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Joseph Thornton to Evolution, Molecular

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This is a "connection" page, showing publications Joseph Thornton has written about Evolution, Molecular.
Joseph Thornton
Connection Strength
11.013
Evolution, Molecular
  1. The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family. Nat Ecol Evol. 2025 Sep; 9(9):1656-1669.
    View in: PubMed
    Score: 0.591
  2. Robustness of Ancestral Sequence Reconstruction to Among-site and Among-lineage Evolutionary Heterogeneity. Mol Biol Evol. 2025 Apr 01; 42(4).
    View in: PubMed
    Score: 0.578
  3. Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2414756122.
    View in: PubMed
    Score: 0.570
  4. Epistasis facilitates functional evolution in an ancient transcription factor. Elife. 2024 May 20; 12.
    View in: PubMed
    Score: 0.544
  5. Simple mechanisms for the evolution of protein complexity. Protein Sci. 2022 11; 31(11):e4449.
    View in: PubMed
    Score: 0.489
  6. Epistatic drift causes gradual decay of predictability in protein evolution. Science. 2022 05 20; 376(6595):823-830.
    View in: PubMed
    Score: 0.474
  7. A hydrophobic ratchet entrenches molecular complexes. Nature. 2020 12; 588(7838):503-508.
    View in: PubMed
    Score: 0.429
  8. Origin of complexity in haemoglobin evolution. Nature. 2020 05; 581(7809):480-485.
    View in: PubMed
    Score: 0.412
  9. Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development. Elife. 2018 10 09; 7.
    View in: PubMed
    Score: 0.369
  10. Pervasive contingency and entrenchment in a billion years of Hsp90 evolution. Proc Natl Acad Sci U S A. 2018 04 24; 115(17):4453-4458.
    View in: PubMed
    Score: 0.356
  11. Alternative evolutionary histories in the sequence space of an ancient protein. Nature. 2017 09 21; 549(7672):409-413.
    View in: PubMed
    Score: 0.342
  12. Evolution of protein specificity: insights from ancestral protein reconstruction. Curr Opin Struct Biol. 2017 12; 47:113-122.
    View in: PubMed
    Score: 0.341
  13. Reconstructing Ancient Proteins to Understand the Causes of Structure and Function. Annu Rev Biophys. 2017 05 22; 46:247-269.
    View in: PubMed
    Score: 0.331
  14. Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty. Mol Biol Evol. 2017 02 01; 34(2):247-261.
    View in: PubMed
    Score: 0.328
  15. Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites. Elife. 2015 Jun 15; 4:e07864.
    View in: PubMed
    Score: 0.293
  16. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell. 2014 Sep 25; 159(1):58-68.
    View in: PubMed
    Score: 0.279
  17. Historical contingency and its biophysical basis in glucocorticoid receptor evolution. Nature. 2014 Aug 14; 512(7513):203-7.
    View in: PubMed
    Score: 0.273
  18. Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. PLoS Genet. 2014 Jan; 10(1):e1004058.
    View in: PubMed
    Score: 0.265
  19. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11475-80.
    View in: PubMed
    Score: 0.256
  20. Evolution of minimal specificity and promiscuity in steroid hormone receptors. PLoS Genet. 2012; 8(11):e1003072.
    View in: PubMed
    Score: 0.245
  21. Evolution of increased complexity in a molecular machine. Nature. 2012 Jan 09; 481(7381):360-4.
    View in: PubMed
    Score: 0.231
  22. Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. PLoS Genet. 2011 Jun; 7(6):e1002117.
    View in: PubMed
    Score: 0.222
  23. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. PLoS Biol. 2010 Oct 05; 8(10).
    View in: PubMed
    Score: 0.212
  24. Evolution of steroid receptors from an estrogen-sensitive ancestral receptor. Mol Cell Endocrinol. 2011 Mar 01; 334(1-2):31-8.
    View in: PubMed
    Score: 0.211
  25. Analyzing protein structure and function using ancestral gene reconstruction. Curr Opin Struct Biol. 2010 Jun; 20(3):360-6.
    View in: PubMed
    Score: 0.205
  26. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 2009 Sep 24; 461(7263):515-9.
    View in: PubMed
    Score: 0.197
  27. A mixed branch length model of heterotachy improves phylogenetic accuracy. Mol Biol Evol. 2008 Jun; 25(6):1054-66.
    View in: PubMed
    Score: 0.177
  28. Crystal structure of an ancient protein: evolution by conformational epistasis. Science. 2007 Sep 14; 317(5844):1544-8.
    View in: PubMed
    Score: 0.170
  29. The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications. Endocrinology. 2006 Aug; 147(8):3861-9.
    View in: PubMed
    Score: 0.156
  30. Evolution of hormone-receptor complexity by molecular exploitation. Science. 2006 Apr 07; 312(5770):97-101.
    View in: PubMed
    Score: 0.155
  31. No magic pill for phylogenetic error. Trends Genet. 2005 Jun; 21(6):310-1.
    View in: PubMed
    Score: 0.146
  32. Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. Nat Commun. 2024 12 03; 15(1):10515.
    View in: PubMed
    Score: 0.141
  33. Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science. 2003 Sep 19; 301(5640):1714-7.
    View in: PubMed
    Score: 0.130
  34. Evolutionary Shortcuts via Multinucleotide Substitutions and Their Impact on Natural Selection Analyses. Mol Biol Evol. 2023 07 05; 40(7).
    View in: PubMed
    Score: 0.128
  35. Contingency and chance erase necessity in the experimental evolution of ancestral proteins. Elife. 2021 06 01; 10.
    View in: PubMed
    Score: 0.111
  36. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5671-6.
    View in: PubMed
    Score: 0.110
  37. EvoChromo: towards a synthesis of chromatin biology and evolution. Development. 2019 09 26; 146(19).
    View in: PubMed
    Score: 0.099
  38. Epistasis in protein evolution. Protein Sci. 2016 07; 25(7):1204-18.
    View in: PubMed
    Score: 0.077
  39. Evolution of an ancient protein function involved in organized multicellularity in animals. Elife. 2016 Jan 07; 5:e10147.
    View in: PubMed
    Score: 0.076
  40. Thermodynamic system drift in protein evolution. PLoS Biol. 2014 Nov; 12(11):e1001994.
    View in: PubMed
    Score: 0.070
  41. The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci. 2012 Jun; 21(6):769-85.
    View in: PubMed
    Score: 0.059
  42. Evolution of a new function by degenerative mutation in cephalochordate steroid receptors. PLoS Genet. 2008 Sep 12; 4(9):e1000191.
    View in: PubMed
    Score: 0.046
  43. Is there a star tree paradox? Mol Biol Evol. 2006 Oct; 23(10):1819-23.
    View in: PubMed
    Score: 0.039
  44. Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 2021 11 02; 37(5):109940.
    View in: PubMed
    Score: 0.029
  45. Evolution of the androgen receptor: structure-function implications. Bioessays. 1998 Oct; 20(10):860-9.
    View in: PubMed
    Score: 0.023
  46. A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription. Gen Comp Endocrinol. 2016 09 15; 236:105-114.
    View in: PubMed
    Score: 0.020
  47. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55.
    View in: PubMed
    Score: 0.009
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