AndreyRzhetsky1nBzA6QBCufAsW9naE/t8mL1sc65/A==Andrey Rzhetsky41.78927490000000-87.601250000000002339Rzhetsky, AndreyProfessorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 100872326642912Yao L, Evans JA, Rzhetsky ATrends in biotechnologyWITHDRAWN: Novel opportunities for computational biology and sociology in drug discovery. Trends Biotechnol. 2010 Feb 05.Trends Biotechnol2010-02-05T00:00:002010WITHDRAWN: Novel opportunities for computational biology and sociology in drug discovery.SavasTayw2NwGIF1GuTQkntjbwjr93A=Savas Tay41.7886000000000087.598699999999993573Tay, SavasProfessor2020-06-30NIHSOLWAY, JULIAN2015-09-01Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma GenesR01HL12271229485041Chattopadhyay I, Kiciman E, Elliott JW, Shaman JL, Rzhetsky AeLifeConjunction of factors triggering waves of seasonal influenza. Elife. 2018 02 27; 7.Elife2018-02-27T00:00:002018Conjunction of factors triggering waves of seasonal influenza.Authorship 1076685Medicine-Hospital Medicine30171177Romero-Calvo I, Weber CR, Ray M, Brown M, Kirby K, Nandi RK, Long TM, Sparrow SM, Ugolkov A, Qiang W, Zhang Y, Brunetti T, Kindler H, Segal JP, Rzhetsky A, Mazar AP, Buschmann MM, Weichselbaum R, Roggin K, White KPMolecular cancer research : MCRHuman Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors. Mol Cancer Res. 2019 01; 17(1):70-83.Mol Cancer Res2018-08-31T00:00:002018Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors.Authorship 10990515Authorship 1115735Authorship 1144983Authorship 1169322Authorship 11943912Authorship 1228583Authorship 12492611Authorship 125296528783162Wang K, Gaitsch H, Poon H, Cox NJ, Rzhetsky ANature geneticsClassification of common human diseases derived from shared genetic and environmental determinants. Nat Genet. 2017 Sep; 49(9):1319-1325.Nat Genet2017-08-07T00:00:002017Classification of common human diseases derived from shared genetic and environmental determinants.30135590Mork RL, Hogan PG, Muenks CE, Boyle MG, Thompson RM, Morelli JJ, Sullivan ML, Gehlert SJ, Ross DG, Yn A, Bubeck Wardenburg J, Rzhetsky A, Burnham CD, Fritz SAPediatric researchComprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households. Pediatr Res. 2018 11; 84(5):668-676.Pediatr Res2018-07-19T00:00:002018Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households.29957506Gray CL, Lobdell DT, Rappazzo KM, Jian Y, Jagai JS, Messer LC, Patel AP, DeFlorio-Barker SA, Lyttle C, Solway J, Rzhetsky AEnvironmental researchAssociations between environmental quality and adult asthma prevalence in medical claims data. Environ Res. 2018 10; 166:529-536.Environ Res2018-06-27T00:00:002018Associations between environmental quality and adult asthma prevalence in medical claims data.30449672Leypunskiy E, Kiciman E, Shah M, Walch OJ, Rzhetsky A, Dinner AR, Rust MJCurrent biology : CBGeographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns. Curr Biol. 2018 12 03; 28(23):3763-3775.e5.Curr Biol2018-11-15T00:00:002018Geographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns.30301884Melamed RD, Rzhetsky ANature communicationsPatchwork of contrasting medication cultures across the USA. Nat Commun. 2018 10 09; 9(1):4022.Nat Commun2018-10-09T00:00:002018Patchwork of contrasting medication cultures across the USA.29698408Kim JS, Gao X, Rzhetsky APLoS computational biologyRIDDLE: Race and ethnicity Imputation from Disease history with Deep LEarning. PLoS Comput Biol. 2018 04; 14(4):e1006106.PLoS Comput Biol2018-04-26T00:00:002018RIDDLE: Race and ethnicity Imputation from Disease history with Deep LEarning.29090959Krishack PA, Wang K, Rzhetsky A, Solway J, Sperling AI, Verhoef PAAmerican journal of respiratory cell and molecular biologyPreexisting Type 2 Immune Activation Protects against the Development of Sepsis. Am J Respir Cell Mol Biol. 2017 11; 57(5):628-630.Am J Respir Cell Mol Biol2017-11-01T00:00:002017Preexisting Type 2 Immune Activation Protects against the Development of Sepsis.Authorship 1256031230503843Hogan PG, Mork RL, Boyle MG, Muenks CE, Morelli JJ, Thompson RM, Sullivan ML, Gehlert SJ, Merlo JR, McKenzie MG, Wardenburg JB, Rzhetsky A, Burnham CD, Fritz SAThe Journal of infectionInterplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus. J Infect. 2019 03; 78(3):200-207.J Infect2018-11-29T00:00:002018Interplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus.Authorship 101661Authorship 112921Authorship 127831Authorship 11791Authorship 1283141230827500Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJAmerican journal of human geneticsGRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Am J Hum Genet. 2019 03 07; 104(3):503-519.Am J Hum Genet2019-02-28T00:00:002019GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.Authorship 143641Authorship 135851Authorship 130221Authorship 128472Authorship 128818630949582Zhang C, Tu HL, Jia G, Mukhtar T, Taylor V, Rzhetsky A, Tay SScience advancesUltra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation. Sci Adv. 2019 04; 5(4):eaav7959.Sci Adv2019-04-03T00:00:002019Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation.Authorship 142482Authorship 176012Authorship 165463Authorship 184251Authorship 187061Authorship 191662Authorship 143942Authorship 184462Authorship 184472D008957Concepts & Ideas2239260.664805Models, GeneticAuthorship 186885Authorship 197923Authorship 213803Authorship 1832611Authorship 1926310Authorship 192644Authorship 192924Authorship 196301Authorship 201884Authorship 168775Authorship 236082Authorship 204172D009323Activities & Behaviors22370.94554Natural Language ProcessingAuthorship 210708Authorship 243227Authorship 2134225Authorship 227634Authorship 130600231264964Danchev V, Rzhetsky A, Evans JAeLifeCentralized scientific communities are less likely to generate replicable results. Elife. 2019 07 02; 8.Elife2019-07-02T00:00:002019Centralized scientific communities are less likely to generate replicable results.Authorship 257344Authorship 226273Authorship 232293Authorship 262781Authorship 244821Authorship 132491731430271Khan A, Plana-Ripoll O, Antonsen S, Brandt J, Geels C, Landecker H, Sullivan PF, Pedersen CB, Rzhetsky APLoS biologyEnvironmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark. PLoS Biol. 2019 08; 17(8):e3000353.PLoS Biol2019-08-20T00:00:002019Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark.Authorship 2565730Authorship 301062Authorship 324591Authorship 320254Authorship 280774Authorship 311091Authorship 291511Authorship 408863Authorship 344632Authorship 1345271331784369Mork RL, Hogan PG, Muenks CE, Boyle MG, Thompson RM, Sullivan ML, Morelli JJ, Seigel J, Orscheln RC, Bubeck Wardenburg J, Gehlert SJ, Burnham CD, Rzhetsky A, Fritz SAThe Lancet. Infectious diseasesLongitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study. Lancet Infect Dis. 2020 02; 20(2):188-198.Lancet Infect Dis2019-11-26T00:00:002019Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study.Authorship 388853Authorship 396775Authorship 320973Authorship 1346231331796735Jia G, Li Y, Zhang H, Chattopadhyay I, Boeck Jensen A, Blair DR, Davis L, Robinson PN, Dahlén T, Brunak S, Benson M, Edgren G, Cox NJ, Gao X, Rzhetsky ANature communicationsEstimating heritability and genetic correlations from large health datasets in the absence of genetic data. Nat Commun. 2019 12 03; 10(1):5508.Nat Commun2019-12-03T00:00:002019Estimating heritability and genetic correlations from large health datasets in the absence of genetic data.Authorship 355151Authorship 337562Authorship 358843Authorship 381841Authorship 344102Authorship 3715716Authorship 387941Authorship 1365531432227144Hogan PG, Mork RL, Thompson RM, Muenks CE, Boyle MG, Sullivan ML, Morelli JJ, Williams CV, Sanchez N, Hunstad DA, Wardenburg JB, Gehlert SJ, Burnham CD, Rzhetsky A, Fritz SAJAMA pediatricsEnvironmental Methicillin-resistant Staphylococcus aureus Contamination, Persistent Colonization, and Subsequent Skin and Soft Tissue Infection. JAMA Pediatr. 2020 06 01; 174(6):552-562.JAMA Pediatr2020-06-01T00:00:002020Environmental Methicillin-resistant Staphylococcus aureus Contamination, Persistent Colonization, and Subsequent Skin and Soft Tissue Infection.Authorship 93342Authorship 1368651132296164Zhong X, Yin Z, Jia G, Zhou D, Wei Q, Faucon A, Evans P, Gamazon ER, Li B, Tao R, Rzhetsky A, Bastarache L, Cox NJGenetics in medicine : official journal of the American College of Medical GeneticsElectronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis. Genet Med. 2020 07; 22(7):1191-1200.Genet Med2020-04-16T00:00:002020Electronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis.Authorship 449192Authorship 450922Authorship 463801Authorship 419752Authorship 4244673Authorship 436695Authorship 13815711Authorship 138141432521007Hogan PG, Parrish KL, Mork RL, Boyle MG, Muenks CE, Thompson RM, Morelli JJ, Sullivan ML, Hunstad DA, Bubeck Wardenburg J, Rzhetsky A, Gehlert SJ, Burnham CD, Fritz SAClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaHOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection-A Randomized Clinical Trial. Clin Infect Dis. 2021 12 06; 73(11):e4568-e4577.Clin Infect Dis2021-12-06T00:00:002021HOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection-A Randomized Clinical Trial.32511231Zhang H, Dahlén T, Khan A, Edgren G, Rzhetsky APLoS computational biologyMeasurable health effects associated with the daylight saving time shift. PLoS Comput Biol. 2020 06; 16(6):e1007927.PLoS Comput Biol2020-06-08T00:00:002020Measurable health effects associated with the daylight saving time shift.Authorship 464743Authorship 98091Authorship 95931Authorship 86602Authorship 120601Authorship 158034Authorship 216764Authorship 304213Authorship 348165Authorship 980818412650Rzhetsky A, Nei MMolecular biology and evolutionTheoretical foundation of the minimum-evolution method of phylogenetic inference. Mol Biol Evol. 1993 Sep; 10(5):1073-95.Mol Biol Evol1993-09-01T00:00:001993Theoretical foundation of the minimum-evolution method of phylogenetic inference.8978080Rzhetsky A, Dopazo J, Snyder E, Dangler CA, Ayala FJGeneticsAssessing dissimilarity of genes by comparing their RNAse A mismatch cleavage patterns. Genetics. 1996 Dec; 144(4):1975-83.Genetics1996-12-01T00:00:001996Assessing dissimilarity of genes by comparing their RNAse A mismatch cleavage patterns.1404422Rzhetsky A, Nei MJournal of molecular evolutionStatistical properties of the ordinary least-squares, generalized least-squares, and minimum-evolution methods of phylogenetic inference. J Mol Evol. 1992 Oct; 35(4):367-75.J Mol Evol1992-10-01T00:00:001992Statistical properties of the ordinary least-squares, generalized least-squares, and minimum-evolution methods of phylogenetic inference.8896378Rzhetsky A, Sitnikova TMolecular biology and evolutionWhen is it safe to use an oversimplified substitution model in tree-making? Mol Biol Evol. 1996 Nov; 13(9):1255-65.Mol Biol Evol1996-11-01T00:00:001996When is it safe to use an oversimplified substitution model in tree-making?9192649Rzhetsky A, Ayala FJ, Hsu LC, Chang C, Yoshida AProceedings of the National Academy of Sciences of the United States of AmericaExon/intron structure of aldehyde dehydrogenase genes supports the "introns-late" theory. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6820-5.Proc Natl Acad Sci U S A1997-06-24T00:00:001997Exon/intron structure of aldehyde dehydrogenase genes supports the "introns-late" theory.10089887Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel RCellA spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999 Mar 05; 96(5):725-36.Cell1999-03-05T00:00:001999A spatial map of olfactory receptor expression in the Drosophila antenna.8647409Rzhetsky AGeneticsEstimating substitution rates in ribosomal RNA genes. Genetics. 1995 Oct; 141(2):771-83.Genetics1995-10-01T00:00:001995Estimating substitution rates in ribosomal RNA genes.10520750Qu XY, Hauptschein RS, Rzhetsky A, Scotto L, Chien MC, Ye X, Frigeri F, Rao PH, Pasqualucci L, Gamberi B, Deaven LL, Zhang P, Chaganti RS, Dalla-Favera R, Russo JJDNA sequence : the journal of DNA sequencing and mappingAnalysis of a 69-kb contiguous genomic sequence at a putative tumor suppressor gene locus on human chromosome 6q27. DNA Seq. 1998; 9(4):189-204.DNA Seq1998-01-01T00:00:001998Analysis of a 69-kb contiguous genomic sequence at a putative tumor suppressor gene locus on human chromosome 6q27.9490025Yoshida A, Rzhetsky A, Hsu LC, Chang CEuropean journal of biochemistryHuman aldehyde dehydrogenase gene family. Eur J Biochem. 1998 Feb 01; 251(3):549-57.Eur J Biochem1998-02-01T00:00:001998Human aldehyde dehydrogenase gene family.10628997Morozov P, Sitnikova T, Churchill G, Ayala FJ, Rzhetsky AGeneticsA new method for characterizing replacement rate variation in molecular sequences. Application of the Fourier and wavelet models to Drosophila and mammalian proteins. Genetics. 2000 Jan; 154(1):381-95.Genetics2000-01-01T00:00:002000A new method for characterizing replacement rate variation in molecular sequences. Application of the Fourier and wavelet models to Drosophila and mammalian proteins.8919870Kumar S, Rzhetsky AJournal of molecular evolutionEvolutionary relationships of eukaryotic kingdoms. J Mol Evol. 1996 Feb; 42(2):183-93.J Mol Evol1996-02-01T00:00:001996Evolutionary relationships of eukaryotic kingdoms.9435239Ayala FJ, Rzhetsky A, Ayala FJProceedings of the National Academy of Sciences of the United States of AmericaOrigin of the metazoan phyla: molecular clocks confirm paleontological estimates. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):606-11.Proc Natl Acad Sci U S A1998-01-20T00:00:001998Origin of the metazoan phyla: molecular clocks confirm paleontological estimates.Authorship 141663833077832Schuster B, Junkin M, Kashaf SS, Romero-Calvo I, Kirby K, Matthews J, Weber CR, Rzhetsky A, White KP, Tay SNature communicationsAutomated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020 10 19; 11(1):5271.Nat Commun2020-10-19T00:00:002020Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids.11262941Rzhetsky A, Morozov PPacific Symposium on Biocomputing. Pacific Symposium on BiocomputingMarkov chain Monte Carlo computation of confidence intervals for substitution-rate variation in proteins. Pac Symp Biocomput. 2001; 203-14.Pac Symp Biocomput2001-01-01T00:00:002001Markov chain Monte Carlo computation of confidence intervals for substitution-rate variation in proteins.11483364Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Pt?cek LJ, Rosier M, Dean M, Allikmets RGeneTwo new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. Gene. 2001 Jul 25; 273(1):89-96.Gene2001-07-25T00:00:002001Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.10893652Tilson MD, Rzhetsky ACurrent medical research and opinionA novel hypothesis regarding the evolutionary origins of the immunoglobulin fold. Curr Med Res Opin. 2000; 16(2):88-93.Curr Med Res Opin2000-01-01T00:00:002000A novel hypothesis regarding the evolutionary origins of the immunoglobulin fold.11125485Migliazza A, Cayanis E, Bosch-Albareda F, Komatsu H, Martinotti S, Toniato E, Kalachikov S, Bonaldo MF, Jelene P, Ye X, Rzhetsky A, Qu X, Chien M, Inghirami G, Gaidano G, Vitolo U, Saglio G, Resegotti L, Zhang P, Soares MB, Russo J, Fischer SG, Edelman IS, Efstratiadis A, Dalla-Favera RCurrent topics in microbiology and immunologyMolecular pathogenesis of B-cell chronic lymphocytic leukemia: analysis of 13q14 chromosomal deletions. Curr Top Microbiol Immunol. 2000; 252:275-84.Curr Top Microbiol Immunol2000-01-01T00:00:002000Molecular pathogenesis of B-cell chronic lymphocytic leukemia: analysis of 13q14 chromosomal deletions.11729170Gomez SM, Lo SH, Rzhetsky AGeneticsProbabilistic prediction of unknown metabolic and signal-transduction networks. Genetics. 2001 Nov; 159(3):1291-8.Genetics2001-11-01T00:00:002001Probabilistic prediction of unknown metabolic and signal-transduction networks.11856881Annilo T, Tammur J, Hutchinson A, Rzhetsky A, Dean M, Allikmets RCytogenetics and cell geneticsHuman and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Cytogenet Cell Genet. 2001; 94(3-4):196-201.Cytogenet Cell Genet2001-01-01T00:00:002001Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4.11472995Friedman C, Kra P, Yu H, Krauthammer M, Rzhetsky ABioinformatics (Oxford, England)GENIES: a natural-language processing system for the extraction of molecular pathways from journal articles. Bioinformatics. 2001; 17 Suppl 1:S74-82.Bioinformatics2001-01-01T00:00:002001GENIES: a natural-language processing system for the extraction of molecular pathways from journal articles.11163981Koike T, Rzhetsky AGeneA graphic editor for analyzing signal-transduction pathways. Gene. 2000 Dec 23; 259(1-2):235-44.Gene2000-12-23T00:00:002000A graphic editor for analyzing signal-transduction pathways.11928495Gomez SM, Rzhetsky APacific Symposium on Biocomputing. Pacific Symposium on BiocomputingTowards the prediction of complete protein--protein interaction networks. Pac Symp Biocomput. 2002; 413-24.Pac Symp Biocomput2002-01-01T00:00:002002Towards the prediction of complete protein--protein interaction networks.12755517Friedman C, Kra P, Rzhetsky AJournal of biomedical informaticsTwo biomedical sublanguages: a description based on the theories of Zellig Harris. J Biomed Inform. 2002 Aug; 35(4):222-35.J Biomed Inform2002-08-01T00:00:002002Two biomedical sublanguages: a description based on the theories of Zellig Harris.12169554Krauthammer M, Kra P, Iossifov I, Gomez SM, Hripcsak G, Hatzivassiloglou V, Friedman C, Rzhetsky ABioinformatics (Oxford, England)Of truth and pathways: chasing bits of information through myriads of articles. Bioinformatics. 2002; 18 Suppl 1:S249-57.Bioinformatics2002-01-01T00:00:002002Of truth and pathways: chasing bits of information through myriads of articles.12379152Karev GP, Wolf YI, Rzhetsky AY, Berezovskaya FS, Koonin EVBMC evolutionary biologyBirth and death of protein domains: a simple model of evolution explains power law behavior. BMC Evol Biol. 2002 Oct 14; 2:18.BMC Evol Biol2002-10-14T00:00:002002Birth and death of protein domains: a simple model of evolution explains power law behavior.12364793Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, M?ller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FCScience (New York, N.Y.)Immunity-related genes and gene families in Anopheles gambiae. Science. 2002 Oct 04; 298(5591):159-65.Science2002-10-04T00:00:002002Immunity-related genes and gene families in Anopheles gambiae.11257221Scott K, Brady R, Cravchik A, Morozov P, Rzhetsky A, Zuker C, Axel RCellA chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell. 2001 Mar 09; 104(5):661-73.Cell2001-03-09T00:00:002001A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila.11435397Dean M, Rzhetsky A, Allikmets RGenome researchThe human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001 Jul; 11(7):1156-66.Genome Res2001-07-01T00:00:002001The human ATP-binding cassette (ABC) transporter superfamily.12968781Yu H, Hatzivassiloglou V, Rzhetsky A, Wilbur WJJournal of biomedical informaticsAutomatically identifying gene/protein terms in MEDLINE abstracts. J Biomed Inform. 2002 Oct-Dec; 35(5-6):322-30.J Biomed Inform2002-10-01T00:00:002002Automatically identifying gene/protein terms in MEDLINE abstracts.14871876Iossifov I, Krauthammer M, Friedman C, Hatzivassiloglou V, Bader JS, White KP, Rzhetsky ABioinformatics (Oxford, England)Probabilistic inference of molecular networks from noisy data sources. Bioinformatics. 2004 May 22; 20(8):1205-13.Bioinformatics2004-02-10T00:00:002004Probabilistic inference of molecular networks from noisy data sources.15471992Krauthammer M, Kaufmann CA, Gilliam TC, Rzhetsky AProceedings of the National Academy of Sciences of the United States of AmericaMolecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15148-53.Proc Natl Acad Sci U S A2004-10-07T00:00:002004Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.12803476Roth CW, Holm I, Graille M, Dehoux P, Rzhetsky A, Wincker P, Weissenbach J, Brey PTMolecules and cellsIdentification of the Anopheles gambiae ATP-binding cassette transporter superfamily genes. Mol Cells. 2003 Apr 30; 15(2):150-8.Mol Cells2003-04-30T00:00:002003Identification of the Anopheles gambiae ATP-binding cassette transporter superfamily genes.16543380Rzhetsky A, Iossifov I, Loh JM, White KPProceedings of the National Academy of Sciences of the United States of AmericaMicroparadigms: chains of collective reasoning in publications about molecular interactions. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4940-5.Proc Natl Acad Sci U S A2006-03-16T00:00:002006Microparadigms: chains of collective reasoning in publications about molecular interactions.16867190Wilbur WJ, Rzhetsky A, Shatkay HBMC bioinformaticsNew directions in biomedical text annotation: definitions, guidelines and corpus construction. BMC Bioinformatics. 2006 Jul 25; 7:356.BMC Bioinformatics2006-07-25T00:00:002006New directions in biomedical text annotation: definitions, guidelines and corpus construction.Medicine-Pulmonary and Critical CarePediatrics-Academic PediatricsPsychiatry and Behavioral Neuroscience-Research14555619Gomez SM, Noble WS, Rzhetsky ABioinformatics (Oxford, England)Learning to predict protein-protein interactions from protein sequences. Bioinformatics. 2003 Oct 12; 19(15):1875-81.Bioinformatics2003-10-12T00:00:002003Learning to predict protein-protein interactions from protein sequences.18311168Rodriguez-Esteban R, Rzhetsky AEMBO reportsSix senses in the literature. The bleak sensory landscape of biomedical texts. EMBO Rep. 2008 Mar; 9(3):212-5.EMBO Rep2008-03-01T00:00:002008Six senses in the literature. The bleak sensory landscape of biomedical texts.17471252Cokol M, Iossifov I, Rodriguez-Esteban R, Rzhetsky AEMBO reportsHow many scientific papers should be retracted? EMBO Rep. 2007 May; 8(5):422-3.EMBO Rep2007-05-01T00:00:002007How many scientific papers should be retracted?17609372Rzhetsky A, Wajngurt D, Park N, Zheng TProceedings of the National Academy of Sciences of the United States of AmericaProbing genetic overlap among complex human phenotypes. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11694-9.Proc Natl Acad Sci U S A2007-07-03T00:00:002007Probing genetic overlap among complex human phenotypes.18326631Feldman I, Rzhetsky A, Vitkup DProceedings of the National Academy of Sciences of the United States of AmericaNetwork properties of genes harboring inherited disease mutations. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4323-8.Proc Natl Acad Sci U S A2008-03-07T00:00:002008Network properties of genes harboring inherited disease mutations.15448271Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, De Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJScience (New York, N.Y.)The genomic sequence of the accidental pathogen Legionella pneumophila. 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Curr Pediatr Rep. 2022; 10(3):57-92.Curr Pediatr Rep2022-08-22T00:00:002022Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.36350878Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay SPLoS computational biologyOrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584.PLoS Comput Biol2022-11-09T00:00:002022OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics.35927250Shi C, Babiker N, Urbanek JK, Grossman RL, Huisingh-Scheetz M, Rzhetsky Anpj agingFree-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts. NPJ Aging. 2022 Jun 06; 8(1):7.NPJ Aging2022-06-06T00:00:002022Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts.36070757Zhang H, Khan A, Rzhetsky ACell reports. MedicineGene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders. Cell Rep Med. 2022 09 20; 3(9):100736.Cell Rep Med2022-09-06T00:00:002022Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders.36344522Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway JNature communicationsDiscerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712.Nat Commun2022-11-07T00:00:002022Discerning asthma endotypes through comorbidity mapping.Authorship 160616336711636Long Y, Khan A, Rzhetsky AmedRxiv : the preprint server for health sciencesPeri- and Post-natal Risk Factors Associated with Health of Newborns: A pregnant mother's infections and immune diseases, and her baby's delivery method predict immune health of the newborn. medRxiv. 2023 Jan 17.medRxiv2023-01-17T00:00:002023Peri- and Post-natal Risk Factors Associated with Health of Newborns: A pregnant mother's infections and immune diseases, and her baby's delivery method predict immune health of the newborn.D001185Activities & BehaviorsObjectsOccupations1322940.790623Artificial Intelligencehttp://www.healthstats.orgCenter for Health Statisticshttp://chicagoitm.orgUChicago-Rush Institute for Translational Medicinehttp://zed.uchicago.eduZero Knowledge Discovery Lab2011-08-31NIHRZHETSKY, ANDREY2000-04-01Computer System for Functional Analysis of Genomic DataR01GM0613722018-06-30NIHRZHETSKY, ANDREY2000-04-01Training in Emerging Multidisciplinary Approaches to Mental Health and DiseaseT32MH0200652020-04-30NIHRZHETSKY, ANDREY2016-07-082/2-Measuring translational dynamics and the proteome to identify potential brain biomarkers for psychiatric diseaseR01MH1109052012-06-30NIHRZHETSKY, ANDREY2009-07-01Large-scale Discovery of Scientific Hypotheses;Computation Over Expert OpinionsR01LM0101322017-08-31NIHRZHETSKY, ANDREY2011-09-22Conte Center for Computational Systems Genomics of Neuropsychiatric PhenotypesP50MH0942672018-05-31NIHSOLWAY, JULIAN2013-09-01Training of Junior Faculty for Careers in Omics of Lung DiseasesK12HL1199952019-05-31NIHLIU, CHUNYU2014-06-10Genetic variants affect brain gene expression and risks of psychiatric disordersU01MH103340Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorD016247Activities & Behaviors611200.934199Information Storage and RetrievalAuthorship 1628805336969368Felín MS, Wang K, Moreira A, Grose A, Leahy K, Zhou Y, Clouser FA, Siddiqui M, Leong N, Goodall P, Michalowski M, Ismail M, Christmas M, Schrantz S, Caballero Z, Norero X, Estripeaut D, Ellis D, Raggi C, Castro C, Rengifo-Herrera C, Moossazadeh D, Ramirez M, Pandey A, Ashi K, Dovgin S, Dixon A, Li X, Begeman I, Heichman S, Lykins J, Villalobos-Cerrud D, Fabrega L, Montalvo JLS, Mendivil C, Quijada MR, Fernández-Pirla S, de La Guardia V, Wong D, de Guevara ML, Flores C, Borace J, García A, Caballero N, de Saez MTM, Politis M, Ross S, Dogra M, Dhamsania V, Graves N, Kirchberg M, Mathur K, Aue A, Restrepo CM, Llanes A, Guzman G, Rebellon A, Boyer K, Heydemann P, Noble AG, Swisher C, Rabiah P, Withers S, Hull T, Frim D, McLone D, Su C, Blair M, Latkany P, Mui E, Vasconcelos-Santos DV, Villareal A, Perez A, Galvis CAN, Montes MV, Perez NIC, Ramirez M, Chittenden C, Wang E, Garcia-López LL, Muñoz-Ortiz J, Rivera-Valdivia N, Bohorquez-Granados MC, de-la-Torre GC, Padrieu G, Hernandez JDV, Celis-Giraldo D, Dávila JAA, Torres E, Oquendo MM, Arteaga-Rivera JY, Nicolae DL, Rzhetsky A, Roizen N, Stillwaggon E, Sawers L, Peyron F, Wallon M, Chapey E, Levigne P, Charter C, De Frias M, Montoya J, Press C, Ramirez R, Contopoulos-Ioannidis D, Maldonado Y, Liesenfeld O, Gomez C, Wheeler K, Zehar S, McAuley J, Limonne D, Houze S, Abraham S, Piarroux R, Tesic V, Beavis K, Abeleda A, Sautter M, El Mansouri B, El Bachir A, Amarir F, El Bissati K, Holfels E, Penn R, Cohen W, de-la-Torre A, Britton G, Motta J, Ortega-Barria E, Romero IL, Meier P, Grigg M, Gómez-Marín J, Kosagisharaf JR, Llorens XS, Reyes O, McLeod RCurrent pediatrics reportsBuilding Programs to Eradicate Toxoplasmosis Part II: Education. Curr Pediatr Rep. 2022 Sep; 10(3):93-108.Curr Pediatr Rep2022-08-01T00:00:002022Building Programs to Eradicate Toxoplasmosis Part II: Education.D019295Occupations2395280.76301Computational BiologyAuthorship 1641101437403494Bhui K, Newbury JB, Latham RM, Ucci M, Nasir ZA, Turner B, O'Leary C, Fisher HL, Marczylo E, Douglas P, Stansfeld S, Jackson SK, Tyrrel S, Rzhetsky A, Kinnersley R, Kumar P, Duchaine C, Coulon FBJPsych openAir quality and mental health: evidence, challenges and future directions. BJPsych Open. 2023 Jul 05; 9(4):e120.BJPsych Open2023-07-05T00:00:002023Air quality and mental health: evidence, challenges and future directions.Biochem/Mol BioHuman GeneticsMedicineUniversity of ChicagoNancy JeanCox2WFmE4EXCuiXhHlsaUXv9Gq0+s+oNancy Jean Cox41.78927490000000-87.601250000000001011Cox, Nancy JeanEmeritus/EmeritaJon E.GrantJon E. Grant41.78927490000000-87.601250000000001148Grant, Jon E.ProfessorJonathanPritchardJonathan K. Pritchard41.78927490000000-87.601250000000001284Pritchard, JonathanPROFESSORGreggMenakerGregg Menaker41.78927490000000-87.60125000000000129Menaker, GreggClinical Assistant Professor37744780Felín MS, Wang K, Raggi C, Moreira A, Pandey A, Grose A, Caballero Z, Rengifo-Herrera C, Ramirez M, Moossazadeh D, Castro C, Montalvo JLS, Leahy K, Zhou Y, Clouser FA, Siddiqui M, Leong N, Goodall P, Michalowski M, Ismail M, Christmas M, Schrantz S, Norero X, Estripeaut D, Ellis D, Ashi K, Dovgin S, Dixon A, Li X, Begeman I, Heichman S, Lykins J, Villalobos-Cerrud D, Fabrega L, Mendivil C, Quijada MR, Fernández-Pirla S, de La Guardia V, Wong D, de LadrónGuevara M, Flores C, Borace J, García A, Caballero N, de Saez MTM, Politis M, Ross S, Dogra M, Dhamsania V, Graves N, Kirchberg M, Mathur K, Aue A, Restrepo CM, Llanes A, Guzman G, Rebollon A, Boyer K, Heydemann P, Noble AG, Swisher C, Rabiah P, Withers S, Hull T, Su C, Blair M, Latkany P, Mui E, Vasconcelos-Santos DV, Villareal A, Perez A, Galvis CAN, Montes MV, Perez NIC, Ramirez M, Chittenden C, Wang E, Garcia-López LL, Muñoz-Ortiz J, Rivera-Valdivia N, Bohorquez-Granados MC, de-la-Torre GC, Padrieu G, Hernandez JDV, Celis-Giraldo D, Acosta Dávila JA, Torres E, Oquendo MM, Arteaga-Rivera JY, Nicolae D, Rzhetsky A, Roizen N, Stillwaggon E, Sawers L, Peyron F, Wallon M, Chapey E, Levigne P, Charter C, De Frias M, Montoya J, Press C, Ramirez R, Contopoulos-Ioannidis D, Maldonado Y, Liesenfeld O, Gomez C, Wheeler K, Holfels E, Frim D, McLone D, Penn R, Cohen W, Zehar S, McAuley J, Limonne D, Houze S, Abraham S, Piarroux R, Tesic V, Beavis K, Abeleda A, Sautter M, El Mansouri B, El Bachir A, Amarir F, El Bissati K, de-la-Torre A, Britton G, Motta J, Ortega-Barria E, Romero IL, Meier P, Grigg M, Gómez-Marín J, Kosagisharaf JR, Llorens XS, Reyes O, McLeod RCurrent pediatrics reportsBuilding Programs to Eradicate Toxoplasmosis Part III: Epidemiology and Risk Factors. Curr Pediatr Rep. 2022 Sep; 10(3):109-124.Curr Pediatr Rep2022-06-22T00:00:002022Building Programs to Eradicate Toxoplasmosis Part III: Epidemiology and Risk Factors.Authorship 16662191LainieRoss23BmGLI1DO/RmHllZ0mg9mHvLainie Ross41.78927490000000-87.601250000000001639Ross, LainieProfessorJulianSolway3XFmB7YUeczMknJtY0fp/Cv/+94=Julian Solway41.78927490000000-87.601250000000001704Solway, JulianProfessor3.143680.00597293460research areas1.130180.01616839coauthor of56.442112.35260similar to11130selected publicationsAlanLeffAlan Leff41.78927490000000-87.601250000000002537Leff, AlanEmeritus/EmeritaRobertGibbonsRobert Gibbons41.78927490000000-87.60125000000000277Gibbons, RobertProfessorJamesLiaoJames Liao41.78927490000000-87.60125000000000382Liao, JamesProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorYujiaWenYujia Wen41.78927490000000-87.60125000000000845Wen, YujiaPostdoctoral ScholarEricEltonEric Elton41.78927490000000-87.60125000000000970Elton, EricClinical Assistant ProfessorAuthorship 1692692038177845Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky ANature computational scienceThe high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nat Comput Sci. 2023 May; 3(5):403-417.Nat Comput Sci2023-05-22T00:00:002023The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.38214655Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky ANature computational scienceAuthor Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nat Comput Sci. 2023 Jul; 3(7):658.Nat Comput Sci2023-07-01T00:00:002023Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.Authorship 16943320true1ProfessorProfessortrue1PROFESSORPROFESSORtrue1ProfessorProfessortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Emeritus/EmeritaEmeritus/Emeritatrue1Postdoctoral ScholarPostdoctoral Scholartrue1Emeritus/EmeritaEmeritus/Emeritatrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 650061Authorship 661674Authorship 666556Authorship 716142Authorship 7171316Authorship 73507525255227Blair DR, Wang K, Nestorov S, Evans JA, Rzhetsky APLoS computational biologyQuantifying the impact and extent of undocumented biomedical synonymy. PLoS Comput Biol. 2014 Sep; 10(9):e1003799.PLoS Comput Biol2014-09-25T00:00:002014Quantifying the impact and extent of undocumented biomedical synonymy.25926297Melamed RD, Emmett KJ, Madubata C, Rzhetsky A, Rabadan RNature communicationsGenetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes. Nat Commun. 2015 Apr 30; 6:7033.Nat Commun2015-04-30T00:00:002015Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes.24625521Rzhetsky A, Bagley SC, Wang K, Lyttle CS, Cook EH, Altman RB, Gibbons RDPLoS computational biologyEnvironmental and state-level regulatory factors affect the incidence of autism and intellectual disability. PLoS Comput Biol. 2014 Mar; 10(3):e1003518.PLoS Comput Biol2014-03-13T00:00:002014Environmental and state-level regulatory factors affect the incidence of autism and intellectual disability.24678533Maltsev N, Rzhetsky A, Conrad Gilliam TAdvances in experimental medicine and biologySystems analysis of human multigene disorders. Preface. Adv Exp Med Biol. 2014; 799:v - viii.Adv Exp Med Biol2014-01-01T00:00:002014Systems analysis of human multigene disorders. Preface.24895436Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJNucleic acids researchDiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46.Nucleic Acids Res2014-06-03T00:00:002014DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections.Authorship 81239526252133Yao L, Li Y, Ghosh S, Evans JA, Rzhetsky ANature biotechnologyHealth ROI as a measure of misalignment of biomedical needs and resources. Nat Biotechnol. 2015 08; 33(8):807-11.Nat Biotechnol2015-08-01T00:00:002015Health ROI as a measure of misalignment of biomedical needs and resources.Authorship 84441126554009Rzhetsky A, Foster JG, Foster IT, Evans JAProceedings of the National Academy of Sciences of the United States of AmericaChoosing experiments to accelerate collective discovery. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14569-74.Proc Natl Acad Sci U S A2015-11-09T00:00:002015Choosing experiments to accelerate collective discovery.Chicago60637ILAuthorship 92732927353665Lykins J, Wang K, Wheeler K, Clouser F, Dixon A, El Bissati K, Zhou Y, Lyttle C, Rzhetsky A, McLeod RClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaUnderstanding Toxoplasmosis in the United States Through "Large Data" Analyses. Clin Infect Dis. 2016 08 15; 63(4):468-75.Clin Infect Dis2016-06-26T00:00:002016Understanding Toxoplasmosis in the United States Through "Large Data" Analyses.IshanuChattopadhyayIshanu Chattopadhyay0.000000000000000.000000000000003385Chattopadhyay, IshanuAssistant ProfessorAuthorship 62578223734675Soldatova LN, Rzhetsky A, De Grave K, King RDJournal of biomedical semanticsRepresentation of probabilistic scientific knowledge. J Biomed Semantics. 2013 Apr 15; 4 Suppl 1:S7.J Biomed Semantics2013-04-15T00:00:002013Representation of probabilistic scientific knowledge.Authorship 96143325356441Balkir AS, Foster I, Rzhetsky AProceedings of the ... International Symposium on High Performance Distributed ComputingA Distributed Look-up Architecture for Text Mining Applications using MapReduce. Proc Int Symp High Perform Distrib Comput. 2011 Nov; 2011.Proc Int Symp High Perform Distrib Comput2011-11-01T00:00:002011A Distributed Look-up Architecture for Text Mining Applications using MapReduce.