MollyPrzeworskiMolly Przeworski41.78927490000000-87.601250000000001825Przeworski, MollyPROFESSORplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 104638528590247Baker Z, Schumer M, Haba Y, Bashkirova L, Holland C, Rosenthal GG, Przeworski MeLifeRepeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates. 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Elife. 2023 01 17; 12.Elife2023-01-17T00:00:002023Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs.Authorship 160928436779395Gao Z, Zhang Y, Cramer N, Przeworski M, Moorjani PeLifeLimited role of generation time changes in driving the evolution of the mutation spectrum in humans. Elife. 2023 02 13; 12.Elife2023-02-13T00:00:002023Limited role of generation time changes in driving the evolution of the mutation spectrum in humans.http://jnpopgen.orgNovembre Lab Sitehttp://genapps.uchicago.edu/newlabweb/index.htmlLab web sitehttp://blekhmanlab.orgBlekhman Lab Websitehttp://manyuanlonglab.uchicago.edu/Long Lab Websitejnovembreblekhman2024-12-31NIHPRZEWORSKI, MOLLY F2007-09-17Recombination rate variation and evolution in vertebratesR01GM0830982011-02-28NIHPRZEWORSKI, MOLLY F2005-03-01Identifying human adaptations: theory and applicationsR01GM0728612021-03-31NIHPRZEWORSKI, MOLLY F2017-05-15Mutation rate variation in primatesR01GM1229752021-12-31NIHPRZEWORSKI, MOLLY F2017-03-08Natural selection in recent human evolutionR01GM121372Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 1646591337502971Hoge C, de Manuel M, Mahgoub M, Okami N, Fuller Z, Banerjee S, Baker Z, McNulty M, Andolfatto P, Macfarlan TS, Schumer M, Tzika AC, Przeworski MbioRxiv : the preprint server for biologyPatterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features. bioRxiv. 2023 Jul 11.bioRxiv2023-07-11T00:00:002023Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features.Human GeneticsMedicineUniversity of ChicagoXiangZhouXiang Zhou41.78927490000000-87.601250000000001144Zhou, XiangPostdoctoral ScholarJonathanPritchardJonathan K. Pritchard41.78927490000000-87.601250000000001284Pritchard, JonathanPROFESSOR37745549Spisak N, de Manuel M, Milligan W, Sella G, Przeworski MbioRxiv : the preprint server for biologyDisentangling sources of clock-like mutations in germline and soma. bioRxiv. 2023 Sep 12.bioRxiv2023-09-12T00:00:002023Disentangling sources of clock-like mutations in germline and soma.Authorship 1666275BryanHowieBryan Howie41.78927490000000-87.601250000000001425Howie, BryanPostdoctoral ScholarPeter S.CarbonettoPeter S. Carbonetto41.78927490000000-87.601250000000001504Carbonetto, Peter S.0000-0003-1144-6780Research Assistant Professor5.296560.0105005267research areas1.487110.027137719coauthor of96.629317.6460similar to1192selected publicationsMark A.AbneyMark A. Abney41.78927490000000-87.601250000000001909Abney, Mark A.0000-0002-1718-5676Research Associate ProfessorAuthorship 167085237830496Baker Z, Przeworski M, Sella GeLifeDown the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence. Elife. 2023 Oct 13; 12.Elife2023-10-13T00:00:002023Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence.DanielWilsonDaniel J. Wilson41.78927490000000-87.601250000000002342Wilson, DanielGuySellaGuy Sella41.78927490000000-87.60125000000000260Sella, GuyManyuanLongManyuan Long41.78927490000000-87.601250000000002617Long, ManyuanProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorAnnaDi RienzoAnna Di Rienzo41.78927490000000-87.60125000000000993Di Rienzo, AnnaProfessorAuthorship 168475238014124Veller C, Przeworski M, Coop GbioRxiv : the preprint server for biologyCausal interpretations of family GWAS in the presence of heterogeneous effects. bioRxiv. 2023 Nov 16.bioRxiv2023-11-16T00:00:002023Causal interpretations of family GWAS in the presence of heterogeneous effects.Authorship 1701831338386752Hoge C, de Manuel M, Mahgoub M, Okami N, Fuller Z, Banerjee S, Baker Z, McNulty M, Andolfatto P, Macfarlan TS, Schumer M, Tzika AC, Przeworski MScience (New York, N.Y.)Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features. Science. 2024 Feb 23; 383(6685):eadj7026.Science2024-02-23T00:00:002024Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features.https://pcarbo.github.io/personal websitehttps://github.com/pcarbo/GitHubhttp://www.linkedin.com/pub/peter-carbonetto/59/8ab/7aLinkedInhttp://scholar.google.com/citations?user=ghacqrQAAAAJGoogle Scholarhttps://stephenslab.uchicago.eduStephens lab website38458164Przeworski MAmerican journal of human genetics2023 ASHG Scientific Achievement Award. Am J Hum Genet. 2024 Mar 07; 111(3):425-427.Am J Hum Genet2024-03-07T00:00:0020242023 ASHG Scientific Achievement Award.Authorship 1708361true1true1true1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1PROFESSORPROFESSORtrue1Postdoctoral ScholarPostdoctoral Scholartrue1Postdoctoral ScholarPostdoctoral Scholartrue1PROFESSORPROFESSORtrue1Research Assistant ProfessorResearch Assistant Professortrue1ProfessorProfessortrue1Post Doctoral ScholarPost Doctoral Scholartrue1ProfessorProfessortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Associate ProfessorAssociate ProfessorAuthorship 709495Authorship 705894Authorship 7112513Authorship 750182Authorship 7696710Authorship 782102Authorship 78190223851028Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci LHuman molecular geneticsDifferent selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. 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Bioinformatics. 2014 Jul 15; 30(14):2035-42.Bioinformatics2014-03-21T00:00:002014TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception.25806687Williams AL, Genovese G, Dyer T, Altemose N, Truax K, Jun G, Patterson N, Myers SR, Curran JE, Duggirala R, Blangero J, Reich D, Przeworski M, T2D-GENES ConsortiumeLifeNon-crossover gene conversions show strong GC bias and unexpected clustering in humans. Elife. 2015 Mar 25; 4.Elife2015-03-25T00:00:002015Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.25000986Ségurel L, Wyman MJ, Przeworski MAnnual review of genomics and human geneticsDeterminants of mutation rate variation in the human germline. 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Science. 2015 11 20; 350(6263):928-32.Science2015-11-20T00:00:002015Stable recombination hotspots in birds.Authorship 84826626619199Morton ER, Lynch J, Froment A, Lafosse S, Heyer E, Przeworski M, Blekhman R, Ségurel LPLoS geneticsVariation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence. PLoS Genet. 2015 Nov; 11(11):e1005658.PLoS Genet2015-11-30T00:00:002015Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence.Authorship 85458426761240Gao Z, Wyman MJ, Sella G, Przeworski MPLoS biologyInterpreting the Dependence of Mutation Rates on Age and Time. PLoS Biol. 2016 Jan; 14(1):e1002355.PLoS Biol2016-01-13T00:00:002016Interpreting the Dependence of Mutation Rates on Age and Time.Authorship 89774427140627Moorjani P, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich DProceedings of the National Academy of Sciences of the United States of AmericaA genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5652-7.Proc Natl Acad Sci U S A2016-05-02T00:00:002016A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.Authorship 94037427601674Moorjani P, Amorim CE, Arndt PF, Przeworski MProceedings of the National Academy of Sciences of the United States of AmericaVariation in the molecular clock of primates. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10607-12.Proc Natl Acad Sci U S A2016-09-06T00:00:002016Variation in the molecular clock of primates.JohnNovembreJohn Novembre0.000000000000000.000000000000002807Novembre, JohnProfessorAuthorship 623025Authorship 615341223413192Leffler EM, Gao Z, Pfeifer S, Ségurel L, Auton A, Venn O, Bowden R, Bontrop R, Wall JD, Sella G, Donnelly P, McVean G, Przeworski MScience (New York, N.Y.)Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science. 2013 Mar 29; 339(6127):1578-82.Science2013-02-14T00:00:002013Multiple instances of ancient balancing selection shared between humans and chimpanzees.23640739Meyer WK, Zhang S, Hayakawa S, Imai H, Przeworski MAmerican journal of physical anthropologyThe convergent evolution of blue iris pigmentation in primates took distinct molecular paths. Am J Phys Anthropol. 2013 Jul; 151(3):398-407.Am J Phys Anthropol2013-05-02T00:00:002013The convergent evolution of blue iris pigmentation in primates took distinct molecular paths.Authorship 96127327760127Moorjani P, Gao Z, Przeworski MPLoS biologyHuman Germline Mutation and the Erratic Evolutionary Clock. PLoS Biol. 2016 Oct; 14(10):e2000744.PLoS Biol2016-10-19T00:00:002016Human Germline Mutation and the Erratic Evolutionary Clock.