Kenneth S. Polonsky to Diabetes Mellitus, Type 2
This is a "connection" page, showing publications Kenneth S. Polonsky has written about Diabetes Mellitus, Type 2.
Connection Strength
3.410
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Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. 2012 Jul; 61(7):1793-800.
Score: 0.214
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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic ß cell death and diabetes. J Clin Invest. 2010 Nov; 120(11):4031-9.
Score: 0.193
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes. 2010 Feb; 59(2):479-85.
Score: 0.181
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Retinol-binding protein 4, insulin resistance, and type 2 diabetes. N Engl J Med. 2006 Jun 15; 354(24):2596-8.
Score: 0.143
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Diabetic pancreatic beta cells ARNT all they should be. Cell Metab. 2005 Aug; 2(2):78-80.
Score: 0.135
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med. 2001 Sep 27; 345(13):971-80.
Score: 0.103
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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes. Cell. 2001 Jun 15; 105(6):705-7.
Score: 0.101
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Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes. Exp Clin Endocrinol Diabetes. 1999; 107 Suppl 4:S124-7.
Score: 0.085
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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998 Mar; 47(3):358-64.
Score: 0.080
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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes. 1996 Nov; 45(11):1503-10.
Score: 0.073
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Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes. 1996 Nov; 45(11):1626-30.
Score: 0.073
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Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol. 1996 Oct; 271(4 Pt 1):E742-7.
Score: 0.073
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Maturity onset diabetes of the young (MODY). Diabet Med. 1996 Sep; 13(9 Suppl 6):S90-5.
Score: 0.073
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Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function. Am J Physiol. 1996 Apr; 270(4 Pt 1):E572-9.
Score: 0.070
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med. 1996 Mar 21; 334(12):777-83.
Score: 0.070
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol. 1996 Jan; 270(1 Pt 1):E133-40.
Score: 0.069
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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Jul; 96(1):520-7.
Score: 0.067
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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes. 1995 Jun; 44(6):699-704.
Score: 0.066
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Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research. Diabetes. 1995 Jun; 44(6):705-17.
Score: 0.066
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Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes. 1994 Jul; 43(7):871-7.
Score: 0.062
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8.
Score: 0.062
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92.
Score: 0.061
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Maturity-onset diabetes of the young. Life Sci. 1994; 55(6):413-22.
Score: 0.060
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Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15; 306(4):G301-9.
Score: 0.060
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Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest. 1993 Jul; 92(1):262-71.
Score: 0.058
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Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab. 1993 Jan; 76(1):44-8.
Score: 0.056
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Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes. 1992 Mar; 41(3):368-77.
Score: 0.053
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Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring). 2012 Jun; 20(6):1266-72.
Score: 0.053
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Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities. J Clin Endocrinol Metab. 1991 Apr; 72(4):934-44.
Score: 0.050
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Ginseng and ginsenoside Re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care. 2011 May; 34(5):1071-6.
Score: 0.050
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Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus. Am J Med. 1990 Aug 20; 89(2A):11S-16S; discussion 51S-53S.
Score: 0.048
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Effect of temporal distribution of calories on diurnal patterns of glucose levels and insulin secretion in NIDDM. Diabetes Care. 1990 Jul; 13(7):748-55.
Score: 0.047
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Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1989 Sep; 69(3):571-6.
Score: 0.045
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Reevaluation of urine C-peptide as measure of insulin secretion. Diabetes. 1988 Sep; 37(9):1195-201.
Score: 0.042
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Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med. 1988 May 12; 318(19):1231-9.
Score: 0.041
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Mutant insulin syndrome: identification of two families with [LeuA3]insulin and determination of its biological activity. Trans Assoc Am Physicians. 1986; 99:132-42.
Score: 0.035
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Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine. 2002 Apr; 9(3):254-8.
Score: 0.027
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Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times. Diabetes. 2002 Feb; 51 Suppl 1:S227-33.
Score: 0.026
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Diabetes mellitus and genetically programmed defects in beta-cell function. Nature. 2001 Dec 13; 414(6865):788-91.
Score: 0.026
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Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes. 2001 Aug; 50(8):1828-33.
Score: 0.025
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Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism. 2000 Dec; 49(12):1579-87.
Score: 0.024
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000 Oct; 26(2):163-75.
Score: 0.024
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Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes. Diabetes. 2000 Aug; 49(8):1334-40.
Score: 0.024
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest. 2000 Aug; 106(3):329-33.
Score: 0.024
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Dynamics of insulin secretion in obesity and diabetes. Int J Obes Relat Metab Disord. 2000 Jun; 24 Suppl 2:S29-31.
Score: 0.024
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998 May 15; 101(10):2215-22.
Score: 0.020
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Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998 Feb 01; 128(3):176-85.
Score: 0.020
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Temporal profiles and clinical significance of pulsatile insulin secretion. Horm Res. 1998; 49(3-4):178-84.
Score: 0.020
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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature. 1996 Dec 05; 384(6608):455-8.
Score: 0.018
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Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction. J Clin Endocrinol Metab. 1996 Jun; 81(6):2061-8.
Score: 0.018
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Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation. Diabetes. 1996 Apr; 45(4):478-87.
Score: 0.018
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):532-8.
Score: 0.018
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Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats. Am J Physiol. 1996 Mar; 270(3 Pt 1):E504-12.
Score: 0.018
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes. 1995 Dec; 44(12):1447-57.
Score: 0.017
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Insulin secretion in insulin-resistant women with a history of gestational diabetes. Metabolism. 1995 Aug; 44(8):1067-73.
Score: 0.017
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Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography. Diabetes. 1995 Apr; 44(4):437-40.
Score: 0.016
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Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol. 1994 Aug; 267(2 Pt 1):E250-9.
Score: 0.016
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Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes. 1994 Jan; 43(1):40-6.
Score: 0.015
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Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1993 Nov; 77(5):1287-93.
Score: 0.015
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Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1993 Jul; 77(1):6-10.
Score: 0.015
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Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1992 Jul; 35(7):681-9.
Score: 0.014
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Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes. J Clin Endocrinol Metab. 1991 Feb; 72(2):444-54.
Score: 0.012
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Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab. 1990 Jun; 70(6):1594-602.
Score: 0.012
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Res Clin Pract. 2009 Dec; 86(3):186-92.
Score: 0.011
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Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8452-7.
Score: 0.010
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Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring). 2008 Jun; 16(6):1349-54.
Score: 0.010
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Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes. Diabetes. 1984 Nov; 33(11):1112-9.
Score: 0.008
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C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes. 1984 May; 33(5):486-94.
Score: 0.008
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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med. 2001 Oct; 7(10):1133-7.
Score: 0.006
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Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance. Diabetes. 1998 Aug; 47(8):1259-65.
Score: 0.005
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Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev. 1997 Oct; 18(5):716-38.
Score: 0.005
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Defects in insulin secretion and action in women with a history of gestational diabetes. Diabetes. 1995 May; 44(5):506-12.
Score: 0.004