XiaoxiZhuangz3hhHqAbHszMknJtY0fp/Cv/+94=Xiaoxi Zhuang41.78927490000000-87.60125000000000285Zhuang, Xiaoxidopamine, basal ganglia, plasticity, learning, memory, neurological disorders, psychiatric disordersWe investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10712252027-06-30NIHHEDEKER, DONALD ;ZHUANG, XIAOXI2017-07-01Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469Anesthesia and Critical CareD003342Anatomy38860.9371Corpus StriatumNeurobiologyAuthorship 1092101230056831Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, Zhuang XNeuronMettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning. Neuron. 2018 07 25; 99(2):283-292.e5.Neuron2018-06-28T00:00:002018Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.D004298Chemicals & Drugs842750.860372DopamineAuthorship 2679610D009473Physiology711870.830156Neuronal PlasticityAuthorship 266901Authorship 303596Authorship 364604Authorship 339639Authorship 469063Authorship 393286Authorship 432414Authorship 412248Authorship 487547Authorship 49093315799973Chen L, Cagniard B, Mathews T, Jones S, Koh HC, Ding Y, Carvey PM, Ling Z, Kang UJ, Zhuang XThe Journal of biological chemistryAge-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 2005 Jun 03; 280(22):21418-26.J Biol Chem2005-03-30T00:00:002005Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.15763133Zhuang X, Masson J, Gingrich JA, Rayport S, Hen RJournal of neuroscience methodsTargeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods. 2005 Apr 15; 143(1):27-32.J Neurosci Methods2004-11-24T00:00:002004Targeted gene expression in dopamine and serotonin neurons of the mouse brain.Authorship 144543633617535Chi W, Liu W, Fu W, Xia S, Heckscher ES, Zhuang XPLoS geneticsRNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.PLoS Genet2021-02-22T00:00:002021RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila.18184785Chen L, Ding Y, Cagniard B, Van Laar AD, Mortimer A, Chi W, Hastings TG, Kang UJ, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceUnregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci. 2008 Jan 09; 28(2):425-33.J Neurosci2008-01-09T00:00:002008Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.19793969Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceAdenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci. 2009 Sep 30; 29(39):12115-24.J Neurosci2009-09-30T00:00:002009Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.16950153Cagniard B, Beeler JA, Britt JP, McGehee DS, Marinelli M, Zhuang XNeuronDopamine scales performance in the absence of new learning. Neuron. 2006 Sep 07; 51(5):541-7.Neuron2006-09-07T00:00:002006Dopamine scales performance in the absence of new learning.20437561Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang XAnnals of neurologyDopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol. 2010 May; 67(5):639-47.Ann Neurol2010-05-01T00:00:002010Dopamine-dependent motor learning: insight into levodopa's long-duration response.22118191Beeler JA, Frazier CR, Zhuang XThe European journal of neuroscienceDopaminergic enhancement of local food-seeking is under global homeostatic control. Eur J Neurosci. 2012 Jan; 35(1):146-59.Eur J Neurosci2011-11-27T00:00:002011Dopaminergic enhancement of local food-seeking is under global homeostatic control.22712685Beeler JA, McCutcheon JE, Cao ZF, Murakami M, Alexander E, Roitman MF, Zhuang XThe European journal of neuroscienceTaste uncoupled from nutrition fails to sustain the reinforcing properties of food. Eur J Neurosci. 2012 Aug; 36(4):2533-46.Eur J Neurosci2012-06-19T00:00:002012Taste uncoupled from nutrition fails to sustain the reinforcing properties of food.18971482Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceA cAMP pathway underlying reward prediction in associative learning. J Neurosci. 2008 Oct 29; 28(44):11401-8.J Neurosci2008-10-29T00:00:002008A cAMP pathway underlying reward prediction in associative learning.21120145Beeler JA, Daw N, Frazier CR, Zhuang XFrontiers in behavioral neuroscienceTonic dopamine modulates exploitation of reward learning. Front Behav Neurosci. 2010; 4:170.Front Behav Neurosci2010-11-04T00:00:002010Tonic dopamine modulates exploitation of reward learning.22833718Beeler JA, Frazier CR, Zhuang XFrontiers in integrative neurosciencePutting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci. 2012; 6:49.Front Integr Neurosci2012-07-20T00:00:002012Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources.Authorship 153193735217610Chi W, Iyengar ASR, Fu W, Liu W, Berg AE, Wu CF, Zhuang XProceedings of the National Academy of Sciences of the United States of AmericaDrosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes. Proc Natl Acad Sci U S A. 2022 03 01; 119(9).Proc Natl Acad Sci U S A2022-03-01T00:00:002022Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes.Authorship 1587621036028313Zhang HJ, Zammit M, Kao CM, Govind AP, Mitchell S, Holderman N, Bhuiyan M, Freifelder R, Kucharski A, Zhuang X, Mukherjee J, Chen CT, Green WNThe Journal of neuroscience : the official journal of the Society for NeuroscienceTrapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging. J Neurosci. 2023 01 04; 43(1):2-13.J Neurosci2022-08-26T00:00:002022Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging.ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://neurobiology.uchicago.edu/page/wei-weiDepartmental Sitehttp://voices.uchicago.edu/drsisodialab/Sisodia Labhttp://he-group.uchicago.eduMy Lab Sitehttps://cpb-us-w2.wpmucdn.com/voices.uchicago.edu/dist/e/772/files/2019/10/ACFrOgCOWaX1k-0F2phup4Kdbe_UAJxPHs-eXWdz39eZftkvJP7iTAjzrBTAsWiLe56mP9fcDklTlbjhSM51HQSgUi5KmcOHeOnzQgwUSY10fRhBD4-L14dlPBG7hpM.pdfZhuang Labhttp://www.hansellab-uchicago.comHansel Lab websitehttp://voices.uchicago.edu/weilab/Lab Website2024-11-30NIHZHUANG, XIAOXI2019-12-01Drosophila and mouse models of PNPO deficiencyR01NS1111222011-07-31NIHZHUANG, XIAOXI2010-08-15Reward mechanisms in feeding and obesityR56DK0885152020-02-29NIHDELGADO, JARY YAMIR2018-03-01Dynamics of m6A methylated Arc mRNAR21NS1031592022-05-31NIHZHUANG, XIAOXI2017-09-01RNA methylation in synaptic plasticity and drug-seekingR01DA0433612011-08-31NIHZHUANG, XIAOXI2009-09-01Targeting adenylyl cyclase to prevent L-DOPA-induced dyskinesiaR21NS0624252015-03-31NIHZHUANG, XIAOXI2013-04-01Nicotine mitigates dopamine blockade-induced aberrant plasticity and learningR21NS0833832012-01-31NIHZHUANG, XIAOXI2010-02-01Animal models of dopamine-independent motor controlR21NS0702692010-04-30NIHZHUANG, XIAOXI2008-06-01Gene Dose Effect of DJ-1 and PINK1 on Tissue DegenerationR03NS0584152021-04-30NIHZHUANG, XIAOXI2016-05-15Preventing Experience Dependent Aberrant Plasticity Under Dopamine DeficiencyR01NS0953742017-03-31NIHZHUANG, XIAOXI2012-04-01Genomic analysis of feeding behavior and fitness in DrosophilaR01GM1007682004-08-31NIHZHUANG, XIAOXI2001-09-28MUTAGENESIS PERMITTING CONTROLLED GENE EXPRESSIONR21AR0488082017-06-30NIHZHUANG, XIAOXI2015-07-01Genetic dissection of neural pathways for appetitive associative learningR21DA0396292024-07-31NIHDICKINSON, BRYAN ;ZHUANG, XIAOXI2019-09-25Base-resolution mapping and site-specific epitranscriptomic studies in the brainR01MH1221422008-11-30NIHZHUANG, XIAOXI2003-12-03GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROLR01MH0662162008-08-31NIHZHUANG, XIAOXI2006-09-25Epigenetic Mechanisms in Motor Habits StabilityR03DA022269Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorD007858Physiology1362790.773369LearningD017448Chemicals & Drugs24570.950398Receptors, Dopamine D2ChemistryUniversity of ChicagoLinanChenLinan Chen41.78927490000000-87.601250000000001041Chen, LinanYunminDingYunmin Ding41.78927490000000-87.601250000000001187Ding, YunminRes Assoc (Assoc Prof)PaulVezinaPaul Vezina41.78927490000000-87.601250000000001492Vezina, PaulPROFESSORPeggyMasonPeggy Mason41.78927490000000-87.601250000000001594Mason, PeggyProfessorWeiWeiwGdgHIF1GuTQkntjbwjr93A=Wei Wei41.78927490000000-87.601250000000001677Wei, WeiProfessorJeffBeelerJeff A. Beeler41.78927490000000-87.601250000000002389Beeler, Jeff2.779410.029661160research areas3.616440.05598588coauthor of32.24737.1324860similar to1123selected publicationsElizabethGroveElizabeth Grove41.78927490000000-87.60125000000000473Grove, ElizabethProfessorSangram S.SisodiaxHF6ArIaHeX5hHlsaUXv9Gq0+s+oSangram S. Sisodia41.78927490000000-87.60125000000000510Sisodia, Sangram S.ProfessorChristian R.Hansel1GpoBbIQFczMknJtY0fp/Cv/+94=Christian R. Hansel41.78927490000000-87.60125000000000738Hansel, Christian R.ProfessorDaniel S.Mc Gehee029qDKQdHOn5lXtnYwj78G3z/Mq65vtbdGw=Daniel S. Mc Gehee41.78927490000000-87.60125000000000956Mc Gehee, Daniel S.ProfessorAuthorship 1682581137949069Zou Z, Wei J, Chen Y, Kang Y, Shi H, Yang F, Shi Z, Chen S, Zhou Y, Sepich-Poore C, Zhuang X, Zhou X, Jiang H, Wen Z, Jin P, Luo C, He CMolecular cellFMRP phosphorylation modulates neuronal translation through YTHDF1. Mol Cell. 2023 Dec 07; 83(23):4304-4317.e8.Mol Cell2023-11-09T00:00:002023FMRP phosphorylation modulates neuronal translation through YTHDF1.http://weiw@uchicago.eduEmail: weiw@uchicago.edu2025-05-31NIHZHUANG, XIAOXI2023-06-01Generating mouse models with cell type-specific and reversible GABA deficiencyR21NS132597Principal InvestigatorAuthorship 170902938483349Kahl M, Xu Z, Arumugam S, Edens B, Fischietti M, Zhu AC, Platanias LC, He C, Zhuang X, Ma YCHuman molecular geneticsm6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 Mar 14.Hum Mol Genet2024-03-14T00:00:002024m6A RNA methylation regulates mitochondrial function.true1true1true1ProfessorProfessortrue1Res Assoc (Assoc Prof)Res Assoc (Assoc Prof)true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1PROFESSORPROFESSORAuthorship 661724Authorship 73187425609609Chen L, Xie Z, Turkson S, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceA53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci. 2015 Jan 21; 35(3):890-905.J Neurosci2015-01-21T00:00:002015A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.24806695Augustin SM, Beeler JA, McGehee DS, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceCyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci. 2014 May 07; 34(19):6692-9.J Neurosci2014-05-07T00:00:002014Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons.BSD-NeurologyPsychiatry & Behav. NeurosciChicago60637ILAuthorship 89700727170121Koranda JL, Krok AC, Xu J, Contractor A, McGehee DS, Beeler JA, Zhuang XThe Journal of neuroscience : the official journal of the Society for NeuroscienceChronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency. J Neurosci. 2016 05 11; 36(19):5228-40.J Neurosci2016-05-11T00:00:002016Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency.26281715Beeler JA, Faust RP, Turkson S, Ye H, Zhuang XBiological psychiatryLow Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. Biol Psychiatry. 2016 06 01; 79(11):887-97.Biol Psychiatry2015-07-26T00:00:002015Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.Authorship 621201Authorship 60906923246005Beeler JA, Frank MJ, McDaid J, Alexander E, Turkson S, Bernardez Sarria MS, Bernandez MS, McGehee DS, Zhuang XCell reportsA role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease. Cell Rep. 2012 Dec 27; 2(6):1747-61.Cell Rep2012-12-13T00:00:002012A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.23588357Zhuang X, Mazzoni P, Kang UJNature reviews. NeurologyThe role of neuroplasticity in dopaminergic therapy for Parkinson disease. Nat Rev Neurol. 2013 May; 9(5):248-56.Nat Rev Neurol2013-04-16T00:00:002013The role of neuroplasticity in dopaminergic therapy for Parkinson disease.