SaraSzuchetSara Szuchet41.78927490000000-87.601250000000002049Szuchet, SaraOligodendrocyteMultiple SclerosisMyelin SheathMyelinated Axonsubstrate adhesionCell CultureCentral Nervous SystemDemyelinating Diseasesneuro degenerative diseasesThe long-term goal of my laboratory is to decipher the etiology and pathogenesis of multiple sclerosis (MS) – a CNS demyelinating and neurodegenerative disease that cripples the young and bright. With the firm belief that in order to decrypt the breakdown of myelin in MS, we have to understand how it is formed, our current efforts are centered on two major projects. One, defining the molecular mechanism of myelin sheath formation by following the synthesis of myelin membranes (MyMs), their packaging into myelinophore organelles (MFOs) and transportation along an oligodendrocyte process using live imaging of embryonic avian optic nerve at different stages of development; purifying and characterizing the contents of MFOs. Two, testing the hypothesis that ectosomes are the conveyors of signals that coordinate and orchestrate the modular structure of the myelinated axon. We are developing technologies to obtain pure cell-specific ectosomes by molecularly color-code them. We are also customizing a microfluidic platform suitable to integrate multiple processes in a single lab-on-a-chip format. We plan to establish unique EM grid compatible bi-chamber for OLG-neuron cultures and capture the formation of cell-specific ectosomes using correlative light and electron microscopy and phase contrast cryo-electron tomography. We will assemble tomograms of the initial OLG-neuron encounter so that we can structurally model the interface in a 3D space.Professorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD002448Physiology1544180.884621Cell AdhesionPediatrics-Kennedy CenterMolecular Genetics and Cell BiologyMedicine-GastroenterologyAuthorship 114923Authorship 116572Authorship 112672Authorship 128363Authorship 198791Authorship 178641Authorship 190318Authorship 189471Authorship 2064112/1956Facultad of Exact Sciences, University of Buenos Aires ArgentinaFacultad of Exact Sciences, University of Buenos Aires, ChemistryLicenciada in ChemistryChemistry09/1963Cambridge UniversityUKCambridge University, Physical BiochemistryDoctor of PhilosophyPhysical Biochemistry12/1966Department of Chemistry, Princeton UniversityUSADepartment of Chemistry, Princeton University, Nucleic Acid ChemistryPost-doctoral FellowNucleic Acid Chemistry06/2002NINDS, NIHMaryland, USANINDS, NIH, Developmental NeurogeneticsVisiting ScientistDevelopmental Neurogenetics09/1994La Jolla Cancer Research FoundationLa Jolla, CA, USALa Jolla Cancer Research Foundation, Molecular BiologyVisiting ScientistMolecular Biology12/1959University of ChileSantiago, ChileUniversity of Chile, ChemistryN/AChemistryThe University of Chicago20162015Big Vision Award NINDS, NIH20022001Ruth L Kirschstein National Research Service AwardNational Multiple Sclerosis Society19941993Dana Haughton Senior FellowshipAmerican Cancer Society19941993American Cancer Society ScholarNational Multiple Sclerosis Society Fellowship19781976National Multiple Sclerosis SocietyUniversity of Cambridge, UK19631962Oliver Gatty Research StudentGirton College, Cambridge, UK19631961Tucker-Price Research ScholarArgentina19601959Fellowship Consejo Nacional de Investigacions Cientificas y TechnicasAuthorship 17692Authorship 245561Authorship 233853Authorship 233652Authorship 2692Authorship 232901Authorship 35034Authorship 34732Authorship 28364Authorship 35503Authorship 35895Authorship 35541Authorship 34791Authorship 46128Authorship 46294Authorship 62086Authorship 71462Authorship 80561Authorship 39582Authorship 7961Authorship 43142Authorship 88354Authorship 89522Authorship 84462Authorship 9171Authorship 9313Authorship 9912Authorship 50362Authorship 45471Authorship 469431Authorship 66761Authorship 7261Authorship 78181Authorship 50502Authorship 9473Authorship 72831Authorship 76762D012756Living Beings832380.966598SheepAuthorship 87823Authorship 77311Authorship 85232Authorship 86632Authorship 84381Authorship 449996Authorship 45462Authorship 58142Authorship 66961Authorship 71931Authorship 850228406679Ludwin SK, Szuchet SGliaMyelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled. Glia. 1993 Aug; 8(4):219-31.Glia1993-08-01T00:00:001993Myelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled.8474142Yim SH, Sherin JE, Szuchet SJournal of neuroscience researchOligodendrocyte proteoglycans: modulation by cell-substratum adhesion. J Neurosci Res. 1993 Mar 01; 34(4):401-13.J Neurosci Res1993-03-01T00:00:001993Oligodendrocyte proteoglycans: modulation by cell-substratum adhesion.8530188Fierro-Renoy JF, Szuchet S, Falcone M, Macchia E, DeGroot LGliaThree different thyroid hormone receptor isoforms are detected in a pure culture of ovine oligodendrocytes. Glia. 1995 Aug; 14(4):322-8.Glia1995-08-01T00:00:001995Three different thyroid hormone receptor isoforms are detected in a pure culture of ovine oligodendrocytes.8915895Sanyal B, Polak PE, Szuchet SJournal of neuroscience researchDifferential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes. J Neurosci Res. 1996 Oct 15; 46(2):187-97.J Neurosci Res1996-10-15T00:00:001996Differential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes.JothamAustinJotham Austin0.000000000000000.000000000000002979Austin, JothamResearch Associate Professor10978849Szuchet S, Watanabe K, Yamaguchi YInternational journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceDifferentiation/regeneration of oligodendrocytes entails the assembly of a cell-associated matrix. Int J Dev Neurosci. 2000 Nov; 18(7):705-20.Int J Dev Neurosci2000-11-01T00:00:002000Differentiation/regeneration of oligodendrocytes entails the assembly of a cell-associated matrix.1662283Soliven B, Szuchet S, Nelson DJThe Journal of membrane biologyTumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes. J Membr Biol. 1991 Nov; 124(2):127-37.J Membr Biol1991-11-01T00:00:001991Tumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes.11754216Szuchet S, Plachetzki DC, Karialukas RGliaOligodendrocytes express an alpha/beta-interferon-susceptible Mx gene: molecular characterization of the encoded protein. Glia. 2002 Feb; 37(2):183-9.Glia2002-02-01T00:00:002002Oligodendrocytes express an alpha/beta-interferon-susceptible Mx gene: molecular characterization of the encoded protein.11383877Arvanitis DL, Stavridou AI, Mori de Moro G, Szuchet SCell and tissue researchReactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H. Cell Tissue Res. 2001 Apr; 304(1):11-9.Cell Tissue Res2001-04-01T00:00:002001Reactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H.1789575Szuchet S, Yim SHAnnals of the New York Academy of SciencesAdhesion-induced differentiation of oligodendrocytes signals the synthesis and polarization of heparan sulfate proteoglycans and sulfated glycoproteins. Ann N Y Acad Sci. 1991; 633:530-4.Ann N Y Acad Sci1991-01-01T00:00:001991Adhesion-induced differentiation of oligodendrocytes signals the synthesis and polarization of heparan sulfate proteoglycans and sulfated glycoproteins.15043933Szuchet S, Plachetzki DC, Seeger MA, Domowicz MS, Szele FGBiophysical chemistryNOVOcan: a molecular link among selected glial cells. Biophys Chem. 2004 Mar 01; 108(1-3):245-58.Biophys Chem2004-03-01T00:00:002004NOVOcan: a molecular link among selected glial cells.11350070Szuchet S, Plachetzki DC, Eaton KSBiochemical and biophysical research communicationsOligodendrocyte transmembrane protein: a novel member of the glutamate-binding protein subfamily. Biochem Biophys Res Commun. 2001 May 18; 283(4):900-7.Biochem Biophys Res Commun2001-05-18T00:00:002001Oligodendrocyte transmembrane protein: a novel member of the glutamate-binding protein subfamily.13816017DERECHIN M, SZUCHET SArchives of biochemistry and biophysicsGelation phenomena in degraded fibrinogen and fibrin. Arch Biochem Biophys. 1960 Mar; 87:100-3.Arch Biochem Biophys1960-03-01T00:00:001960Gelation phenomena in degraded fibrinogen and fibrin.13408230SZUCHET S, DERECHIN MProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)Relation between degree of fibrinogen proteolysis by plasmin and fibrinolytic paracoagulation. Proc Soc Exp Biol Med. 1957 Feb; 94(2):267-9.Proc Soc Exp Biol Med1957-02-01T00:00:001957Relation between degree of fibrinogen proteolysis by plasmin and fibrinolytic paracoagulation.13885558DERECHIN M, JOHNSON P, SZUCHET SThe Biochemical journalFurther studies with human plasminogen. Biochem J. 1962 Aug; 84:336-9.Biochem J1962-08-01T00:00:001962Further studies with human plasminogen.237563Weiner RE, Szuchet SBiochimica et biophysica actaThe molecular weight of bovine lactoferrin. Biochim Biophys Acta. 1975 May 30; 393(1):143-7.Biochim Biophys Acta1975-05-30T00:00:001975The molecular weight of bovine lactoferrin.2462818Vartanian T, Dawson G, Szuchet SAnnals of the New York Academy of SciencesIntracellular messengers. Influence of oligodendrocyte substratum adhesion. Ann N Y Acad Sci. 1988; 540:433-6.Ann N Y Acad Sci1988-01-01T00:00:001988Intracellular messengers. Influence of oligodendrocyte substratum adhesion.2435511Szuchet S, Polak PE, Yim SHDevelopmental neuroscienceMature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes. Dev Neurosci. 1986; 8(4):208-21.Dev Neurosci1986-01-01T00:00:001986Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes.2148557Hertz L, Soliven B, Hertz E, Szuchet S, Nelson DJGliaChannel-mediated and carrier-mediated uptake of K+ into cultured ovine oligodendrocytes. Glia. 1990; 3(6):550-7.Glia1990-01-01T00:00:001990Channel-mediated and carrier-mediated uptake of K+ into cultured ovine oligodendrocytes.D009457Anatomy421040.95032Neuroglia2663420Soliven B, Szuchet S, Arnason BG, Nelson DJDevelopmental neuroscienceExpression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis. Dev Neurosci. 1989; 11(2):118-31.Dev Neurosci1989-01-01T00:00:001989Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis.D009186Anatomy31840.945414Myelin Sheath22132705Szuchet S, Nielsen JA, Lovas G, Domowicz MS, de Velasco JM, Maric D, Hudson LDThe European journal of neuroscienceThe genetic signature of perineuronal oligodendrocytes reveals their unique phenotype. Eur J Neurosci. 2011 Dec; 34(12):1906-22.Eur J Neurosci2011-12-02T00:00:002011The genetic signature of perineuronal oligodendrocytes reveals their unique phenotype.21597840Arvanitis D, Kouklis P, Demoro G, Goutas N, Kittas C, Szuchet SOncology reportsImmunostaining of ductal breast carcinomas with the monoclonal-antibody-h. Oncol Rep. 1995 Nov; 2(6):991-5.Oncol Rep1995-11-01T00:00:001995Immunostaining of ductal breast carcinomas with the monoclonal-antibody-h.D009836Anatomy291230.931377Oligodendroglia2838593Soliven B, Szuchet S, Arnason BG, Nelson DJThe Journal of neuroscience : the official journal of the Society for NeuroscienceVoltage-gated potassium currents in cultured ovine oligodendrocytes. J Neurosci. 1988 Jun; 8(6):2131-41.J Neurosci1988-06-01T00:00:001988Voltage-gated potassium currents in cultured ovine oligodendrocytes.3216367Soliven B, Szuchet S, Arnason BG, Nelson DJThe Journal of membrane biologyForskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes. J Membr Biol. 1988 Oct; 105(2):177-86.J Membr Biol1988-10-01T00:00:001988Forskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes.3007768Yim SH, Monsma S, Hertz L, Szuchet SJournal of neuroscience researchLipid and glycolipid metabolism of cultured astrocytes: a time course study. J Neurosci Res. 1986; 15(1):29-37.J Neurosci Res1986-01-01T00:00:001986Lipid and glycolipid metabolism of cultured astrocytes: a time course study.3745167Yim SH, Szuchet S, Polak PEThe Journal of biological chemistryCultured oligodendrocytes. A role for cell-substratum interaction in phenotypic expression. J Biol Chem. 1986 Sep 05; 261(25):11808-15.J Biol Chem1986-09-05T00:00:001986Cultured oligodendrocytes. A role for cell-substratum interaction in phenotypic expression.6251943Szuchet S, Stefansson K, Wollmann RL, Dawson G, Arnason BGBrain researchMaintenance of isolated oligodendrocytes in long-term culture. Brain Res. 1980 Oct 27; 200(1):151-64.Brain Res1980-10-27T00:00:001980Maintenance of isolated oligodendrocytes in long-term culture.6502227Massa PT, Szuchet S, Mugnaini EThe Journal of neuroscience : the official journal of the Society for NeuroscienceCell-cell interactions of isolated and cultured oligodendrocytes: formation of linear occluding junctions and expression of peculiar intramembrane particles. J Neurosci. 1984 Dec; 4(12):3128-39.J Neurosci1984-12-01T00:00:001984Cell-cell interactions of isolated and cultured oligodendrocytes: formation of linear occluding junctions and expression of peculiar intramembrane particles.6846820Szuchet S, Polak PEAnalytical biochemistryA simple cell disrupter designed for small cells with relatively large nuclei. Anal Biochem. 1983 Feb 01; 128(2):453-8.Anal Biochem1983-02-01T00:00:001983A simple cell disrupter designed for small cells with relatively large nuclei.2431483Vartanian T, Szuchet S, Dawson G, Campagnoni ATScience (New York, N.Y.)Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein. Science. 1986 Dec 12; 234(4782):1395-8.Science1986-12-12T00:00:001986Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.7230879Szuchet S, Arnason BG, Polak PEJournal of neuroscience methodsSeparation of ovine oligodendrocytes into two distinct bands on a linear sucrose gradient. J Neurosci Methods. 1980 Oct; 3(1):7-19.J Neurosci Methods1980-10-01T00:00:001980Separation of ovine oligodendrocytes into two distinct bands on a linear sucrose gradient.2465269Szuchet S, Polak PE, Yim SH, Arvanitis DGliaPlasma membrane of cultured oligodendrocytes: III. Relatedness to myelin. Glia. 1988; 1(2):141-50.Glia1988-01-01T00:00:001988Plasma membrane of cultured oligodendrocytes: III. Relatedness to myelin.4819761Szuchet S, Zobel CRBiochemistryThe dissociation of myosin in acid. Biochemistry. 1974 Mar 26; 13(7):1482-91.Biochemistry1974-03-26T00:00:001974The dissociation of myosin in acid.7479786LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LIProceedings of the National Academy of Sciences of the United States of AmericaFunctional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10369-73.Proc Natl Acad Sci U S A1995-10-24T00:00:001995Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.7572287Soliven B, Szuchet SInternational journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceSignal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha. Int J Dev Neurosci. 1995 Jun-Jul; 13(3-4):351-67.Int J Dev Neurosci1995-06-01T00:00:001995Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha.3002020Stowring L, Haase AT, Petursson G, Georgsson G, Palsson P, Lutley R, Roos R, Szuchet SVirologyDetection of visna virus antigens and RNA in glial cells in foci of demyelination. Virology. 1985 Mar; 141(2):311-8.Virology1985-03-01T00:00:001985Detection of visna virus antigens and RNA in glial cells in foci of demyelination.1306158Arvanitis D, Dumas M, Szuchet SDevelopmental neuroscienceMyelin palingenesis. 2. Immunocytochemical localization of myelin/oligodendrocyte glycolipids in multilamellar structures. Dev Neurosci. 1992; 14(5-6):328-35.Dev Neurosci1992-01-01T00:00:001992Myelin palingenesis. 2. Immunocytochemical localization of myelin/oligodendrocyte glycolipids in multilamellar structures.4799941Szuchet S, Yphantis DABiochemistryEquilibrium sedimentation of proteins in acid solutions. Dissociation of aldolase by aqueous acetic acid. Biochemistry. 1973 Dec 04; 12(25):5115-27.Biochemistry1973-12-04T00:00:001973Equilibrium sedimentation of proteins in acid solutions. Dissociation of aldolase by aqueous acetic acid.6580624Szuchet S, Yim SH, Monsma SProceedings of the National Academy of Sciences of the United States of AmericaLipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):7019-23.Proc Natl Acad Sci U S A1983-11-01T00:00:001983Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis.6680171Szuchet S, Dumas MNeurologic clinicsAn in-vitro approach to the study of oligodendrocytes and their involvement in multiple sclerosis. Neurol Clin. 1983 Aug; 1(3):729-55.Neurol Clin1983-08-01T00:00:001983An in-vitro approach to the study of oligodendrocytes and their involvement in multiple sclerosis.6173754Oger J, Szuchet S, Antel J, Arnason BGNatureA monoclonal antibody against human T suppressor lymphocytes binds specifically to the surface of cultured oligodendrocytes. Nature. 1982 Jan 07; 295(5844):66-8.Nature1982-01-07T00:00:001982A monoclonal antibody against human T suppressor lymphocytes binds specifically to the surface of cultured oligodendrocytes.6200605Szuchet S, Yim SHJournal of neuroscience researchCharacterization of a subset of oligodendrocytes separated on the basis of selective adherence properties. J Neurosci Res. 1984; 11(2):131-44.J Neurosci Res1984-01-01T00:00:001984Characterization of a subset of oligodendrocytes separated on the basis of selective adherence properties.7237158Mack SR, Szuchet SBrain researchSynthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture. Brain Res. 1981 Jun 09; 214(1):180-5.Brain Res1981-06-09T00:00:001981Synthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture.879796Szuchet SArchives of biochemistry and biophysicsEffect of purification procedures on the self-association of myosin at high ionic strength. Arch Biochem Biophys. 1977 Apr 30; 180(2):493-503.Arch Biochem Biophys1977-04-30T00:00:001977Effect of purification procedures on the self-association of myosin at high ionic strength.1275504Szuchet S, Yphantis DAArchives of biochemistry and biophysicsEquilibrium centrifugation of proteins in acidic solutions. Beta-lactoglobulin A in aqueous acetic, propionic, and butyric acids. Arch Biochem Biophys. 1976 Apr; 173(2):495-516.Arch Biochem Biophys1976-04-01T00:00:001976Equilibrium centrifugation of proteins in acidic solutions. Beta-lactoglobulin A in aqueous acetic, propionic, and butyric acids.1321254Vartanian T, Szuchet S, Dawson GJournal of neuroscience researchOligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling. J Neurosci Res. 1992 May; 32(1):69-78.J Neurosci Res1992-05-01T00:00:001992Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling.7299846Mack SR, Szuchet S, Dawson GJournal of neuroscience researchSynthesis of gangliosides by cultured oligodendrocytes. J Neurosci Res. 1981; 6(3):361-7.J Neurosci Res1981-01-01T00:00:001981Synthesis of gangliosides by cultured oligodendrocytes.7334534Wollmann RL, Szuchet S, Barlow J, Jerkovic MJournal of neuroscience researchUltrastructural changes accompanying the growth of isolated oligodendrocytes. J Neurosci Res. 1981; 6(6):757-69.J Neurosci Res1981-01-01T00:00:001981Ultrastructural changes accompanying the growth of isolated oligodendrocytes.7520088Soliven B, Takeda M, Szuchet SJournal of neuroscience researchDepolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes. J Neurosci Res. 1994 May 01; 38(1):91-100.J Neurosci Res1994-05-01T00:00:001994Depolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes.2448785Vartanian T, Sprinkle TJ, Dawson G, Szuchet SProceedings of the National Academy of Sciences of the United States of AmericaOligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors. Proc Natl Acad Sci U S A. 1988 Feb; 85(3):939-43.Proc Natl Acad Sci U S A1988-02-01T00:00:001988Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.2976738Polak PE, Szuchet SGliaPlasma membrane of cultured oligodendrocytes: I. Isolation, purification, and initial characterization. Glia. 1988; 1(1):39-53.Glia1988-01-01T00:00:001988Plasma membrane of cultured oligodendrocytes: I. Isolation, purification, and initial characterization.2976739Szuchet S, Polak PE, Yim SH, Lange YGliaPlasma membrane of cultured oligodendrocytes: II. Possible structural and functional domains. Glia. 1988; 1(1):54-63.Glia1988-01-01T00:00:001988Plasma membrane of cultured oligodendrocytes: II. Possible structural and functional domains.4008637Dumas M, Zurbriggen A, Vandevelde M, Yim SH, Arnason BG, Szuchet S, Meier CJournal of neuroimmunologyA monoclonal antibody that binds to both astrocytes and myelin sheaths. J Neuroimmunol. 1985 Jul; 9(1-2):55-67.J Neuroimmunol1985-07-01T00:00:001985A monoclonal antibody that binds to both astrocytes and myelin sheaths.7533846Schirmer EC, Farooqui J, Polak PE, Szuchet SJournal of neuroscience researchGRASP: a novel heparin-binding serum glycoprotein that mediates oligodendrocyte-substratum adhesion. J Neurosci Res. 1994 Nov 01; 39(4):457-73.J Neurosci Res1994-11-01T00:00:001994GRASP: a novel heparin-binding serum glycoprotein that mediates oligodendrocyte-substratum adhesion.1284852Arvanitis D, Polak PE, Szuchet SDevelopmental neuroscienceMyelin palingenesis. 1. Electron microscopical localization of myelin/oligodendrocyte proteins in multilamellar structures by the immunogold method. Dev Neurosci. 1992; 14(5-6):313-27.Dev Neurosci1992-01-01T00:00:001992Myelin palingenesis. 1. Electron microscopical localization of myelin/oligodendrocyte proteins in multilamellar structures by the immunogold method.2478466Vartanian T, Dawson G, Soliven B, Nelson DJ, Szuchet SGliaPhosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. Glia. 1989; 2(5):370-9.Glia1989-01-01T00:00:001989Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP.3207269Mikol DD, Szuchet S, Stefansson KAnnals of the New York Academy of SciencesA peanut agglutinin binding glycoprotein in CNS myelin and oligodendrocytes. Ann N Y Acad Sci. 1988; 540:409-12.Ann N Y Acad Sci1988-01-01T00:00:001988A peanut agglutinin binding glycoprotein in CNS myelin and oligodendrocytes.1015828Szuchet SArchives of biochemistry and biophysicsEquilibrium centrifugation of proteins in acid solutions. Ovalbumin in aqueous acetic, propionic, and butyric acids. Arch Biochem Biophys. 1976 Dec; 177(2):437-60.Arch Biochem Biophys1976-12-01T00:00:001976Equilibrium centrifugation of proteins in acid solutions. Ovalbumin in aqueous acetic, propionic, and butyric acids.ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://he-group.uchicago.eduMy Lab Sitehttps://voices.uchicago.edu/saraszuchet/https://voices.uchicago.edu/saraszuchet/ChemistryMedicineNeurologyPathologyUniversity of ChicagoThomas JKellyThomas J Kelly41.78927490000000-87.601250000000001082Kelly, Thomas JClinical Associate ProfessorRaymond P.RoosxXBmBLI1F+nMg3Vob0H3vWfp+4Wo6r1Xc3h9eaOOFmI=Raymond P. Roos41.78927490000000-87.601250000000001191Roos, Raymond P.ProfessorEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorMiriamDomowiczMiriam Domowicz41.78927490000000-87.601250000000001627Domowicz, MiriamResearch Associate ProfessorRobertWollmannRobert Wollmann41.78927490000000-87.601250000000001645Wollmann, RobertProfessor-Clinical DeptBarry G.ArnasonBarry G. Arnason41.78927490000000-87.601250000000001802Arnason, Barry G.Professor3.576940.00291543268research areas0.3735050.01665696coauthor of16.46292.5461660similar to1158selected publicationsRichardKraigRichard Kraig41.78927490000000-87.601250000000002091Kraig, RichardProfessorTaoXieTao Xie41.78927490000000-87.601250000000002254Xie, TaoProfessorJamesBrorsonJames Brorson41.78927490000000-87.60125000000000306Brorson, JamesAssociate ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorBettySolivenBetty Soliven41.78927490000000-87.6012500000000078Soliven, BettyProfessortrue1ProfessorProfessortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Clinical Associate ProfessorClinical Associate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Professor-Clinical DeptProfessor-Clinical Depttrue1Research Associate ProfessorResearch Associate ProfessorAuthorship 71599125682762Szuchet S, Nielsen LL, Domowicz MS, Austin JR, Arvanitis DLJournal of structural biologyCNS myelin sheath is stochastically built by homotypic fusion of myelin membranes within the bounds of an oligodendrocyte process. J Struct Biol. 2015 Apr; 190(1):56-72.J Struct Biol2015-02-12T00:00:002015CNS myelin sheath is stochastically built by homotypic fusion of myelin membranes within the bounds of an oligodendrocyte process.Chicago60637IL