Ying-JiePengYing-Jie Peng41.78927490000000-87.601250000000002150Peng, Ying-JieResearch Professorplugins:FeaturedVideosFeatured Videosprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000860DisordersPhenomena1726380.668837HypoxiaD002344Anatomy132320.786475Carotid BodyAuthorship 106541228685420Prabhakar NR, Peng YJAdvances in experimental medicine and biologyOxygen Sensing by the Carotid Body: Past and Present. Adv Exp Med Biol. 2017; 977:3-8.Adv Exp Med Biol2017-01-01T00:00:002017Oxygen Sensing by the Carotid Body: Past and Present.D006862Chemicals & Drugs12500.938143Hydrogen Sulfide29330795Peng YJ, Prabhakar NRMethods in molecular biology (Clifton, N.J.)Measurement of Sensory Nerve Activity from the Carotid Body. Methods Mol Biol. 2018; 1742:115-124.Methods Mol Biol2018-01-01T00:00:002018Measurement of Sensory Nerve Activity from the Carotid Body.29470646Prabhakar NR, Peng YJ, Yuan G, Nanduri JCell and tissue researchReactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 2018 05; 372(2):427-431.Cell Tissue Res2018-02-22T00:00:002018Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.30086385Peng YJ, Makarenko VV, Gridina A, Chupikova I, Zhang X, Kumar GK, Fox AP, Prabhakar NRRespiratory physiology & neurobiologyH2S mediates carotid body response to hypoxia but not anoxia. Respir Physiol Neurobiol. 2019 01; 259:75-85.Respir Physiol Neurobiol2018-08-04T00:00:002018H2S mediates carotid body response to hypoxia but not anoxia.30357741Peng YJ, Zhang X, Nanduri J, Prabhakar NRAdvances in experimental medicine and biologyTherapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model. Adv Exp Med Biol. 2018; 1071:109-114.Adv Exp Med Biol2018-01-01T00:00:002018Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.29148180Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NRThe Journal of physiologyDNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity. J Physiol. 2018 08; 596(15):3087-3100.J Physiol2018-01-04T00:00:002018DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.30631432Prabhakar NR, Peng YJ, Nanduri JF1000ResearchRecent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 2018; 7.F1000Res2018-12-06T00:00:002018Recent advances in understanding the physiology of hypoxic sensing by the carotid body.31483699Makarenko VV, Peng YJ, Khan SA, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyLong-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019 11 01; 122(5):1874-1883.J Neurophysiol2019-09-04T00:00:002019Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia.31544168Nanduri J, Peng YJ, Wang N, Prabhakar NRCurrent opinion in physiologyNeural Activation of Molecular Circuitry in Intermittent Hypoxia. Curr Opin Physiol. 2019 Feb; 7:9-14.Curr Opin Physiol2018-11-29T00:00:002018Neural Activation of Molecular Circuitry in Intermittent Hypoxia.D010100Chemicals & Drugs2287250.682362Oxygen32208891Peng YJ, Gridina A, Wang B, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyOlfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia. J Neurophysiol. 2020 05 01; 123(5):1886-1895.J Neurophysiol2020-03-25T00:00:002020Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.32730232Prabhakar NR, Peng YJ, Nanduri JThe Journal of clinical investigationHypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. 2020 10 01; 130(10):5042-5051.J Clin Invest2020-10-01T00:00:002020Hypoxia-inducible factors and obstructive sleep apnea.11729902Peng Y, Kline DD, Dick TE, Prabhakar NRAdvances in experimental medicine and biologyChronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen. Adv Exp Med Biol. 2001; 499:33-8.Adv Exp Med Biol2001-01-01T00:00:002001Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen.11792862Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaDefective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):821-6.Proc Natl Acad Sci U S A2002-01-15T00:00:002002Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.12533494Peng YJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia. J Appl Physiol (1985). 2003 Jun; 94(6):2342-9.J Appl Physiol (1985)2003-01-17T00:00:002003Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia.14635713Peng Y, Yuan G, Overholt JL, Kumar GK, Prabhakar NRAdvances in experimental medicine and biologySystemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction. Adv Exp Med Biol. 2003; 536:559-64.Adv Exp Med Biol2003-01-01T00:00:002003Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction.14660497Prabhakar NR, Peng YJJournal of applied physiology (Bethesda, Md. : 1985)Peripheral chemoreceptors in health and disease. J Appl Physiol (1985). 2004 Jan; 96(1):359-66.J Appl Physiol (1985)2004-01-01T00:00:002004Peripheral chemoreceptors in health and disease.15258129Peng YJ, Rennison J, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups. J Appl Physiol (1985). 2004 Nov; 97(5):2020-5.J Appl Physiol (1985)2004-07-16T00:00:002004Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups.15063668Prabhakar NR, Peng YJ, Overholt JL, Kumar GKMethods in enzymologyDetection of oxygen sensing during intermittent hypoxia. Methods Enzymol. 2004; 381:107-20.Methods Enzymol2004-01-01T00:00:002004Detection of oxygen sensing during intermittent hypoxia.15652785Malik MT, Peng YJ, Kline DD, Adhikary G, Prabhakar NRRespiratory physiology & neurobiologyImpaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B. Respir Physiol Neurobiol. 2005 Jan 15; 145(1):23-31.Respir Physiol Neurobiol2005-01-15T00:00:002005Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B.Pharmacological and Physiological Sciences33539264Wang B, Peng YJ, Su X, Zhang C, Nagati JS, Garcia JA, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia. J Appl Physiol (1985). 2021 04 01; 130(4):1122-1132.J Appl Physiol (1985)2021-02-04T00:00:002021Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.18187605Pawar A, Peng YJ, Jacono FJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 May; 104(5):1287-94.J Appl Physiol (1985)2008-01-10T00:00:002008Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.16888052Jacono FJ, Peng YJ, Nethery D, Faress JA, Lee Z, Kern JA, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia. J Appl Physiol (1985). 2006 Dec; 101(6):1795-802.J Appl Physiol (1985)2006-08-03T00:00:002006Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia.16887872Peng YJ, Yuan G, Jacono FJ, Kumar GK, Prabhakar NRThe Journal of physiology5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol. 2006 Oct 01; 576(Pt 1):289-95.J Physiol2006-08-03T00:00:0020065-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase.17317339Prabhakar NR, Peng YJ, Kumar GK, Pawar ARespiratory physiology & neurobiologyAltered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):148-53.Respir Physiol Neurobiol2007-01-11T00:00:002007Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.16973705Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NRThe Journal of physiologyHeterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol. 2006 Dec 01; 577(Pt 2):705-16.J Physiol2006-09-14T00:00:002006Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.33729866Gridina A, Su X, Khan SA, Peng YJ, Wang B, Nanduri J, Fox AP, Prabhakar NRJournal of neurophysiologyGaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. J Neurophysiol. 2021 05 01; 125(5):1533-1542.J Neurophysiol2021-03-17T00:00:002021Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells.19147445Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaIntermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1199-204.Proc Natl Acad Sci U S A2009-01-14T00:00:002009Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.19335094Raghuraman G, Rai V, Peng YJ, Prabhakar NR, Kumar GKAntioxidants & redox signalingPattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal. 2009 Aug; 11(8):1777-89.Antioxid Redox Signal2009-08-01T00:00:002009Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases.19369559Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NRThe Journal of neuroscience : the official journal of the Society for NeuroscienceNADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci. 2009 Apr 15; 29(15):4903-10.J Neurosci2009-04-15T00:00:002009NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.19536494Prabhakar NR, Peng YJ, Kumar GK, Nanduri J, Di Giulio C, Lahiri SAdvances in experimental medicine and biologyLong-term regulation of carotid body function: acclimatization and adaptation--invited article. Adv Exp Med Biol. 2009; 648:307-17.Adv Exp Med Biol2009-01-01T00:00:002009Long-term regulation of carotid body function: acclimatization and adaptation--invited article.20556885Peng YJ, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaH2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10719-24.Proc Natl Acad Sci U S A2010-06-08T00:00:002010H2S mediates O2 sensing in the carotid body.33909496Peng YJ, Su X, Wang B, Matthews T, Nanduri J, Prabhakar NRJournal of neurophysiologyRole of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia. J Neurophysiol. 2021 06 01; 125(6):2054-2067.J Neurophysiol2021-04-28T00:00:002021Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia.34079475Wang N, Peng YJ, Su X, Prabhakar NR, Nanduri JFrontiers in physiologyHistone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure. Front Physiol. 2021; 12:688322.Front Physiol2021-05-17T00:00:002021Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure.22723632Prabhakar NR, Kumar GK, Peng YJJournal of applied physiology (Bethesda, Md. : 1985)Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol (1985). 2012 Oct 15; 113(8):1304-10.J Appl Physiol (1985)2012-06-21T00:00:002012Sympatho-adrenal activation by chronic intermittent hypoxia.Authorship 1474822Authorship 1474831Authorship 1474844Authorship 1474852Authorship 1474862Authorship 1474871Authorship 1474882Authorship 1474892Authorship 1474902Authorship 1474911Authorship 1474921Authorship 1474932Authorship 1474941Authorship 1474952Authorship 1474966Authorship 1474975Authorship 1474986Authorship 1474991Authorship 1475001Authorship 1475015Authorship 1475022Authorship 1475032Authorship 1475042Authorship 1475054Authorship 1475062Authorship 1475071Authorship 1475082Authorship 1475091Authorship 1475102Authorship 1475111Authorship 1475121Authorship 1475131Authorship 1475142Authorship 1475151Authorship 1475162Authorship 1475172Authorship 1475181Authorship 1475192Authorship 1475202Authorship 1475212Authorship 1475221Authorship 147523112044639Peng YJ, Wang N, Gong QL, Li PNeuroscience lettersCaudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats. Neurosci Lett. 2002 Jun 07; 325(2):134-8.Neurosci Lett2002-06-07T00:00:002002Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats.9682825Peng YJ, Gong QL, Li PNeuroscience lettersGABA(A) receptors in the rostral ventrolateral medulla mediate the depressor response induced by stimulation of the greater splanchnic nerve afferent fibres in rats. Neurosci Lett. 1998 Jun 19; 249(2-3):95-8.Neurosci Lett1998-06-19T00:00:001998GABA(A) receptors in the rostral ventrolateral medulla mediate the depressor response induced by stimulation of the greater splanchnic nerve afferent fibres in rats.15927691Wang J, Peng YJ, Zhu DNRegulatory peptidesAmino acids modulate the hypotensive effect of angiotensin-(1-7) at the caudal ventrolateral medulla in rats. Regul Pept. 2005 Jul 15; 129(1-3):1-7.Regul Pept2005-07-15T00:00:002005Amino acids modulate the hypotensive effect of angiotensin-(1-7) at the caudal ventrolateral medulla in rats.11499011Shen LL, Peng YJ, Wu GQ, Cao YX, Li PSheng li xue bao : [Acta physiologica Sinica][The coherence analysis between neuronal discharge in the rostral ventrolateral medulla and the cardiovascular activity in rats]. Sheng Li Xue Bao. 1999 Apr; 51(2):168-74.Sheng Li Xue Bao1999-04-01T00:00:001999[The coherence analysis between neuronal discharge in the rostral ventrolateral medulla and the cardiovascular activity in rats].22108299Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakar NR, Garcia JGAmerican journal of respiratory cell and molecular biologyParticulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):524-31.Am J Respir Cell Mol Biol2011-11-22T00:00:002011Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.34322038Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GMFrontiers in physiologyIntermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995.Front Physiol2021-07-12T00:00:002021Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.22232674Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaEpigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20.Proc Natl Acad Sci U S A2012-01-09T00:00:002012Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.16777938Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NRThe Journal of physiologyChronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol. 2006 Aug 15; 575(Pt 1):229-39.J Physiol2006-06-15T00:00:002006Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.21288809Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaHypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3065-70.Proc Natl Acad Sci U S A2011-01-31T00:00:002011Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.21636565Peng YJ, Raghuraman G, Khan SA, Kumar GK, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase. J Appl Physiol (1985). 2011 Oct; 111(4):964-70.J Appl Physiol (1985)2011-06-02T00:00:002011Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.22016368Peng YJ, Nanduri J, Zhang X, Wang N, Raghuraman G, Seagard J, Kumar GK, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia. J Appl Physiol (1985). 2012 Jan; 112(1):187-96.J Appl Physiol (1985)2011-10-20T00:00:002011Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia.12907705Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaInduction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10073-8.Proc Natl Acad Sci U S A2003-08-07T00:00:002003Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas.14660510Peng YJ, Prabhakar NRJournal of applied physiology (Bethesda, Md. : 1985)Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985). 2004 Mar; 96(3):1236-42; discussion 1196.J Appl Physiol (1985)2003-12-05T00:00:002003Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity.15705529Jacono FJ, Peng YJ, Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyModulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor. Respir Physiol Neurobiol. 2005 Feb 15; 145(2-3):135-42.Respir Physiol Neurobiol2005-02-15T00:00:002005Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor.15800194Kline DD, Buniel MC, Glazebrook P, Peng YJ, Ramirez-Navarro A, Prabhakar NR, Kunze DLThe Journal of neuroscience : the official journal of the Society for NeuroscienceKv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J Neurosci. 2005 Mar 30; 25(13):3389-99.J Neurosci2005-03-30T00:00:002005Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration.15854156Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK, Dick TEClinical and experimental pharmacology & physiologyCardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):447-9.Clin Exp Pharmacol Physiol2005-05-01T00:00:002005Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.16686431Prabhakar NR, Peng YJ, Yuan G, Kumar GKNovartis Foundation symposiumReactive oxygen species facilitate oxygen sensing. Novartis Found Symp. 2006; 272:95-9; discussion 100-5, 131-40.Novartis Found Symp2006-01-01T00:00:002006Reactive oxygen species facilitate oxygen sensing.D018035Chemicals & Drugs21370.945156Receptors, Odorant35757963Peng YJ, Nanduri J, Wang N, Khan SA, Pamenter ME, Prabhakar NRActa physiologica (Oxford, England)Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats. Acta Physiol (Oxf). 2022 10; 236(2):e13851.Acta Physiol (Oxf)2022-06-27T00:00:002022Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats.24973414Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NRThe Journal of physiologyRegulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014 Sep 01; 592(17):3841-58.J Physiol2014-06-27T00:00:002014Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats.24395806Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaInherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1174-9.Proc Natl Acad Sci U S A2014-01-06T00:00:002014Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.24328859Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GLThe Biochemical journalHypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression. Biochem J. 2014 Mar 01; 458(2):203-11.Biochem J2014-03-01T00:00:002014Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression.23770311Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NRRespiratory physiology & neurobiologyCentral and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53.Respir Physiol Neurobiol2013-06-11T00:00:002013Central and peripheral factors contributing to obstructive sleep apneas.25377087Makarenko VV, Peng YJ, Yuan G, Fox AP, Kumar GK, Nanduri J, Prabhakar NRAmerican journal of physiology. Cell physiologyCaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C146-54.Am J Physiol Cell Physiol2014-11-05T00:00:002014CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body.23913764Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NRExperimental physiologyRole of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol. 2013 Nov; 98(11):1620-30.Exp Physiol2013-08-02T00:00:002013Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.35965023Prabhakar NR, Peng YJ, Nanduri JHandbook of clinical neurologyAdaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia. Handb Clin Neurol. 2022; 188:103-123.Handb Clin Neurol2022-01-01T00:00:002022Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.36417539Gray OA, Yoo J, Sobreira DR, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Nobréga MA, Di Rienzo AScience advancesA pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942.Sci Adv2022-11-23T00:00:002022A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans.36656752Browe BM, Peng YJ, Nanduri J, Prabhakar NR, Garcia AJeLifeGasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12.Elife2023-01-19T00:00:002023Gasotransmitter modulation of hypoglossal motoneuron activity.https://integrativephysiology.uchicago.edu/faculty/name/alfredo-garcia/Faculty Profilehttps://integrativephysiology.uchicago.edu/Institute for Integrative Physiology and Center for Systems Biology of Oxygen Sensing37029496Prabhakar NR, Peng YJ, Nanduri JThe Journal of physiologyCarotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea. J Physiol. 2023 Dec; 601(24):5481-5494.J Physiol2023-05-05T00:00:002023Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea.37406126Peng YJ, Nanduri J, Wang N, Kumar GK, Bindokas V, Paul BD, Chen X, Fox AP, Vignane T, Filipovic MR, Prabhakar NRScience advancesHypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 07 07; 9(27):eadf3026.Sci Adv2023-07-05T00:00:002023Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78.MedicineUniversity of ChicagoWillard W.SharpWillard W. Sharp41.78927490000000-87.601250000000001035Sharp, Willard W.Associate ProfessorGeorgeBakris0GBoa7McCszMknJtY0fp/Cv/+94=George Bakris41.78927490000000-87.601250000000001393Bakris, GeorgeProfessorVytautasBindokasVytautas Bindokas41.78927490000000-87.601250000000001571Bindokas, VytautasResearch Associate ProfessorNanduri R.Prabhakar2WNnD7QHEMzMknJtY0fp/Cv/+94=Nanduri R. Prabhakar41.78927490000000-87.601250000000001680Prabhakar, Nanduri R.ProfessorTeresita M.HoganTeresita M. Hogan41.78927490000000-87.601250000000001731Hogan, Teresita M.ProfessorAuthorship 1670051Authorship 1670062Authorship 1670072Authorship 1670086Authorship 1670096Authorship 1670101Authorship 1670112Jan-MarinoRamirezJan-Marino Ramirez41.78927490000000-87.601250000000002020Ramirez, Jan-Marino10.52460.00482364266research areas17.36130.026556915coauthor of666.2057.5831460similar to1172selected publicationsDiane BurkeChaneyDiane Burke Chaney41.78927490000000-87.601250000000002281Chaney, Diane BurkeClinical AssociateGayatriRaghuramanGayatri Raghuraman41.78927490000000-87.601250000000002504Raghuraman, GayatriJayasriNanduriJayasri Nanduri41.78927490000000-87.601250000000002544Nanduri, JayasriResearch ProfessorStephenArcherStephen Archer41.78927490000000-87.601250000000002615Archer, StephenProfessortrue1true1true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Research ProfessorResearch Professortrue1Clinical AssociateClinical Associatetrue1Research ProfessorResearch Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professor25772710Nanduri J, Peng YJ, Yuan G, Kumar GK, Prabhakar NRJournal of molecular medicine (Berlin, Germany)Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl). 2015 May; 93(5):473-80.J Mol Med (Berl)2015-03-15T00:00:002015Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome.25583660Kumar GK, Nanduri J, Peng YJ, Prabhakar NRRespiratory physiology & neurobiologyNeuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol. 2015 Apr; 209:115-9.Respir Physiol Neurobiol2015-01-10T00:00:002015Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.25880505Prabhakar NR, Peng YJ, Kumar GK, Nanduri JComprehensive PhysiologyPeripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. 2015 Apr; 5(2):561-77.Compr Physiol2015-04-01T00:00:002015Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.25900831Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NRScience signalingProtein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21; 8(373):ra37.Sci Signal2015-04-21T00:00:002015Protein kinase G-regulated production of H2S governs oxygen sensing.26303481Kumar GK, Peng YJ, Nanduri J, Prabhakar NRAdvances in experimental medicine and biologyCarotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla. Adv Exp Med Biol. 2015; 860:195-9.Adv Exp Med Biol2015-01-01T00:00:002015Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla.Medicine-Emergency MedicineMedicine-EndocrinologyChicago60637IL26561606Makarenko VV, Ahmmed GU, Peng YJ, Khan SA, Nanduri J, Kumar GK, Fox AP, Prabhakar NRJournal of neurophysiologyCaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia. J Neurophysiol. 2016 Jan 01; 115(1):345-54.J Neurophysiol2015-11-11T00:00:002015CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.Authorship 912862Authorship 913491Authorship 913632Authorship 912431Authorship 913041Authorship 913412Authorship 913441Authorship 913621Authorship 913133Authorship 913716Authorship 912793Authorship 913732Authorship 913611Authorship 912723Authorship 912763Authorship 912952Authorship 913031Authorship 913553Authorship 9137910AlfredoGarciaAlfredo Garcia0.000000000000000.000000000000003289Garcia, AlfredoAssistant ProfessorAuthorship 93093227531649Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NRScience signalingH2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016 08 16; 9(441):ra80.Sci Signal2016-08-16T00:00:002016H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.Authorship 95351227506145Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NRThe Journal of physiologyEpigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. J Physiol. 2017 01 01; 595(1):63-77.J Physiol2016-10-02T00:00:002016Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.Authorship 99526128115703Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NRProceedings of the National Academy of Sciences of the United States of AmericaComplementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418.Proc Natl Acad Sci U S A2017-01-23T00:00:002017Complementary roles of gasotransmitters CO and H2S in sleep apnea.