David Grdina to Radiation-Protective Agents
This is a "connection" page, showing publications David Grdina has written about Radiation-Protective Agents.
Connection Strength
7.659
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Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70.
Score: 0.443
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SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. Radiat Res. 2011 Jan; 175(1):57-65.
Score: 0.349
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Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009 Mar 01; 73(3):886-96.
Score: 0.310
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Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha. Radiat Res. 2007 Apr; 167(4):465-74.
Score: 0.272
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Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065. Free Radic Biol Med. 2006 Mar 15; 40(6):1004-16.
Score: 0.247
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Radioprotectors: current status and new directions. Radiat Res. 2005 Jun; 163(6):704-5.
Score: 0.239
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Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Int J Radiat Oncol Biol Phys. 2004 Oct 01; 60(2):553-63.
Score: 0.229
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Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol. 2002 Dec; 29(6 Suppl 19):22-8.
Score: 0.201
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Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine. Radiat Res. 2002 Jul; 158(1):101-9.
Score: 0.195
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Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Int J Radiat Oncol Biol Phys. 2002 May 01; 53(1):180-9.
Score: 0.193
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Relationships between cytoprotection and mutation prevention by WR-1065. Mil Med. 2002 Feb; 167(2 Suppl):51-3.
Score: 0.190
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Inhibition of spontaneous metastases formation by amifostine. Int J Cancer. 2002 Jan 10; 97(2):135-41.
Score: 0.189
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Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):103-11.
Score: 0.189
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Radioprotectants: current status and new directions. Oncology. 2002; 63 Suppl 2:2-10.
Score: 0.189
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Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. Int J Radiat Biol. 2000 May; 76(5):633-9.
Score: 0.168
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Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II. Cancer Res. 2000 Mar 01; 60(5):1186-8.
Score: 0.166
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Amifostine: mechanisms of action underlying cytoprotection and chemoprevention. Drug Metabol Drug Interact. 2000; 16(4):237-79.
Score: 0.164
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WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun-Jul; 30(6-7):283-94.
Score: 0.137
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Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells. Radiat Res. 2017 07; 188(1):66-74.
Score: 0.137
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The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutat Res. 1996 Sep 23; 356(2):147-54.
Score: 0.131
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Antimutagenic effects of amifostine: clinical implications. Semin Oncol. 1996 Aug; 23(4 Suppl 8):53-7.
Score: 0.130
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Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065. Cancer Res. 1995 Nov 01; 55(21):4788-92.
Score: 0.123
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The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention. Carcinogenesis. 1995 Nov; 16(11):2699-705.
Score: 0.123
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Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis. 1994 Jul; 9(4):355-60.
Score: 0.112
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Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065). Radiat Res. 1994 Apr; 138(1):44-52.
Score: 0.110
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Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. Cell Biol Toxicol. 2014 Feb; 30(1):55-66.
Score: 0.109
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Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection. Free Radic Biol Med. 2012 Nov 15; 53(10):1838-47.
Score: 0.099
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Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice. Int J Radiat Biol. 1992 Mar; 61(3):387-92.
Score: 0.096
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Reversion of radiosensitivity in azacytidine-treated XRS5 cells does not result in full radioprotection by WR-1065. Int J Radiat Oncol Biol Phys. 1992; 23(5):999-1002.
Score: 0.094
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Chemical protection and cell-cycle effects on radiation-induced mutagenesis. Cell Prolif. 1992 Jan; 25(1):23-9.
Score: 0.094
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Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326. Int J Radiat Oncol Biol Phys. 1992; 22(4):813-5.
Score: 0.094
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Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons. Adv Space Res. 1992; 12(2-3):257-63.
Score: 0.094
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Misoprostol, a PGE1 analog, protects mice from fission-neutron injury. Radiat Res. 1991 Oct; 128(1 Suppl):S12-7.
Score: 0.093
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Protection by WR-151327 against late-effect damage from fission-spectrum neutrons. Radiat Res. 1991 Oct; 128(1 Suppl):S124-7.
Score: 0.093
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The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation. Cell Prolif. 1991 May; 24(3):271-80.
Score: 0.090
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Association of WR-1065 with CHO AA8 cells, nuclei, and nucleoids. Radiat Res. 1991 Feb; 125(2):152-7.
Score: 0.089
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Pathological effects of the radiation protector WR-151327 in mice. Radiat Res. 1990 Oct; 124(1):79-84.
Score: 0.087
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Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat Res. 2010 Feb; 173(2):175-83.
Score: 0.083
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Protection by WR1065 and WR151326 against fission-neutron-induced mutations at the HGPRT locus in V79 cells. Radiat Res. 1989 Mar; 117(3):500-10.
Score: 0.078
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Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia. Radiat Res. 1989 Feb; 117(2):251-8.
Score: 0.077
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Radiation protectors: the unexpected benefits. Drug Metab Rev. 1989; 20(1):13-42.
Score: 0.077
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The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair. Br J Cancer. 1989 Jan; 59(1):17-21.
Score: 0.077
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Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J. 2009 Mar; 33(3):612-24.
Score: 0.076
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WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med. 2008 Dec 15; 45(12):1674-81.
Score: 0.075
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Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl. Experientia. 1988 Aug 15; 44(8):707-8.
Score: 0.075
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Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008 Aug; 84(8):623-34.
Score: 0.075
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Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors. Cell Tissue Kinet. 1988 May; 21(3):193-200.
Score: 0.073
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Radioprotectors in treatment therapy to reduce risk in secondary tumor induction. Pharmacol Ther. 1988; 39(1-3):21-5.
Score: 0.072
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Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression. Pharmacol Ther. 1988; 39(1-3):133-7.
Score: 0.072
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2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Radiat Res. 1988 Jan; 113(1):145-54.
Score: 0.072
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Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res. 1987 Oct; 112(1):156-63.
Score: 0.070
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Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2. Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Jul; 52(1):67-76.
Score: 0.069
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The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells. Br J Cancer. 1987 May; 55(5):477-82.
Score: 0.068
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The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells. Br J Cancer. 1986 Dec; 54(6):933-41.
Score: 0.066
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The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis. 1985 Jun; 6(6):929-31.
Score: 0.060
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Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiat Res. 2004 Nov; 162(5):536-46.
Score: 0.057
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Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochim Biophys Acta. 2003 Mar 20; 1637(2):151-5.
Score: 0.051
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Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic Biol Med. 2001 Jun 15; 30(12):1426-39.
Score: 0.045
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Radioprotection by WR-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation. Int J Radiat Oncol Biol Phys. 1994 Nov 15; 30(4):867-72.
Score: 0.029
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Accumulation of CHO cells in G2 phase following exposure to WR-1065. Radiat Res. 1991 May; 126(2):223-8.
Score: 0.023
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Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065. Br J Cancer. 1989 Dec; 60(6):893-6.
Score: 0.020
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Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Int J Radiat Oncol Biol Phys. 1986 Aug; 12(8):1475-8.
Score: 0.016
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A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiat Res. 1986 May; 106(2):224-33.
Score: 0.016
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Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol. Cancer Res. 1986 Mar; 46(3):1132-5.
Score: 0.016