mice: evidence for a channeling defect.8042977Lyle S, Geller DH, Ng K, Stanczak J, Westley J, Schwartz NBThe Biochemical journalKinetic mechanism of adenosine 5'-phosphosulphate kinase from rat chondrosarcoma. Biochem J. 1994 Jul 15; 301 ( Pt 2):355-9.Biochem J1994-07-15T00:00:001994Kinetic mechanism of adenosine 5'-phosphosulphate kinase from rat chondrosarcoma.4857056Schwartz NB, Rodén L, Dorfman ABiochemical and biophysical research communicationsBiosynthesis of chondroitin sulfate: interaction between xylosyltransferase and galactosyltransferase. Biochem Biophys Res Commun. 1974 Feb 04; 56(3):717-24.Biochem Biophys Res Commun1974-02-04T00:00:001974Biosynthesis of chondroitin sulfate: interaction between xylosyltransferase and galactosyltransferase.8115367Schwartz NB, Hennig AK, Krueger RC, Krzystolik M, Li H, Mangoura DProgress in clinical and biological researchDevelopmental expression of S103L cross-reacting proteoglycans in embryonic chick. Prog Clin Biol Res. 1993; 383B:505-14.Prog Clin Biol Res1993-01-01T00:00:001993Developmental expression of S103L cross-reacting proteoglycans in embryonic chick.3133380Campbell SC, Schwartz NBThe Journal of cell biologyKinetics of intracellular processing of chondroitin sulfate proteoglycan core protein and other matrix components. J Cell Biol. 1988 Jun; 106(6):2191-202.J Cell Biol1988-06-01T00:00:001988Kinetics of intracellular processing of chondroitin sulfate proteoglycan core protein and other matrix components.21396923Domowicz MS, Henry JG, Wadlington N, Navarro A, Kraig RP, Schwartz NBBrain researchAstrocyte precursor response to embryonic brain injury. Brain Res. 2011 May 10; 1389:35-49.Brain Res2011-03-09T00:00:002011Astrocyte precursor response to embryonic brain injury.3733750Bird TA, Schwartz NB, Peterkofsky BThe Journal of biological chemistryMechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig. J Biol Chem. 1986 Aug 25; 261(24):11166-72.J Biol Chem1986-08-25T00:00:001986Mechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig.6284029Sugahara K, Schwartz NBArchives of biochemistry and biophysicsDefect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. I. Characterization of the defect. Arch Biochem Biophys. 1982 Apr 01; 214(2):589-601.Arch Biochem Biophys1982-04-01T00:00:001982Defect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. I. Characterization of the defect.6161752Dorfman A, Vertel BM, Schwartz NBCurrent topics in developmental biologyImmunological methods in the study of chondroitin sulfate proteoglycans. Curr Top Dev Biol. 1980; 14(Pt 2):169-98.Curr Top Dev Biol1980-01-01T00:00:001980Immunological methods in the study of chondroitin sulfate proteoglycans.7235185Schwartz NBThe Alabama journal of medical sciencesSynthesis of cartilage proteoglycans. Ala J Med Sci. 1981 Jan; 18(1):41-5.Ala J Med Sci1981-01-01T00:00:001981Synthesis of cartilage proteoglycans.6407883Brennan MJ, Oldberg A, Ruoslahti E, Brown K, Schwartz NDevelopmental biologyImmunological evidence for two distinct chondroitin sulfate proteoglycan core proteins: differential expression in cartilage matrix deficient mice. Dev Biol. 1983 Jul; 98(1):139-47.Dev Biol1983-07-01T00:00:001983Immunological evidence for two distinct chondroitin sulfate proteoglycan core proteins: differential expression in cartilage matrix deficient mice.2957484Vernillo AT, Schwartz NBJournal of periodontal researchThe effects of phenytoin (5,5-diphenylhydantoin) on human gingival fibroblasts in culture. J Periodontal Res. 1987 Jul; 22(4):307-12.J Periodontal Res1987-07-01T00:00:001987The effects of phenytoin (5,5-diphenylhydantoin) on human gingival fibroblasts in culture.8180221Lyle S, Stanczak J, Ng K, Schwartz NBBiochemistryRat chondrosarcoma ATP sulfurylase and adenosine 5'-phosphosulfate kinase reside on a single bifunctional protein. Biochemistry. 1994 May 17; 33(19):5920-5.Biochemistry1994-05-17T00:00:001994Rat chondrosarcoma ATP sulfurylase and adenosine 5'-phosphosulfate kinase reside on a single bifunctional protein.134712Schwartz NB, Ho PL, Dorfman ABiochemical and biophysical research communicationsEffect of beta-xylosides on synthesis of cartilage-specific proteoglycan in chondrocyte cultures. Biochem Biophys Res Commun. 1976 Aug 09; 71(3):851-6.Biochem Biophys Res Commun1976-08-09T00:00:001976Effect of beta-xylosides on synthesis of cartilage-specific proteoglycan in chondrocyte cultures.3993934Olson CA, Krueger R, Schwartz NBAnalytical biochemistryDeglycosylation of chondroitin sulfate proteoglycan by hydrogen fluoride in pyridine. Anal Biochem. 1985 Apr; 146(1):232-7.Anal Biochem1985-04-01T00:00:001985Deglycosylation of chondroitin sulfate proteoglycan by hydrogen fluoride in pyridine.4372604Schwartz NB, Galligani L, Ho PL, Dorfman AProceedings of the National Academy of Sciences of the United States of AmericaStimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):4047-51.Proc Natl Acad Sci U S A1974-10-01T00:00:001974Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells.2365711Krueger RC, Fields TA, Hildreth J, Schwartz NBThe Journal of biological chemistryChick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment. J Biol Chem. 1990 Jul 15; 265(20):12075-87.J Biol Chem1990-07-15T00:00:001990Chick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment.18948137King LA, Schwartz NB, Domowicz MSJournal of neuroscience methodsGlial migratory streams in the developing hindbrain: a slice culture approach. J Neurosci Methods. 2009 Feb 15; 177(1):30-43.J Neurosci Methods2008-10-02T00:00:002008Glial migratory streams in the developing hindbrain: a slice culture approach.811171Schwartz NB, Dorfman AArchives of biochemistry and biophysicsPurification of rat chondrosarcoma xylosyltransferase. Arch Biochem Biophys. 1975 Nov; 171(1):136-44.Arch Biochem Biophys1975-11-01T00:00:001975Purification of rat chondrosarcoma xylosyltransferase.7167591Schwartz NBProgress in clinical and biological researchDefect in proteoglycan synthesis in brachymorphic mice. Prog Clin Biol Res. 1982; 110 Pt B:97-103.Prog Clin Biol Res1982-01-01T00:00:001982Defect in proteoglycan synthesis in brachymorphic mice.7493984Li H, Deyrup A, Mensch JR, Domowicz M, Konstantinidis AK, Schwartz NBThe Journal of biological chemistryThe isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. J Biol Chem. 1995 Dec 08; 270(49):29453-9.J Biol Chem1995-12-08T00:00:001995The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase.1167359Schwartz NBFEBS lettersBiosynthesis of chondroitin sulfate: immunoprecipitation of interacting xylosyltransferase and galactosyltransferase. FEBS Lett. 1975 Jan 01; 49(3):342-5.FEBS Lett1975-01-01T00:00:001975Biosynthesis of chondroitin sulfate: immunoprecipitation of interacting xylosyltransferase and galactosyltransferase.Authorship 150248334626419Cortes M, Cortes LK, Schwartz NBMethods in molecular biology (Clifton, N.J.)Mapping Proteoglycan Function Using Novel Genetic Strategies. Methods Mol Biol. 2022; 2303:731-752.Methods Mol Biol2022-01-01T00:00:002022Mapping Proteoglycan Function Using Novel Genetic Strategies.2501297Ng KF, Schwartz NBThe Journal of biological chemistrySolubilization and partial purification of hyaluronate synthetase from oligodendroglioma cells. J Biol Chem. 1989 Jul 15; 264(20):11776-83.J Biol Chem1989-07-15T00:00:001989Solubilization and partial purification of hyaluronate synthetase from oligodendroglioma cells.22252624Cortes M, Mensch JR, Domowicz M, Schwartz NBMethods in molecular biology (Clifton, N.J.)Proteoglycans: gene cloning. Methods Mol Biol. 2012; 836:3-21.Methods Mol Biol2012-01-01T00:00:002012Proteoglycans: gene cloning.570971Schwartz NBThe Journal of biological chemistrySynthesis and secretion of an altered chondroitin sulfate proteoglycan. J Biol Chem. 1979 Apr 10; 254(7):2271-7.J Biol Chem1979-04-10T00:00:001979Synthesis and secretion of an altered chondroitin sulfate proteoglycan.666832Schwartz NB, Ostrowski V, Brown KS, Pratt RMBiochemical and biophysical research communicationsDefective PAPS-synthesis in epiphyseal cartilage from brachymorphic mice. Biochem Biophys Res Commun. 1978 May 15; 82(1):173-8.Biochem Biophys Res Commun1978-05-15T00:00:001978Defective PAPS-synthesis in epiphyseal cartilage from brachymorphic mice.4214614Schwartz NB, Rodén LCarbohydrate researchBiosynthesis of chondroitin sulfate. Purification of UDP-D-xylose:core protein beta-D-xylosyltransferase by affinity chromatography. Carbohydr Res. 1974 Oct; 37(1):167-80.Carbohydr Res1974-10-01T00:00:001974Biosynthesis of chondroitin sulfate. Purification of UDP-D-xylose:core protein beta-D-xylosyltransferase by affinity chromatography.870306Schwartz NB, Justo SNEndocrinologyAcute changes in serum gonadotrophins and steroids following orchidectomy in the rat: role of the adrenal gland. Endocrinology. 1977 Jun; 100(6):1550-6.Endocrinology1977-06-01T00:00:001977Acute changes in serum gonadotrophins and steroids following orchidectomy in the rat: role of the adrenal gland.6426856Hoffmann HP, Schwartz NB, Rodén L, Prockop DJConnective tissue researchLocation of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells. Connect Tissue Res. 1984; 12(2):151-63.Connect Tissue Res1984-01-01T00:00:001984Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells.6725288Geetha-Habib M, Campbell SC, Schwartz NBThe Journal of biological chemistrySubcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein. J Biol Chem. 1984 Jun 10; 259(11):7300-10.J Biol Chem1984-06-10T00:00:001984Subcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein.9117261Schwartz NB, Domowicz M, Krueger RC, Li H, Mangoura DPerspectives on developmental neurobiologyBrain aggrecan. Perspect Dev Neurobiol. 1996; 3(4):291-306.Perspect Dev Neurobiol1996-01-01T00:00:001996Brain aggrecan.1282844Hennig A, Krueger R, Mangoura D, Schwartz NBCellular and molecular biology (Noisy-le-Grand, France)Chondroitin sulfate proteoglycan expression during neuronal development. Cell Mol Biol (Noisy-le-grand). 1992 Aug-Sep; 38(5-6):585-93.Cell Mol Biol (Noisy-le-grand)1992-08-01T00:00:001992Chondroitin sulfate proteoglycan expression during neuronal development.8037674Vertel BM, Grier BL, Li H, Schwartz NBThe Biochemical journalThe chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor. Biochem J. 1994 Jul 01; 301 ( Pt 1):211-6.Biochem J1994-07-01T00:00:001994The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor.9545271Deyrup AT, Krishnan S, Cockburn BN, Schwartz NBThe Journal of biological chemistryDeletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. J Biol Chem. 1998 Apr 17; 273(16):9450-6.J Biol Chem1998-04-17T00:00:001998Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme.10978841Domowicz M, Mangoura D, Schwartz NBInternational journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceCell specific-chondroitin sulfate proteoglycan expression during CNS morphogenesis in the chick embryo. Int J Dev Neurosci. 2000 Nov; 18(7):629-41.Int J Dev Neurosci2000-11-01T00:00:002000Cell specific-chondroitin sulfate proteoglycan expression during CNS morphogenesis in the chick embryo.11334997Krueger RC, Santore MT, Dawson G, Schwartz NBBrain research. Developmental brain researchIncreased extracellular magnesium modulates proliferation in fetal neural cells in culture. Brain Res Dev Brain Res. 2001 Apr 30; 127(2):99-109.Brain Res Dev Brain Res2001-04-30T00:00:002001Increased extracellular magnesium modulates proliferation in fetal neural cells in culture.22383528Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson GThe Journal of biological chemistryNeutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem. 2012 Apr 20; 287(17):13620-32.J Biol Chem2012-03-01T00:00:002012Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.3937551Philipson LH, Westley J, Schwartz NBBiochemistryEffect of hyaluronidase treatment of intact cells on hyaluronate synthetase activity. Biochemistry. 1985 Dec 31; 24(27):7899-906.Biochemistry1985-12-31T00:00:001985Effect of hyaluronidase treatment of intact cells on hyaluronate synthetase activity.6284030Sugahara K, Schwartz NBArchives of biochemistry and biophysicsDefect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. II. Tissue distribution of the defect. Arch Biochem Biophys. 1982 Apr 01; 214(2):602-9.Arch Biochem Biophys1982-04-01T00:00:001982Defect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. II. Tissue distribution of the defect.1150655Schwartz NB, Rodén LThe Journal of biological chemistryBiosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans. J Biol Chem. 1975 Jul 10; 250(13):5200-7.J Biol Chem1975-07-10T00:00:001975Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.7576700Juul SE, Krueger RC, Scofield L, Hershenson MB, Schwartz NBAmerican journal of respiratory cell and molecular biologyHyperoxia alone causes changes in lung proteoglycans and hyaluronan in neonatal rat pups. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):629-38.Am J Respir Cell Mol Biol1995-12-01T00:00:001995Hyperoxia alone causes changes in lung proteoglycans and hyaluronan in neonatal rat pups.126838Schwartz NB, Dorfman AConnective tissue researchStimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer. Connect Tissue Res. 1975; 3(2):115-22.Connect Tissue Res1975-01-01T00:00:001975Stimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer.8042976Lyle S, Geller DH, Ng K, Westley J, Schwartz NBThe Biochemical journalKinetic mechanism of ATP-sulphurylase from rat chondrosarcoma. Biochem J. 1994 Jul 15; 301 ( Pt 2):349-54.Biochem J1994-07-15T00:00:001994Kinetic mechanism of ATP-sulphurylase from rat chondrosarcoma.8226878Li H, Schwartz NB, Vertel BMThe Journal of biological chemistrycDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia. J Biol Chem. 1993 Nov 05; 268(31):23504-11.J Biol Chem1993-11-05T00:00:001993cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia.Authorship 150915434749772Domowicz MS, Chan WC, Claudio-Vázquez P, Gonzalez T, Schwartz NBJournal of neuroinflammationBrain transcriptome analysis of a CLN2 mouse model as a function of disease progression. J Neuroinflammation. 2021 Nov 08; 18(1):262.J Neuroinflammation2021-11-08T00:00:002021Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression.Authorship 154158135465334Schwartz NB, Domowicz MSFrontiers in cell and developmental biologyRoles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development. Front Cell Dev Biol. 2022; 10:745372.Front Cell Dev Biol2022-04-08T00:00:002022Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development.D011508Chemicals & Drugs8380.980808Chondroitin Sulfate ProteoglycansAuthorship 156371535880738Morin A, Helling BA, Krishnan S, Risner LE, Walker ND, Schwartz NBeLifeSurveying the experience of postdocs in the United States before and during the COVID-19 pandemic. Elife. 2022 07 26; 11.Elife2022-07-26T00:00:002022Surveying the experience of postdocs in the United States before and during the COVID-19 pandemic.36255674Schwartz NB, Domowicz MSAdvances in neurobiologyChemistry and Function of Glycosaminoglycans in the Nervous System. Adv Neurobiol. 2023; 29:117-162.Adv Neurobiol2023-01-01T00:00:002023Chemistry and Function of Glycosaminoglycans in the Nervous System.Authorship 1592291ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorD053674Chemicals & Drugs8420.977531Aggrecanshttp://www.boneandcancer.orgLab homepagehttp://he-group.uchicago.eduMy Lab Sitehttps://scholar.google.com/citations?user=YRifvyAAAAAJ&hl=enGoogle ScholarD013430Chemicals & Drugs2230.987434Sulfate AdenylyltransferaseChemistryMedicineNeurologyPediatricsRadiologyUniversity of ChicagoHeatherFaganHeather Fagan41.78927490000000-87.601250000000001199Fagan, HeatherASSOCIATE PROFESSOR6.437930.00208213556research areas8.016980.04101227coauthor of43.60478.0202160similar to11137selected publicationsMiriamDomowiczMiriam Domowicz41.78927490000000-87.601250000000001627Domowicz, MiriamResearch Associate ProfessorAnneCarpinelliAnne Carpinelli41.78927490000000-87.601250000000001817Carpinelli, AnneClinical AssociateRichardKraigRichard Kraig41.78927490000000-87.601250000000002091Kraig, RichardProfessorKristenLauingKristen Lauing41.78927490000000-87.601250000000002191Lauing, KristenKalyaniTrivediKalyani R. Trivedi41.78927490000000-87.601250000000002488Trivedi, KalyaniAssistant ProfessorKatherineSchmalzerKatherine Schmalzer41.78927490000000-87.601250000000002589Schmalzer, KatherinePostdoctoral ScholarTong-ChuanHew2FhDoEXCuiXhHlsaUXv9Gq0+s+oTong-Chuan He41.78927490000000-87.60125000000000550He, Tong-ChuanAssociate ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorGregoryKarczmarGregory Karczmar41.78927490000000-87.60125000000000779Karczmar, GregoryProfessorLouisPhilipsonx2pgXIF1GuTQkntjbwjr93A=Louis Philipson41.78927490000000-87.6012500000000083Philipson, LouisProfessorChristopher W.ClardyChristopher W. Clardy41.78927490000000-87.60125000000000857Clardy, Christopher W.Associate Professortrue1true1ProfessorProfessortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Clinical AssociateClinical Associatetrue1ASSOCIATE PROFESSORASSOCIATE PROFESSORtrue1ProfessorProfessortrue1Postdoctoral ScholarPostdoctoral Scholartrue1Research Associate ProfessorResearch Associate Professortrue1Ralph W. Gerard Professor of Biological Sciences, EmeritusRalph W. Gerard Professor of Biological Sciences, Emeritustrue1ProfessorProfessorAuthorship 697963Authorship 685033Authorship 734284Authorship 743861Authorship 756846Authorship 78413425151376Schwartz NB, Domowicz MSAdvances in neurobiologyChemistry and function of glycosaminoglycans in the nervous system. Adv Neurobiol. 2014; 9:89-115.Adv Neurobiol2014-01-01T00:00:002014Chemistry and function of glycosaminoglycans in the nervous system.25446537Lauing KL, Cortes M, Domowicz MS, Henry JG, Baria AT, Schwartz NBDevelopmental biologyAggrecan is required for growth plate cytoarchitecture and differentiation. Dev Biol. 2014 Dec 15; 396(2):224-36.Dev Biol2014-10-18T00:00:002014Aggrecan is required for growth plate cytoarchitecture and differentiation.25325971Cortes M, Cortes LK, Schwartz NBMethods in molecular biology (Clifton, N.J.)Mapping proteoglycan functions with glycosidases. Methods Mol Biol. 2015; 1229:443-55.Methods Mol Biol2015-01-01T00:00:002015Mapping proteoglycan functions with glycosidases.25735299Foxley S, Domowicz M, Karczmar GS, Schwartz NMedical physics3D high spectral and spatial resolution imaging of ex vivo mouse brain. Med Phys. 2015 Mar; 42(3):1463-72.Med Phys2015-03-01T00:00:0020153D high spectral and spatial resolution imaging of ex vivo mouse brain.25688887Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson GACS chemical neuroscienceDelivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS Chem Neurosci. 2015 Mar 18; 6(3):494-504.ACS Chem Neurosci2015-03-05T00:00:002015Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain.24161523Mis EK, Liem KF, Kong Y, Schwartz NB, Domowicz M, Weatherbee SDDevelopmental biologyForward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 01; 385(1):67-82.Dev Biol2013-10-23T00:00:002013Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length.Chicago60637ILMedicine-EndocrinologyAuthorship 512162Authorship 500032Authorship 518721Authorship 509352Authorship 519792Authorship 513961376529Sugahara K, Schwartz NB, Dorfman AThe Journal of biological chemistryBiosynthesis of hyaluronic acid by Streptococcus. J Biol Chem. 1979 Jul 25; 254(14):6252-61.J Biol Chem1979-07-25T00:00:001979Biosynthesis of hyaluronic acid by Streptococcus.2957695Smalheiser NR, Schwartz NBProceedings of the National Academy of Sciences of the United States of AmericaCranin: a laminin-binding protein of cell membranes. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6457-61.Proc Natl Acad Sci U S A1987-09-01T00:00:001987Cranin: a laminin-binding protein of cell membranes.7188901Campbell CS, Schwartz NBEndocrinologyThe impact of constant light on the estrous cycle of the rat. Endocrinology. 1980 Apr; 106(4):1230-8.Endocrinology1980-04-01T00:00:001980The impact of constant light on the estrous cycle of the rat.4208690Schwartz NB, Abram D, Feingold DSBiochemistryL-Rhamnulose 1-phosphate aldolase of Escherichia coli. The role of metal in enzyme structure. Biochemistry. 1974 Apr 09; 13(8):1726-30.Biochemistry1974-04-09T00:00:001974L-Rhamnulose 1-phosphate aldolase of Escherichia coli. The role of metal in enzyme structure.6817602Schwartz NBAdvances in experimental medicine and biologyRole of ovarian inhibin (folliculostatin) in regulating FSH secretion in the female rat. Adv Exp Med Biol. 1982; 147:15-36.Adv Exp Med Biol1982-01-01T00:00:001982Role of ovarian inhibin (folliculostatin) in regulating FSH secretion in the female rat.3620981Smalheiser NR, Schwartz NBBrain researchKinetic analysis of 'rapid onset' neurite formation in NG108-15 cells reveals a dual role for substratum-bound laminin. Brain Res. 1987 Jul; 431(1):111-21.Brain Res1987-07-01T00:00:001987Kinetic analysis of 'rapid onset' neurite formation in NG108-15 cells reveals a dual role for substratum-bound laminin.