Kenneth S. Polonsky to Islets of Langerhans
This is a "connection" page, showing publications Kenneth S. Polonsky has written about Islets of Langerhans.
Connection Strength
5.592
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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19575-80.
Score: 0.226
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Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets. J Physiol. 2006 Apr 15; 572(Pt 2):379-92.
Score: 0.213
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Diabetic pancreatic beta cells ARNT all they should be. Cell Metab. 2005 Aug; 2(2):78-80.
Score: 0.206
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RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem. 2004 Jun 04; 279(23):24794-802.
Score: 0.187
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Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. FASEB J. 2004 May; 18(7):878-80.
Score: 0.187
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Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E241-6.
Score: 0.184
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Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E41-9.
Score: 0.181
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A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Metabolism. 2003 May; 52(5):528-34.
Score: 0.176
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Increased islet apoptosis in Pdx1+/- mice. J Clin Invest. 2003 Apr; 111(8):1147-60.
Score: 0.175
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Diabetes mellitus and genetically programmed defects in beta-cell function. Nature. 2001 Dec 13; 414(6865):788-91.
Score: 0.160
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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes. Cell. 2001 Jun 15; 105(6):705-7.
Score: 0.155
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Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab. 2000 Feb; 278(2):E340-51.
Score: 0.141
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Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes. 1999 May; 48(5):989-96.
Score: 0.133
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Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes. Exp Clin Endocrinol Diabetes. 1999; 107 Suppl 4:S124-7.
Score: 0.130
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Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem. 1998 Sep 18; 273(38):24457-64.
Score: 0.128
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Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. J Clin Invest. 1998 Apr 15; 101(8):1623-32.
Score: 0.124
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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998 Mar; 47(3):358-64.
Score: 0.123
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Insulin production: from gene to granule. Diabetologia. 1997 Oct; 40 Suppl 3:B33-8.
Score: 0.120
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Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest. 1997 Aug 01; 100(3):530-7.
Score: 0.118
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Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes. 1996 Nov; 45(11):1626-30.
Score: 0.112
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Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function. Am J Physiol. 1996 Apr; 270(4 Pt 1):E572-9.
Score: 0.108
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med. 1996 Mar 21; 334(12):777-83.
Score: 0.108
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol. 1996 Jan; 270(1 Pt 1):E133-40.
Score: 0.106
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Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research. Diabetes. 1995 Jun; 44(6):705-17.
Score: 0.102
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Compensation in pancreatic beta-cell function in subjects with glucokinase mutations. Diabetes. 1994 May; 43(5):718-23.
Score: 0.094
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BH3-only molecule Bim mediates ß-cell death in IRS2 deficiency. Diabetes. 2014 Oct; 63(10):3378-87.
Score: 0.094
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Complex patterns of metabolic and Ca²? entrainment in pancreatic islets by oscillatory glucose. Biophys J. 2013 Jul 02; 105(1):29-39.
Score: 0.089
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Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion. Diabetes. 1993 Jul; 42(7):948-55.
Score: 0.089
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Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest. 1993 Jul; 92(1):262-71.
Score: 0.089
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Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab. 1993 May; 76(5):1241-7.
Score: 0.088
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Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus. Am J Med. 1990 Aug 20; 89(2A):11S-16S; discussion 51S-53S.
Score: 0.073
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Lack of effect of high-dose biosynthetic human C-peptide on pancreatic hormone release in normal subjects. Metabolism. 1990 Aug; 39(8):827-32.
Score: 0.073
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Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1989 Sep; 69(3):571-6.
Score: 0.068
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Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring). 2008 Jun; 16(6):1349-54.
Score: 0.062
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Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics. Diabetes. 1987 Oct; 36(10):1195-202.
Score: 0.060
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Current approaches to measurement of insulin secretion. Diabetes Metab Rev. 1986; 2(3-4):315-29.
Score: 0.053
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C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog. J Clin Invest. 1984 Nov; 74(5):1821-9.
Score: 0.049
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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest. 2004 Oct; 114(7):928-36.
Score: 0.049
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Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes. 2004 Jan; 53(1):91-8.
Score: 0.046
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C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes. 2004 Jan; 53(1):250-64.
Score: 0.046
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Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem. 2003 Mar 14; 278(11):9796-801.
Score: 0.043
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Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times. Diabetes. 2002 Feb; 51 Suppl 1:S227-33.
Score: 0.040
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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 2001 Nov; 50(11):2472-80.
Score: 0.040
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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med. 2001 Oct; 7(10):1133-7.
Score: 0.039
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med. 2001 Sep 27; 345(13):971-80.
Score: 0.039
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Calpains play a role in insulin secretion and action. Diabetes. 2001 Sep; 50(9):2013-20.
Score: 0.039
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Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity. Diabetes. 2001 Jan; 50(1):150-8.
Score: 0.037
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Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism. 2000 Dec; 49(12):1579-87.
Score: 0.037
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest. 2000 Aug; 106(3):329-33.
Score: 0.036
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Dynamics of insulin secretion in obesity and diabetes. Int J Obes Relat Metab Disord. 2000 Jun; 24 Suppl 2:S29-31.
Score: 0.036
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Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism. Metabolism. 1999 Jul; 48(7):857-64.
Score: 0.034
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Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. Diabetes. 1998 Dec; 47(12):1881-8.
Score: 0.032
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Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance. Diabetes. 1998 Aug; 47(8):1259-65.
Score: 0.032
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Temporal profiles and clinical significance of pulsatile insulin secretion. Horm Res. 1998; 49(3-4):178-84.
Score: 0.030
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. Diabetes. 1997 Sep; 46(9):1434-9.
Score: 0.030
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Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol. 1996 Oct; 271(4 Pt 1):E742-7.
Score: 0.028
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Maturity onset diabetes of the young (MODY). Diabet Med. 1996 Sep; 13(9 Suppl 6):S90-5.
Score: 0.028
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):532-8.
Score: 0.027
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Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats. Am J Physiol. 1996 Mar; 270(3 Pt 1):E504-12.
Score: 0.027
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes. 1995 Dec; 44(12):1447-57.
Score: 0.026
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Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochem Biophys Res Commun. 1995 Jul 26; 212(3):894-9.
Score: 0.026
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Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol. 1994 Aug; 267(2 Pt 1):E250-9.
Score: 0.024
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Maturity-onset diabetes of the young. Life Sci. 1994; 55(6):413-22.
Score: 0.023
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Alterations in the kinetics of C-peptide and insulin secretion in hyperthyroidism. J Clin Endocrinol Metab. 1993 Jan; 76(1):79-84.
Score: 0.022
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Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas. J Clin Invest. 1986 Nov; 78(5):1193-8.
Score: 0.014
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In vivo pulsatility of pancreatic islet peptides. Am J Physiol. 1986 Aug; 251(2 Pt 1):E215-26.
Score: 0.014
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The limitations to and valid use of C-peptide as a marker of the secretion of insulin. Diabetes. 1986 Apr; 35(4):379-86.
Score: 0.013
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Long-term follow-up of canine segmental pancreatic autografts. Diabetes. 1985 Feb; 34(2):174-8.
Score: 0.012
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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion. J Biol Chem. 2005 Feb 11; 280(6):4992-5003.
Score: 0.012
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GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E242-7.
Score: 0.010
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998 May 15; 101(10):2215-22.
Score: 0.008
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Reduced levels of messenger ribonucleic acid for calcium channel, glucose transporter-2, and glucokinase are associated with alterations in insulin secretion in fasted rats. Endocrinology. 1994 Sep; 135(3):1010-7.
Score: 0.006
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Natural history of intrahepatic canine islet cell autografts. J Clin Invest. 1986 Nov; 78(5):1339-48.
Score: 0.004