CarlosVillalba-GaleaCarlos Villalba-Galea41.78927490000000-87.60125000000000246Villalba-Galea, Carlosprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD004560Phenomena19230.985221ElectricityBiochemistry and Molecular BiologyOrganismal Biology and AnatomyMedicine-GastroenterologyAuthorship 1133124Authorship 120754230266757Corbin-Leftwich A, Small HE, Robinson HH, Villalba-Galea CA, Boland LMThe Journal of general physiologyA Xenopus oocyte model system to study action potentials. J Gen Physiol. 2018 11 05; 150(11):1583-1593.J Gen Physiol2018-09-28T00:00:002018A Xenopus oocyte model system to study action potentials.29379118Delgado-Ramírez M, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Arreola J, Adney SK, Villalba-Galea CA, Logothetis DE, Rodríguez-Menchaca AAScientific reportsRegulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate. Sci Rep. 2018 01 29; 8(1):1769.Sci Rep2018-01-29T00:00:002018Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate.Authorship 168511Authorship 222262Authorship 238923Authorship 250392Authorship 371701Authorship 287523Authorship 361541Authorship 495061Authorship 385051Authorship 445346Authorship 137832232447198Herrera-Arozamena C, Estrada-Valencia M, Martí-Marí O, Pérez C, de la Fuente Revenga M, Villalba-Galea CA, Rodríguez-Franco MIEuropean journal of medicinal chemistryOptical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups. Eur J Med Chem. 2020 Aug 15; 200:112403.Eur J Med Chem2020-05-13T00:00:002020Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.Authorship 481151Authorship 492487Authorship 496903Authorship 139106132636742Villalba-Galea CAFrontiers in pharmacologyModulation of KV7 Channel Deactivation by PI(4,5)P2. Front Pharmacol. 2020; 11:895.Front Pharmacol2020-06-19T00:00:002020Modulation of KV7 Channel Deactivation by PI(4,5)P2.Authorship 18230210620283Zoghbi ME, Bolaños P, Villalba-Galea C, Marcano A, Hernández E, Fill M, Escobar ALBiophysical journalSpatial Ca(2+) distribution in contracting skeletal and cardiac muscle cells. Biophys J. 2000 Jan; 78(1):164-73.Biophys J2000-01-01T00:00:002000Spatial Ca(2+) distribution in contracting skeletal and cardiac muscle cells.11099353Fill M, Zahradníková A, Villalba-Galea CA, Zahradník I, Escobar AL, Györke SThe Journal of general physiologyRyanodine receptor adaptation. J Gen Physiol. 2000 Dec; 116(6):873-82.J Gen Physiol2000-12-01T00:00:002000Ryanodine receptor adaptation.Authorship 142763133324211Villalba-Galea CA, Chiem ATFrontiers in pharmacologyHysteretic Behavior in Voltage-Gated Channels. Front Pharmacol. 2020; 11:579596.Front Pharmacol2020-11-02T00:00:002020Hysteretic Behavior in Voltage-Gated Channels.D015640Physiology603230.801138Ion Channel Gating18818307Villalba-Galea CA, Sandtner W, Starace DM, Bezanilla FProceedings of the National Academy of Sciences of the United States of AmericaS4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17600-7.Proc Natl Acad Sci U S A2008-09-25T00:00:002008S4-based voltage sensors have three major conformations.15193860Zoghbi ME, Copello JA, Villalba-Galea CA, Vélez P, Diaz Sylvester PL, Bolaños P, Marcano A, Fill M, Escobar ALCell calciumDifferential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes. Cell Calcium. 2004 Aug; 36(2):119-34.Cell Calcium2004-08-01T00:00:002004Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes.19564425Villalba-Galea CA, Miceli F, Taglialatela M, Bezanilla FThe Journal of general physiologyCoupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol. 2009 Jul; 134(1):5-14.J Gen Physiol2009-07-01T00:00:002009Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.16417485Augustine GJ, Morgan JR, Villalba-Galea CA, Jin S, Prasad K, Lafer EMBiochemical Society transactionsClathrin and synaptic vesicle endocytosis: studies at the squid giant synapse. Biochem Soc Trans. 2006 Feb; 34(Pt 1):68-72.Biochem Soc Trans2006-02-01T00:00:002006Clathrin and synaptic vesicle endocytosis: studies at the squid giant synapse.21454672Lacroix J, Halaszovich CR, Schreiber DN, Leitner MG, Bezanilla F, Oliver D, Villalba-Galea CAThe Journal of biological chemistryControlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential. J Biol Chem. 2011 May 20; 286(20):17945-53.J Biol Chem2011-03-17T00:00:002011Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.22993507Villalba-Galea CAFrontiers in pharmacologyVoltage-Controlled Enzymes: The New JanusBifrons. Front Pharmacol. 2012; 3:161.Front Pharmacol2012-09-13T00:00:002012Voltage-Controlled Enzymes: The New JanusBifrons.19167283Villalba-Galea CA, Sandtner W, Dimitrov D, Mutoh H, Knöpfel T, Bezanilla FBiophysical journalCharge movement of a voltage-sensitive fluorescent protein. Biophys J. 2009 Jan; 96(2):L19-21.Biophys J2009-01-01T00:00:002009Charge movement of a voltage-sensitive fluorescent protein.22481094Villalba-Galea CACellular signallingNew insights in the activity of voltage sensitive phosphatases. Cell Signal. 2012 Aug; 24(8):1541-7.Cell Signal2012-03-28T00:00:002012New insights in the activity of voltage sensitive phosphatases.23071266Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla FThe Journal of general physiologyMolecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov; 140(5):481-93.J Gen Physiol2012-10-15T00:00:002012Molecular mechanism for depolarization-induced modulation of Kv channel closure.12632197Mejía-Alvarez R, Manno C, Villalba-Galea CA, del Valle Fernández L, Costa RR, Fill M, Gharbi T, Escobar ALPflugers Archiv : European journal of physiologyPulsed local-field fluorescence microscopy: a new approach for measuring cellular signals in the beating heart. Pflugers Arch. 2003 Mar; 445(6):747-58.Pflugers Arch2003-01-14T00:00:002003Pulsed local-field fluorescence microscopy: a new approach for measuring cellular signals in the beating heart.14644760Escobar AL, Ribeiro-Costa R, Villalba-Galea C, Zoghbi ME, Pérez CG, Mejía-Alvarez RAmerican journal of physiology. Heart and circulatory physiologyDevelopmental changes of intracellular Ca2+ transients in beating rat hearts. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H971-8.Am J Physiol Heart Circ Physiol2003-11-26T00:00:002003Developmental changes of intracellular Ca2+ transients in beating rat hearts.22896666Halaszovich CR, Leitner MG, Mavrantoni A, Le A, Frezza L, Feuer A, Schreiber DN, Villalba-Galea CA, Oliver DJournal of lipid researchA human phospholipid phosphatase activated by a transmembrane control module. J Lipid Res. 2012 Nov; 53(11):2266-74.J Lipid Res2012-08-15T00:00:002012A human phospholipid phosphatase activated by a transmembrane control module.D010744Chemicals & Drugs32510.955768Phosphoric Monoester Hydrolaseshttps://coateslab.uchicago.edu/Coates Lab Website http://nerve.bsd.uchicago.eduExcitability, Molecular Basishttp://kosslab.uchicago.eduKosslabhttp://nerve.bsd.uchicago.edu/FBLab Sitehttp://recombinant-antibodies.orgRecombinant Antibody NetworkD006639Chemicals & Drugs40550.979834HistidineD008564Concepts & IdeasPhysiology1244350.873711Membrane PotentialsAuthorship 162324136995318Villalba-Galea CAThe Journal of general physiologyAbout hysteresis in Shaker: A note on Cowgill and Chanda. J Gen Physiol. 2023 05 01; 155(5).J Gen Physiol2023-03-30T00:00:002023About hysteresis in Shaker: A note on Cowgill and Chanda.Biochem/Mol BioHuman GeneticsSurgeryUniversity of ChicagoSudhaChakrapaniSudha Chakrapani41.78927490000000-87.601250000000001126Chakrapani, SudhaXiangZhouXiang Zhou41.78927490000000-87.601250000000001144Zhou, XiangPostdoctoral ScholarAnthonyKossiakoff1mlmGLIcGOf5hHlsaUXv9Gq0+s+oAnthony Kossiakoff41.78927490000000-87.601250000000001188Kossiakoff, AnthonyProfessorAlainLabroAlain J. Labro41.78927490000000-87.601250000000001296Labro, AlainKapuluruReddyKapuluru Reddy41.78927490000000-87.60125000000000189Reddy, KapuluruAssociate ProfessorMichael I.CoatesMichael I. Coates41.78927490000000-87.601250000000002032Coates, Michael I.Professor2.493270.00529608139research areas1.957690.02826256coauthor of56.80812.2165660similar to1131selected publicationsLorenSchechterLoren S. Schechter41.78927490000000-87.601250000000002483Schechter, LorenClinical AssociateEduardoPerozo0nJsGa4PFszMknJtY0fp/Cv/+94=Eduardo Perozo41.78927490000000-87.601250000000002512Perozo, EduardoProfessorDorothyHanckDorothy Hanck41.78927490000000-87.601250000000002657Hanck, DorothyEmeritus/Emerita, ProfessorCallum F.RossCallum F. Ross41.78927490000000-87.60125000000000347Ross, Callum F.ProfessorFranciscoBezanillaFrancisco Bezanilla41.78927490000000-87.60125000000000987Bezanilla, FranciscoProfessorAuthorship 169557238236165Mehrdel B, Villalba-Galea CAThe Journal of general physiologyEffect of a sensing charge mutation on the deactivation of KV7.2 channels. J Gen Physiol. 2024 Mar 04; 156(3).J Gen Physiol2024-01-18T00:00:002024Effect of a sensing charge mutation on the deactivation of KV7.2 channels.true1true1true1true1Postdoctoral ScholarPostdoctoral Scholartrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Postdoctoral ScholarPostdoctoral Scholartrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Clinical AssociateClinical AssociateAuthorship 689041Authorship 699027Authorship 708832Authorship 791652Authorship 70102125296308Villalba-Galea CABiophysical journalHv1 proton channel opening is preceded by a voltage-independent transition. Biophys J. 2014 Oct 07; 107(7):1564-72.Biophys J2014-10-07T00:00:002014Hv1 proton channel opening is preceded by a voltage-independent transition.24127524Villalba-Galea CA, Frezza L, Sandtner W, Bezanilla FThe Journal of general physiologySensing charges of the Ciona intestinalis voltage-sensing phosphatase. J Gen Physiol. 2013 Nov; 142(5):543-55.J Gen Physiol2013-10-14T00:00:002013Sensing charges of the Ciona intestinalis voltage-sensing phosphatase.24218396Bezanilla F, Villalba-Galea CAThe Journal of general physiologyThe gating charge should not be estimated by fitting a two-state model to a Q-V curve. J Gen Physiol. 2013 Dec; 142(6):575-8.J Gen Physiol2013-11-11T00:00:002013The gating charge should not be estimated by fitting a two-state model to a Q-V curve.24487958Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B, Schulten K, Kossiakoff A, Perozo ENature structural & molecular biologyStructural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol. 2014 Mar; 21(3):244-52.Nat Struct Mol Biol2014-02-02T00:00:002014Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.24268143Priest MF, Lacroix JJ, Villalba-Galea CA, Bezanilla FBiophysical journalS3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel. Biophys J. 2013 Nov 19; 105(10):2312-22.Biophys J2013-11-19T00:00:002013S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.1010Authorship 80036126074820Villalba-Galea CAFrontiers in pharmacologyCorrigendum: Voltage-controlled enzymes: the new Janus Bifrons. Front Pharmacol. 2015; 6:109.Front Pharmacol2015-05-29T00:00:002015Corrigendum: Voltage-controlled enzymes: the new Janus Bifrons.Authorship 80973226217228Kohout SC, Villalba-Galea CAFrontiers in pharmacologyEditorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes. Front Pharmacol. 2015; 6:142.Front Pharmacol2015-07-08T00:00:002015Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes.Medicine-CardiologyChicago60637ILAuthorship 87068626880756Corbin-Leftwich A, Mossadeq SM, Ha J, Ruchala I, Le AH, Villalba-Galea CAThe Journal of general physiologyRetigabine holds KV7 channels open and stabilizes the resting potential. J Gen Physiol. 2016 Mar; 147(3):229-41.J Gen Physiol2016-02-15T00:00:002016Retigabine holds KV7 channels open and stabilizes the resting potential.RaymondHulseRaymond Hulse0.000000000000000.000000000000002740Hulse, RaymondPostdoctoral ScholarAuthorship 61354323359697Ruscic KJ, Miceli F, Villalba-Galea CA, Dai H, Mishina Y, Bezanilla F, Goldstein SAProceedings of the National Academy of Sciences of the United States of AmericaIKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):E559-66.Proc Natl Acad Sci U S A2013-01-28T00:00:002013IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits.Authorship 96194127689426Villalba-Galea CAChannels (Austin, Tex.)Hysteresis in voltage-gated channels. Channels (Austin). 2017 Mar 04; 11(2):140-155.Channels (Austin)2016-09-30T00:00:002016Hysteresis in voltage-gated channels.