ShilpaKeerthivasanShilpa Keerthivasan41.78927490000000-87.601250000000001989Keerthivasan, ShilpaPostdoctoral Fellowprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonRadiation and Cellular OncologyMedicine-RheumatologyAuthorship 113311430266714Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC, Wu M, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL, LaFleur M, Wucherpfennig KW, Pure E, Dranoff G, Carroll MC, Turley SJCancer immunology researchFAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018 12; 6(12):1472-1485.Cancer Immunol Res2018-09-28T00:00:002018FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors.Authorship 323541Authorship 134153231699795Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJCancer discoverySingle-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy. Cancer Discov. 2020 02; 10(2):232-253.Cancer Discov2019-11-07T00:00:002019Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy.Authorship 1359571032084389McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RACell stem cellDistinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5.Cell Stem Cell2020-02-20T00:00:002020Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.Authorship 1360811432103181Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JLNaturePeripheral T cell expansion predicts tumour infiltration and clinical response. Nature. 2020 03; 579(7798):274-278.Nature2020-02-26T00:00:002020Peripheral T cell expansion predicts tumour infiltration and clinical response.D011971Chemicals & Drugs771350.929286Receptors, ImmunologicAuthorship 137547532405063Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan SNature medicineHigh systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nat Med. 2020 05; 26(5):693-698.Nat Med2020-05-11T00:00:002020High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.Authorship 453141D006706Physiology2174080.832439HomeostasisGokhan M.Mutlu0G98H611OfnamXNnYUHhvWD+6g==Gokhan M. Mutlu0.000000000000000.000000000000002890Mutlu, Gokhan M.ProfessorAuthorship 1423491033149148Desbois M, Udyavar AR, Ryner L, Kozlowski C, Guan Y, Dürrbaum M, Lu S, Fortin JP, Koeppen H, Ziai J, Chang CW, Keerthivasan S, Plante M, Bourgon R, Bais C, Hegde P, Daemen A, Turley S, Wang YNature communicationsIntegrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer. Nat Commun. 2020 11 04; 11(1):5583.Nat Commun2020-11-04T00:00:002020Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.Medicine-Hematology and OncologyAuthorship 143933533547461Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan SNature medicineAuthor Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nat Med. 2021 Mar; 27(3):560.Nat Med2021-03-01T00:00:002021Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.Authorship 146195233903764Kapoor VN, Müller S, Keerthivasan S, Brown M, Chalouni C, Storm EE, Castiglioni A, Lane R, Nitschke M, Dominguez CX, Astarita JL, Krishnamurty AT, Carbone CB, Senbabaoglu Y, Wang AW, Wu X, Cremasco V, Roose-Girma M, Tam L, Doerr J, Chen MZ, Lee WP, Modrusan Z, Yang YA, Bourgon R, Sandoval W, Shaw AS, de Sauvage FJ, Mellman I, Moussion C, Turley SJNature immunologyGremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. Nat Immunol. 2021 05; 22(5):571-585.Nat Immunol2021-04-26T00:00:002021Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.21685328Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff BJ, Le Poole IC, Miele L, Osborne BAJournal of immunology (Baltimore, Md. : 1950)Notch signaling regulates mouse and human Th17 differentiation. J Immunol. 2011 Jul 15; 187(2):692-701.J Immunol2011-06-17T00:00:002011Notch signaling regulates mouse and human Th17 differentiation.Authorship 147971134260887Keerthivasan S, Senbabaoglu Y, Martinez-Martin N, Husain B, Verschueren E, Wong A, Yang YA, Sun Y, Pham V, Hinkle T, Oei Y, Madireddi S, Corpuz R, Tam L, Carlisle S, Roose-Girma M, Modrusan Z, Ye Z, Koerber JT, Turley SJImmunityHomeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity. 2021 07 13; 54(7):1511-1526.e8.Immunity2021-07-13T00:00:002021Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1.17574778Keerthivasan S, Keerthivasan G, Mittal S, Chauhan SSGeneTranscriptional upregulation of human cathepsin L by VEGF in glioblastoma cells. Gene. 2007 Sep 15; 399(2):129-36.Gene2007-05-13T00:00:002007Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells.Authorship 151440234879110Astarita JL, Keerthivasan S, Husain B, Senbabaoglu Y, Verschueren E, Gierke S, Pham VC, Peterson SM, Chalouni C, Pierce AA, Lill JR, Gonzalez LC, Martinez-Martin N, Turley SJPloS oneThe neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology. PLoS One. 2021; 16(12):e0260800.PLoS One2021-12-08T00:00:002021The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.Authorship 15847818Authorship 1591441536027053Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Berichel JL, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon HCancer discoverySpatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discov. 2022 11 02; 12(11):2606-2625.Cancer Discov2022-11-02T00:00:002022Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors.36599350Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, Rishipathak D, Peng J, Senbabaoglu Y, Modrusan Z, Keerthivasan S, Madireddi S, Chen YJ, Fraser EJ, Leng N, Hamidi H, Koeppen H, Ziai J, Hashimoto K, Fassò M, Williams P, McDermott DF, Rosenberg JE, Powles T, Emens LA, Hegde PS, Mellman I, Turley SJ, Wilson MS, Mariathasan S, Molinero L, Merchant M, West NRCell reports. MedicineCD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy. Cell Rep Med. 2023 01 17; 4(1):100878.Cell Rep Med2023-01-03T00:00:002023CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.D00007264520360.953494Cancer-Associated Fibroblastshttp://cweberlab.comChristopher Weber Labhttps://mutlulab.uchicago.edu/Mutlu Labhttps://voices.uchicago.edu/gounarilab/Gounari Lab SiteD009000Anatomy1132140.883215MonocytesD016676Anatomy25550.950444Macrophages, AlveolarAuthorship 1619701737079217Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JHGeroScienceTransfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023 Aug; 45(4):2559-2587.Geroscience2023-04-20T00:00:002023Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.MedicinePathologyUniversity of ChicagoJustinGriffithJustin Griffith41.78927490000000-87.601250000000001357Griffith, JustinClinical Assistant ProfessorAmyStarkAmy Stark41.78927490000000-87.601250000000001375Stark, AmyPostdoctoral ScholarFotiniGounariFotini Gounari41.78927490000000-87.60125000000000138Gounari, FotiniAssociate ProfessorEugeneWyattEugene Wyatt41.78927490000000-87.60125000000000170Wyatt, EugenePostdoctoral FellowRaviSalgiaRavi Salgia41.78927490000000-87.601250000000001937Salgia, RaviEmeritus/Emerita, ProfessorShashiBellamShashi Bellam41.78927490000000-87.601250000000001976Bellam, ShashiClinical Assistant Professor0.787650.0121513159research areas0.7321440.03070044coauthor of25.3524.1514660similar to1119selected publicationsMichelle M.LebeauMichelle M. Lebeau41.78927490000000-87.601250000000002029Lebeau, Michelle M.ProfessorJoseNazariJose Nazari41.78927490000000-87.601250000000002308Nazari, JoseClinical Assistant ProfessorRalph R.WeichselbaumxXB+DqgWEf/5hHlsaUXv9Gq0+s+oRalph R. Weichselbaum41.78927490000000-87.601250000000002521Weichselbaum, Ralph R.ProfessorLucianaMolineroLuciana Molinero41.78927490000000-87.601250000000002654Molinero, LucianaRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)Thomas F.GajewskiThomas F. Gajewski41.78927490000000-87.60125000000000355Gajewski, Thomas F.ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorChristopherWeberChristopher Weber41.78927490000000-87.60125000000000975Weber, ChristopherAssociate Professortrue1Postdoctoral FellowPostdoctoral Fellowtrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Postdoctoral ScholarPostdoctoral Scholartrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)true1Clinical Assistant ProfessorClinical Assistant Professortrue1ProfessorProfessortrue1Postdoctoral FellowPostdoctoral Fellowtrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 766476Authorship 718131Authorship 74640924574339Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari FScience translational medicineß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28.Sci Transl Med2014-02-26T00:00:002014ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.24371308Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari FProceedings of the National Academy of Sciences of the United States of Americaß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6.Proc Natl Acad Sci U S A2013-12-26T00:00:002013ß-Catenin induces T-cell transformation by promoting genomic instability.24904593Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LMFrontiers in immunologyNOTCH1 Can Initiate NF-?B Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Front Immunol. 2014; 5:249.Front Immunol2014-05-26T00:00:002014NOTCH1 Can Initiate NF-?B Activation via Cytosolic Interactions with Components of the T Cell Signalosome.Chicago60637ILAuthorship 60164222887772Aghajani K, Keerthivasan S, Yu Y, Gounari FGenesis (New York, N.Y. : 2000)Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells. Genesis. 2012 Dec; 50(12):908-13.Genesis2012-09-12T00:00:002012Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells.