UrsulaStorbUrsula B. Storb41.78927490000000-87.601250000000001819Storb, UrsulaB.PROFESSOR EMERITAPROFESSORprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD001402Anatomy1957240.691726B-LymphocytesAuthorship 104709628464323Ratnam S, Bozek G, Martin T, Gallagher SJ, Payne CJ, Storb UMolecular reproduction and developmentSsm1b expression and function in germ cells of adult mice and in early embryos. Mol Reprod Dev. 2017 Jul; 84(7):596-613.Mol Reprod Dev2017-06-05T00:00:002017Ssm1b expression and function in germ cells of adult mice and in early embryos.TerenceMartinTerence E. Martin41.7886000000000087.598699999999993502Martin, TerenceEmeritus/Emerita, ProfessorD005803Genes & Molecular Sequences341110.943128Genes, ImmunoglobulinD003564Chemicals & Drugs16430.965039Cytidine DeaminaseRadiation and Cellular OncologyMedicine-GastroenterologyAuthorship 104554Authorship 113123Authorship 101762Authorship 10402Authorship 123131Authorship 111051Authorship 112963Authorship 117732Authorship 11753Authorship 136064Authorship 125524Authorship 132873Authorship 143691Authorship 147181Authorship 16545Authorship 13471Authorship 153052Authorship 147735Authorship 162794Authorship 147191Authorship 154851Authorship 151004Authorship 150431Authorship 136945Authorship 170822Authorship 140404Authorship 143212Authorship 184144Authorship 147382Authorship 2008618Authorship 165084Authorship 149253Authorship 186151Authorship 188594Authorship 176742Authorship 179532Authorship 202313Authorship 186872Authorship 19492Authorship 20385Authorship 23233Authorship 212714Authorship 223495Authorship 231476Authorship 185391Authorship 22674Authorship 269652Authorship 25753Authorship 254382Authorship 190121Authorship 24175Authorship 215588Authorship 305775Authorship 284293Authorship 271243Authorship 336977Authorship 3161Authorship 316381Authorship 35256Authorship 26547Authorship 300755Authorship 33093Authorship 33244Authorship 34581Authorship 379277Authorship 421314Authorship 36325Authorship 36378Authorship 335685Authorship 47901Authorship 5073Authorship 6224Authorship 48401Authorship 6851Authorship 68721Authorship 72652Authorship 601Authorship 38845Authorship 65821Authorship 6921Authorship 74202Authorship 74803Authorship 81821Authorship 91274Authorship 97764Authorship 403195Authorship 95753Authorship 478455Authorship 67211Authorship 69741Authorship 48452Authorship 75826Authorship 79603Authorship 79723Authorship 49175Authorship 89143Authorship 50933Authorship 66371Authorship 67371Authorship 71352Authorship 72932Authorship 76061Authorship 76193Authorship 792Authorship 95833Authorship 67901Authorship 71344Authorship 72921Authorship 49195Authorship 74491Authorship 79502Authorship 79572Authorship 93774Authorship 60601Authorship 65831Authorship 73183Authorship 79834Authorship 82053Authorship 91151Authorship 108246Authorship 122921Authorship 122931Authorship 128052Authorship 164137Authorship 175814Authorship 215051Authorship 224932D007146Chemicals & Drugs12420.985569Immunoglobulin lambda-ChainsAuthorship 27805Authorship 283945Authorship 288914Authorship 29821Authorship 326705Authorship 391541Authorship 40461Authorship 47781Authorship 48283Authorship 49184Authorship 6811Authorship 69582Authorship 72981Authorship 795218725937Storb U, Kruisbeek AMCurrent opinion in immunologyLymphocyte development. Curr Opin Immunol. 1996 Apr; 8(2):155-9.Curr Opin Immunol1996-04-01T00:00:001996Lymphocyte development.8725944Storb UCurrent opinion in immunologyThe molecular basis of somatic hypermutation of immunoglobulin genes. Curr Opin Immunol. 1996 Apr; 8(2):206-14.Curr Opin Immunol1996-04-01T00:00:001996The molecular basis of somatic hypermutation of immunoglobulin genes.8413244Eisenbeis CF, Singh H, Storb UMolecular and cellular biologyPU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol. 1993 Oct; 13(10):6452-61.Mol Cell Biol1993-10-01T00:00:001993PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.8417353Engler P, Weng A, Storb UMolecular and cellular biologyInfluence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol Cell Biol. 1993 Jan; 13(1):571-7.Mol Cell Biol1993-01-01T00:00:001993Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.8738912Storb U, Peters A, Klotz E, Rogerson B, Hackett JSeminars in immunologyThe mechanism of somatic hypermutation studied with transgenic and transfected target genes. Semin Immunol. 1996 Jun; 8(3):131-40.Semin Immunol1996-06-01T00:00:001996The mechanism of somatic hypermutation studied with transgenic and transfected target genes.8574852Peters A, Storb UImmunitySomatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity. 1996 Jan; 4(1):57-65.Immunity1996-01-01T00:00:001996Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.1402684Engler P, Klotz E, Storb UThe Journal of experimental medicineN region diversity of a transgenic substrate in fetal and adult lymphoid cells. J Exp Med. 1992 Nov 01; 176(5):1399-404.J Exp Med1992-11-01T00:00:001992N region diversity of a transgenic substrate in fetal and adult lymphoid cells.8906822Klotz EL, Storb UJournal of immunology (Baltimore, Md. : 1950)Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer. J Immunol. 1996 Nov 15; 157(10):4458-63.J Immunol1996-11-15T00:00:001996Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.9464529Fuller K, Storb UMolecular immunologyIdentification and characterization of the murine Rag1 promoter. Mol Immunol. 1997 Aug-Sep; 34(12-13):939-54.Mol Immunol1997-08-01T00:00:001997Identification and characterization of the murine Rag1 promoter.9602347Storb UImmunological reviewsProgress in understanding the mechanism and consequences of somatic hypermutation. Immunol Rev. 1998 Apr; 162:5-11.Immunol Rev1998-04-01T00:00:001998Progress in understanding the mechanism and consequences of somatic hypermutation.9088980Kurtz BS, Witte PL, Storb UInternational immunologyGamma 2b provides only some of the signals normally given via mu in B cell development. Int Immunol. 1997 Mar; 9(3):415-26.Int Immunol1997-03-01T00:00:001997Gamma 2b provides only some of the signals normally given via mu in B cell development.9670955Klotz EL, Hackett J, Storb UJournal of immunology (Baltimore, Md. : 1950)Somatic hypermutation of an artificial test substrate within an Ig kappa transgene. J Immunol. 1998 Jul 15; 161(2):782-90.J Immunol1998-07-15T00:00:001998Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.9236193Kim N, Kage K, Matsuda F, Lefranc MP, Storb UThe Journal of experimental medicineB lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes. J Exp Med. 1997 Aug 04; 186(3):413-9.J Exp Med1997-08-04T00:00:001997B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.9364218Shen HM, Cheo DL, Friedberg E, Storb UMolecular immunologyThe inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes. Mol Immunol. 1997 May; 34(7):527-33.Mol Immunol1997-05-01T00:00:001997The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.9853828Storb U, Peters A, Klotz E, Kim N, Shen HM, Hackett J, Rogerson B, O'Brien R, Martin TEThe International journal of developmental biologyImmunoglobulin transgenes as targets for somatic hypermutation. Int J Dev Biol. 1998; 42(7):977-82.Int J Dev Biol1998-01-01T00:00:001998Immunoglobulin transgenes as targets for somatic hypermutation.Comm: Developmental BiologyHarinderSinghHarinder Singh0.000000000000000.000000000000003073Singh, HarinderPROFESSOR 9199354Ezekiel UR, Sun T, Bozek G, Storb UMolecular and cellular biologyThe composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences. Mol Cell Biol. 1997 Jul; 17(7):4191-7.Mol Cell Biol1997-07-01T00:00:001997The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.1490348Storb U, Engler P, Klotz E, Weng A, Haasch D, Pinkert C, Doglio L, Glymour M, Brinster RCurrent topics in microbiology and immunologyRearrangement and expression of immunoglobulin genes in transgenic mice. Curr Top Microbiol Immunol. 1992; 182:137-41.Curr Top Microbiol Immunol1992-01-01T00:00:001992Rearrangement and expression of immunoglobulin genes in transgenic mice.9479844Storb U, Peters A, Klotz E, Kim N, Shen HM, Kage K, Rogerson B, Martin TECurrent topics in microbiology and immunologySomatic hypermutation of immunoglobulin genes is linked to transcription. Curr Top Microbiol Immunol. 1998; 229:11-9.Curr Top Microbiol Immunol1998-01-01T00:00:001998Somatic hypermutation of immunoglobulin genes is linked to transcription.9794411Satyaraj E, Storb UJournal of immunology (Baltimore, Md. : 1950)Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer. J Immunol. 1998 Nov 01; 161(9):4795-802.J Immunol1998-11-01T00:00:001998Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.10920242Engler P, Storb UMammalian genome : official journal of the International Mammalian Genome SocietyA linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation. Mamm Genome. 2000 Aug; 11(8):694-5.Mamm Genome2000-08-01T00:00:002000A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.9602361Storb U, Peters A, Klotz E, Kim N, Shen HM, Hackett J, Rogerson B, Martin TEImmunological reviewsCis-acting sequences that affect somatic hypermutation of Ig genes. Immunol Rev. 1998 Apr; 162:153-60.Immunol Rev1998-04-01T00:00:001998Cis-acting sequences that affect somatic hypermutation of Ig genes.11156622Wang Z, Engler P, Longacre A, Storb UGenome researchAn efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection. Genome Res. 2001 Jan; 11(1):137-42.Genome Res2001-01-01T00:00:002001An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection.11205325Storb U, Shen HM, Michael N, Kim NPhilosophical transactions of the Royal Society of London. Series B, Biological sciencesSomatic hypermutation of immunoglobulin and non-immunoglobulin genes. Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29; 356(1405):13-9.Philos Trans R Soc Lond B Biol Sci2001-01-29T00:00:002001Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.9624052Shen HM, Peters A, Baron B, Zhu X, Storb UScience (New York, N.Y.)Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 1998 Jun 12; 280(5370):1750-2.Science1998-06-12T00:00:001998Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.9705951Storb U, Klotz EL, Hackett J, Kage K, Bozek G, Martin TEThe Journal of experimental medicineA hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript. J Exp Med. 1998 Aug 17; 188(4):689-98.J Exp Med1998-08-17T00:00:001998A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.10698319Engler P, Storb UMolecular immunologyHypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate. Mol Immunol. 1999 Dec; 36(17):1169-73.Mol Immunol1999-12-01T00:00:001999Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.10882420Shen HM, Michael N, Kim N, Storb UInternational immunologyThe TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int Immunol. 2000 Jul; 12(7):1085-93.Int Immunol2000-07-01T00:00:002000The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.9607914Kim N, Storb UThe Journal of experimental medicineThe role of DNA repair in somatic hypermutation of immunoglobulin genes. J Exp Med. 1998 Jun 01; 187(11):1729-33.J Exp Med1998-06-01T00:00:001998The role of DNA repair in somatic hypermutation of immunoglobulin genes.9724778Engler P, Doglio LT, Bozek G, Storb UProceedings of the National Academy of Sciences of the United States of AmericaA cis-acting element that directs the activity of the murine methylation modifier locus Ssm1. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10763-8.Proc Natl Acad Sci U S A1998-09-01T00:00:001998A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.11257137Sun T, Storb UThe Journal of experimental medicineInsertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement. J Exp Med. 2001 Mar 19; 193(6):699-712.J Exp Med2001-03-19T00:00:002001Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.10475610Sun T, Ezekiel UR, Erskine L, Agulo R, Bozek G, Roth D, Storb UMolecular immunologySignal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends. Mol Immunol. 1999 Jun; 36(8):551-8.Mol Immunol1999-06-01T00:00:001999Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.11825571Michael N, Martin TE, Nicolae D, Kim N, Padjen K, Zhan P, Nguyen H, Pinkert C, Storb UImmunityEffects of sequence and structure on the hypermutability of immunoglobulin genes. Immunity. 2002 Jan; 16(1):123-34.Immunity2002-01-01T00:00:002002Effects of sequence and structure on the hypermutability of immunoglobulin genes.1613457Hackett J, Stebbins C, Rogerson B, Davis MM, Storb UThe Journal of experimental medicineAnalysis of a T cell receptor gene as a target of the somatic hypermutation mechanism. J Exp Med. 1992 Jul 01; 176(1):225-31.J Exp Med1992-07-01T00:00:001992Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.11007471Longacre A, Storb UCellA novel cytidine deaminase affects antibody diversity. Cell. 2000 Sep 01; 102(5):541-4.Cell2000-09-01T00:00:002000A novel cytidine deaminase affects antibody diversity.11869685Sun T, Clark MR, Storb UImmunityA point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity. 2002 Feb; 16(2):245-55.Immunity2002-02-01T00:00:002002A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.1729607Rudin CM, Storb UMolecular and cellular biologyTwo conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors. Mol Cell Biol. 1992 Jan; 12(1):309-20.Mol Cell Biol1992-01-01T00:00:001992Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.12713818Diaz M, Storb UDNA repairA novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes. DNA Repair (Amst). 2003 May 13; 2(5):623-7.DNA Repair (Amst)2003-05-13T00:00:002003A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.12932357Michael N, Shen HM, Longerich S, Kim N, Longacre A, Storb UImmunityThe E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity. 2003 Aug; 19(2):235-42.Immunity2003-08-01T00:00:002003The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.1756738Rogerson B, Hackett J, Peters A, Haasch D, Storb UThe EMBO journalMutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication. EMBO J. 1991 Dec; 10(13):4331-41.EMBO J1991-12-01T00:00:001991Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.12663677Longacre A, Sun T, Goldsby RE, Preston BD, Storb UInternational immunologyIg gene somatic hypermutation in mice defective for DNA polymerase delta proofreading. Int Immunol. 2003 Apr; 15(4):477-81.Int Immunol2003-04-01T00:00:002003Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.1918967Blomberg BB, Rudin CM, Storb UJournal of immunology (Baltimore, Md. : 1950)Identification and localization of an enhancer for the human lambda L chain Ig gene complex. J Immunol. 1991 Oct 01; 147(7):2354-8.J Immunol1991-10-01T00:00:001991Identification and localization of an enhancer for the human lambda L chain Ig gene complex.15328407Shen HM, Storb UProceedings of the National Academy of Sciences of the United States of AmericaActivation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12997-3002.Proc Natl Acad Sci U S A2004-08-24T00:00:002004Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.12242429Fu YX, Storb UScience (New York, N.Y.)Immunology. Autoreactive B cells migrate into T cell territory. Science. 2002 Sep 20; 297(5589):2006-8.Science2002-09-20T00:00:002002Immunology. Autoreactive B cells migrate into T cell territory.1967016Denis KA, Provost S, Witte ON, Brinster RL, Storb UDevelopmental immunologyDelay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules. Dev Immunol. 1990; 1(2):105-12.Dev Immunol1990-01-01T00:00:001990Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.16860389Volgina VV, Sun T, Bozek G, Martin TE, Storb UMolecular immunologyScarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain. Mol Immunol. 2007 Feb; 44(6):1417-28.Mol Immunol2006-07-24T00:00:002006Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.17015724Shen HM, Tanaka A, Bozek G, Nicolae D, Storb UJournal of immunology (Baltimore, Md. : 1950)Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J Immunol. 2006 Oct 15; 177(8):5386-92.J Immunol2006-10-15T00:00:002006Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.2202665Storb UImmunological reviewsThe published data. Immunol Rev. 1990 Jun; 115:253-7; discussion 258-60.Immunol Rev1990-06-01T00:00:001990The published data.15851057Longerich S, Storb UTrends in genetics : TIGThe contested role of uracil DNA glycosylase in immunoglobulin gene diversification. Trends Genet. 2005 May; 21(5):253-6.Trends Genet2005-05-01T00:00:002005The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.16464563Longerich S, Basu U, Alt F, Storb UCurrent opinion in immunologyAID in somatic hypermutation and class switch recombination. Curr Opin Immunol. 2006 Apr; 18(2):164-74.Curr Opin Immunol2006-02-07T00:00:002006AID in somatic hypermutation and class switch recombination.1901887Engler P, Roth P, Kim JY, Storb UJournal of immunology (Baltimore, Md. : 1950)Factors affecting the rearrangement efficiency of an Ig test gene. J Immunol. 1991 Apr 15; 146(8):2826-35.J Immunol1991-04-15T00:00:001991Factors affecting the rearrangement efficiency of an Ig test gene.16314506Shen HM, Ratnam S, Storb UMolecular and cellular biologyTargeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol Cell Biol. 2005 Dec; 25(24):10815-21.Mol Cell Biol2005-12-01T00:00:002005Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.18067961Shen HM, Bozek G, Pinkert CA, McBride K, Wang L, Kenter A, Storb UMolecular immunologyExpression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol. 2008 Apr; 45(7):1883-92.Mol Immunol2007-12-11T00:00:002007Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.2116989Hagman J, Rudin CM, Haasch D, Chaplin D, Storb UGenes & developmentA novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B. Genes Dev. 1990 Jun; 4(6):978-92.Genes Dev1990-06-01T00:00:001990A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.17681497Longerich S, Meira L, Shah D, Samson LD, Storb UDNA repairAlkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination. DNA Repair (Amst). 2007 Dec 01; 6(12):1764-73.DNA Repair (Amst)2007-08-06T00:00:002007Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.2351831Rudin CM, Engler P, Storb UJournal of immunology (Baltimore, Md. : 1950)Differential splicing of thymosin beta 4 mRNA. J Immunol. 1990 Jun 15; 144(12):4857-62.J Immunol1990-06-15T00:00:001990Differential splicing of thymosin beta 4 mRNA.2425036Storb U, Pinkert C, Arp B, Engler P, Gollahon K, Manz J, Brady W, Brinster RLThe Journal of experimental medicineTransgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J Exp Med. 1986 Aug 01; 164(2):627-41.J Exp Med1986-08-01T00:00:001986Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.19380635Shen HM, Poirier MG, Allen MJ, North J, Lal R, Widom J, Storb UThe Journal of experimental medicineThe activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription. J Exp Med. 2009 May 11; 206(5):1057-71.J Exp Med2009-04-20T00:00:002009The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.2044153Engler P, Haasch D, Pinkert CA, Doglio L, Glymour M, Brinster R, Storb UCellA strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell. 1991 Jun 14; 65(6):939-47.Cell1991-06-14T00:00:001991A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.19738437Storb U, Shen HM, Nicolae DCell cycle (Georgetown, Tex.)Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils. Cell Cycle. 2009 Oct 01; 8(19):3097-101.Cell Cycle2009-10-01T00:00:002009Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.18036997Longerich S, Orelli BJ, Martin RW, Bishop DK, Storb UDNA repairBrca1 in immunoglobulin gene conversion and somatic hypermutation. DNA Repair (Amst). 2008 Feb 01; 7(2):253-66.DNA Repair (Amst)2007-11-26T00:00:002007Brca1 in immunoglobulin gene conversion and somatic hypermutation.3104790O'Brien RL, Brinster RL, Storb UNatureSomatic hypermutation of an immunoglobulin transgene in kappa transgenic mice. Nature. 1987 Mar 26-Apr 1; 326(6111):405-9.Nature1987-03-01T00:00:001987Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.2358776Hackett J, Rogerson BJ, O'Brien RL, Storb UThe Journal of experimental medicineAnalysis of somatic mutations in kappa transgenes. J Exp Med. 1990 Jul 01; 172(1):131-7.J Exp Med1990-07-01T00:00:001990Analysis of somatic mutations in kappa transgenes.303524Storb U, Hager L, Wilson R, Putnam DBiochemistryExpression of immunoglobulin and globin genes in B and T lymphocytes and other cells. Biochemistry. 1977 Dec 13; 16(25):5432-8.Biochemistry1977-12-13T00:00:001977Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.4555796Storb U, Weiser RSJournal of the Reticuloendothelial SocietyAntibodies of different immunoglobulin classes released by single cells. J Reticuloendothel Soc. 1972 Mar; 11(3):218-28.J Reticuloendothel Soc1972-03-01T00:00:001972Antibodies of different immunoglobulin classes released by single cells.6793877Storb U, Arp B, Wilson RNatureThe switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes. Nature. 1981 Nov 05; 294(5836):90-2.Nature1981-11-05T00:00:001981The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.7719940Ezekiel UR, Engler P, Stern D, Storb UImmunityAsymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination. Immunity. 1995 Apr; 2(4):381-9.Immunity1995-04-01T00:00:001995Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.2454261Tsang H, Pinkert C, Hagman J, Lostrum M, Brinster RL, Storb UJournal of immunology (Baltimore, Md. : 1950)Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice. J Immunol. 1988 Jul 01; 141(1):308-14.J Immunol1988-07-01T00:00:001988Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.2498429Kenny JJ, Finkelman F, Macchiarini F, Kopp WC, Storb U, Longo DLJournal of immunology (Baltimore, Md. : 1950)Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice. J Immunol. 1989 Jun 15; 142(12):4466-74.J Immunol1989-06-15T00:00:001989Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.2629197Pinkert CA, Manz J, Linton PJ, Klinman NR, Storb UVeterinary immunology and immunopathologyElevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes. Vet Immunol Immunopathol. 1989 Dec; 23(3-4):321-32.Vet Immunol Immunopathol1989-12-01T00:00:001989Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.4919145Storb U, Weiser RSJournal of immunology (Baltimore, Md. : 1950)Antibody production by host cells in x-irradiated recipients of allogeneic spleen cells. J Immunol. 1970 Oct; 105(4):957-63.J Immunol1970-10-01T00:00:001970Antibody production by host cells in x-irradiated recipients of allogeneic spleen cells.5011755Storb UJournal of immunology (Baltimore, Md. : 1950)Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes. J Immunol. 1972 Mar; 108(3):755-64.J Immunol1972-03-01T00:00:001972Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes.6164985Walfield A, Selsing E, Arp B, Storb UNucleic acids researchMisalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene. Nucleic Acids Res. 1981 Mar 11; 9(5):1101-9.Nucleic Acids Res1981-03-11T00:00:001981Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.6255429Walfield AM, Storb U, Selsing E, Zentgraf HNucleic acids researchComparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion". Nucleic Acids Res. 1980 Oct 24; 8(20):4689-707.Nucleic Acids Res1980-10-24T00:00:001980Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".6438533Ritchie KA, Brinster RL, Storb UNatureAllelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice. Nature. 1984 Dec 6-12; 312(5994):517-20.Nature1984-12-01T00:00:001984Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.6799835Miller J, Selsing E, Storb UNatureStructural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression. Nature. 1982 Feb 04; 295(5848):428-30.Nature1982-02-04T00:00:001982Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.508729Wilson R, Miller J, Storb UBiochemistryRearrangement of immunoglobulin genes. Biochemistry. 1979 Oct 30; 18(22):5013-21.Biochemistry1979-10-30T00:00:001979Rearrangement of immunoglobulin genes.7555712Weng A, Magnuson T, Storb UDevelopment (Cambridge, England)Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells. Development. 1995 Sep; 121(9):2853-9.Development1995-09-01T00:00:001995Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells.4870367Storb U, Weiser RSJournal of the Reticuloendothelial SocietyKinetics of mouse spleen cell populations during the immune response. J Reticuloendothel Soc. 1968 Apr; 5(2):81-106.J Reticuloendothel Soc1968-04-01T00:00:001968Kinetics of mouse spleen cell populations during the immune response.3139764Gollahon KA, Hagman J, Brinster RL, Storb UJournal of immunology (Baltimore, Md. : 1950)Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement. J Immunol. 1988 Oct 15; 141(8):2771-80.J Immunol1988-10-15T00:00:001988Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.819583Storb U, Marvin SJournal of immunology (Baltimore, Md. : 1950)Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA. J Immunol. 1976 Jul; 117(1):259-68.J Immunol1976-07-01T00:00:001976Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.96443Storb UProceedings of the National Academy of Sciences of the United States of AmericaDirect demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization. Proc Natl Acad Sci U S A. 1978 Jun; 75(6):2905-8.Proc Natl Acad Sci U S A1978-06-01T00:00:001978Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.821055Storb U, Hager L, Putnam D, Buck L, Farin F, Clagett JProceedings of the National Academy of Sciences of the United States of AmericaSequences related to immunoglobulin kappa chain messenger RNA in T cells. Proc Natl Acad Sci U S A. 1976 Jul; 73(7):2467-71.Proc Natl Acad Sci U S A1976-07-01T00:00:001976Sequences related to immunoglobulin kappa chain messenger RNA in T cells.5676185Church RB, Storb U, McCarthy BJ, Weiser RSJournal of immunology (Baltimore, Md. : 1950)Synthesis of specific RNA molecules during immune response in the mouse spleen. J Immunol. 1968 Sep; 101(3):399-408.J Immunol1968-09-01T00:00:001968Synthesis of specific RNA molecules during immune response in the mouse spleen.698188Wilson R, Walfield AM, Murakami A, Storb UBiochemistryImmunoglobulin genes in DNA restriction fragments. Biochemistry. 1978 Jul 25; 17(15):3096-101.Biochemistry1978-07-25T00:00:001978Immunoglobulin genes in DNA restriction fragments.6328416Selsing E, Voss J, Storb UNucleic acids researchImmunoglobulin gene 'remnant' DNA--implications for antibody gene recombination. Nucleic Acids Res. 1984 May 25; 12(10):4229-46.Nucleic Acids Res1984-05-25T00:00:001984Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.6791832Selsing E, Storb UCellSomatic mutation of immunoglobulin light-chain variable-region genes. Cell. 1981 Jul; 25(1):47-58.Cell1981-07-01T00:00:001981Somatic mutation of immunoglobulin light-chain variable-region genes.22393257Kodgire P, Mukkawar P, North JA, Poirier MG, Storb UMolecular and cellular biologyNucleosome stability dramatically impacts the targeting of somatic hypermutation. Mol Cell Biol. 2012 May; 32(10):2030-40.Mol Cell Biol2012-03-05T00:00:002012Nucleosome stability dramatically impacts the targeting of somatic hypermutation.6300779Wilson R, Storb UNucleic acids researchAssociation of two different repetitive DNA elements near immunoglobulin light chain genes. Nucleic Acids Res. 1983 Mar 25; 11(6):1803-17.Nucleic Acids Res1983-03-25T00:00:001983Association of two different repetitive DNA elements near immunoglobulin light chain genes.7616056Storb U, Roth P, Kurtz BKImmunologic researchGamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Immunol Res. 1994; 13(4):291-8.Immunol Res1994-01-01T00:00:001994Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.7797077Eisenbeis CF, Singh H, Storb UGenes & developmentPip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 01; 9(11):1377-87.Genes Dev1995-06-01T00:00:001995Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.7869028Roth PE, Kurtz B, Lo D, Storb UThe Journal of experimental medicinelambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line. J Exp Med. 1995 Mar 01; 181(3):1059-70.J Exp Med1995-03-01T00:00:001995lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.3081435Storb U, Ritchie KA, O'Brien R, Arp B, Brinster RImmunological reviewsExpression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes. Immunol Rev. 1986 Feb; 89:85-102.Immunol Rev1986-02-01T00:00:001986Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.3109454Storb UAnnual review of immunologyTransgenic mice with immunoglobulin genes. Annu Rev Immunol. 1987; 5:151-74.Annu Rev Immunol1987-01-01T00:00:001987Transgenic mice with immunoglobulin genes.3139761Miller J, Ogden S, McMullen M, Andres H, Storb UJournal of immunology (Baltimore, Md. : 1950)The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns. J Immunol. 1988 Oct 01; 141(7):2497-502.J Immunol1988-10-01T00:00:001988The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.6971400Storb U, Near R, Putnam D, Clagett JMolecular immunologyImmunoglobulin messenger RNAs of T lymphocytes. Mol Immunol. 1980 Jul; 17(7):947-57.Mol Immunol1980-07-01T00:00:001980Immunoglobulin messenger RNAs of T lymphocytes.1343097Zhao J, Storb UDevelopmental immunologyFusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate. Dev Immunol. 1992; 2(4):285-93.Dev Immunol1992-01-01T00:00:001992Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.8011204Kruisbeek A, Storb UCurrent opinion in immunologyLymphocyte development. Curr Opin Immunol. 1994 Apr; 6(2):199-202.Curr Opin Immunol1994-04-01T00:00:001994Lymphocyte development.5339963Storb U, Weiser RSJournal of the Reticuloendothelial SocietyAntibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy. J Reticuloendothel Soc. 1967 Jan; 4(1):51-68.J Reticuloendothel Soc1967-01-01T00:00:001967Antibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy.6165381Near RI, Storb UBiochemistryImmunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice. Biochemistry. 1981 Apr 28; 20(9):2386-94.Biochemistry1981-04-28T00:00:001981Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.828279Storb UProgress in nucleic acid research and molecular biologyHeterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA. Prog Nucleic Acid Res Mol Biol. 1976; 19:227-31.Prog Nucleic Acid Res Mol Biol1976-01-01T00:00:001976Heterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA.6255428Storb U, Arp B, Wilson RNucleic acids researchMyeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains. Nucleic Acids Res. 1980 Oct 24; 8(20):4681-7.Nucleic Acids Res1980-10-24T00:00:001980Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.6417544Brinster RL, Ritchie KA, Hammer RE, O'Brien RL, Arp B, Storb UNatureExpression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature. 1983 Nov 24-30; 306(5941):332-6.Nature1983-11-01T00:00:001983Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.106877Near RI, Storb UBiochemistryRNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes. Biochemistry. 1979 Mar 20; 18(6):964-72.Biochemistry1979-03-20T00:00:001979RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.6806667Arp B, McMullen MD, Storb UNatureSequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain. Nature. 1982 Jul 08; 298(5870):184-7.Nature1982-07-08T00:00:001982Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.6812053Selsing E, Miller J, Wilson R, Storb UProceedings of the National Academy of Sciences of the United States of AmericaEvolution of mouse immunoglobulin lambda genes. Proc Natl Acad Sci U S A. 1982 Aug; 79(15):4681-5.Proc Natl Acad Sci U S A1982-08-01T00:00:001982Evolution of mouse immunoglobulin lambda genes.7620323Doglio L, Kim JY, Bozek G, Storb UDevelopmental immunologyExpression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage. Dev Immunol. 1994; 4(1):13-26.Dev Immunol1994-01-01T00:00:001994Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.8245779Roth PE, Doglio L, Manz JT, Kim JY, Lo D, Storb UThe Journal of experimental medicineImmunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development. J Exp Med. 1993 Dec 01; 178(6):2007-21.J Exp Med1993-12-01T00:00:001993Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.20100870Tanaka A, Shen HM, Ratnam S, Kodgire P, Storb UThe Journal of experimental medicineAttracting AID to targets of somatic hypermutation. J Exp Med. 2010 Feb 15; 207(2):405-15.J Exp Med2010-01-25T00:00:002010Attracting AID to targets of somatic hypermutation.4639284Storb U, Martin TEBiochimica et biophysica actaNumber and activity of free and membrane-bound spleen ribosomes during the course of the immune response. Biochim Biophys Acta. 1972 Oct 27; 281(3):406-15.Biochim Biophys Acta1972-10-27T00:00:001972Number and activity of free and membrane-bound spleen ribosomes during the course of the immune response.5785349Storb U, Bauer W, Storb R, Fliedner TM, Weiser RSJournal of immunology (Baltimore, Md. : 1950)Ultrastructure of rosette-forming cells in the mouse during the antibody response. J Immunol. 1969 Jun; 102(6):1474-85.J Immunol1969-06-01T00:00:001969Ultrastructure of rosette-forming cells in the mouse during the antibody response.6260146Storb U, Wilson R, Selsing E, Walfield ABiochemistryRearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells. Biochemistry. 1981 Feb 17; 20(4):990-6.Biochemistry1981-02-17T00:00:001981Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.6267606Miller J, Bothwell A, Storb UProceedings of the National Academy of Sciences of the United States of AmericaPhysical linkage of the constant region genes for immunoglobulins lambda I and lambda III. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3829-33.Proc Natl Acad Sci U S A1981-06-01T00:00:001981Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.6314334Storb U, Arp BProceedings of the National Academy of Sciences of the United States of AmericaMethylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation. Proc Natl Acad Sci U S A. 1983 Nov; 80(21):6642-6.Proc Natl Acad Sci U S A1983-11-01T00:00:001983Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.8824592Brass AL, Kehrli E, Eisenbeis CF, Storb U, Singh HGenes & developmentPip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 1996 Sep 15; 10(18):2335-47.Genes Dev1996-09-15T00:00:001996Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.7799966Weng A, Engler P, Storb UMolecular and cellular biologyThe bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status. Mol Cell Biol. 1995 Jan; 15(1):572-9.Mol Cell Biol1995-01-01T00:00:001995The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.8112297Kim JY, Kurtz B, Huszar D, Storb UThe EMBO journalCrossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation. EMBO J. 1994 Feb 15; 13(4):827-34.EMBO J1994-02-15T00:00:001994Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.10429667Kim N, Bozek G, Lo JC, Storb UThe Journal of experimental medicineDifferent mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J Exp Med. 1999 Jul 05; 190(1):21-30.J Exp Med1999-07-05T00:00:001999Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.10508184Shen X, Bozek G, Pinkert CA, Storb UInternational immunologyThe C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation. Int Immunol. 1999 Oct; 11(10):1663-71.Int Immunol1999-10-01T00:00:001999The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.11232290Storb U, Peters A, Kim N, Shen HM, Bozek G, Michael N, Hackett J, Klotz E, Reynolds JD, Loeb LA, Martin TECold Spring Harbor symposia on quantitative biologyMolecular aspects of somatic hypermutation of immunoglobulin genes. Cold Spring Harb Symp Quant Biol. 1999; 64:227-34.Cold Spring Harb Symp Quant Biol1999-01-01T00:00:001999Molecular aspects of somatic hypermutation of immunoglobulin genes.11312254Shen HM, Peters A, Kao D, Storb UInternational immunologyThe 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression. Int Immunol. 2001 May; 13(5):665-74.Int Immunol2001-05-01T00:00:002001The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.11376332Storb UNature immunologyDNA polymerases in immunity: profiting from errors. Nat Immunol. 2001 Jun; 2(6):484-5.Nat Immunol2001-06-01T00:00:002001DNA polymerases in immunity: profiting from errors.12419200Storb U, Stavnezer JCurrent biology : CBImmunoglobulin genes: generating diversity with AID and UNG. Curr Biol. 2002 Oct 29; 12(21):R725-7.Curr Biol2002-10-29T00:00:002002Immunoglobulin genes: generating diversity with AID and UNG.12431391Kim N, Martin TE, Simon MC, Storb UMolecular immunologyThe transcription factor Spi-B is not required for somatic hypermutation. Mol Immunol. 2003 Jan; 39(10):577-83.Mol Immunol2003-01-01T00:00:002003The transcription factor Spi-B is not required for somatic hypermutation.8357172Storb UAnnals of the New York Academy of SciencesSteps in the generation of autoantibodies. Ann N Y Acad Sci. 1993 Jun 21; 681:29-32.Ann N Y Acad Sci1993-06-21T00:00:001993Steps in the generation of autoantibodies.15899878Padjen K, Ratnam S, Storb UMolecular and cellular biologyDNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1. Mol Cell Biol. 2005 Jun; 25(11):4782-91.Mol Cell Biol2005-06-01T00:00:002005DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.2016544Rudin CM, Hackett J, Storb UJournal of immunology (Baltimore, Md. : 1950)Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement. J Immunol. 1991 May 01; 146(9):3205-10.J Immunol1991-05-01T00:00:001991Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.16301749Longerich S, Tanaka A, Bozek G, Nicolae D, Storb UThe Journal of experimental medicineThe very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med. 2005 Nov 21; 202(10):1443-54.J Exp Med2005-11-21T00:00:002005The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.17338178Storb U, Shen HM, Longerich S, Ratnam S, Tanaka A, Bozek G, Pylawka SAdvances in experimental medicine and biologyTargeting of AID to immunoglobulin genes. Adv Exp Med Biol. 2007; 596:83-91.Adv Exp Med Biol2007-01-01T00:00:002007Targeting of AID to immunoglobulin genes.2499652Hagman J, Lo D, Doglio LT, Hackett J, Rudin CM, Haasch D, Brinster R, Storb UThe Journal of experimental medicineInhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene. J Exp Med. 1989 Jun 01; 169(6):1911-29.J Exp Med1989-06-01T00:00:001989Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.20691478Ratnam S, Bozek G, Nicolae D, Storb UMolecular immunologyThe pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol. 2010 Oct; 47(16):2611-8.Mol Immunol2010-08-05T00:00:002010The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.2710121Storb U, Haasch D, Arp B, Sanchez P, Cazenave PA, Miller JMolecular and cellular biologyPhysical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol Cell Biol. 1989 Feb; 9(2):711-8.Mol Cell Biol1989-02-01T00:00:001989Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.3073699Storb U, Engler P, Manz J, Gollahon K, Denis K, Lo D, Brinster RAnnals of the New York Academy of SciencesExpression of immunoglobulin genes in transgenic mice and transfected cells. Ann N Y Acad Sci. 1988; 546:51-6.Ann N Y Acad Sci1988-01-01T00:00:001988Expression of immunoglobulin genes in transgenic mice and transfected cells.3110776Engler P, Storb UProceedings of the National Academy of Sciences of the United States of AmericaHigh-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4949-53.Proc Natl Acad Sci U S A1987-07-01T00:00:001987High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.3139821Manz J, Denis K, Witte O, Brinster R, Storb UThe Journal of experimental medicineFeedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains. J Exp Med. 1988 Oct 01; 168(4):1363-81.J Exp Med1988-10-01T00:00:001988Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.3263422O'Brien RL, Marrack P, Storb U, Kappler JWJournal of immunology (Baltimore, Md. : 1950)B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells. J Immunol. 1988 Nov 15; 141(10):3335-41.J Immunol1988-11-15T00:00:001988B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.3927171Storb U, Denis KA, Brinster RL, Witte ONNaturePre-B cells in kappa-transgenic mice. Nature. 1985 Jul 25-31; 316(6026):356-8.Nature1985-07-01T00:00:001985Pre-B cells in kappa-transgenic mice.4555795Storb U, Weiser RSJournal of the Reticuloendothelial SocietyCoexistence of 19S and 7S hemolysins in splenic foci. J Reticuloendothel Soc. 1972 Mar; 11(3):207-17.J Reticuloendothel Soc1972-03-01T00:00:001972Coexistence of 19S and 7S hemolysins in splenic foci.6245134Wilson R, Storb U, Arp BJournal of immunology (Baltimore, Md. : 1950)Immunoglobulin gene rearrangements in hybridoma cells. J Immunol. 1980 May; 124(5):2071-6.J Immunol1980-05-01T00:00:001980Immunoglobulin gene rearrangements in hybridoma cells.6431295Storb U, O'Brien RL, McMullen MD, Gollahon KA, Brinster RLNatureHigh expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes. Nature. 1984 Jul 19-25; 310(5974):238-41.Nature1984-07-01T00:00:001984High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.6796941Selsing E, Storb UNucleic acids researchMapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement. Nucleic Acids Res. 1981 Nov 11; 9(21):5725-35.Nucleic Acids Res1981-11-11T00:00:001981Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.6985939Putnam D, Clagett J, Storb UJournal of immunology (Baltimore, Md. : 1950)Immunoglobulin synthesis by T cells: quantitative and qualitative aspects. J Immunol. 1980 Feb; 124(2):902-12.J Immunol1980-02-01T00:00:001980Immunoglobulin synthesis by T cells: quantitative and qualitative aspects.D027041Physiology10320.970509Somatic Hypermutation, ImmunoglobulinChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://bishoplab.bsd.uchicago.edu/Bishop Lab Websitehttp://he-group.uchicago.eduMy Lab Sitehttps://voices.uchicago.edu/clarklab/Clark Laboratory2022-06-30NIHGLICK, BENJAMIN S1975-07-01Molecular and Cellular Biology TrainingT32GM0071832001-11-30NIHSTORB, URSULA B1986-09-30CONTROL OF IMMUNOGLOBULIN SYNTHESISR37AI0247801987-02-28NIHSTORB, URSULA B1979-03-01CONTROL OF IMMUNOGLOBULIN SYNTHESISR01CA0257542001-01-31NIHSTORB, URSULA B1986-09-01EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICER01HD0230891991-11-30NIHSTORB, URSULA B1986-09-30CONTROL OF IMMUNOGLOBULIN SYNTHESISR01AI0247801990-03-31NIHSTORB, URSULA B1985-04-01EXPRESSION OF IMMUNOGLOBULIN GENESR01HD0194882001-08-31NIHSTORB, URSULA B1987-07-01MUTATION OF IG GENESR01GM0386491986-05-31NIHSTORB, URSULA B1983-06-01T LYMPHOCYTE SPECIFIC GENESR01CA0359792014-07-31NIHSTORB, URSULA B2000-05-01Mechanism of Immunoglobulin HypermutationR56AI0473802012-01-31NIHSTORB, URSULA B2009-02-15AID in somatic mutation of immunoglobulin genesR21AI0811672012-05-31NIHSTORB, URSULA B2000-05-01Mechanism of Immunoglobulin HypermutationR01AI0473802007-11-30NIHSTORB, URSULA B2002-12-01Immunoglobulin Somatic MutationR01AI0531302010-04-30NIHSTORB, URSULA B2008-05-01Identification of the DNA methylation/chromatin modifier Ssm1R03HD0582712006-06-30NIHSTORB, URSULA B1996-07-01EXPRESSION OF IMMUNOGLOBULIN GENESR01AI039535Co-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorChemistryMedicineMol Gen/Cell BioPathologyUniversity of ChicagoFrancoisRobinFrancois Robin41.78927490000000-87.601250000000001071Robin, FrancoisPostdoctoral ScholarMichaelAllenMichael Allen41.78927490000000-87.601250000000001113Allen, MichaelRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)RobertHaselkornRobert Haselkorn41.78927490000000-87.601250000000001490Haselkorn, RobertProfessor EmeritusUzma D.SiddiquiUzma D. Siddiqui41.78927490000000-87.601250000000001758Siddiqui, Uzma D.Professor6.220770.000830479470research areas0.6615760.05383945coauthor of79.637812.70960similar to11153selected publicationsDouglas K.Bishop02BgGKkaCczbgn4qdUXm+mb7+MTz7LFLDouglas K. Bishop41.78927490000000-87.601250000000002358Bishop, Douglas K.ProfessorRaniaRizkRania Rizk41.78927490000000-87.601250000000002401Rizk, RaniaPostdoctoral FellowYongsungKangYongsung Kang41.78927490000000-87.60125000000000463Kang, YongsungPostdoctoral ScholarAnita S.Chong1mFhBK8SOfnamXNnYUHhvWD+6g==Anita S. Chong41.78927490000000-87.60125000000000535Chong, Anita S.ProfessorDan LiviuNicolaeDan Liviu Nicolae41.78927490000000-87.60125000000000578Nicolae, Dan LiviuProfessorMarcus RamsayClarkMarcus Ramsay Clark41.78927490000000-87.60125000000000625Clark, Marcus RamsayProfessorMartinWeigertMartin Weigert41.78927490000000-87.60125000000000931Weigert, MartinPROFESSORtrue1ProfessorProfessortrue1PROFESSOR PROFESSOR true1ProfessorProfessortrue1RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)true1ProfessorProfessortrue1Postdoctoral ScholarPostdoctoral Scholartrue1Postdoctoral ScholarPostdoctoral Scholartrue1Postdoctoral FellowPostdoctoral Fellowtrue1PROFESSORPROFESSORtrue1Professor EmeritusProfessor Emeritustrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1PROFESSORPROFESSORtrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 657721Authorship 720452Authorship 746318Authorship 762221Authorship 764521Authorship 783511Authorship 7722125791797Storb U, Chiller JM, Weiser RSProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)Influence of metabolic inhibitors on the capacity of spleen cells to form hemolytic plaques and rosettes. Proc Soc Exp Biol Med. 1969 Jul; 131(3):835-40.Proc Soc Exp Biol Med1969-07-01T00:00:001969Influence of metabolic inhibitors on the capacity of spleen cells to form hemolytic plaques and rosettes.14304910STORB U, CORVAZIER P, KUENZER WKlinische Wochenschrift[FETAL FIBRINOGEN. IV. STUDIES ON THE IMMUNOLOGICAL AND PHYSICO-CHEMICAL BEHAVIOR OF FETAL FIBRINOGEN]. Klin Wochenschr. 1965 May 01; 43:488-93.Klin Wochenschr1965-05-01T00:00:001965[FETAL FIBRINOGEN. IV. STUDIES ON THE IMMUNOLOGICAL AND PHYSICO-CHEMICAL BEHAVIOR OF FETAL FIBRINOGEN].1857406McDevitt HO, Storb UNatureDissent on forensic evidence. Nature. 1991 Jul 18; 352(6332):184.Nature1991-07-18T00:00:001991Dissent on forensic evidence.24507160Storb UAdvances in immunologyWhy does somatic hypermutation by AID require transcription of its target genes? Adv Immunol. 2014; 122:253-77.Adv Immunol2014-01-01T00:00:002014Why does somatic hypermutation by AID require transcription of its target genes?24803651Ratnam S, Engler P, Bozek G, Mao L, Podlutsky A, Austad S, Martin T, Storb UDevelopment (Cambridge, England)Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis. Development. 2014 May; 141(10):2024-34.Development2014-05-01T00:00:002014Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.9683069Hentschel H, Storb U, Teckhaus L, Elger MAnatomy and embryologyThe central vessel of the renal countercurrent bundles of two marine elasmobranchs--dogfish (Scyliorhinus caniculus) and skate (Raja erinacea)--as revealed by light and electron microscopy with computer-assisted reconstruction. Anat Embryol (Berl). 1998 Jul; 198(1):73-89.Anat Embryol (Berl)1998-07-01T00:00:001998The central vessel of the renal countercurrent bundles of two marine elasmobranchs--dogfish (Scyliorhinus caniculus) and skate (Raja erinacea)--as revealed by light and electron microscopy with computer-assisted reconstruction.6058294Halpern B, Storb U, Fray ANatureDelayed hypersensitivity in vitro. Nature. 1967 Jul 22; 215(5099):400-1.Nature1967-07-22T00:00:001967Delayed hypersensitivity in vitro.Surgery-TransplantStatistics Authorship 514711Authorship 516441Authorship 626075Authorship 5149014857184Storb UBiochemical and biophysical research communicationsEvidence for multiple immunoglobulin genes. Biochem Biophys Res Commun. 1974 Mar 15; 57(1):31-8.Biochem Biophys Res Commun1974-03-15T00:00:001974Evidence for multiple immunoglobulin genes.6030551Storb U, Chambers V, Storb R, Weiser RSJournal of the Reticuloendothelial SocietyAntibody-carrying cells in the immune response II. Ultrastructure of "rosette"-forming cells. J Reticuloendothel Soc. 1967 Jan; 4(1):69-83.J Reticuloendothel Soc1967-01-01T00:00:001967Antibody-carrying cells in the immune response II. Ultrastructure of "rosette"-forming cells.23752228Kodgire P, Mukkawar P, Ratnam S, Martin TE, Storb UThe Journal of experimental medicineChanges in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID. J Exp Med. 2013 Jul 01; 210(7):1481-92.J Exp Med2013-06-10T00:00:002013Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.4717760Storb UBiochemical and biophysical research communicationsTurnover of myeloma messenger DNA. Biochem Biophys Res Commun. 1973 Jun 19; 52(4):1483-91.Biochem Biophys Res Commun1973-06-19T00:00:001973Turnover of myeloma messenger DNA.