Graeme Bell to Diabetes Mellitus, Type 2
This is a "connection" page, showing publications Graeme Bell has written about Diabetes Mellitus, Type 2.
Connection Strength
5.196
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MODY: history, genetics, pathophysiology, and clinical decision making. Diabetes Care. 2011 Aug; 34(8):1878-84.
Score: 0.204
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Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees. Diabetologia. 2006 May; 49(5):1106-8.
Score: 0.140
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Gene symbol: IPF1. Disease: MODY 4. Hum Genet. 2005 May; 116(6):538.
Score: 0.132
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Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population. J Hum Genet. 2005; 50(2):92-98.
Score: 0.130
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Linkage of calpain 10 to type 2 diabetes: the biological rationale. Diabetes. 2004 Feb; 53 Suppl 1:S19-25.
Score: 0.121
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Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects. Diabetes. 2001 Mar; 50(3):694-6.
Score: 0.099
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Identification of three missense mutations in the peroxisome proliferator-activated receptor alpha gene in Japanese subjects with maturity-onset diabetes of the young. J Hum Genet. 2001; 46(5):285-8.
Score: 0.098
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beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. Diabetes. 2000 Nov; 49(11):1955-7.
Score: 0.097
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000 Oct; 26(2):163-75.
Score: 0.096
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No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY. Diabetologia. 2000 Aug; 43(8):1064-9.
Score: 0.095
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A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene. Diabetologia. 2000 Jun; 43(6):818-9.
Score: 0.094
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Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. Diabetes. 2000 Feb; 49(2):302-5.
Score: 0.092
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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 06; 570(7759):71-76.
Score: 0.088
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Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):379-384.
Score: 0.080
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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data. 2017 12 19; 4:170179.
Score: 0.079
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. J Clin Invest. 1997 Sep 15; 100(6):1400-5.
Score: 0.078
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Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM. Diabetes. 1997 Sep; 46(9):1504-8.
Score: 0.078
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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 11; 66(11):2903-2914.
Score: 0.078
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017 07; 66(7):2019-2032.
Score: 0.075
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Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4. Diabetes. 1997 Mar; 46(3):528-35.
Score: 0.075
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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature. 1996 Dec 05; 384(6608):455-8.
Score: 0.074
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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) Nature. 1996 Dec 05; 384(6608):458-60.
Score: 0.074
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The genetic architecture of type 2 diabetes. Nature. 2016 08 04; 536(7614):41-47.
Score: 0.072
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Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas. Cardiovasc Diabetol. 2016 Jun 08; 15:86.
Score: 0.071
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Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle. Diabetologia. 1996 Jun; 39(6):725-30.
Score: 0.071
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A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):3937-41.
Score: 0.071
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med. 1996 Mar 21; 334(12):777-83.
Score: 0.070
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet. 2016 05 15; 25(10):2070-2081.
Score: 0.070
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Resting beta-cells - A functional reserve? Diabetes Metab. 2016 Jun; 42(3):157-61.
Score: 0.070
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes. 1995 Dec; 44(12):1447-57.
Score: 0.069
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Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet. 2015 Jan; 11(1):e1004876.
Score: 0.065
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The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese. Chin Med J (Engl). 1995 Jan; 108(1):5-9.
Score: 0.065
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Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet. 2015 Mar 15; 24(6):1646-54.
Score: 0.064
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Glucokinase: structural analysis of a protein involved in susceptibility to diabetes. J Biol Chem. 1994 Sep 02; 269(35):21925-8.
Score: 0.063
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Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA. 2014 Jun 11; 311(22):2305-14.
Score: 0.062
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar; 46(3):234-44.
Score: 0.061
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Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. Diabetes Care. 2014; 37(1):202-9.
Score: 0.059
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GSK-3ß function in bone regulates skeletal development, whole-body metabolism, and male life span. Endocrinology. 2013 Oct; 154(10):3702-18.
Score: 0.059
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Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation. Diabetes. 1992 Nov; 41(11):1436-45.
Score: 0.056
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In vitro scan for enhancers at the TCF7L2 locus. Diabetologia. 2013 Jan; 56(1):121-5.
Score: 0.055
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Exome sequencing and genetic testing for MODY. PLoS One. 2012; 7(5):e38050.
Score: 0.054
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An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers. PLoS One. 2012; 7(5):e36501.
Score: 0.054
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Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young. Diabetes. 1992 Apr; 41(4):401-7.
Score: 0.053
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Association of the KCNJ11 variant E23K with type 2 diabetes in Indo-Trinidadians. West Indian Med J. 2011 Dec; 60(6):604-7.
Score: 0.052
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Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia. 2011 Aug; 54(8):2047-55.
Score: 0.050
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Onset features and subsequent clinical evolution of childhood diabetes over several years. Pediatr Diabetes. 2011 Jun; 12(4 Pt 1):326-34.
Score: 0.050
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Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60. Transl Res. 2010 Jul; 156(1):7-14.
Score: 0.047
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes. 2010 Feb; 59(2):479-85.
Score: 0.045
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A brief perspective on insulin production. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:189-96.
Score: 0.045
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Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes. 2008 Apr; 57(4):1131-5.
Score: 0.040
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Calpain-10 gene and protein expression in human skeletal muscle: effect of acute lipid-induced insulin resistance and type 2 diabetes. J Clin Endocrinol Metab. 2008 Mar; 93(3):992-8.
Score: 0.040
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Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes. 2007 Dec; 56(12):3033-44.
Score: 0.039
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Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab. 2006 Sep-Oct; 89(1-2):174-84.
Score: 0.036
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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 2006 Jun; 55(6):1713-22.
Score: 0.036
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Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. Diabetologia. 2006 Jul; 49(7):1560-6.
Score: 0.036
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Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10. Diabetes. 2005 Dec; 54(12):3573-6.
Score: 0.034
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The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. Diabetologia. 2005 Oct; 48(10):2018-24.
Score: 0.034
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Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta. 2005 Jun 10; 1740(3):319-25.
Score: 0.032
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Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes. 2004 Oct; 53(10):2713-8.
Score: 0.032
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Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes. 2004 Jun; 53(6):1609-13.
Score: 0.031
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Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population. Mol Genet Metab. 2004 Feb; 81(2):122-6.
Score: 0.030
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Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet. 2003 Nov; 73(5):1208-12.
Score: 0.030
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Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy. J Diabetes Complications. 2003 Nov-Dec; 17(6):369-73.
Score: 0.030
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Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects. Diabetes. 2003 Jan; 52(1):209-13.
Score: 0.028
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Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Diabetes. 2002 Dec; 51(12):3561-7.
Score: 0.028
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Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Sep; 87(9):4297-300.
Score: 0.028
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Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Jun; 87(6):2606-10.
Score: 0.027
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Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am J Hum Genet. 2002 May; 70(5):1096-106.
Score: 0.027
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Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury. Spinal Cord. 2002 Mar; 40(3):110-7.
Score: 0.027
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Diabetes mellitus and genetically programmed defects in beta-cell function. Nature. 2001 Dec 13; 414(6865):788-91.
Score: 0.026
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med. 2001 Sep 27; 345(13):971-80.
Score: 0.026
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Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet. 2001 Sep; 69(3):544-52.
Score: 0.026
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A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest. 2000 Oct; 106(7):R69-73.
Score: 0.024
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Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene. Diabetes. 2000 Jun; 49(6):961-8.
Score: 0.024
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Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3) Diabetologia. 2000 Jun; 43(6):816-8.
Score: 0.024
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Diabetes, dependence, asymptotics, selection and significance. Nat Genet. 1997 Oct; 17(2):148.
Score: 0.020
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The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships. Diabetes. 1997 Jul; 46(7):1227-9.
Score: 0.019
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Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K. Diabetes. 1997 Apr; 46(4):720-5.
Score: 0.019
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Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation. Diabetes. 1997 Apr; 46(4):726-30.
Score: 0.019
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Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). Hum Mol Genet. 1997 Apr; 6(4):583-6.
Score: 0.019
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Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM. Diabetologia. 1997 Apr; 40(4):473-5.
Score: 0.019
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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. Diabetologia. 1997 Feb; 40(2):217-24.
Score: 0.019
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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes. 1996 Nov; 45(11):1503-10.
Score: 0.018
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Maturity onset diabetes of the young (MODY). Diabet Med. 1996 Sep; 13(9 Suppl 6):S90-5.
Score: 0.018
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Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations. Acta Diabetol. 1996 Sep; 33(3):193-7.
Score: 0.018
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A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet. 1996 Jun; 13(2):161-6.
Score: 0.018
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):532-8.
Score: 0.018
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An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM. Diabetes. 1996 Mar; 45(3):291-4.
Score: 0.018
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Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese. Diabetes. 1996 Feb; 45(2):267-9.
Score: 0.017
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol. 1996 Jan; 270(1 Pt 1):E133-40.
Score: 0.017
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Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity. Diabetologia. 1995 Dec; 38(12):1466-74.
Score: 0.017
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Linkage studies in NIDDM with markers near the sulphonylurea receptor gene. Diabetologia. 1995 Dec; 38(12):1479-81.
Score: 0.017
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Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase. Diabetologia. 1995 Sep; 38(9):1055-60.
Score: 0.017
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Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes. 1995 Aug; 44(8):999-1001.
Score: 0.017
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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes. 1995 Jun; 44(6):699-704.
Score: 0.017
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No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. Diabetes. 1995 May; 44(5):597-600.
Score: 0.017
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Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes. Acta Diabetol. 1995 Mar; 32(1):17-22.
Score: 0.016
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Clinical characteristics of subjects with a missense mutation in glucokinase. Diabet Med. 1995 Mar; 12(3):209-17.
Score: 0.016
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Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects. Diabetologia. 1995 Feb; 38(2):211-5.
Score: 0.016
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Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects. Diabet Med. 1994 Mar; 11(2):193-7.
Score: 0.015
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Maturity-onset diabetes of the young. Life Sci. 1994; 55(6):413-22.
Score: 0.015
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Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes. 1994 Jan; 43(1):40-6.
Score: 0.015
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Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family. Diabetologia. 1993 May; 36(5):433-7.
Score: 0.014
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Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene. Diabetologia. 1993 Feb; 36(2):170-1.
Score: 0.014
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Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes. Nat Genet. 1992 Oct; 2(2):153-6.
Score: 0.014
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Linkage analysis of maturity-onset diabetes of the young with microsatellite polymorphisms. No linkage to ADA or GLUT2 genes in two families. Diabetes. 1992 Aug; 41(8):962-7.
Score: 0.014
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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature. 1992 Apr 23; 356(6371):721-2.
Score: 0.013
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MODY: a model for the study of the molecular genetics of NIDDM. J Lab Clin Med. 1992 Mar; 119(3):206-10.
Score: 0.013
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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep; 21(9):1417-25.
Score: 0.013
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Res Clin Pract. 2009 Dec; 86(3):186-92.
Score: 0.011
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Control of pancreas and liver gene expression by HNF transcription factors. Science. 2004 Feb 27; 303(5662):1378-81.
Score: 0.008
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Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Apr; 87(4):1669-73.
Score: 0.007
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Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. Kidney Int. 2000 Mar; 57(3):898-907.
Score: 0.006
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Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet. 1995 Feb; 4(2):223-30.
Score: 0.004