GregoryDwyerGregory Dwyer41.78927490000000-87.601250000000002551Dwyer, GregoryHost-Pathogen InteractionsEco-evolutionary dynamicsMathematical ecolotyStatistical ComputingClimate ChangeQuantitative EcologyMy lab studies the ecology and evolution of pathogens, and how pathogens drive the evolution and population dynamics of their hosts. Two major questions that we ask are, how does host variation affect pathogen epidemics and pathogen evolution? And, how does pathogen variation modulate the effects of pathogens on host population dynamics? We attempt to answer these questions by first constructing mathematical models of host-pathogen dynamics, and then by testing the models using a combination of experiments and observations of epidemics in nature. We use insect pathogens as test systems, but the general usefulness of the advanced computing techniques that we use has led to studies of human papillomavirus and salmon conservation. Insect pathogens play a key role in preventing the destruction of forests, and this role has driven new projects on the ecology and economics of biological control, and on the effects of climate change on insect outbreaks.Professorplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1008543Authorship 101460426365355Fleming-Davies AE, Dukic V, Andreasen V, Dwyer GEcology lettersEffects of host heterogeneity on pathogen diversity and evolution. Ecol Lett. 2015 Nov; 18(11):1252-1261.Ecol Lett2015-09-14T00:00:002015Effects of host heterogeneity on pathogen diversity and evolution.27622965Hudson AI, Fleming-Davies AE, Páez DJ, Dwyer GJournal of evolutionary biologyGenotype-by-genotype interactions between an insect and its pathogen. J Evol Biol. 2016 12; 29(12):2480-2490.J Evol Biol2016-09-29T00:00:002016Genotype-by-genotype interactions between an insect and its pathogen.Authorship 104012428514636Páez DJ, Dukic V, Dushoff J, Fleming-Davies A, Dwyer GThe American naturalistEco-Evolutionary Theory and Insect Outbreaks. Am Nat. 2017 Jun; 189(6):616-629.Am Nat2017-04-05T00:00:002017Eco-Evolutionary Theory and Insect Outbreaks.Ecology and EvolutionAuthorship 1080362Authorship 1080375Authorship 108038Authorship 108039Authorship 108040Authorship 1080411Authorship 1080422Authorship 108043Authorship 108044Authorship 1080451Authorship 1080461Authorship 108047Authorship 1080483Authorship 108049Authorship 108050Authorship 108051Authorship 108052Authorship 108053Authorship 108061University of Chicago2014Quantrell Award for Excellence in Undergraduate TeachingEcological Society of America1998George Mercer Award for an Outstanding Paper by an Author of Age Less Than 40 1990University of WashingtonSeattle, WAUniversity of Washington, ZoologyPh.D.Zoology1983Cornell UniversityIthaca, NYCornell University, BiologyB.A. with HonorsBiology18811455Dwyer G, Elkinton JS, Hajek AEThe American naturalistSpatial scale and the spread of a fungal pathogen of gypsy moth. Am Nat. 1998 Sep; 152(3):485-94.Am Nat1998-09-01T00:00:001998Spatial scale and the spread of a fungal pathogen of gypsy moth.10856195Dwyer G, Dushoff J, Elkinton JS, Levin SAThe American naturalistPathogen-Driven Outbreaks in Forest Defoliators Revisited: Building Models from Experimental Data. Am Nat. 2000 Aug; 156(2):105-120.Am Nat2000-08-01T00:00:002000Pathogen-Driven Outbreaks in Forest Defoliators Revisited: Building Models from Experimental Data.Hunter, AF, and Dwyer, GIntegrative BiologyOutbreaks and interacting factors: Insect population explosions synthesized and dissected. Integrative Biology. 1998; 1:166-177.1998-01-01T00:00:001998Outbreaks and interacting factors: Insect population explosions synthesized and dissectedDwyer, G, and Elkinton, JSJ. Anim. Ecol.Using simple models to predict virus epizootics in gypsy-moth populations. J. Anim. Ecol. 1993; 62:1-11.1993-01-01T00:00:001993Using simple models to predict virus epizootics in gypsy-moth populationsDrury, K. L. S., J. M. Drake, D. M. Lodge, and G. Dwyer.Ecological ModellingImmigration events dispersed in space and time: factors affecting invasion success. Ecological Modelling. 2007; 206:63-78.2007-01-01T00:00:002007Immigration events dispersed in space and time: factors affecting invasion successDrake, J. M., Drury, K. L. S., Lodge, D. M., Blukacz, A., Yan, N. D., and Dwyer, G.Biological invasionsDemographic stochasticity, environmental variability, and windows of invasion risk for Bythotrephes longimanus in North America. Biological invasions. 2006; 8:843-861.2006-01-01T00:00:002006Demographic stochasticity, environmental variability, and windows of invasion risk for Bythotrephes longimanus in North AmericaDwyer, GEcologyThe roles of density, stage and patchiness in the transmission of an insect virus. Ecology. 1991; 72:559-574.1991-01-01T00:00:001991The roles of density, stage and patchiness in the transmission of an insect virus29208707Ranjeva SL, Baskerville EB, Dukic V, Villa LL, Lazcano-Ponce E, Giuliano AR, Dwyer G, Cobey SProceedings of the National Academy of Sciences of the United States of AmericaRecurring infection with ecologically distinct HPV types can explain high prevalence and diversity. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13573-13578.Proc Natl Acad Sci U S A2017-12-05T00:00:002017Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity.D'Amico, V., Elkinton, J. S., Dwyer, G., Willis, R. B., and Montgomery, M. E.EcologyFoliage damage does not affect within-season transmission of an insect virus. Ecology. 1998; 79:1104-1110.1998-01-01T00:00:001998Foliage damage does not affect within-season transmission of an insect virusD'Amico, V, Elkinton, JS, Dwyer, G, Burand, JP, Buonaccorsi, JPEcologyVirus transmission in gypsy moths is not a mass-action process. Ecology. 1996; 77:201-206.1996-01-01T00:00:001996Virus transmission in gypsy moths is not a mass-action processDwyer, GAm NatDensity-dependence and spatial structure in the dynamics of insect pathogens. Am Nat. 1994; 143:533-562.1994-01-01T00:00:001994Density-dependence and spatial structure in the dynamics of insect pathogensDwyer, G, Levin, SA, and Buttel, LEcological MonographsA simulation model of the population dynamics and evolution of myxomatosis. Ecological Monographs. 1990; 60:423-447.1990-01-01T00:00:001990A simulation model of the population dynamics and evolution of myxomatosis29590105Kennedy DA, Dwyer GPLoS biologyEffects of multiple sources of genetic drift on pathogen variation within hosts. PLoS Biol. 2018 03; 16(3):e2004444.PLoS Biol2018-03-28T00:00:002018Effects of multiple sources of genetic drift on pathogen variation within hosts.18811331Dwyer G, Elkinton JS, Buonaccorsi JPThe American naturalistHost heterogeneity in susceptibility and disease dynamics: tests of a mathematical model. Am Nat. 1997 Dec; 150(6):685-707.Am Nat1997-12-01T00:00:001997Host heterogeneity in susceptibility and disease dynamics: tests of a mathematical model.18811264Morris WF, Dwyer GThe American naturalistPopulation consequences of constitutive and inducible plant resistance: herbivore spatial spread. Am Nat. 1997 Jun; 149(6):1071-90.Am Nat1997-06-01T00:00:001997Population consequences of constitutive and inducible plant resistance: herbivore spatial spread.Elkinton, JS, Dwyer, G, and Sharov, AComputers and Electronics in AgricultureModelling the epizootiology of gypsy moth nuclear polyhedrosis virus. Computers and Electronics in Agriculture. 1995; 13:91-102.1995-01-01T00:00:001995Modelling the epizootiology of gypsy moth nuclear polyhedrosis virus11475051Perry WL, Feder JL, Dwyer G, Lodge DMEvolution; international journal of organic evolutionHybrid zone dynamics and species replacement between Orconectes crayfishes in a northern Wisconsin lake. Evolution. 2001 Jun; 55(6):1153-66.Evolution2001-06-01T00:00:002001Hybrid zone dynamics and species replacement between Orconectes crayfishes in a northern Wisconsin lake.Dwyer, G, and Elkinton, JSEcologyHost dispersal and the spatial spread of insect pathogens. Ecology. 1995; 143:533-562.1995-01-01T00:00:001995Host dispersal and the spatial spread of insect pathogensDwyer, GEcologyOn the spatial spread of insect pathogens: theory and experiment. Ecology. 1992; 73:479-494.1992-01-01T00:00:001992On the spatial spread of insect pathogens: theory and experimentMedicine-GastroenterologyAuthorship 163582D009036Living Beings13310.958177MothsAuthorship 252261Authorship 132506531444482Ranjeva SL, Mihaljevic JR, Joseph MB, Giuliano AR, Dwyer GThe ISME journalUntangling the dynamics of persistence and colonization in microbial communities. ISME J. 2019 12; 13(12):2998-3010.ISME J2019-08-23T00:00:002019Untangling the dynamics of persistence and colonization in microbial communities.Authorship 265741Authorship 306353Authorship 289182Authorship 361662Authorship 294981Authorship 295492Authorship 134443231738098Gallagher ME, Dwyer GThe American naturalistCombined Effects of Natural Enemies and Competition for Resources on a Forest Defoliator: A Theoretical and Empirical Analysis. Am Nat. 2019 12; 194(6):807-822.Am Nat2019-10-23T00:00:002019Combined Effects of Natural Enemies and Competition for Resources on a Forest Defoliator: A Theoretical and Empirical Analysis.Authorship 327742Authorship 364733Authorship 136062532097039Kyle CH, Liu J, Gallagher ME, Dukic V, Dwyer GThe American naturalistStochasticity and Infectious Disease Dynamics: Density and Weather Effects on a Fungal Insect Pathogen. Am Nat. 2020 03; 195(3):504-523.Am Nat2020-01-15T00:00:002020Stochasticity and Infectious Disease Dynamics: Density and Weather Effects on a Fungal Insect Pathogen.Authorship 136480632216670Mihaljevic JR, Polivka CM, Mehmel CJ, Li C, Dukic V, Dwyer GThe American naturalistAn Empirical Test of the Role of Small-Scale Transmission in Large-Scale Disease Dynamics. Am Nat. 2020 04; 195(4):616-635.Am Nat2020-03-03T00:00:002020An Empirical Test of the Role of Small-Scale Transmission in Large-Scale Disease Dynamics.Authorship 410503Authorship 138462332579548Polivka CM, Mihaljevic JR, Dwyer GPloS oneUse of a mechanistic growth model in evaluating post-restoration habitat quality for juvenile salmonids. PLoS One. 2020; 15(6):e0234072.PLoS One2020-06-24T00:00:002020Use of a mechanistic growth model in evaluating post-restoration habitat quality for juvenile salmonids.Authorship 475683Authorship 197022Authorship 46280310458161Stahl EA, Dwyer G, Mauricio R, Kreitman M, Bergelson JNatureDynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis. Nature. 1999 Aug 12; 400(6745):667-71.Nature1999-08-12T00:00:001999Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis.D007814Living Beings571170.950199Larva11700291Bergelson J, Dwyer G, Emerson JJAnnual review of geneticsModels and data on plant-enemy coevolution. Annu Rev Genet. 2001; 35:469-99.Annu Rev Genet2001-01-01T00:00:002001Models and data on plant-enemy coevolution.15729637Dwyer G, Firestone J, Stevens TEThe American naturalistShould models of disease dynamics in herbivorous insects include the effects of variability in host-plant foliage quality? Am Nat. 2005 Jan; 165(1):16-31.Am Nat2004-11-19T00:00:002004Should models of disease dynamics in herbivorous insects include the effects of variability in host-plant foliage quality?16670978Dwyer G, Morris WFThe American naturalistResource-dependent dispersal and the speed of biological invasions. Am Nat. 2006 Feb; 167(2):165-76.Am Nat2005-12-12T00:00:002005Resource-dependent dispersal and the speed of biological invasions.16685639Crozier L, Dwyer GThe American naturalistCombining population-dynamic and ecophysiological models to predict climate-induced insect range shifts. Am Nat. 2006 Jun; 167(6):853-66.Am Nat2006-06-01T00:00:002006Combining population-dynamic and ecophysiological models to predict climate-induced insect range shifts.15254536Dwyer G, Dushoff J, Yee SHNatureThe combined effects of pathogens and predators on insect outbreaks. Nature. 2004 Jul 15; 430(6997):341-5.Nature2004-07-15T00:00:002004The combined effects of pathogens and predators on insect outbreaks.17030819Elderd BD, Dukic VM, Dwyer GProceedings of the National Academy of Sciences of the United States of AmericaUncertainty in predictions of disease spread and public health responses to bioterrorism and emerging diseases. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15693-7.Proc Natl Acad Sci U S A2006-10-09T00:00:002006Uncertainty in predictions of disease spread and public health responses to bioterrorism and emerging diseases.17714279Abbott KC, Dwyer GThe Journal of animal ecologyFood limitation and insect outbreaks: complex dynamics in plant-herbivore models. J Anim Ecol. 2007 Sep; 76(5):1004-14.J Anim Ecol2007-09-01T00:00:002007Food limitation and insect outbreaks: complex dynamics in plant-herbivore models.18976065Elderd BD, Dushoff J, Dwyer GThe American naturalistHost-pathogen interactions, insect outbreaks, and natural selection for disease resistance. Am Nat. 2008 Dec; 172(6):829-42.Am Nat2008-12-01T00:00:002008Host-pathogen interactions, insect outbreaks, and natural selection for disease resistance.16475089Drury KL, Dwyer GThe American naturalistCombining stochastic models with experiments to understand the dynamics of monarch butterfly colonization. Am Nat. 2005 Dec; 166(6):731-50.Am Nat2005-10-04T00:00:002005Combining stochastic models with experiments to understand the dynamics of monarch butterfly colonization.21951910Barrett LG, Bell T, Dwyer G, Bergelson JEcology lettersCheating, trade-offs and the evolution of aggressiveness in a natural pathogen population. Ecol Lett. 2011 Nov; 14(11):1149-57.Ecol Lett2011-09-23T00:00:002011Cheating, trade-offs and the evolution of aggressiveness in a natural pathogen population.20384645Parker BJ, Elderd BD, Dwyer GThe Journal of animal ecologyHost behaviour and exposure risk in an insect-pathogen interaction. J Anim Ecol. 2010 Jul; 79(4):863-70.J Anim Ecol2010-04-09T00:00:002010Host behaviour and exposure risk in an insect-pathogen interaction.18821838Abbott KC, Dwyer GThe American naturalistUsing mechanistic models to understand synchrony in forest insect populations: the North American gypsy moth as a case study. Am Nat. 2008 Nov; 172(5):613-24.Am Nat2008-11-01T00:00:002008Using mechanistic models to understand synchrony in forest insect populations: the North American gypsy moth as a case study.22322229Fuller E, Elderd BD, Dwyer GThe American naturalistPathogen persistence in the environment and insect-baculovirus interactions: disease-density thresholds, epidemic burnout, and insect outbreaks. Am Nat. 2012 Mar; 179(3):E70-96.Am Nat2012-01-27T00:00:002012Pathogen persistence in the environment and insect-baculovirus interactions: disease-density thresholds, epidemic burnout, and insect outbreaks.Authorship 151938134978965Dwyer G, Mihaljevic JR, Dukic VThe American naturalistCan Eco-Evo Theory Explain Population Cycles in the Field? Am Nat. 2022 01; 199(1):108-125.Am Nat2021-11-22T00:00:002021Can Eco-Evo Theory Explain Population Cycles in the Field?D054884Phenomena1082300.827518Host-Pathogen InteractionsD016367Living Beings17340.977959Baculoviridaehttp://www.thorntonlab.orgThornton Lab websitehttps://cobeylab.uchicago.edu/Cobey Labhttps://voices.uchicago.edu/trevorpricelab/Price Lab websitehttps://voices.uchicago.edu/dwyerlab/Greg Dwyer Labhttp://bergelson.uchicago.eduMy laboratory websitehttp://manyuanlonglab.uchicago.edu/Long Lab Websitehttps://www.kronforstlab.org/Kronforst Lab Websitehttps://stefanoallesina.github.io/Allesina labsarahcobey2015-02-28NIHDWYER, GREGORY2010-09-01Natural Selection, Host-Pathogen Interactions, and Insect OutbreaksR01GM096655Principal InvestigatorD008954Concepts & IdeasDevices59917480.587465Models, BiologicalAuthorship 162037237130239Andreasen V, Dwyer GThe American naturalistSeasonality and the Coexistence of Pathogen Strains. Am Nat. 2023 05; 201(5):639-658.Am Nat2023-03-30T00:00:002023Seasonality and the Coexistence of Pathogen Strains.University of ChicagoMarcus R.KronforstMarcus R. Kronforst41.78927490000000-87.601250000000001048Kronforst, Marcus R.ProfessorStefanoAllesinaStefano Allesina41.78927490000000-87.601250000000001237Allesina, StefanoProfessorEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorJosephThorntonJoseph Thornton41.78927490000000-87.601250000000001722Thornton, JosephProfessorMartinKreitman2ml7DoF1GuTQkntjbwjr93A=Martin Kreitman41.78927490000000-87.601250000000002043Kreitman, MartinProfessorTrevor D.PriceTrevor D. Price41.78927490000000-87.601250000000002239Price, Trevor D.Professor7.466720.00782576121research areas0.200280.01133583coauthor of31.50763.7937960similar to1150selected publicationsManyuanLongManyuan Long41.78927490000000-87.601250000000002617Long, ManyuanProfessorJoyBergelsonJoy Bergelson41.78927490000000-87.60125000000000464Bergelson, JoyResearch ProfessorMichael Z.LudwigMichael Z. Ludwig41.78927490000000-87.60125000000000622Ludwig, Michael Z.Research Associate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Research ProfessorResearch Professortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 662813Authorship 665213Authorship 667802Authorship 687794Authorship 78153425141148Kennedy DA, Dukic V, Dwyer GThe American naturalistPathogen growth in insect hosts: inferring the importance of different mechanisms using stochastic models and response-time data. Am Nat. 2014 Sep; 184(3):407-23.Am Nat2014-08-07T00:00:002014Pathogen growth in insect hosts: inferring the importance of different mechanisms using stochastic models and response-time data.25560556Eakin L, Wang M, Dwyer GThe American naturalistThe effects of the avoidance of infectious hosts on infection risk in an insect-pathogen interaction. Am Nat. 2015 Jan; 185(1):100-12.Am Nat2014-11-19T00:00:002014The effects of the avoidance of infectious hosts on infection risk in an insect-pathogen interaction.23966566Elderd BD, Rehill BJ, Haynes KJ, Dwyer GProceedings of the National Academy of Sciences of the United States of AmericaInduced plant defenses, host-pathogen interactions, and forest insect outbreaks. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14978-83.Proc Natl Acad Sci U S A2013-08-21T00:00:002013Induced plant defenses, host-pathogen interactions, and forest insect outbreaks.24021521Elderd BD, Dwyer G, Dukic VEpidemicsPopulation-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics. Epidemics. 2013 Sep; 5(3):146-56.Epidemics2013-07-25T00:00:002013Population-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics.25905513Hughes JS, Cobbold CA, Haynes K, Dwyer GThe American naturalistEffects of forest spatial structure on insect outbreaks: insights from a host-parasitoid model. Am Nat. 2015 May; 185(5):E130-52.Am Nat2015-03-26T00:00:002015Effects of forest spatial structure on insect outbreaks: insights from a host-parasitoid model.1010Authorship 83554226201381Páez DJ, Fleming-Davies AE, Dwyer GJournal of evolutionary biologyEffects of pathogen exposure on life-history variation in the gypsy moth (Lymantria dispar). J Evol Biol. 2015 Oct; 28(10):1828-39.J Evol Biol2015-08-08T00:00:002015Effects of pathogen exposure on life-history variation in the gypsy moth (Lymantria dispar).Authorship 84918226655986Fleming-Davies AE, Dwyer GThe American naturalistPhenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence. Am Nat. 2015 Dec; 186(6):797-806.Am Nat2015-10-15T00:00:002015Phenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence.Chicago60637ILSarah E.CobeySarah E. Cobey0.000000000000000.000000000000002698Cobey, Sarah E.Professor