RichardMitchellRichard W. Mitchell41.78927490000000-87.601250000000002456Mitchell, RichardW.prns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000109Chemicals & Drugs531760.957716AcetylcholineAuthorship 10691111Authorship 10691436Authorship 10691313PhysicsMargaretGardelMargaret L. Gardel41.7886000000000087.598699999999993493Gardel, MargaretProfessorD001980Anatomy762290.897048BronchiD009130Anatomy763540.873482Muscle, SmoothAuthorship 1105363Authorship 1105604Authorship 1106612Authorship 1108095Authorship 1111446Authorship 1105882Authorship 1100853Authorship 11259329Authorship 1103551Authorship 11200116Authorship 1123071Authorship 1126448Authorship 1129352Authorship 1139357Authorship 1139742Authorship 1142411Authorship 1146994Authorship 1147101Authorship 1149712Authorship 1154311Authorship 1155511Authorship 1124431Authorship 1164532Authorship 1165472Authorship 1163351Authorship 1177463Authorship 1188191Authorship 1142403Authorship 1198111Authorship 1151542Authorship 1153931Authorship 1154676Authorship 1163481Authorship 1166802Authorship 1166974Authorship 1168401Authorship 1204901Authorship 1204763Authorship 1220018Authorship 1174577Authorship 1242291Authorship 1243172Authorship 1233111Authorship 1250891Authorship 1252374Authorship 1185431Authorship 1188016Authorship 1236154Authorship 1238588Authorship 1254381Authorship 1197773Authorship 1252192Authorship 1206513Authorship 1211847Authorship 12137315Authorship 1238361Authorship 1243971Authorship 12505423950872Mitchell RW, Antonissen LA, Kepron W, Kroeger EA, Stephens NLThe Journal of pharmacology and experimental therapeuticsEffect of atropine on the hyperresponsiveness of ragweed-sensitized canine tracheal smooth muscle. J Pharmacol Exp Ther. 1986 Mar; 236(3):803-9.J Pharmacol Exp Ther1986-03-01T00:00:001986Effect of atropine on the hyperresponsiveness of ragweed-sensitized canine tracheal smooth muscle.4414612Stephens NL, Mitchell RWThe American journal of physiologyMechanism of action of respiratory acidosis on tracheal smooth muscle. Am J Physiol. 1974 Sep; 227(3):647-51.Am J Physiol1974-09-01T00:00:001974Mechanism of action of respiratory acidosis on tracheal smooth muscle.3694537Mitchell RW, Kroeger EA, Kepron W, Stephens NLThe Journal of pharmacology and experimental therapeuticsLocal parasympathetic mechanisms for ragweed-sensitized canine trachealis hyperresponsiveness. J Pharmacol Exp Ther. 1987 Dec; 243(3):907-14.J Pharmacol Exp Ther1987-12-01T00:00:001987Local parasympathetic mechanisms for ragweed-sensitized canine trachealis hyperresponsiveness.304678Skoog C, Kromer U, Mitchell RW, Hoogstraten J, Stephens NLThe American journal of physiologyCharacterization of frog muscle mitochondria. Am J Physiol. 1978 Jan; 234(1):C1-6.Am J Physiol1978-01-01T00:00:001978Characterization of frog muscle mitochondria.25054970Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJPloS oneRole of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS One. 2014; 9(7):e102737.PLoS One2014-07-23T00:00:002014Role of dystrophin in airway smooth muscle phenotype, contraction and lung function.22551156Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJBritish journal of pharmacologyEpithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.Br J Pharmacol2012-10-01T00:00:002012Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase.14103Stephens NL, Mitchell RWJournal of applied physiology: respiratory, environmental and exercise physiologyEffect of respiratory acidosis and activity on airway smooth muscle intracellular pH. J Appl Physiol Respir Environ Exerc Physiol. 1977 Mar; 42(3):408-12.J Appl Physiol Respir Environ Exerc Physiol1977-03-01T00:00:001977Effect of respiratory acidosis and activity on airway smooth muscle intracellular pH.16844912Dupasquier CM, Weber AM, Ander BP, Rampersad PP, Steigerwald S, Wigle JT, Mitchell RW, Kroeger EA, Gilchrist JS, Moghadasian MM, Lukas A, Pierce GNAmerican journal of physiology. Heart and circulatory physiologyEffects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2987-96.Am J Physiol Heart Circ Physiol2006-07-14T00:00:002006Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits.6643198Mitchell RW, Stephens NLJournal of applied physiology: respiratory, environmental and exercise physiologyMaximum shortening velocity of smooth muscle: zero load-clamp vs. afterloaded method. J Appl Physiol Respir Environ Exerc Physiol. 1983 Nov; 55(5):1630-3.J Appl Physiol Respir Environ Exerc Physiol1983-11-01T00:00:001983Maximum shortening velocity of smooth muscle: zero load-clamp vs. afterloaded method.457546Antonissen LA, Mitchell RW, Kroeger EA, Kepron W, Tse KS, Stephens NLJournal of applied physiology: respiratory, environmental and exercise physiologyMechanical alterations of airway smooth muscle in a canine asthmatic model. J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr; 46(4):681-7.J Appl Physiol Respir Environ Exerc Physiol1979-04-01T00:00:001979Mechanical alterations of airway smooth muscle in a canine asthmatic model.2937474Stephens NL, Packer CS, Mitchell RWBulletin europeen de physiopathologie respiratoireMechanical properties of airway smooth muscle. Bull Eur Physiopathol Respir. 1986; 22 Suppl 7:178-90.Bull Eur Physiopathol Respir1986-01-01T00:00:001986Mechanical properties of airway smooth muscle.14516722Burdyga T, Mitchell RW, Ragozzino J, Ford LERespiratory physiology & neurobiologyForce and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways. Respir Physiol Neurobiol. 2003 Sep 16; 137(2-3):141-9.Respir Physiol Neurobiol2003-09-16T00:00:002003Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.7359363Antonissen LA, Mitchell RW, Kroeger EA, Kepron W, Stephens NL, Bergen JThe Journal of pharmacology and experimental therapeuticsHistamine pharmacology in airway smooth muscle from a canine model of asthma. J Pharmacol Exp Ther. 1980 Apr; 213(1):150-5.J Pharmacol Exp Ther1980-04-01T00:00:001980Histamine pharmacology in airway smooth muscle from a canine model of asthma.11356813Maass-Moreno R, Burdyga T, Mitchell RW, Seow CY, Ragozzino J, Ford LEJournal of applied physiology (Bethesda, Md. : 1985)Simple freezing apparatus for resolving rapid metabolic events associated with smooth muscle activation. J Appl Physiol (1985). 2001 Jun; 90(6):2453-9.J Appl Physiol (1985)2001-06-01T00:00:002001Simple freezing apparatus for resolving rapid metabolic events associated with smooth muscle activation.11356814Mitchell RW, Seow CY, Burdyga T, Maass-Moreno R, Pratusevich VR, Ragozzino J, Ford LEJournal of applied physiology (Bethesda, Md. : 1985)Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle. J Appl Physiol (1985). 2001 Jun; 90(6):2460-5.J Appl Physiol (1985)2001-06-01T00:00:002001Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle.2898152Kroeger EA, Bergen JM, Mitchell RWProgress in clinical and biological researchEffect of active sensitization on canine airway smooth muscle responsiveness to adrenergic and cholinergic mechanisms in vitro. Prog Clin Biol Res. 1988; 263:219-30.Prog Clin Biol Res1988-01-01T00:00:001988Effect of active sensitization on canine airway smooth muscle responsiveness to adrenergic and cholinergic mechanisms in vitro.9609739Wylam ME, Gungor N, Mitchell RW, Umans JGThe American journal of physiologyEosinophils, major basic protein, and polycationic peptides augment bovine airway myocyte Ca2+ mobilization. Am J Physiol. 1998 06; 274(6):L997-L1005.Am J Physiol1998-06-01T00:00:001998Eosinophils, major basic protein, and polycationic peptides augment bovine airway myocyte Ca2+ mobilization.11997244Qi D, Mitchell RW, Burdyga T, Ford LE, Kuo KH, Seow CYAmerican journal of physiology. Cell physiologyMyosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1298-305.Am J Physiol Cell Physiol2002-06-01T00:00:002002Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation.D014132Anatomy672930.89296Trachea8381630Mitchell RW, Koenig SM, Popovich KJ, Kelly E, Tallet J, Leff ARThe American review of respiratory diseasePertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis. Am Rev Respir Dis. 1993 Feb; 147(2):327-31.Am Rev Respir Dis1993-02-01T00:00:001993Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis.8572245Mitchell RW, Ndukwu IM, Herrnreiter A, Uzendoski K, Gitter B, Solway J, Leff ARThe American journal of physiologyDifferential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis. Am J Physiol. 1995 Dec; 269(6 Pt 1):L837-42.Am J Physiol1995-12-01T00:00:001995Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis.8464221Ferguson MK, Williams U, Leff AR, Mitchell RWLymphologyLength-tension characteristics of bovine tracheobronchial lymphatic smooth muscle. Lymphology. 1993 Mar; 26(1):19-24.Lymphology1993-03-01T00:00:001993Length-tension characteristics of bovine tracheobronchial lymphatic smooth muscle.8503558Strek ME, White SR, Ndukwu IM, Munoz NM, Williams FS, Vita AJ, Leff AR, Mitchell RWThe American review of respiratory diseasePhysiologic significance of epithelial removal on guinea pig tracheal smooth muscle response to acetylcholine and serotonin. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1477-82.Am Rev Respir Dis1993-06-01T00:00:001993Physiologic significance of epithelial removal on guinea pig tracheal smooth muscle response to acetylcholine and serotonin.1498727Mitchell RW, Murphy TM, Leff ARCanadian journal of physiology and pharmacologyPhysiological mechanisms mediating enhanced force generation during development and immune sensitization. Can J Physiol Pharmacol. 1992 Apr; 70(4):615-23.Can J Physiol Pharmacol1992-04-01T00:00:001992Physiological mechanisms mediating enhanced force generation during development and immune sensitization.1550250Ikeda K, Mitchell RW, Guest KA, Seow CY, Kirchhoff CF, Murphy TM, Leff ARThe American journal of physiologyOntogeny of shortening velocity in porcine trachealis. Am J Physiol. 1992 Mar; 262(3 Pt 1):L280-5.Am J Physiol1992-03-01T00:00:001992Ontogeny of shortening velocity in porcine trachealis.9316498Ndukwu IM, White SR, Leff AR, Mitchell RWThe American journal of physiologyEP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. Am J Physiol. 1997 Sep; 273(3 Pt 1):L626-33.Am J Physiol1997-09-01T00:00:001997EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis.9185978Mitchell RW, Ndukwu IM, Leff AR, Padrid PAAmerican journal of veterinary researchMuscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro. Am J Vet Res. 1997 Jun; 58(6):672-6.Am J Vet Res1997-06-01T00:00:001997Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro.9338437Mitchell RW, Rabe KF, Magnussen H, Leff ARJournal of applied physiology (Bethesda, Md. : 1985)Passive sensitization of human airways induces myogenic contractile responses in vitro. J Appl Physiol (1985). 1997 Oct; 83(4):1276-81.J Appl Physiol (1985)1997-10-01T00:00:001997Passive sensitization of human airways induces myogenic contractile responses in vitro.9559905Mitchell RW, Cozzi P, Ndukwu IM, Spaethe S, Leff AR, Padrid PABritish journal of pharmacologyDifferential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo. Br J Pharmacol. 1998 Mar; 123(6):1198-204.Br J Pharmacol1998-03-01T00:00:001998Differential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo.9887072Halayko AJ, Camoretti-Mercado B, Forsythe SM, Vieira JE, Mitchell RW, Wylam ME, Hershenson MB, Solway JThe American journal of physiologyDivergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes. Am J Physiol. 1999 01; 276(1):L197-206.Am J Physiol1999-01-01T00:00:001999Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes.10781442Mitchell RW, Halayko AJ, Kahraman S, Solway J, Wylam MEAmerican journal of physiology. Lung cellular and molecular physiologySelective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1091-100.Am J Physiol Lung Cell Mol Physiol2000-05-01T00:00:002000Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.1670916Murphy TM, Roy L, Phillips IJ, Mitchell RW, Kelly EA, Munoz NM, Leff ARThe American review of respiratory diseaseEffect of maturation on topographic distribution of bronchoconstrictor responses in large diameter airways of young swine. Am Rev Respir Dis. 1991 Jan; 143(1):126-31.Am Rev Respir Dis1991-01-01T00:00:001991Effect of maturation on topographic distribution of bronchoconstrictor responses in large diameter airways of young swine.1757374Mitchell RW, Murphy TM, Kelly E, Leff ARJournal of applied physiology (Bethesda, Md. : 1985)Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine. J Appl Physiol (1985). 1991 Oct; 71(4):1489-95.J Appl Physiol (1985)1991-10-01T00:00:001991Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine.12851423Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway JJournal of applied physiology (Bethesda, Md. : 1985)Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J Appl Physiol (1985). 2003 Aug; 95(2):844-53.J Appl Physiol (1985)2003-08-01T00:00:002003Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?15309016Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PGThe Journal of allergy and clinical immunologyMethodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug; 114(2 Suppl):S18-31.J Allergy Clin Immunol2004-08-01T00:00:002004Methodologic advancements in the study of airway smooth muscle.1928367Murphy TM, Mitchell RW, Phillips IJ, Leff ARThe American journal of physiologyOntogenic expression of acetylcholinesterase activity in trachealis of young swine. Am J Physiol. 1991 Oct; 261(4 Pt 1):L322-6.Am J Physiol1991-10-01T00:00:001991Ontogenic expression of acetylcholinesterase activity in trachealis of young swine.1996660Mitchell RW, Kelly E, Leff ARThe American journal of physiologyEffect of in vitro preconditioning on tracheal smooth muscle responsiveness. Am J Physiol. 1991 Feb; 260(2 Pt 1):L168-73.Am J Physiol1991-02-01T00:00:001991Effect of in vitro preconditioning on tracheal smooth muscle responsiveness.12600823Liu HW, Halayko AJ, Fernandes DJ, Harmon GS, McCauley JA, Kocieniewski P, McConville J, Fu Y, Forsythe SM, Kogut P, Bellam S, Dowell M, Churchill J, Lesso H, Kassiri K, Mitchell RW, Hershenson MB, Camoretti-Mercado B, Solway JAmerican journal of respiratory cell and molecular biologyThe RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):39-47.Am J Respir Cell Mol Biol2003-01-10T00:00:002003The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor.16484363Chen B, Liu G, Shardonofsky F, Dowell M, Lakser O, Mitchell RW, Fredberg JJ, Pinto LH, Solway JJournal of applied physiology (Bethesda, Md. : 1985)Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol (1985). 2006 Jul; 101(1):249-55.J Appl Physiol (1985)2006-02-16T00:00:002006Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice.Medicine-Pulmonary and Critical CareRadiology-Thoracic Imaging2058690Murphy TM, Mitchell RW, Halayko A, Roach J, Roy L, Kelly EA, Munoz NM, Stephens NL, Leff ARThe American journal of physiologyEffect of maturational changes in myosin content and morphometry on airway smooth muscle contraction. Am J Physiol. 1991 Jun; 260(6 Pt 1):L471-80.Am J Physiol1991-06-01T00:00:001991Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction.2252242Wylam ME, Samsel RW, Umans JG, Mitchell RW, Leff AR, Schumacker PTThe American review of respiratory diseaseEndotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1263-7.Am Rev Respir Dis1990-12-01T00:00:001990Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.1908687Mitchell RW, Kelly E, Leff ARAmerican journal of respiratory cell and molecular biologyReduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization. Am J Respir Cell Mol Biol. 1991 Jul; 5(1):56-62.Am J Respir Cell Mol Biol1991-07-01T00:00:001991Reduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization.15465883Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Stelmack GL, Halayko AJ, Solway J, Mitchell RWJournal of applied physiology (Bethesda, Md. : 1985)Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol (1985). 2005 Feb; 98(2):489-97.J Appl Physiol (1985)2004-10-01T00:00:002004Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle.17470619An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang LThe European respiratory journalAirway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007 May; 29(5):834-60.Eur Respir J2007-05-01T00:00:002007Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.18167028Pinto LH, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J, Kedainis D, Siepka SM, Shimomura K, Song EJ, Husain A, Lakser OJ, Mitchell RW, Dowell ML, Brown M, Camoretti-Mercado B, Naclerio R, Sperling AI, Levin SI, Turek FW, Solway JMammalian genome : official journal of the International Mammalian Genome SocietyGene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mamm Genome. 2008 Jan; 19(1):2-14.Mamm Genome2008-01-01T00:00:002008Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.15531570Bai TR, Bates JH, Brusasco V, Camoretti-Mercado B, Chitano P, Deng LH, Dowell M, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Hai CM, Halayko AJ, Hirst SJ, James AL, Janssen LJ, Jones KA, King GG, Lakser OJ, Lambert RK, Lauzon AM, Lutchen KR, Maksym GN, Meiss RA, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Schellenberg RR, Seow CY, Sieck GC, Smith PG, Smolensky AV, Solway J, Stephens NL, Stewart AG, Tang DD, Wang LJournal of applied physiology (Bethesda, Md. : 1985)On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol (1985). 2004 Dec; 97(6):2029-34.J Appl Physiol (1985)2004-12-01T00:00:002004On the terminology for describing the length-force relationship and its changes in airway smooth muscle.2382731Mitchell RW, Murphy TM, Kelly E, Leff ARThe American journal of physiologyMaturation of acetylcholinesterase expression in tracheal smooth muscle contraction. Am J Physiol. 1990 Aug; 259(2 Pt 1):L130-5.Am J Physiol1990-08-01T00:00:001990Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction.19387033Lavoie TL, Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Seow CY, Mitchell RW, Solway JProceedings of the American Thoracic SocietyDisrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma? Proc Am Thorac Soc. 2009 May 01; 6(3):295-300.Proc Am Thorac Soc2009-05-01T00:00:002009Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?20110395Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Mitchell RW, Solway JThe European respiratory journalMEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J. 2010 Sep; 36(3):630-7.Eur Respir J2010-01-28T00:00:002010MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.D009119PhenomenaPhysiology912830.907486Muscle Contraction2474528Koenig SM, Mitchell RW, Kelly E, White SR, Leff AR, Popovich KJJournal of applied physiology (Bethesda, Md. : 1985)Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction. J Appl Physiol (1985). 1989 Jul; 67(1):181-5.J Appl Physiol (1985)1989-07-01T00:00:001989Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction.18094087Mitchell RW, Dowell ML, Solway J, Lakser OJProceedings of the American Thoracic SocietyForce fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 01; 5(1):68-72.Proc Am Thorac Soc2008-01-01T00:00:002008Force fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle.18768574Lakser OJ, Dowell ML, Hoyte FL, Chen B, Lavoie TL, Ferreira C, Pinto LH, Dulin NO, Kogut P, Churchill J, Mitchell RW, Solway JThe European respiratory journalSteroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J. 2008 Nov; 32(5):1224-30.Eur Respir J2008-09-03T00:00:002008Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma.8203543Ndukwu IM, Solway J, Arbetter K, Uzendoski K, Leff AR, Mitchell RWThe American journal of physiologyImmune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis. Am J Physiol. 1994 May; 266(5 Pt 1):L485-92.Am J Physiol1994-05-01T00:00:001994Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis.2759942Murphy TM, Mitchell RW, Blake JS, Mack MM, Kelly EA, Munoz NM, Leff ARJournal of applied physiology (Bethesda, Md. : 1985)Expression of airway contractile properties and acetylcholinesterase activity in swine. J Appl Physiol (1985). 1989 Jul; 67(1):174-80.J Appl Physiol (1985)1989-07-01T00:00:001989Expression of airway contractile properties and acetylcholinesterase activity in swine.8175585Hershenson MB, Wylam ME, Punjabi N, Umans JG, Schumacker PT, Mitchell RW, Solway JJournal of applied physiology (Bethesda, Md. : 1985)Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro. J Appl Physiol (1985). 1994 Feb; 76(2):743-9.J Appl Physiol (1985)1994-02-01T00:00:001994Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.8074246Mitchell RW, Rühlmann E, Magnussen H, Leff AR, Rabe KFThe American journal of physiologyPassive sensitization of human bronchi augments smooth muscle shortening velocity and capacity. Am J Physiol. 1994 Aug; 267(2 Pt 1):L218-22.Am J Physiol1994-08-01T00:00:001994Passive sensitization of human bronchi augments smooth muscle shortening velocity and capacity.8338177Mitchell RW, Ndukuw IM, Ikeda K, Arbetter K, Leff ARThe American journal of physiologyEffect of immune sensitization on stimulated ACh release from trachealis muscle in vitro. Am J Physiol. 1993 Jul; 265(1 Pt 1):L13-8.Am J Physiol1993-07-01T00:00:001993Effect of immune sensitization on stimulated ACh release from trachealis muscle in vitro.7695137Padrid PA, Mitchell RW, Ndukwu IM, Spaethe S, Shiue P, Cozzi P, Leff AR, Shiou P [corrected to Shiue P]American journal of veterinary researchCyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats. Am J Vet Res. 1995 Jan; 56(1):109-15.Am J Vet Res1995-01-01T00:00:001995Cyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats.3403434White SR, Popovich KJ, Mitchell RW, Koenig SM, Mack MM, Munoz NM, Leff ARJournal of applied physiology (Bethesda, Md. : 1985)Antagonism of relaxation to isoproterenol caused by agonist interactions. J Appl Physiol (1985). 1988 Jun; 64(6):2501-7.J Appl Physiol (1985)1988-06-01T00:00:001988Antagonism of relaxation to isoproterenol caused by agonist interactions.9074987Mitchell RW, Rühlmann E, Magnussen H, Muñoz NM, Leff AR, Rabe KFJournal of applied physiology (Bethesda, Md. : 1985)Conservation of bronchiolar wall area during constriction and dilation of human airways. J Appl Physiol (1985). 1997 Mar; 82(3):954-8.J Appl Physiol (1985)1997-03-01T00:00:001997Conservation of bronchiolar wall area during constriction and dilation of human airways.2708194Mitchell RW, Koenig SM, Kelly E, Stephens NL, Leff ARJournal of applied physiology (Bethesda, Md. : 1985)Ca2+-dependent facilitated shortening in isotonic contraction of trachealis muscle. J Appl Physiol (1985). 1989 Feb; 66(2):632-7.J Appl Physiol (1985)1989-02-01T00:00:001989Ca2+-dependent facilitated shortening in isotonic contraction of trachealis muscle.8279571Mitchell RW, Ndukwu IM, Arbetter K, Solway J, Leff ARThe American journal of physiologyEffect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis. Am J Physiol. 1993 Dec; 265(6 Pt 1):L549-54.Am J Physiol1993-12-01T00:00:001993Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis.http://chicagoitm.orgUChicago-Rush Institute for Translational Medicine1993-07-31NIHMITCHELL, RICHARD W1989-08-01NEURAL &PHARMACOLOGICAL CONTROL OF AIRWAY SMOOTH MUSCLER01HL042758Principal InvestigatorMedicinePathologyRadiologyUniversity of ChicagoAnaBarionAna Barion41.78927490000000-87.601250000000001085Barion, AnaJulianSolway3XFmB7YUeczMknJtY0fp/Cv/+94=Julian Solway41.78927490000000-87.601250000000001704Solway, JulianProfessorStevenWhiteSteven White41.78927490000000-87.601250000000002172White, StevenProfessor3.840850.00166409292research areas1.705970.014365112coauthor of45.60261.9913860similar to1161selected publicationsAlanLeffAlan Leff41.78927490000000-87.601250000000002537Leff, AlanEmeritus/EmeritaMary ElizabethStrekMary Elizabeth Strek41.78927490000000-87.601250000000002563Strek, Mary ElizabethProfessorStevenLevinSteven Levin41.78927490000000-87.601250000000002585Levin, StevenClinical Assistant ProfessorRichardGoreRichard Gore41.78927490000000-87.60125000000000261Gore, RichardClinical ProfessorMark K.FergusonMark K. Ferguson41.78927490000000-87.601250000000002653Ferguson, Mark K.ProfessorLuciaSchugerLucia Schuger41.78927490000000-87.6012500000000087Schuger, LuciaPROFESSORTeraLavoieTera Lavoie41.78927490000000-87.60125000000000909Lavoie, TeraStevenMontnerSteven Montner41.78927490000000-87.60125000000000951Montner, StevenProfessorMichaelRakotzMichael Rakotz41.78927490000000-87.60125000000000969Rakotz, Michaeltrue1true1true1true1true1Emeritus/EmeritaEmeritus/Emeritatrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1PROFESSORPROFESSORtrue1ProfessorProfessortrue1Clinical ProfessorClinical Professortrue1ProfessorProfessortrue1ProfessorProfessorOrthopaedic Surg & Rehab MedSurgery-CardiacChicago60637IL