Nanduri R.Prabhakar2WNnD7QHEMzMknJtY0fp/Cv/+94=Nanduri R. Prabhakar41.78927490000000-87.601250000000001680Prabhakar, Nanduri R.Nanduri R. Prabhakar, Ph.D., D.Sc.
Harold Hines Jr. Professor of Medicine
Director, Center for Systems Biology
Director, Oxygen Sensing Department of Medicine
The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.Professorplugins:FeaturedVideosFeatured Videosprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 100584228221004Samanta D, Prabhakar NR, Semenza GLWiley interdisciplinary reviews. Systems biology and medicineSystems biology of oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med. 2017 07; 9(4).Wiley Interdiscip Rev Syst Biol Med2017-02-21T00:00:002017Systems biology of oxygen homeostasis.D000860DisordersPhenomena1716360.669241HypoxiaAuthorship 1045251228556776Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GMeLifeHIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 05 30; 6.Elife2017-05-30T00:00:002017HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.D002344Anatomy132320.786218Carotid BodyAuthorship 106443128685420Prabhakar NR, Peng YJAdvances in experimental medicine and biologyOxygen Sensing by the Carotid Body: Past and Present. Adv Exp Med Biol. 2017; 977:3-8.Adv Exp Med Biol2017-01-01T00:00:002017Oxygen Sensing by the Carotid Body: Past and Present.D006862Chemicals & Drugs12500.938047Hydrogen SulfideRadiation and Cellular OncologyAuthorship 1199651Authorship 1209253Authorship 1223986Authorship 1228262Authorship 1227932Authorship 1237384Authorship 1237958Authorship 121053229330795Peng YJ, Prabhakar NRMethods in molecular biology (Clifton, N.J.)Measurement of Sensory Nerve Activity from the Carotid Body. Methods Mol Biol. 2018; 1742:115-124.Methods Mol Biol2018-01-01T00:00:002018Measurement of Sensory Nerve Activity from the Carotid Body.29470646Prabhakar NR, Peng YJ, Yuan G, Nanduri JCell and tissue researchReactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 2018 05; 372(2):427-431.Cell Tissue Res2018-02-22T00:00:002018Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.30086385Peng YJ, Makarenko VV, Gridina A, Chupikova I, Zhang X, Kumar GK, Fox AP, Prabhakar NRRespiratory physiology & neurobiologyH2S mediates carotid body response to hypoxia but not anoxia. Respir Physiol Neurobiol. 2019 01; 259:75-85.Respir Physiol Neurobiol2018-08-04T00:00:002018H2S mediates carotid body response to hypoxia but not anoxia.29359806Semenza GL, Prabhakar NRThe Journal of physiologyThe role of hypoxia-inducible factors in carotid body (patho) physiology. J Physiol. 2018 08; 596(15):2977-2983.J Physiol2018-02-12T00:00:002018The role of hypoxia-inducible factors in carotid body (patho) physiology.29330798Nanduri J, Prabhakar NRMethods in molecular biology (Clifton, N.J.)Immunohistochemistry of the Carotid Body. Methods Mol Biol. 2018; 1742:155-166.Methods Mol Biol2018-01-01T00:00:002018Immunohistochemistry of the Carotid Body.30357741Peng YJ, Zhang X, Nanduri J, Prabhakar NRAdvances in experimental medicine and biologyTherapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model. Adv Exp Med Biol. 2018; 1071:109-114.Adv Exp Med Biol2018-01-01T00:00:002018Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.29148180Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NRThe Journal of physiologyDNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity. J Physiol. 2018 08; 596(15):3087-3100.J Physiol2018-01-04T00:00:002018DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.28839104Nanduri J, Semenza GL, Prabhakar NRAmerican journal of physiology. Lung cellular and molecular physiologyEpigenetic changes by DNA methylation in chronic and intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1096-L1100.Am J Physiol Lung Cell Mol Physiol2017-08-24T00:00:002017Epigenetic changes by DNA methylation in chronic and intermittent hypoxia.Authorship 126503130631432Prabhakar NR, Peng YJ, Nanduri JF1000ResearchRecent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 2018; 7.F1000Res2018-12-06T00:00:002018Recent advances in understanding the physiology of hypoxic sensing by the carotid body.Authorship 108011Authorship 118545Authorship 118121Authorship 119762Authorship 122481Authorship 119154Authorship 119751Authorship 125385Authorship 131553Authorship 131545Authorship 140162Authorship 154971Authorship 131561Authorship 131751Authorship 149424Authorship 147487Authorship 151265Authorship 155822Authorship 173186Authorship 174686Authorship 129217531017964Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri JPloS oneHypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2019; 14(4):e0215905.PLoS One2019-04-24T00:00:002019Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.Authorship 172135Authorship 17225Authorship 174722Authorship 174733Authorship 171236Authorship 174706Authorship 174713Authorship 193371Authorship 199905Authorship 184694Authorship 174591Authorship 188221Authorship 169204Authorship 197954Authorship 197992Authorship 218912Authorship 197932Authorship 197963Authorship 197973Authorship 151853Authorship 178271Authorship 19244Authorship 158963Authorship 227802Authorship 201526Authorship 210298Authorship 197984Authorship 204331Authorship 21060305/1979M.S. UniversityBaroda, IndiaM.S. University, PhysiologyPh.D.Physiology01/1982Ruhr UniversityBochum, Federal Republic of GermanyRuhr University, BiologyD.Sc.Biology2017Elected Fellow of the American Physiological Society2017AAIMS Silver Jubilee Oration Award2016Michael de Burgh Daly Award, Physiological Society, U.K.2016Inaugural Lahiri-Cherniack Lecture, American Physiological Society2015Plenary Lecture, Oxford Meeting, Sydney, Australia2015Elected Foreign Member of National Academy of Sciences India2014Inaugural C. von Euler Lecture, Karolinska Nobel Institutet, Stockholm, Sweden2014Plenary Lecture, PanAm Physiological Congress, Brazil2014Prof. Mahabalinos Award, Physiological Society of India2013Mario Toppo Distinguished Scientist Award, ASIOA 2012Julius H.Comroe Distinguished Lecture Award American Physiological Society2010Plenary Lecture. British Physiological Soc. Birmingham, U.K. 2008Neil S. Cherniack Lecture, Case Western Reserve University, Cleveland2008A.S. Paintal Award, University of Delhi2007Dr. P.C.Roy Oration Award. Indian Physiological Society2005Plenary Lecture, Brazilian Physiological Society 2005Plenary Lecture, O2 Homeostasis, University of Cardiff, U.K.2004Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm SwedenPrincipal InvestigatorPrincipal Investigator2020-03-31NIHNanduri Prabhakar2019-04-15Integrative Consequences of Intermittent Hypoxia1P01HL14445401NIHNanduri PrabhakarTherapeutic Targeting of Carotid Body Chemoreflex for Sleep Disordered Breathing5UH3HL123610Authorship 174744Authorship 239422Authorship 246071Authorship 247246Authorship 260755Authorship 224145Authorship 230615Authorship 232121Authorship 189675Authorship 238565Authorship 248371Authorship 238553Authorship 239333Authorship 275991Authorship 239391Authorship 239774Authorship 263285Authorship 210511Authorship 269741Authorship 252343Authorship 132754631483699Makarenko VV, Peng YJ, Khan SA, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyLong-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019 11 01; 122(5):1874-1883.J Neurophysiol2019-09-04T00:00:002019Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia.Authorship 231052Authorship 315531Authorship 268006Authorship 301607Authorship 325072Authorship 309594Authorship 304508Authorship 309191Authorship 244355Authorship 133123431544168Nanduri J, Peng YJ, Wang N, Prabhakar NRCurrent opinion in physiologyNeural Activation of Molecular Circuitry in Intermittent Hypoxia. Curr Opin Physiol. 2019 Feb; 7:9-14.Curr Opin Physiol2018-11-29T00:00:002018Neural Activation of Molecular Circuitry in Intermittent Hypoxia.Authorship 35051Authorship 325051Authorship 356465Authorship 295533Authorship 327404Authorship 33353Authorship 339764Authorship 377294Authorship 34941Authorship 384101Authorship 317162Authorship 40391Authorship 298307Authorship 295541Authorship 377544Authorship 378849Authorship 312381Authorship 354912Authorship 336365D010100Chemicals & Drugs2287250.682051OxygenAuthorship 382412Authorship 420198Authorship 421836Authorship 423421Authorship 30123Authorship 301585Authorship 395211Authorship 369797Authorship 134453631746629Limberg JK, Johnson BD, Mozer MT, Holbein WW, Curry TB, Prabhakar NR, Joyner MJAmerican journal of physiology. Regulatory, integrative and comparative physiologyRole of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans. Am J Physiol Regul Integr Comp Physiol. 2020 01 01; 318(1):R173-R181.Am J Physiol Regul Integr Comp Physiol2019-11-20T00:00:002019Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.Authorship 416298Authorship 35961Authorship 43882Authorship 459034Authorship 465248Authorship 472083Authorship 4727215Authorship 353566Authorship 4688416Authorship 361584Authorship 48393Authorship 486331Authorship 38232Authorship 135679132024429Prabhakar NRPhysiology (Bethesda, Md.)2019 Nobel Prize in Physiology or Medicine. Physiology (Bethesda). 2020 03 01; 35(2):81-83.Physiology (Bethesda)2020-03-01T00:00:0020202019 Nobel Prize in Physiology or Medicine.Authorship 357835Authorship 388205Authorship 497161Authorship 384124Authorship 476732Authorship 3705714Authorship 370989Authorship 66771Authorship 487801Authorship 72071Authorship 136450632208891Peng YJ, Gridina A, Wang B, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyOlfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia. J Neurophysiol. 2020 05 01; 123(5):1886-1895.J Neurophysiol2020-03-25T00:00:002020Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.Authorship 62122Authorship 428782Authorship 4380411Authorship 87834Authorship 45453Authorship 407091Authorship 93141Authorship 97901Authorship 98521Authorship 98831Authorship 98881Authorship 42153Authorship 423401Authorship 424724Authorship 497182Authorship 438776Authorship 44343Authorship 50544Authorship 43731Authorship 450831Authorship 62071Authorship 473811Authorship 451365Authorship 48171Authorship 49512Authorship 488368Authorship 490261Authorship 93221Authorship 88681Authorship 476721Authorship 497152Authorship 50112Authorship 53852Authorship 87463Authorship 139410132730232Prabhakar NR, Peng YJ, Nanduri JThe Journal of clinical investigationHypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. 2020 10 01; 130(10):5042-5051.J Clin Invest2020-10-01T00:00:002020Hypoxia-inducible factors and obstructive sleep apnea.Authorship 14795Authorship 161441Authorship 178713Authorship 18851Authorship 197947Authorship 264784Authorship 278126Authorship 281761Authorship 286483Authorship 33585Authorship 35691Authorship 3690418Authorship 418448Authorship 140688632936698Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri JAmerican journal of physiology. Cell physiologyHypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C922-C932.Am J Physiol Cell Physiol2020-09-16T00:00:002020Hypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia.Authorship 58194Authorship 58462Authorship 60662Authorship 978928822371Bright GR, Agani FH, Haque U, Overholt JL, Prabhakar NRBrain researchHeterogeneity in cytosolic calcium responses to hypoxia in carotid body cells. Brain Res. 1996 Jan 15; 706(2):297-302.Brain Res1996-01-15T00:00:001996Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells.8593588Prabhakar NR, Shenoy BC, Simonson MS, Cherniack NSBrain researchCell selective induction and transcriptional activation of immediate early genes by hypoxia. Brain Res. 1995 Oct 30; 697(1-2):266-70.Brain Res1995-10-30T00:00:001995Cell selective induction and transcriptional activation of immediate early genes by hypoxia.9030322Overholt JL, Bright GR, Prabhakar NRAdvances in experimental medicine and biologyCarbon monoxide and carotid body chemoreception. Adv Exp Med Biol. 1996; 410:341-4.Adv Exp Med Biol1996-01-01T00:00:001996Carbon monoxide and carotid body chemoreception.8629528Cherniack NS, Prabhakar N, Haxhiu MAdvances in experimental medicine and biologyPossible genomic mechanism involved in control systems responses to hypoxia. Adv Exp Med Biol. 1995; 393:89-94.Adv Exp Med Biol1995-01-01T00:00:001995Possible genomic mechanism involved in control systems responses to hypoxia.9030323Prabhakar NR, Rao S, Premkumar D, Pieramici SF, Kumar GK, Kalaria RKAdvances in experimental medicine and biologyRegulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2. Adv Exp Med Biol. 1996; 410:345-8.Adv Exp Med Biol1996-01-01T00:00:001996Regulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2.8704827Prabhakar NR, Kou YR, Kumar GKBiological signalsG proteins in carotid body chemoreception. Biol Signals. 1995 Sep-Oct; 4(5):271-6.Biol Signals1995-09-01T00:00:001995G proteins in carotid body chemoreception.9749948Ernsberger P, Kou YR, Prabhakar NRRespiration physiologyCarotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respir Physiol. 1998 Jun; 112(3):239-51.Respir Physiol1998-06-01T00:00:001998Carotid body I1-imidazoline receptors: binding, visualization and modulatory function.9037552Prabhakar NR, Pieramici SF, Premkumar DR, Kumar GK, Kalaria RNBrain research. Molecular brain researchActivation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons. Brain Res Mol Brain Res. 1996 Dec 31; 43(1-2):341-6.Brain Res Mol Brain Res1996-12-31T00:00:001996Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons.10385030Prabhakar NRRespiration physiologyNO and CO as second messengers in oxygen sensing in the carotid body. Respir Physiol. 1999 Apr 01; 115(2):161-8.Respir Physiol1999-04-01T00:00:001999NO and CO as second messengers in oxygen sensing in the carotid body.8606998Haxhiu MA, Chang CH, Dreshaj IA, Erokwu B, Prabhakar NR, Cherniack NSRespiration physiologyNitric oxide and ventilatory response to hypoxia. Respir Physiol. 1995 Sep; 101(3):257-66.Respir Physiol1995-09-01T00:00:001995Nitric oxide and ventilatory response to hypoxia.9914283Overholt JL, Prabhakar NRJournal of neurophysiologyNorepinephrine inhibits a toxin resistant Ca2+ current in carotid body glomus cells: evidence for a direct G protein mechanism. J Neurophysiol. 1999 Jan; 81(1):225-33.J Neurophysiol1999-01-01T00:00:001999Norepinephrine inhibits a toxin resistant Ca2+ current in carotid body glomus cells: evidence for a direct G protein mechanism.10642381Kumar GK, Kou YR, Overholt JL, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia. J Appl Physiol (1985). 2000 Jan; 88(1):195-202.J Appl Physiol (1985)2000-01-01T00:00:002000Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia.9356397Overholt JL, Prabhakar NRJournal of neurophysiologyCa2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels. J Neurophysiol. 1997 Nov; 78(5):2467-74.J Neurophysiol1997-11-01T00:00:001997Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels.9030289Cherniack NS, Shenoy PC, Mishra R, Simonson M, Prabhakar NRAdvances in experimental medicine and biologyInduction of immediate early response genes by hypoxia. Possible molecular bases for systems adaptation to low pO2. Adv Exp Med Biol. 1996; 410:127-34.Adv Exp Med Biol1996-01-01T00:00:001996Induction of immediate early response genes by hypoxia. Possible molecular bases for systems adaptation to low pO2.10849669Adhikary G, Premkumar DR, Prabhakar NRAdvances in experimental medicine and biologyDual influence of nitric oxide on gene regulation during hypoxia. Adv Exp Med Biol. 2000; 475:285-92.Adv Exp Med Biol2000-01-01T00:00:002000Dual influence of nitric oxide on gene regulation during hypoxia.10846047Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun; 88(6):2287-95.J Appl Physiol (1985)2000-06-01T00:00:002000Oxygen sensing by the carotid body chemoreceptors.10849652Premkumar DR, Adhikary G, Overholt JL, Simonson MS, Cherniack NS, Prabhakar NRAdvances in experimental medicine and biologyIntracellular pathways linking hypoxia to activation of c-fos and AP-1. Adv Exp Med Biol. 2000; 475:101-9.Adv Exp Med Biol2000-01-01T00:00:002000Intracellular pathways linking hypoxia to activation of c-fos and AP-1.9611124Kumar GK, Overholt JL, Bright GR, Hui KY, Lu H, Gratzl M, Prabhakar NRThe American journal of physiologyRelease of dopamine and norepinephrine by hypoxia from PC-12 cells. Am J Physiol. 1998 06; 274(6):C1592-600.Am J Physiol1998-06-01T00:00:001998Release of dopamine and norepinephrine by hypoxia from PC-12 cells.9858051Prabhakar NRRespiration physiologyEndogenous carbon monoxide in control of respiration. Respir Physiol. 1998 Oct; 114(1):57-64.Respir Physiol1998-10-01T00:00:001998Endogenous carbon monoxide in control of respiration.10200181Summers BA, Overholt JL, Prabhakar NRJournal of neurophysiologyNitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J Neurophysiol. 1999 Apr; 81(4):1449-57.J Neurophysiol1999-04-01T00:00:001999Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism.10712445Overholt JL, Ficker E, Yang T, Shams H, Bright GR, Prabhakar NRJournal of neurophysiologyHERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J Neurophysiol. 2000 Mar; 83(3):1150-7.J Neurophysiol2000-03-01T00:00:002000HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.10849712Kumar GK, Yu RK, Overholt JL, Prabhakar NRAdvances in experimental medicine and biologyRole of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body. Adv Exp Med Biol. 2000; 475:705-13.Adv Exp Med Biol2000-01-01T00:00:002000Role of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body.9729288Mishra RR, Adhikary G, Simonson MS, Cherniack NS, Prabhakar NRBrain research. Molecular brain researchRole of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydroxylase gene expression. Brain Res Mol Brain Res. 1998 Aug 15; 59(1):74-83.Brain Res Mol Brain Res1998-08-15T00:00:001998Role of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydroxylase gene expression.11356820Clanton TL, Wright VP, Reiser PJ, Klawitter PF, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Selected Contribution: Improved anoxic tolerance in rat diaphragm following intermittent hypoxia. J Appl Physiol (1985). 2001 Jun; 90(6):2508-13.J Appl Physiol (1985)2001-06-01T00:00:002001Selected Contribution: Improved anoxic tolerance in rat diaphragm following intermittent hypoxia.11729925Longobardo G, Evangelisti C, Prabhakar N, Cherniack NSAdvances in experimental medicine and biologyNeural drives and breathing stability. Adv Exp Med Biol. 2001; 499:453-8.Adv Exp Med Biol2001-01-01T00:00:002001Neural drives and breathing stability.11729935Overholt JL, Summers BA, Ficker E, Prabhakar NRAdvances in experimental medicine and biologyCO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body. Adv Exp Med Biol. 2001; 499:61-6.Adv Exp Med Biol2001-01-01T00:00:002001CO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body.11729902Peng Y, Kline DD, Dick TE, Prabhakar NRAdvances in experimental medicine and biologyChronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen. Adv Exp Med Biol. 2001; 499:33-8.Adv Exp Med Biol2001-01-01T00:00:002001Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen.11729913Kim DK, Summers BA, Prabhakar NR, Kumar GKAdvances in experimental medicine and biologyNeurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release. Adv Exp Med Biol. 2001; 499:39-43.Adv Exp Med Biol2001-01-01T00:00:002001Neurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release.11792862Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaDefective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):821-6.Proc Natl Acad Sci U S A2002-01-15T00:00:002002Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.11934709Prabhakar NRAmerican journal of respiratory and critical care medicineSleep apneas: an oxidative stress? Am J Respir Crit Care Med. 2002 Apr 01; 165(7):859-60.Am J Respir Crit Care Med2002-04-01T00:00:002002Sleep apneas: an oxidative stress?10749847Kline DD, Yang T, Premkumar DR, Thomas AJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J Appl Physiol (1985). 2000 Apr; 88(4):1496-508.J Appl Physiol (1985)2000-04-01T00:00:002000Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3.12149478Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YCProceedings of the National Academy of Sciences of the United States of AmericaThe essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10488-93.Proc Natl Acad Sci U S A2002-07-29T00:00:002002The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.12162863Prabhakar NR, Kline DDHigh altitude medicine & biologyVentilatory changes during intermittent hypoxia: importance of pattern and duration. High Alt Med Biol. 2002; 3(2):195-204.High Alt Med Biol2002-01-01T00:00:002002Ventilatory changes during intermittent hypoxia: importance of pattern and duration.10967345Prabhakar NR, Overholt JLRespiration physiologyCellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels. Respir Physiol. 2000 Sep; 122(2-3):209-21.Respir Physiol2000-09-01T00:00:002000Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels.10980033Summers BA, Overholt JL, Prabhakar NRJournal of neurophysiologyAugmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. J Neurophysiol. 2000 Sep; 84(3):1636-44.J Neurophysiol2000-09-01T00:00:002000Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway.11504675Prabhakar NR, Fields RD, Baker T, Fletcher ECAmerican journal of physiology. Lung cellular and molecular physiologyIntermittent hypoxia: cell to system. Am J Physiol Lung Cell Mol Physiol. 2001 Sep; 281(3):L524-8.Am J Physiol Lung Cell Mol Physiol2001-09-01T00:00:002001Intermittent hypoxia: cell to system.11299293Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol (1985). 2001 May; 90(5):1986-94.J Appl Physiol (1985)2001-05-01T00:00:002001Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms.11850522Kline DD, Overholt JL, Prabhakar NRThe Journal of physiologyMutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. 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Neurosci Lett. 1990 Dec 11; 120(2):183-6.Neurosci Lett1990-12-11T00:00:001990Chemoreceptor responses to substance P, physalaemin and eledoisin: evidence for neurokinin-1 receptors in the cat carotid body.12809615Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyTachykinins in the control of breathing by hypoxia: pre- and post-genomic era. Respir Physiol Neurobiol. 2003 May 30; 135(2-3):145-54.Respir Physiol Neurobiol2003-05-30T00:00:002003Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era.11729895Adhikary G, Kline D, Yuan G, Kumar GK, Simonson MS, Cherniack NS, Prabhakar NRAdvances in experimental medicine and biologyGene regulation during intermittent hypoxia: evidence for the involvement of reactive oxygen species. 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Adv Exp Med Biol. 2003; 536:291-6.Adv Exp Med Biol2003-01-01T00:00:002003Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body.1719909Lagercrantz H, Srinivasan M, Yamamoto Y, Prabhakar NAnnals of the New York Academy of SciencesFunctional role of substance P for respiratory control during development. Ann N Y Acad Sci. 1991; 632:48-52.Ann N Y Acad Sci1991-01-01T00:00:001991Functional role of substance P for respiratory control during development.12163513Summers BA, Overholt JL, Prabhakar NRJournal of neurophysiologyCO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells. J Neurophysiol. 2002 Aug; 88(2):604-12.J Neurophysiol2002-08-01T00:00:002002CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells.15258129Peng YJ, Rennison J, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups. J Appl Physiol (1985). 2004 Nov; 97(5):2020-5.J Appl Physiol (1985)2004-07-16T00:00:002004Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups.15063668Prabhakar NR, Peng YJ, Overholt JL, Kumar GKMethods in enzymologyDetection of oxygen sensing during intermittent hypoxia. 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J Neurochem. 2006 Feb; 96(3):694-705.J Neurochem2005-12-22T00:00:002005Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.Pharmacological and Physiological SciencesAuthorship 144045733539264Wang B, Peng YJ, Su X, Zhang C, Nagati JS, Garcia JA, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia. J Appl Physiol (1985). 2021 04 01; 130(4):1122-1132.J Appl Physiol (1985)2021-02-04T00:00:002021Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.16686426Semenza GL, Shimoda LA, Prabhakar NRNovartis Foundation symposiumRegulation of gene expression by HIF-1. Novartis Found Symp. 2006; 272:2-8; discussion 8-14, 33-6.Novartis Found Symp2006-01-01T00:00:002006Regulation of gene expression by HIF-1.17124274Prabhakar NR, Dick TE, Nanduri J, Kumar GKExperimental physiologySystemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol. 2007 Jan; 92(1):39-44.Exp Physiol2006-11-23T00:00:002006Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.18187605Pawar A, Peng YJ, Jacono FJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 May; 104(5):1287-94.J Appl Physiol (1985)2008-01-10T00:00:002008Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.12959918Prabhakar NRAmerican journal of physiology. 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J Physiol. 2006 Oct 01; 576(Pt 1):289-95.J Physiol2006-08-03T00:00:0020065-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase.17317339Prabhakar NR, Peng YJ, Kumar GK, Pawar ARespiratory physiology & neurobiologyAltered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):148-53.Respir Physiol Neurobiol2007-01-11T00:00:002007Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.2218102Runold M, Cherniack NS, Prabhakar NRRespiration physiologyEffect of adenosine on chemosensory activity of the cat aortic body. Respir Physiol. 1990 May-Jun; 80(2-3):299-306.Respir Physiol1990-05-01T00:00:001990Effect of adenosine on chemosensory activity of the cat aortic body.16973705Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NRThe Journal of physiologyHeterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol. 2006 Dec 01; 577(Pt 2):705-16.J Physiol2006-09-14T00:00:002006Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.17627465Prabhakar NR, Kumar GK, Nanduri J, Semenza GLAntioxidants & redox signalingROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal. 2007 Sep; 9(9):1397-403.Antioxid Redox Signal2007-09-01T00:00:002007ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.17702812Kuri BA, Khan SA, Chan SA, Prabhakar NR, Smith CBThe Journal of physiologyIncreased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C. J Physiol. 2007 Oct 01; 584(Pt 1):313-9.J Physiol2007-08-16T00:00:002007Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.18651560Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NRJournal of cellular physiologyInduction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol. 2008 Dec; 217(3):674-85.J Cell Physiol2008-12-01T00:00:002008Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.17627473Semenza GL, Prabhakar NRAntioxidants & redox signalingHIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxid Redox Signal. 2007 Sep; 9(9):1391-6.Antioxid Redox Signal2007-09-01T00:00:002007HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia.Authorship 144929833729866Gridina A, Su X, Khan SA, Peng YJ, Wang B, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyGaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. J Neurophysiol. 2021 05 01; 125(5):1533-1542.J Neurophysiol2021-03-17T00:00:002021Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells.19131525Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJProceedings of the American Thoracic SocietyStrategic plan for pediatric respiratory diseases research: an NHLBI working group report. Proc Am Thorac Soc. 2009 Jan 15; 6(1):1-10.Proc Am Thorac Soc2009-01-15T00:00:002009Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.18692603Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NRRespiratory physiology & neurobiologyTranscriptional responses to intermittent hypoxia. 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J Physiol. 2004 Jun 15; 557(Pt 3):773-83.J Physiol2004-04-23T00:00:002004Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells.19147445Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaIntermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1199-204.Proc Natl Acad Sci U S A2009-01-14T00:00:002009Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.2449416Prabhakar NR, Mitra J, Cherniack NSJournal of applied physiology (Bethesda, Md. : 1985)Role of substance P in hypercapnic excitation of carotid chemoreceptors. J Appl Physiol (1985). 1987 Dec; 63(6):2418-25.J Appl Physiol (1985)1987-12-01T00:00:001987Role of substance P in hypercapnic excitation of carotid chemoreceptors.2445172Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, Cherniack NS, von Euler CActa physiologica ScandinavicaRole of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol Scand. 1987 Sep; 131(1):63-71.Acta Physiol Scand1987-09-01T00:00:001987Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits.18818385Sharma SD, Raghuraman G, Lee MS, Prabhakar NR, Kumar GKJournal of applied physiology (Bethesda, Md. : 1985)Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing. J Appl Physiol (1985). 2009 Jan; 106(1):12-9.J Appl Physiol (1985)2008-09-25T00:00:002008Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.19335094Raghuraman G, Rai V, Peng YJ, Prabhakar NR, Kumar GKAntioxidants & redox signalingPattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal. 2009 Aug; 11(8):1777-89.Antioxid Redox Signal2009-08-01T00:00:002009Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases.19369559Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NRThe Journal of neuroscience : the official journal of the Society for NeuroscienceNADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci. 2009 Apr 15; 29(15):4903-10.J Neurosci2009-04-15T00:00:002009NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.19654002Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NRBiochemical and biophysical research communicationsHypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):212-6.Biochem Biophys Res Commun2009-08-03T00:00:002009Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.20214500Prabhakar NRAntioxidants & redox signalingRedox Pioneer: Professor Gregg L. Semenza. Antioxid Redox Signal. 2010 Aug 15; 13(4):559-64.Antioxid Redox Signal2010-08-15T00:00:002010Redox Pioneer: Professor Gregg L. Semenza.16239252Prabhakar NRExperimental physiologyO2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? Exp Physiol. 2006 Jan; 91(1):17-23.Exp Physiol2005-10-20T00:00:002005O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?19536494Prabhakar NR, Peng YJ, Kumar GK, Nanduri J, Di Giulio C, Lahiri SAdvances in experimental medicine and biologyLong-term regulation of carotid body function: acclimatization and adaptation--invited article. 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J Appl Physiol (1985). 1989 Nov; 67(5):1814-9.J Appl Physiol (1985)1989-11-01T00:00:001989Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface.20556885Peng YJ, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaH2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10719-24.Proc Natl Acad Sci U S A2010-06-08T00:00:002010H2S mediates O2 sensing in the carotid body.17368118Kumar P, Prabhakar NRespiratory physiology & neurobiologySensing hypoxia: carotid body mechanisms and reflexes in health and disease. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):1-3.Respir Physiol Neurobiol2007-02-12T00:00:002007Sensing hypoxia: carotid body mechanisms and reflexes in health and disease.20618070Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NRAntioxidants & redox signalingNADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. Antioxid Redox Signal. 2011 Feb 15; 14(4):533-42.Antioxid Redox Signal2010-10-19T00:00:002010NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats.Authorship 146213633909496Peng YJ, Su X, Wang B, Matthews T, Nanduri J, Prabhakar NRJournal of neurophysiologyRole of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia. J Neurophysiol. 2021 06 01; 125(6):2054-2067.J Neurophysiol2021-04-28T00:00:002021Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia.20705601Souvannakitti D, Nanduri J, Yuan G, Kumar GK, Fox AP, Prabhakar NRThe Journal of neuroscience : the official journal of the Society for NeuroscienceNADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci. 2010 Aug 11; 30(32):10763-72.J Neurosci2010-08-11T00:00:002010NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells.20804864Prabhakar NR, Kumar GK, Nanduri JRespiratory physiology & neurobiologyIntermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS. Respir Physiol Neurobiol. 2010 Dec 31; 174(3):230-4.Respir Physiol Neurobiol2010-09-08T00:00:002010Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS.17705795Nanduri J, Nanduri RPEssays in biochemistryCellular mechanisms associated with intermittent hypoxia. Essays Biochem. 2007; 43:91-104.Essays Biochem2007-01-01T00:00:002007Cellular mechanisms associated with intermittent hypoxia.21621009Prabhakar NRRespiratory physiology & neurobiologySensory plasticity of the carotid body: role of reactive oxygen species and physiological significance. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):375-80.Respir Physiol Neurobiol2011-05-18T00:00:002011Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance.18054527Akada S, Fagerlund MJ, Lindahl SG, Sakamoto A, Prabhakar NR, Eriksson LIRespiratory physiology & neurobiologyPronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation. Respir Physiol Neurobiol. 2008 Feb 29; 160(3):284-8.Respir Physiol Neurobiol2007-10-26T00:00:002007Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.19086051Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G, NHLBI working group reportPediatric pulmonologyStrategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan; 44(1):2-13.Pediatr Pulmonol2009-01-01T00:00:002009Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.21849609Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JMJournal of neurophysiologyHydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55.J Neurophysiol2011-08-17T00:00:002011Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus.2708191Prabhakar NR, Mitra J, Adams EM, Cherniack NSJournal of applied physiology (Bethesda, Md. : 1985)Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol. J Appl Physiol (1985). 1989 Feb; 66(2):598-605.J Appl Physiol (1985)1989-02-01T00:00:001989Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol.Authorship 146941434079475Wang N, Peng YJ, Su X, Prabhakar NR, Nanduri JFrontiers in physiologyHistone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure. Front Physiol. 2021; 12:688322.Front Physiol2021-05-17T00:00:002021Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure.22723632Prabhakar NR, Kumar GK, Peng YJJournal of applied physiology (Bethesda, Md. : 1985)Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol (1985). 2012 Oct 15; 113(8):1304-10.J Appl Physiol (1985)2012-06-21T00:00:002012Sympatho-adrenal activation by chronic intermittent hypoxia.23080136Semenza GL, Prabhakar NRAdvances in experimental medicine and biologyThe role of hypoxia-inducible factors in oxygen sensing by the carotid body. Adv Exp Med Biol. 2012; 758:1-5.Adv Exp Med Biol2012-01-01T00:00:002012The role of hypoxia-inducible factors in oxygen sensing by the carotid body.22256730Prabhakar NRThe PhysiologistInstitute for integrative physiology: resurrection of physiology at the University of Chicago. Physiologist. 2011 Dec; 54(6):235-6.Physiologist2011-12-01T00:00:002011Institute for integrative physiology: resurrection of physiology at the University of Chicago.23080150Prabhakar NRAdvances in experimental medicine and biologyHydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia. Adv Exp Med Biol. 2012; 758:109-13.Adv Exp Med Biol2012-01-01T00:00:002012Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia.2907961Yamamoto Y, Runold M, Prabhakar N, Pantaleo T, Lagercrantz HActa physiologica ScandinavicaSomatostatin in the control of respiration. Acta Physiol Scand. 1988 Dec; 134(4):529-33.Acta Physiol Scand1988-12-01T00:00:001988Somatostatin in the control of respiration.2886198Mitra J, Prabhakar NR, Overholt JL, Cherniack NSBrain research bulletinRespiratory and vasomotor effects of excitatory amino acid on ventral medullary surface. Brain Res Bull. 1987 May; 18(5):681-4.Brain Res Bull1987-05-01T00:00:001987Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.18570888Nanduri J, Wang N, Bergson P, Yuan G, Ficker E, Prabhakar NRBiochemical and biophysical research communicationsMitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem Biophys Res Commun. 2008 Aug 22; 373(2):309-14.Biochem Biophys Res Commun2008-06-18T00:00:002008Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.18602876Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyPost-translational modification of proteins during intermittent hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):272-6.Respir Physiol Neurobiol2008-12-10T00:00:002008Post-translational modification of proteins during intermittent hypoxia.3768733Mitra J, Prabhakar NR, Haxhiu M, Cherniack NSBrain research bulletinComparison of the effects of hypercapnia on phrenic and hypoglossal activity in anesthetized decerebrate and decorticate animals. Brain Res Bull. 1986 Aug; 17(2):181-7.Brain Res Bull1986-08-01T00:00:001986Comparison of the effects of hypercapnia on phrenic and hypoglossal activity in anesthetized decerebrate and decorticate animals.16137743Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NRProgress in biophysics and molecular biologyOxygen sensing in the body. Prog Biophys Mol Biol. 2006 Jul; 91(3):249-86.Prog Biophys Mol Biol2005-08-15T00:00:002005Oxygen sensing in the body.19109370Pawar A, Nanduri J, Yuan G, Khan SA, Wang N, Kumar GK, Prabhakar NRAmerican journal of physiology. Regulatory, integrative and comparative physiologyReactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R735-42.Am J Physiol Regul Integr Comp Physiol2008-12-24T00:00:002008Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia.7540190Prabhakar NR, Gouda E, Kumar GK, Kou YRJournal of the autonomic nervous systemAnalysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats. J Auton Nerv Syst. 1995 Mar 18; 52(1):43-50.J Auton Nerv Syst1995-03-18T00:00:001995Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats.7892214Prabhakar NR, Dinerman JL, Agani FH, Snyder SHProceedings of the National Academy of Sciences of the United States of AmericaCarbon monoxide: a role in carotid body chemoreception. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):1994-7.Proc Natl Acad Sci U S A1995-03-14T00:00:001995Carbon monoxide: a role in carotid body chemoreception.7906485Prabhakar NR, Kou YR, Cragg PA, Cherniack NSAdvances in experimental medicine and biologyEffect of arterial chemoreceptor stimulation: role of norepinephrine in hypoxic chemotransmission. Adv Exp Med Biol. 1993; 337:301-6.Adv Exp Med Biol1993-01-01T00:00:001993Effect of arterial chemoreceptor stimulation: role of norepinephrine in hypoxic chemotransmission.7908747Prabhakar NR, Kou YRRespiration physiologyInhibitory sympathetic action on the carotid body responses to sustained hypoxia. Respir Physiol. 1994 Jan; 95(1):67-79.Respir Physiol1994-01-01T00:00:001994Inhibitory sympathetic action on the carotid body responses to sustained hypoxia.19476715Braga VA, Prabhakar NRJournal of the American Association for Laboratory Animal Science : JAALASRefinement of telemetry for measuring blood pressure in conscious rats. J Am Assoc Lab Anim Sci. 2009 May; 48(3):268-71.J Am Assoc Lab Anim Sci2009-05-01T00:00:002009Refinement of telemetry for measuring blood pressure in conscious rats.19536498Souvannakitti D, Kumar GK, Fox A, Prabhakar NRAdvances in experimental medicine and biologyContrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells. Adv Exp Med Biol. 2009; 648:345-9.Adv Exp Med Biol2009-01-01T00:00:002009Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells.2470465Prabhakar NR, Landis SC, Kumar GK, Mullikin-Kilpatrick D, Cherniack NS, Leeman SBrain researchSubstance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2. Brain Res. 1989 Mar 06; 481(2):205-14.Brain Res1989-03-06T00:00:001989Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2.2481845Prabhakar NR, Runold M, Kumar GK, Cherniack NS, Scarpa APeptidesSubstance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide. Peptides. 1989 Sep-Oct; 10(5):1003-6.Peptides1989-09-01T00:00:001989Substance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide.22108299Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakar NR, Garcia JGAmerican journal of respiratory cell and molecular biologyParticulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):524-31.Am J Respir Cell Mol Biol2011-11-22T00:00:002011Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.20836657Raghuraman G, Kalari A, Dhingra R, Prabhakar NR, Kumar GKAntioxidants & redox signalingEnhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing. Antioxid Redox Signal. 2011 Apr 01; 14(7):1179-90.Antioxid Redox Signal2011-02-06T00:00:002011Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.Authorship 148150434297635Nanduri J, Wang N, Wang BL, Prabhakar NRPhysiological genomicsLysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia. Physiol Genomics. 2021 09 01; 53(9):385-394.Physiol Genomics2021-07-23T00:00:002021Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia.21302291Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NRJournal of cellular physiologyHypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 2011 Nov; 226(11):2925-33.J Cell Physiol2011-11-01T00:00:002011Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.Authorship 1483861134322038Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GMFrontiers in physiologyIntermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995.Front Physiol2021-07-12T00:00:002021Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.2793655Runold M, Lagercrantz H, Prabhakar NR, Fredholm BBJournal of applied physiology (Bethesda, Md. : 1985)Role of adenosine in hypoxic ventilatory depression. J Appl Physiol (1985). 1989 Aug; 67(2):541-6.J Appl Physiol (1985)1989-08-01T00:00:001989Role of adenosine in hypoxic ventilatory depression.3406552van Lunteren E, Prabhakar NR, Cherniack NS, Haxhiu MA, Dick TERespiration physiologyInhibition of expiratory muscle EMG and motor unit activity during augmented breaths in cats. Respir Physiol. 1988 Jun; 72(3):303-14.Respir Physiol1988-06-01T00:00:001988Inhibition of expiratory muscle EMG and motor unit activity during augmented breaths in cats.22232674Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaEpigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20.Proc Natl Acad Sci U S A2012-01-09T00:00:002012Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.16777938Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NRThe Journal of physiologyChronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol. 2006 Aug 15; 575(Pt 1):229-39.J Physiol2006-06-15T00:00:002006Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.Authorship 1486223160005Marek W, Prabhakar NRPflugers Archiv : European journal of physiologyElectrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: II. Responses of respiratory muscles and their motor nerves. Pflugers Arch. 1985 Apr; 403(4):422-8.Pflugers Arch1985-04-01T00:00:001985Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: II. Responses of respiratory muscles and their motor nerves.3187204Mitra J, Prabhakar NR, Overholt JL, Cherniack NSRespiration physiologyRespiratory and vasomotor responses to focal cooling of the ventral medullary surface (VMS) of the rat. Respir Physiol. 1988 Oct; 74(1):35-47.Respir Physiol1988-10-01T00:00:001988Respiratory and vasomotor responses to focal cooling of the ventral medullary surface (VMS) of the rat.3222562Overholt JL, Mitra J, van Lunteren E, Prabhakar NR, Cherniack NSRespiration physiologyNaloxone enhances the response to hypercapnia of spinal and cranial respiratory nerves. Respir Physiol. 1988 Dec; 74(3):299-309.Respir Physiol1988-12-01T00:00:001988Naloxone enhances the response to hypercapnia of spinal and cranial respiratory nerves.23080186Raghuraman G, Prabhakar NR, Kumar GKAdvances in experimental medicine and biologyDifferential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia. Adv Exp Med Biol. 2012; 758:381-5.Adv Exp Med Biol2012-01-01T00:00:002012Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia.21288809Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaHypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3065-70.Proc Natl Acad Sci U S A2011-01-31T00:00:002011Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.3096939Prabhakar NR, Mitra J, Overholt JL, Cherniack NSJournal of applied physiology (Bethesda, Md. : 1985)Analysis of postinspiratory activity of phrenic motoneurons with chemical and vagal reflexes. J Appl Physiol (1985). 1986 Oct; 61(4):1499-509.J Appl Physiol (1985)1986-10-01T00:00:001986Analysis of postinspiratory activity of phrenic motoneurons with chemical and vagal reflexes.3929349Mitra J, Prabhakar NR, Haxhiu MA, Cherniack NSRespiration physiologyThe effects of hypercapnia and cooling the ventral medullary surface on capsaicin induced respiratory reflexes. Respir Physiol. 1985 Jun; 60(3):377-85.Respir Physiol1985-06-01T00:00:001985The effects of hypercapnia and cooling the ventral medullary surface on capsaicin induced respiratory reflexes.4011393Marek W, Prabhakar NR, Loeschcke HHPflugers Archiv : European journal of physiologyElectrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: I. Ventilatory responses. Pflugers Arch. 1985 Apr; 403(4):415-21.Pflugers Arch1985-04-01T00:00:001985Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: I. Ventilatory responses.21636565Peng YJ, Raghuraman G, Khan SA, Kumar GK, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase. J Appl Physiol (1985). 2011 Oct; 111(4):964-70.J Appl Physiol (1985)2011-06-02T00:00:002011Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.6206685Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, von Euler CActa physiologica ScandinavicaEffect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity. Acta Physiol Scand. 1984 Jul; 121(3):301-3.Acta Physiol Scand1984-07-01T00:00:001984Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity.22016368Peng YJ, Nanduri J, Zhang X, Wang N, Raghuraman G, Seagard J, Kumar GK, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia. J Appl Physiol (1985). 2012 Jan; 112(1):187-96.J Appl Physiol (1985)2011-10-20T00:00:002011Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia.22214405Rajamohan SB, Raghuraman G, Prabhakar NR, Kumar GKAntioxidants & redox signalingNADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells. Antioxid Redox Signal. 2012 Aug 01; 17(3):445-59.Antioxid Redox Signal2012-03-02T00:00:002012NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells.22349395Semenza GL, Prabhakar NRJournal of molecular medicine (Berlin, Germany)Gas biology: small molecular medicine. J Mol Med (Berl). 2012 Mar; 90(3):213-5.J Mol Med (Berl)2012-03-01T00:00:002012Gas biology: small molecular medicine.7520191Cragg PA, Runold M, Kou YR, Prabhakar NRRespiration physiologyTachykinin antagonists in carotid body responses to hypoxia and substance P in the rat. Respir Physiol. 1994 Mar; 95(3):295-310.Respir Physiol1994-03-01T00:00:001994Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat.17138622Dick TE, Hsieh YH, Wang N, Prabhakar NExperimental physiologyAcute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat. Exp Physiol. 2007 Jan; 92(1):87-97.Exp Physiol2006-11-30T00:00:002006Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat.17215495Prabhakar NRJournal of neurophysiologyNovel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia". J Neurophysiol. 2007 Mar; 97(3):1877.J Neurophysiol2007-01-10T00:00:002007Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia".7694772Prabhakar NR, Kumar GK, Chang CH, Agani FH, Haxhiu MABrain researchNitric oxide in the sensory function of the carotid body. Brain Res. 1993 Oct 15; 625(1):16-22.Brain Res1993-10-15T00:00:001993Nitric oxide in the sensory function of the carotid body.2874745Prabhakar NR, Mitra J, Van de Graaff W, Haxhiu MA, Cherniack NSThe American journal of physiologyEffect of focal cooling of central chemosensitive areas on cerebral ischemic response. Am J Physiol. 1986 Aug; 251(2 Pt 2):R295-302.Am J Physiol1986-08-01T00:00:001986Effect of focal cooling of central chemosensitive areas on cerebral ischemic response.22811423Prabhakar NR, Semenza GLPhysiological reviewsAdaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev. 2012 Jul; 92(3):967-1003.Physiol Rev2012-07-01T00:00:002012Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.3749614Haxhiu MA, Mitra J, van Lunteren E, Prabhakar N, Bruce EN, Cherniack NSRespiration; international review of thoracic diseasesResponses of hypoglossal and phrenic nerves to decreased respiratory drive in cats. Respiration. 1986; 50(2):130-8.Respiration1986-01-01T00:00:001986Responses of hypoglossal and phrenic nerves to decreased respiratory drive in cats.7872091Kumar GK, Prabhakar NR, Strohl KP, Thomas A, Cragg PAAdvances in experimental medicine and biologyLow PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body. Adv Exp Med Biol. 1994; 360:217-20.Adv Exp Med Biol1994-01-01T00:00:001994Low PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body.4802452Prabhakar NR, Nishith SD, Saxena JPIndian journal of physiology and pharmacologyEffect of distension of urinary bladder on blood pressure and respiration. Indian J Physiol Pharmacol. 1973 Oct-Dec; 17(4):370-5.Indian J Physiol Pharmacol1973-10-01T00:00:001973Effect of distension of urinary bladder on blood pressure and respiration.7509112Cragg PA, Kou YR, Prabhakar NRAdvances in experimental medicine and biologyRole of substance P in rat carotid body responses to hypoxia and capsaicin. Adv Exp Med Biol. 1993; 337:265-70.Adv Exp Med Biol1993-01-01T00:00:001993Role of substance P in rat carotid body responses to hypoxia and capsaicin.7692512Prabhakar NR, Snider RM, Lowe JA, Cao HRegulatory peptidesSelective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345. Regul Pept. 1993 Jul 02; 46(1-2):266-8.Regul Pept1993-07-02T00:00:001993Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.8234254Prabhakar NR, Cao H, Lowe JA, Snider RMProceedings of the National Academy of Sciences of the United States of AmericaSelective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10041-5.Proc Natl Acad Sci U S A1993-11-01T00:00:001993Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345.19845618Prabhakar NR, Kumar GK, Nanduri JAnnals of the New York Academy of SciencesIntermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci. 2009 Oct; 1177:162-8.Ann N Y Acad Sci2009-10-01T00:00:002009Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.8620613Zakharov SI, Pieramici S, Kumar GK, Prabhakar NR, Harvey RDCirculation researchNitric oxide synthase activity in guinea pig ventricular myocytes is not involved in muscarinic inhibition of cAMP-regulated ion channels. Circ Res. 1996 May; 78(5):925-35.Circ Res1996-05-01T00:00:001996Nitric oxide synthase activity in guinea pig ventricular myocytes is not involved in muscarinic inhibition of cAMP-regulated ion channels.8629504Prabhakar NRAdvances in experimental medicine and biologyGases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception. Adv Exp Med Biol. 1995; 393:309-12.Adv Exp Med Biol1995-01-01T00:00:001995Gases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception.20969567Raghuraman G, Prabhakar NR, Kumar GKJournal of neurochemistryPost-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling. J Neurochem. 2010 Dec; 115(6):1568-78.J Neurochem2010-11-19T00:00:002010Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.22664830Prabhakar NRRespiratory physiology & neurobiologyCarbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body. Respir Physiol Neurobiol. 2012 Nov 15; 184(2):165-9.Respir Physiol Neurobiol2012-06-02T00:00:002012Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body.22744006Makarenko VV, Nanduri J, Raghuraman G, Fox AP, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NRAmerican journal of physiology. Cell physiologyEndogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol. 2012 Nov 01; 303(9):C916-23.Am J Physiol Cell Physiol2012-06-27T00:00:002012Endogenous H2S is required for hypoxic sensing by carotid body glomus cells.3109263Van Lunteren E, Mitra J, Prabhakar NR, Haxhiu MA, Cherniack NSThe American journal of physiologyVentral medullary surface inputs to cervical sympathetic respiratory oscillations. Am J Physiol. 1987 Jun; 252(6 Pt 2):R1032-8.Am J Physiol1987-06-01T00:00:001987Ventral medullary surface inputs to cervical sympathetic respiratory oscillations.4008397Prabhakar NR, Marek W, Loeschcke HHJournal of applied physiology (Bethesda, Md. : 1985)Altered breathing pattern elicited by stimulation of abdominal visceral afferents. J Appl Physiol (1985). 1985 Jun; 58(6):1755-60.J Appl Physiol (1985)1985-06-01T00:00:001985Altered breathing pattern elicited by stimulation of abdominal visceral afferents.9679181Kline DD, Yang T, Huang PL, Prabhakar NRThe Journal of physiologyAltered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol. 1998 Aug 15; 511 ( Pt 1):273-87.J Physiol1998-08-15T00:00:001998Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.1553449Mitra J, Dev NB, Romaniuk JR, Trivedi R, Prabhakar NR, Cherniack NSRespiration physiologyCardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats. Respir Physiol. 1992 Jan; 87(1):49-61.Respir Physiol1992-01-01T00:00:001992Cardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats.10797155Premkumar DR, Mishra RR, Overholt JL, Simonson MS, Cherniack NS, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia. J Appl Physiol (1985). 2000 May; 88(5):1898-906.J Appl Physiol (1985)2000-05-01T00:00:002000L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia.10849664Overholt JL, Ficker E, Yang T, Shams H, Bright GR, Prabhakar NRAdvances in experimental medicine and biologyChemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells. Adv Exp Med Biol. 2000; 475:241-8.Adv Exp Med Biol2000-01-01T00:00:002000Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells.10849697Kline DD, Prabhakar NRAdvances in experimental medicine and biologyPeripheral chemosensitivity in mutant mice deficient in nitric oxide synthase. Adv Exp Med Biol. 2000; 475:571-9.Adv Exp Med Biol2000-01-01T00:00:002000Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase.10849699Summers BA, Overholt JL, Prabhakar NRAdvances in experimental medicine and biologyAugmentation of calcium current by hypoxia in carotid body glomus cells. Adv Exp Med Biol. 2000; 475:589-99.Adv Exp Med Biol2000-01-01T00:00:002000Augmentation of calcium current by hypoxia in carotid body glomus cells.1647054Kou YR, Ernsberger P, Cragg PA, Cherniack NS, Prabhakar NRRespiration physiologyRole of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respir Physiol. 1991 Mar; 83(3):353-64.Respir Physiol1991-03-01T00:00:001991Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia.11729880Kline DD, Prabhakar NRAdvances in experimental medicine and biologyRole of nitric oxide in short-term potentiation and long-term facilitation: involvement of NO in breathing stability. Adv Exp Med Biol. 2001; 499:215-9.Adv Exp Med Biol2001-01-01T00:00:002001Role of nitric oxide in short-term potentiation and long-term facilitation: involvement of NO in breathing stability.12692140Kumar GK, Kim DK, Lee MS, Ramachandran R, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation. J Appl Physiol (1985). 2003 Aug; 95(2):536-44.J Appl Physiol (1985)2003-04-11T00:00:002003Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.12907705Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaInduction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10073-8.Proc Natl Acad Sci U S A2003-08-07T00:00:002003Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas.14657041Kim DK, Natarajan N, Prabhakar NR, Kumar GKJournal of applied physiology (Bethesda, Md. : 1985)Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species. J Appl Physiol (1985). 2004 Mar; 96(3):1206-15; discussion 1196.J Appl Physiol (1985)2003-12-02T00:00:002003Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species.14660510Peng YJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985). 2004 Mar; 96(3):1236-42; discussion 1196.J Appl Physiol (1985)2003-12-05T00:00:002003Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity.14673183Li YL, Sun SY, Overholt JL, Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HDThe Journal of physiologyAttenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide. J Physiol. 2004 Feb 15; 555(Pt 1):219-29.J Physiol2003-12-12T00:00:002003Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide.15569687Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NRThe Journal of biological chemistryCa2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005 Feb 11; 280(6):4321-8.J Biol Chem2004-11-29T00:00:002004Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.15705529Jacono FJ, Peng YJ, Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyModulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor. Respir Physiol Neurobiol. 2005 Feb 15; 145(2-3):135-42.Respir Physiol Neurobiol2005-02-15T00:00:002005Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor.15800194Kline DD, Buniel MC, Glazebrook P, Peng YJ, Ramirez-Navarro A, Prabhakar NR, Kunze DLThe Journal of neuroscience : the official journal of the Society for NeuroscienceKv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J Neurosci. 2005 Mar 30; 25(13):3389-99.J Neurosci2005-03-30T00:00:002005Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration.15854156Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK, Dick TEClinical and experimental pharmacology & physiologyCardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):447-9.Clin Exp Pharmacol Physiol2005-05-01T00:00:002005Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.16686431Prabhakar NR, Peng YJ, Yuan G, Kumar GKNovartis Foundation symposiumReactive oxygen species facilitate oxygen sensing. Novartis Found Symp. 2006; 272:95-9; discussion 100-5, 131-40.Novartis Found Symp2006-01-01T00:00:002006Reactive oxygen species facilitate oxygen sensing.2366949Runold M, Cherniack NS, Prabhakar NRNeuroscience lettersEffect of adenosine on isolated and superfused cat carotid body activity. Neurosci Lett. 1990 May 18; 113(1):111-4.Neurosci Lett1990-05-18T00:00:001990Effect of adenosine on isolated and superfused cat carotid body activity.20664070Souvannakitti D, Kuri B, Yuan G, Pawar A, Kumar GK, Smith C, Fox AP, Prabhakar NRAmerican journal of physiology. 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J Mol Med (Berl). 2012 Mar; 90(3):265-72.J Mol Med (Berl)2012-02-16T00:00:002012Gaseous messengers in oxygen sensing.2973083Kieschke J, Mense S, Prabhakar NRProgress in brain researchInfluence of adrenaline and hypoxia on rat muscle receptors in vitro. Prog Brain Res. 1988; 74:91-7.Prog Brain Res1988-01-01T00:00:001988Influence of adrenaline and hypoxia on rat muscle receptors in vitro.7872130Prabhakar NRAdvances in experimental medicine and biologyNeurotransmitters in the carotid body. Adv Exp Med Biol. 1994; 360:57-69.Adv Exp Med Biol1994-01-01T00:00:001994Neurotransmitters in the carotid body.D017382Chemicals & Drugs1464770.796535Reactive Oxygen SpeciesAuthorship 155350235704695Wang N, Prabhakar NR, Nanduri JAmerican journal of physiology. Cell physiologyProtein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431.Am J Physiol Cell Physiol2022-06-15T00:00:002022Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia.Authorship 155794635757963Peng YJ, Nanduri J, Wang N, Khan SA, Pamenter ME, Prabhakar NRActa physiologica (Oxford, England)Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats. Acta Physiol (Oxf). 2022 10; 236(2):e13851.Acta Physiol (Oxf)2022-06-27T00:00:002022Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats.Authorship 638727Authorship 6387310Authorship 6387412Authorship 638753Authorship 638768Authorship 6387710Authorship 638781Authorship 638799Authorship 638806Authorship 638816Authorship 638827Authorship 63883324973414Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NRThe Journal of physiologyRegulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014 Sep 01; 592(17):3841-58.J Physiol2014-06-27T00:00:002014Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats.24690299Limberg JK, Curry TB, Prabhakar NR, Joyner MJMedical hypothesesIs insulin the new intermittent hypoxia? Med Hypotheses. 2014 Jun; 82(6):730-5.Med Hypotheses2014-03-18T00:00:002014Is insulin the new intermittent hypoxia?24395806Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaInherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1174-9.Proc Natl Acad Sci U S A2014-01-06T00:00:002014Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.24382871Prabhakar NR, Peers CPhysiology (Bethesda, Md.)Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body. Physiology (Bethesda). 2014 Jan; 29(1):49-57.Physiology (Bethesda)2014-01-01T00:00:002014Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.24835990Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LACell reportsTET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014 Jun 12; 7(5):1343-1352.Cell Rep2014-05-15T00:00:002014TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.24328859Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GLThe Biochemical journalHypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression. Biochem J. 2014 Mar 01; 458(2):203-11.Biochem J2014-03-01T00:00:002014Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression.23770311Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyCentral and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53.Respir Physiol Neurobiol2013-06-11T00:00:002013Central and peripheral factors contributing to obstructive sleep apneas.23709585Wang N, Khan SA, Prabhakar NR, Nanduri JExperimental physiologyImpairment of pancreatic ß-cell function by chronic intermittent hypoxia. Exp Physiol. 2013 Sep; 98(9):1376-85.Exp Physiol2013-05-24T00:00:002013Impairment of pancreatic ß-cell function by chronic intermittent hypoxia.25377087Makarenko VV, Peng YJ, Yuan G, Fox AP, Kumar GK, Nanduri J, Prabhakar NRAmerican journal of physiology. Cell physiologyCaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C146-54.Am J Physiol Cell Physiol2014-11-05T00:00:002014CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body.24477234Makarenko VV, Usatyuk PV, Yuan G, Lee MM, Nanduri J, Natarajan V, Kumar GK, Prabhakar NRAmerican journal of physiology. Cell physiologyIntermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation. Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C745-52.Am J Physiol Cell Physiol2014-01-29T00:00:002014Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.24124516Nanduri J, Vaddi DR, Khan SA, Wang N, Makerenko V, Prabhakar NRPloS oneXanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia. PLoS One. 2013; 8(10):e75838.PLoS One2013-10-04T00:00:002013Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia.23913764Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NRExperimental physiologyRole of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol. 2013 Nov; 98(11):1620-30.Exp Physiol2013-08-02T00:00:002013Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.Authorship 1590899Authorship 1601877Authorship 1585831Authorship 159671435965023Prabhakar NR, Peng YJ, Nanduri JHandbook of clinical neurologyAdaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia. Handb Clin Neurol. 2022; 188:103-123.Handb Clin Neurol2022-01-01T00:00:002022Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.36229484Cetin-Atalay R, Meliton AY, Sun KA, Glass ME, Woods PS, Peng YJ, Fang Y, Hamanaka RB, Prabhakar NR, Mutlu GMScientific reportsIntermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells. Sci Rep. 2022 10 13; 12(1):17167.Sci Rep2022-10-13T00:00:002022Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.36417539Gray OA, Yoo J, Sobreira DR, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Nobréga MA, Di Rienzo AScience advancesA pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942.Sci Adv2022-11-23T00:00:002022A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans.36656752Browe BM, Peng YJ, Nanduri J, Prabhakar NR, Garcia AJeLifeGasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12.Elife2023-01-19T00:00:002023Gasotransmitter modulation of hypoglossal motoneuron activity.https://integrativephysiology.uchicago.edu/Institute for Integrative Physiology and Center for Systems Biology of Oxygen SensingAuthorship 162962137029496Prabhakar NR, Peng YJ, Nanduri JThe Journal of physiologyCarotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea. J Physiol. 2023 Dec; 601(24):5481-5494.J Physiol2023-05-05T00:00:002023Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea.Authorship 1641141137406126Peng YJ, Nanduri J, Wang N, Kumar GK, Bindokas V, Paul BD, Chen X, Fox AP, Vignane T, Filipovic MR, Prabhakar NRScience advancesHypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 07 07; 9(27):eadf3026.Sci Adv2023-07-05T00:00:002023Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78.Authorship 164635337485063Das KK, Majid DSA, Prabhakar NRFrontiers in physiologyEditorial: Vascular pathophysiology in hypoxia. Front Physiol. 2023; 14:1235383.Front Physiol2023-07-07T00:00:002023Editorial: Vascular pathophysiology in hypoxia.MedicineUniversity of ChicagoDavidBeiserDavid Beiser41.78927490000000-87.601250000000001243Beiser, DavidAssociate ProfessorGeorgeBakris0GBoa7McCszMknJtY0fp/Cv/+94=George Bakris41.78927490000000-87.601250000000001393Bakris, GeorgeProfessorHowardHalpern32poB7EQC+L5hHlsaUXv9Gq0+s+oHoward Halpern41.78927490000000-87.601250000000001456Halpern, HowardProfessorCaiGlushakCai Glushak41.78927490000000-87.601250000000001496Glushak, CaiClinical Professor29.02450.0041771723research areas19.75530.026602322coauthor of668.50629.759460similar to11259selected publicationsTeresita M.HoganTeresita M. Hogan41.78927490000000-87.601250000000001731Hogan, Teresita M.ProfessorAaronFoxAaron Fox41.78927490000000-87.601250000000001772Fox, AaronProfessorJan-MarinoRamirezJan-Marino Ramirez41.78927490000000-87.601250000000002020Ramirez, Jan-MarinoKeeganCheckettKeegan Checkett41.78927490000000-87.60125000000000211Checkett, KeeganAssociate ProfessorYing-JiePengYing-Jie Peng41.78927490000000-87.601250000000002150Peng, Ying-JieResearch ProfessorGayatriRaghuramanGayatri Raghuraman41.78927490000000-87.601250000000002504Raghuraman, GayatriJayasriNanduriJayasri Nanduri41.78927490000000-87.601250000000002544Nanduri, JayasriResearch ProfessorStephenArcherStephen Archer41.78927490000000-87.601250000000002615Archer, StephenProfessorThomas L.FisherThomas L. Fisher41.78927490000000-87.60125000000000431Fisher, Thomas L.Clinical AssociateAuthorship 167760437874694Wang N, Su X, Sams D, Prabhakar NR, Nanduri JAmerican journal of respiratory cell and molecular biologyP300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2024 Feb; 70(2):110-118.Am J Respir Cell Mol Biol2024-02-01T00:00:002024P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.38206933Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri JPloS oneCorrection: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2024; 19(1):e0297301.PLoS One2024-01-11T00:00:002024Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.Authorship 1694165true1true1true1ProfessorProfessortrue1Clinical AssociateClinical Associatetrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Clinical ProfessorClinical Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Research ProfessorResearch Professortrue1Research ProfessorResearch Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 665174Authorship 7085611Authorship 738997Authorship 735597Authorship 760765Authorship 77868125772710Nanduri J, Peng YJ, Yuan G, Kumar GK, Prabhakar NRJournal of molecular medicine (Berlin, Germany)Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl). 2015 May; 93(5):473-80.J Mol Med (Berl)2015-03-15T00:00:002015Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome.25583660Kumar GK, Nanduri J, Peng YJ, Prabhakar NRRespiratory physiology & neurobiologyNeuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol. 2015 Apr; 209:115-9.Respir Physiol Neurobiol2015-01-10T00:00:002015Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.25880505Prabhakar NR, Peng YJ, Kumar GK, Nanduri JComprehensive PhysiologyPeripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. 2015 Apr; 5(2):561-77.Compr Physiol2015-04-01T00:00:002015Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.25900831Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NRScience signalingProtein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21; 8(373):ra37.Sci Signal2015-04-21T00:00:002015Protein kinase G-regulated production of H2S governs oxygen sensing.25751622Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NRPloS oneHIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLoS One. 2015; 10(3):e0119762.PLoS One2015-03-09T00:00:002015HIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.24887113Kåhlin J, Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, Kehr J, Prabhakar N, Poellinger L, Fagerlund MJ, Eriksson LIExperimental physiologyThe human carotid body releases acetylcholine, ATP and cytokines during hypoxia. Exp Physiol. 2014 Aug; 99(8):1089-98.Exp Physiol2014-05-30T00:00:002014The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.Authorship 814502Authorship 81455426303461Nanduri J, Prabhakar NRAdvances in experimental medicine and biologyEpigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications. Adv Exp Med Biol. 2015; 860:1-8.Adv Exp Med Biol2015-01-01T00:00:002015Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.26303481Kumar GK, Peng YJ, Nanduri J, Prabhakar NRAdvances in experimental medicine and biologyCarotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla. Adv Exp Med Biol. 2015; 860:195-9.Adv Exp Med Biol2015-01-01T00:00:002015Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla.Authorship 81627126328879Prabhakar NR, Semenza GLPhysiology (Bethesda, Md.)Oxygen Sensing and Homeostasis. Physiology (Bethesda). 2015 Sep; 30(5):340-8.Physiology (Bethesda)2015-09-01T00:00:002015Oxygen Sensing and Homeostasis.Chicago60637ILMedicine-Emergency MedicineMedicine-EndocrinologyAuthorship 847092Authorship 84751626605404Peers C, Kumar P, Wyatt C, Gauda E, Nurse C, Prabhakar NAdvances in experimental medicine and biologyThis volume of Advances in Experimental Medicine and Biology holds the proceedings of the XVIIIth meeting. Introduction. Adv Exp Med Biol. 2015; 860:v-vi.Adv Exp Med Biol2015-01-01T00:00:002015This volume of Advances in Experimental Medicine and Biology holds the proceedings of the XVIIIth meeting. Introduction.25953833Semenza GL, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. J Appl Physiol (1985). 2015 Nov 15; 119(10):1152-6.J Appl Physiol (1985)2015-05-07T00:00:002015Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.Authorship 85398126265380Prabhakar NR, Semenza GLPflugers Archiv : European journal of physiologyRegulation of carotid body oxygen sensing by hypoxia-inducible factors. Pflugers Arch. 2016 Jan; 468(1):71-75.Pflugers Arch2015-08-13T00:00:002015Regulation of carotid body oxygen sensing by hypoxia-inducible factors.Authorship 85600826561606Makarenko VV, Ahmmed GU, Peng YJ, Khan SA, Nanduri J, Kumar GK, Fox AP, Prabhakar NRJournal of neurophysiologyCaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia. J Neurophysiol. 2016 Jan 01; 115(1):345-54.J Neurophysiol2015-11-11T00:00:002015CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.Authorship 866806Authorship 87267626659724Wang N, Kang HS, Ahmmed G, Khan SA, Makarenko VV, Prabhakar NR, Nanduri JAmerican journal of physiology. Cell physiologyCalpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. Am J Physiol Cell Physiol. 2016 Mar 01; 310(5):C329-36.Am J Physiol Cell Physiol2015-12-09T00:00:002015Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia.26869872Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JMFrontiers in neuroscienceChronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4.Front Neurosci2016-02-04T00:00:002016Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.Authorship 92836127474260Prabhakar NRExperimental physiologyCarotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea. Exp Physiol. 2016 08 01; 101(8):975-85.Exp Physiol2016-08-01T00:00:002016Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea.Authorship 931061027531649Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NRScience signalingH2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016 08 16; 9(441):ra80.Sci Signal2016-08-16T00:00:002016H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.Authorship 507973Authorship 518562Authorship 509923Authorship 513414Authorship 512462Authorship 578743Authorship 625532Authorship 617231Authorship 6220610Authorship 6012324025583Haxhiu MA, Mitra J, van Lunteren E, Prabhakar NR, Cherniack NSThe American journal of physiologyInfluence of central chemoreceptor afferent inputs on respiratory muscle activity. Am J Physiol. 1985 Aug; 249(2 Pt 2):R266-73.Am J Physiol1985-08-01T00:00:001985Influence of central chemoreceptor afferent inputs on respiratory muscle activity.3072119Cherniack NS, Mitra J, Prabhakar NR, Adams EMClinical and experimental hypertension. Part A, Theory and practiceRespiratory and vasomotor influences of the ventrolateral medulla. Clin Exp Hypertens A. 1988; 10 Suppl 1:1-9.Clin Exp Hypertens A1988-01-01T00:00:001988Respiratory and vasomotor influences of the ventrolateral medulla.2616783Cherniack NS, Adams EM, Prabhakar NR, Haxhiu M, Mitra JProgress in brain researchIntegration of cardiorespiratory responses in the ventrolateral medulla. Prog Brain Res. 1989; 81:215-20.Prog Brain Res1989-01-01T00:00:001989Integration of cardiorespiratory responses in the ventrolateral medulla.3725183Mense S, Prabhakar NRNeuroscience lettersSpinal termination of nociceptive afferent fibres from deep tissues in the cat. Neurosci Lett. 1986 May 15; 66(2):169-74.Neurosci Lett1986-05-15T00:00:001986Spinal termination of nociceptive afferent fibres from deep tissues in the cat.6760517Funke PJ, Prabhakar NR, Hertle L, Runkel N, Dahlheim HUrologia internationalisPlasma renin activity and cardiovascular changes in patients with chronic bladder distension. Urol Int. 1982; 37(5):363-8.Urol Int1982-01-01T00:00:001982Plasma renin activity and cardiovascular changes in patients with chronic bladder distension.22846496Nanduri J, Prabhakar NRRespiratory physiology & neurobiologyDevelopmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms. Respir Physiol Neurobiol. 2013 Jan 01; 185(1):105-9.Respir Physiol Neurobiol2012-07-27T00:00:002012Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.19218665Marek W, Muckenhoff K, Prabhakar NRJournal of physiology and pharmacology : an official journal of the Polish Physiological SocietySignificance of pulmonary vagal afferents for respiratory muscle activity in the cat. J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:407-20.J Physiol Pharmacol2008-12-01T00:00:002008Significance of pulmonary vagal afferents for respiratory muscle activity in the cat.23459758Prabhakar NRThe Journal of physiologySensing hypoxia: physiology, genetics and epigenetics. J Physiol. 2013 May 01; 591(9):2245-57.J Physiol2013-03-04T00:00:002013Sensing hypoxia: physiology, genetics and epigenetics.23728973Kumar P, Prabhakar NRComprehensive PhysiologyPeripheral chemoreceptors: function and plasticity of the carotid body. Compr Physiol. 2012 Jan; 2(1):141-219.Compr Physiol2012-01-01T00:00:002012Peripheral chemoreceptors: function and plasticity of the carotid body.23610397Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaMutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1788-96.Proc Natl Acad Sci U S A2013-04-22T00:00:002013Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis.Authorship 9564911Authorship 95577727765905Applebaum MA, Jha AR, Kao C, Hernandez KM, DeWane G, Salwen HR, Chlenski A, Dobratic M, Mariani CJ, Godley LA, Prabhakar N, White K, Stranger BE, Cohn SLOncotargetIntegrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget. 2016 Nov 22; 7(47):76816-76826.Oncotarget2016-11-22T00:00:002016Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.27506145Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NRThe Journal of physiologyEpigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. J Physiol. 2017 01 01; 595(1):63-77.J Physiol2016-10-02T00:00:002016Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.Authorship 995251428115703Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaComplementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418.Proc Natl Acad Sci U S A2017-01-23T00:00:002017Complementary roles of gasotransmitters CO and H2S in sleep apnea.