IvanMoskowitz3m9mGKoaDuXNi1pxY07n8GT98IW47aA=Ivan Moskowitz41.78927490000000-87.6012500000000037Moskowitz, IvanGenetics, MolecularGeneticsGenomicsDevelopmental BiologyDevelopmental Gene Expression RegulationTranscriptional Regulatory ElementsHeart DevelopmentCongenital Heart DiseaseCardiac RhythmCardiac ArrhythmiasThe Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).Professorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 105720728628087Werner MS, Sullivan MA, Shah RN, Nadadur RD, Grzybowski AT, Galat V, Moskowitz IP, Ruthenburg AJNature structural & molecular biologyChromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. Nat Struct Mol Biol. 2017 Jul; 24(7):596-603.Nat Struct Mol Biol2017-06-19T00:00:002017Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.06/2006Harvard Medical SchoolBoston, MAHarvard Medical School, GeneticsFellowshipGenetics06/2001Children's HospitalBoston, MAChildren's Hospital, Congenital Heart DiseaseFellowshipCongenital Heart Disease06/2000Brigham and Women’s HospitalBoston, MA Brigham and Women’s Hospital, PathologyResidencyPathology06/1998University of Wisconsin, School of MedicineMadison, WIUniversity of Wisconsin, School of Medicine, BiochemistryM.D./Ph.D.Biochemistry06/1994Marine Biological LaboratoryWoods Hole, MAMarine Biological Laboratory, EmbryologyEmbryology06/1988Wesleyan UniversityMiddletown, CTWesleyan University, Biochemistry/Molecular BiologyB.A.Biochemistry/Molecular BiologyAmerican Heart Association2015Fellow of the American Heart AssociationAmerican Society of Clinical Investigation2014American Society of Clinical InvestigationAmerican Heart Association2013Established Investigator AwardAmerican Heart Association2006Louis N. and Arnold M. Katz Basic Research PrizeAuthorship 1079072029280435Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IPeLifeTranscription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 12 27; 6.Elife2017-12-27T00:00:002017Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.Anesthesia and Critical CareOrganismal Biology and AnatomyMedicine-Genetic MedicineAuthorship 109101829988018Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MAeLifeA promoter interaction map for cardiovascular disease genetics. Elife. 2018 07 10; 7.Elife2018-07-10T00:00:002018A promoter interaction map for cardiovascular disease genetics.Authorship 1134454Authorship 11347123Authorship 1217919Authorship 125108830352852Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IPProceedings of the National Academy of Sciences of the United States of AmericaEvolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10615-E10624.Proc Natl Acad Sci U S A2018-10-23T00:00:002018Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.30315164Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Das S, van Berlo JH, Garry MG, Garry DJNature communicationsA conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human. Nat Commun. 2018 10 12; 9(1):4237.Nat Commun2018-10-12T00:00:002018A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.30429326Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang YProceedings of the National Academy of Sciences of the United States of AmericaGenetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11349-E11358.Proc Natl Acad Sci U S A2018-11-14T00:00:002018Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.29654098Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJCirculation. Genomic and precision medicineFunctional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research. Circ Genom Precis Med. 2018 04; 11(4):e002178.Circ Genom Precis Med2018-04-01T00:00:002018Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.D006321Anatomy1975380.785182HeartAuthorship 131151Authorship 1284871530896405Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CReLifeA calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8.Elife2019-03-21T00:00:002019A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.Authorship 185999Authorship 129735631120883Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie LPLoS geneticsGata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711.PLoS Genet2019-05-23T00:00:002019Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.Authorship 197794FrancoisSpitz0XF5ArUPOfnamXNnYUHhvWD+6g==Francois Spitz41.7886000000000087.598699999999993775Spitz, FrancoisProfessorAuthorship 227042Authorship 232033Authorship 237194Authorship 253291Authorship 270132Authorship 324461Authorship 285022Authorship 319914Authorship 133562931609246Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IPThe Journal of clinical investigationAtrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. J Clin Invest. 2019 11 01; 129(11):4937-4950.J Clin Invest2019-11-01T00:00:002019Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.Authorship 313857Authorship 375068Authorship 4172812Authorship 448125Authorship 451789Authorship 367182Authorship 135125931915147Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IPDevelopment (Cambridge, England)Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 02 05; 147(3).Development2020-02-05T00:00:002020Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.Authorship 3550312Authorship 378815Authorship 492586Authorship 135729632040509Sun X, Wang Z, Hall JM, Perez-Cervantes C, Ruthenburg AJ, Moskowitz IP, Gribskov M, Yang XHPLoS computational biologyChromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq. PLoS Comput Biol. 2020 02; 16(2):e1007119.PLoS Comput Biol2020-02-10T00:00:002020Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.Authorship 366983Authorship 136476532208162Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IPDevelopmental cellPhosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Dev Cell. 2020 03 23; 52(6):699-713.e11.Dev Cell2020-03-23T00:00:002020Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.Authorship 400918Authorship 1369231432290757Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IPCirculation researchTranscriptional Patterning of the Ventricular Cardiac Conduction System. Circ Res. 2020 07 17; 127(3):e94-e106.Circ Res2020-04-15T00:00:002020Transcriptional Patterning of the Ventricular Cardiac Conduction System.Authorship 1371232032347164Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CRCirculation researchZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43.Circ Res2020-04-29T00:00:002020ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.Authorship 440421Authorship 4879710Authorship 446992Authorship 449036Authorship 448663Authorship 1383181632561646Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IPProceedings of the National Academy of Sciences of the United States of AmericaHedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15712-15723.Proc Natl Acad Sci U S A2020-06-19T00:00:002020Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.Authorship 1394981532717170van Ouwerkerk AF, Hall AW, Kadow ZA, Lazarevic S, Reyat JS, Tucker NR, Nadadur RD, Bosada FM, Bianchi V, Ellinor PT, Fabritz L, Martin JF, de Laat W, Kirchhof P, Moskowitz IP, Christoffels VMCirculation researchEpigenetic and Transcriptional Networks Underlying Atrial Fibrillation. Circ Res. 2020 06 19; 127(1):34-50.Circ Res2020-06-18T00:00:002020Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.Authorship 93781D014158Physiology38111350.694138Transcription, GeneticAuthorship 1402851432841220Lipovsky CE, Jimenez J, Guo Q, Li G, Yin T, Hicks SC, Bhatnagar S, Takahashi K, Zhang DM, Brumback BD, Goldsztejn U, Nadadur RD, Perez-Cervantez C, Moskowitz IP, Liu S, Zhang B, Rentschler SLJCI insightChamber-specific transcriptional responses in atrial fibrillation. JCI Insight. 2020 09 17; 5(18).JCI Insight2020-09-17T00:00:002020Chamber-specific transcriptional responses in atrial fibrillation.Authorship 4149611Authorship 4830639012530Moskowitz IP, Rothman JHDevelopment (Cambridge, England)lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans. Development. 1996 Dec; 122(12):4105-17.Development1996-12-01T00:00:001996lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.11230104McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JGCirculation researchComparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9.Circ Res2001-03-02T00:00:002001Comparison of two murine models of familial hypertrophic cardiomyopathy.11723028Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JGCirculationVentricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9.Circulation2001-11-27T00:00:002001Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.14595838Wakimoto H, Kasahara H, Maguire CT, Moskowitz IP, Izumo S, Berul CIGenesis (New York, N.Y. : 2000)Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice. Genesis. 2003 Nov; 37(3):144-50.Genesis2003-11-01T00:00:002003Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.15289437Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JGDevelopment (Cambridge, England)The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004 Aug; 131(16):4107-16.Development2004-08-01T00:00:002004The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.12957447Patel VV, Arad M, Moskowitz IP, Maguire CT, Branco D, Seidman JG, Seidman CE, Berul CIJournal of the American College of CardiologyElectrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 2003 Sep 03; 42(5):942-51.J Am Coll Cardiol2003-09-03T00:00:002003Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.15866168Kontani K, Moskowitz IP, Rothman JHDevelopmental cellRepression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Dev Cell. 2005 May; 8(5):787-94.Dev Cell2005-05-01T00:00:002005Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.Pediatrics-Hematology and Oncology17604724Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CECellA molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 2007 Jun 29; 129(7):1365-76.Cell2007-06-29T00:00:002007A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.16332958Wolf CM, Moskowitz IP, Arno S, Branco DM, Semsarian C, Bernstein SA, Peterson M, Maida M, Morley GE, Fishman G, Berul CI, Seidman CE, Seidman JGProceedings of the National Academy of Sciences of the United States of AmericaSomatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18123-8.Proc Natl Acad Sci U S A2005-12-06T00:00:002005Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.17459410Viswanathan S, Burch JB, Fishman GI, Moskowitz IP, Benson DWJournal of molecular and cellular cardiologyCharacterization of sinoatrial node in four conduction system marker mice. J Mol Cell Cardiol. 2007 May; 42(5):946-53.J Mol Cell Cardiol2007-02-22T00:00:002007Characterization of sinoatrial node in four conduction system marker mice.17269130Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GIGenesis (New York, N.Y. : 2000)Complex genomic rearrangement in CCS-LacZ transgenic mice. Genesis. 2007 Feb; 45(2):76-82.Genesis2007-02-01T00:00:002007Complex genomic rearrangement in CCS-LacZ transgenic mice.18612386Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JGPloS oneThe role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS One. 2008 Jul 09; 3(7):e2642.PLoS One2008-07-09T00:00:002008The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.19267930Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJBMC geneticsA mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009 Mar 06; 10:12.BMC Genet2009-03-06T00:00:002009A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.20511334Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DRHuman molecular geneticsGenome-wide identification of mouse congenital heart disease loci. Hum Mol Genet. 2010 Aug 15; 19(16):3105-13.Hum Mol Genet2010-05-28T00:00:002010Genome-wide identification of mouse congenital heart disease loci.Authorship 146564934004872Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IPDevelopment (Cambridge, England)Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 Jan 01.Development2020-01-01T00:00:002020Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.21653639Friedland-Little JM, Hoffmann AD, Ocbina PJ, Peterson MA, Bosman JD, Chen Y, Cheng SY, Anderson KV, Moskowitz IPHuman molecular geneticsA novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet. 2011 Oct 01; 20(19):3725-37.Hum Mol Genet2011-06-08T00:00:002011A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.22898775Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IPDevelopmental cellTbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14; 23(2):280-91.Dev Cell2012-08-14T00:00:002012Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.Authorship 147276434144893Rowton M, Guzzetta A, Rydeen AB, Moskowitz IPSeminars in cell & developmental biologyControl of cardiomyocyte differentiation timing by intercellular signaling pathways. Semin Cell Dev Biol. 2021 10; 118:94-106.Semin Cell Dev Biol2021-06-16T00:00:002021Control of cardiomyocyte differentiation timing by intercellular signaling pathways.7720570Moskowitz IP, Gendreau SB, Rothman JHDevelopment (Cambridge, England)Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans. Development. 1994 Nov; 120(11):3325-38.Development1994-11-01T00:00:001994Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.20031619Dellefave LM, Pytel P, Mewborn S, Mora B, Guris DL, Fedson S, Waggoner D, Moskowitz I, McNally EMCirculation. Cardiovascular geneticsSarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation. Circ Cardiovasc Genet. 2009 Oct; 2(5):442-9.Circ Cardiovasc Genet2009-07-24T00:00:002009Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.Authorship 14810422Authorship 1481852234285246Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick MEScientific reportsAuthor Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2021 Jul 20; 11(1):15164.Sci Rep2021-07-20T00:00:002021Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.33093519Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick MEScientific reportsIdentifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2020 10 22; 10(1):18051.Sci Rep2020-10-22T00:00:002020Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.22728936Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IPThe Journal of clinical investigationTBX5 drives Scn5a expression to regulate cardiac conduction system function. J Clin Invest. 2012 Jul; 122(7):2509-18.J Clin Invest2012-06-25T00:00:002012TBX5 drives Scn5a expression to regulate cardiac conduction system function.Authorship 1496191834491912Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keles S, Moskowitz IP, Keller MP, Attie ADThe Journal of clinical investigationIdentification of direct transcriptional targets of NFATC2 that promote ß cell proliferation. J Clin Invest. 2021 11 01; 131(21).J Clin Invest2021-11-01T00:00:002021Identification of direct transcriptional targets of NFATC2 that promote ß cell proliferation.19029823King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JACell cycle (Georgetown, Tex.)E2F3 plays an essential role in cardiac development and function. Cell Cycle. 2008 Dec; 7(23):3775-80.Cell Cycle2008-12-22T00:00:002008E2F3 plays an essential role in cardiac development and function.D053263Physiology1642910.809052Gene Regulatory NetworksAuthorship 150334934643182Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AMeLifeTbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10.Elife2021-10-13T00:00:002021Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.21330551Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CEProceedings of the National Academy of Sciences of the United States of AmericaTranscription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11.Proc Natl Acad Sci U S A2011-02-17T00:00:002011Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]21552265Ocbina PJ, Eggenschwiler JT, Moskowitz I, Anderson KVNature geneticsComplex interactions between genes controlling trafficking in primary cilia. Nat Genet. 2011 Jun; 43(6):547-53.Nat Genet2011-05-08T00:00:002011Complex interactions between genes controlling trafficking in primary cilia.21563299Wang J, Chen L, Wen S, Zhu H, Yu W, Moskowitz IP, Shaw GM, Finnell RH, Schwartz RJBirth defects research. Part A, Clinical and molecular teratologyDefective sumoylation pathway directs congenital heart disease. Birth Defects Res A Clin Mol Teratol. 2011 Jun; 91(6):468-76.Birth Defects Res A Clin Mol Teratol2011-05-11T00:00:002011Defective sumoylation pathway directs congenital heart disease.22543974Smemo S, Campos LC, Moskowitz IP, Krieger JE, Pereira AC, Nobrega MAHuman molecular geneticsRegulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum Mol Genet. 2012 Jul 15; 21(14):3255-63.Hum Mol Genet2012-04-27T00:00:002012Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.12782567Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, Roden DM, Berul CI, Seidman CE, Seidman JGCirculationTransgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 2003 Jun 10; 107(22):2850-6.Circulation2003-06-02T00:00:002003Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.19026577Pytel P, Husain A, Moskowitz I, Raman J, MacLeod H, Anderson AS, Burke M, McNally EMCardiovascular pathology : the official journal of the Society for Cardiovascular PathologyVentricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy. Cardiovasc Pathol. 2010 Mar-Apr; 19(2):e33-6.Cardiovasc Pathol2008-11-21T00:00:002008Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.19369393Hoffmann AD, Peterson MA, Friedland-Little JM, Anderson SA, Moskowitz IPDevelopment (Cambridge, England)sonic hedgehog is required in pulmonary endoderm for atrial septation. Development. 2009 May; 136(10):1761-70.Development2009-04-15T00:00:002009sonic hedgehog is required in pulmonary endoderm for atrial septation.20587527Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LACancer researchDNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 2010 Jul 15; 70(14):5840-50.Cancer Res2010-06-29T00:00:002010DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.21504046Arnolds DE, Moskowitz IPGenesis (New York, N.Y. : 2000)Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice. Genesis. 2011 Nov; 49(11):878-84.Genesis2011-08-24T00:00:002011Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.21538814Arnolds DE, Chu A, McNally EM, Nobrega MA, Moskowitz IPBirth defects research. Part A, Clinical and molecular teratologyThe emerging genetic landscape underlying cardiac conduction system function. Birth Defects Res A Clin Mol Teratol. 2011 Jun; 91(6):578-85.Birth Defects Res A Clin Mol Teratol2011-04-28T00:00:002011The emerging genetic landscape underlying cardiac conduction system function.D053823Chemicals & Drugs53930.939486Hedgehog ProteinsAuthorship 15512910Authorship 155117635649376Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BLCell reportsDifferential Etv2 threshold requirement for endothelial and erythropoietic development. Cell Rep. 2022 05 31; 39(9):110881.Cell Rep2022-05-31T00:00:002022Differential Etv2 threshold requirement for endothelial and erythropoietic development.35640613Yang XH, Goldstein A, Sun Y, Wang Z, Wei M, Moskowitz IP, Cunningham JMNucleic acids researchDetecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors. Nucleic Acids Res. 2022 09 09; 50(16):e91.Nucleic Acids Res2022-09-09T00:00:002022Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.D020825Chemicals & Drugs431180.89214T-Box Domain Proteins36108627Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IPDevelopmental cellHedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9.Dev Cell2022-09-14T00:00:002022Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.Authorship 1604688Authorship 15866825Authorship 1605143036495293McLaughlin MT, Sun MR, Beames TG, Steward AC, Theisen JWM, Chung HM, Everson JL, Moskowitz IP, Sheets MD, Lipinski RJDevelopmental dynamics : an official publication of the American Association of AnatomistsFrem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 04; 252(4):483-494.Dev Dyn2022-12-19T00:00:002022Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.36524479Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Petropoulou E, Jamshidi Y, Benson MD, Keyes MJ, Ngo D, Vasan RS, Yang Q, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, Moskowitz IP, York JD, Wang TJ, Knollmann BC, Roden DMCirculationTranscriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023 03 07; 147(10):824-840.Circulation2022-12-16T00:00:002022Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://cweberlab.comChristopher Weber Labhttp://he-group.uchicago.eduMy Lab Sitehttps://pott-lab.uchicago.edu/Pott Labhttp://voices.uchicago.edu/spitzlab/Spitzlab website2021-02-28NIHCONLON, FRANK LEO2017-04-01Gene Regulatory Networks for Cardiac MorphogenesisR01HL1265092009-08-31NIHMOSKOWITZ, IVAN PAUL2004-09-15A Screen for Mouse Cardiovascular Morphogenesis MutantsK08HL0781802018-07-31NIHMOSKOWITZ, IVAN PAUL2008-04-01Genetic and Molecular Analysis of Congenital Heart DiseaseR01HL0921532023-07-31NIHMOSKOWITZ, IVAN PAUL ;RUTHENBURG, ALEXANDER JACKSON2019-08-17Gene Regulatory Non-Coding RNAs in the Human HeartR01HL1487192020-06-30NIHNOBREGA, MARCELO A.2014-08-08Functional Assays to Screen Genomic HitsR33HL1238572022-08-31NIHMOSKOWITZ, IVAN PAUL2020-09-01Gene Expression Networks for Human Cardiac Differentiation in Down SyndromeR21HD1009212017-03-31NIHMOSKOWITZ, IVAN PAUL2012-04-01Transcriptional Control of Cardiac Conduction System Function by T-box GenesR01HL1140102016-06-30NIHNOBREGA, MARCELO A.2014-08-08Functional Assays to Screen Genomic HitsR21HL1238572019-07-31NIHMOSKOWITZ, IVAN PAUL2014-08-01Etiology of Congenital Heart Disease in Down SyndromeR01HL124836Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorSebastianPottxHJmH7U1DO/RmHllZ0mg9mHvSebastian Pott0.000000000000000.000000000000003142Pott, Sebastian0000-0002-4118-6150Assistant ProfessorAuthorship 1620391937131696Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WTbioRxiv : the preprint server for biologyTbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv. 2023 Apr 22.bioRxiv2023-04-22T00:00:002023Tbx5 maintains atrial identity by regulating an atrial enhancer network.Authorship 1638431437330911Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami KCell reportsETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Rep. 2023 06 27; 42(6):112665.Cell Rep2023-06-17T00:00:002023ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.Ben May DepartmentChemistryHuman GeneticsMedicinePathologyPediatricsUniversity of ChicagoRobert K.HoRobert K. Ho41.78927490000000-87.601250000000001089Ho, Robert K.ProfessorKenneth DavidThompsonKenneth David Thompson41.78927490000000-87.601250000000001161Thompson, Kenneth David37591828Selewa A, Luo K, Wasney M, Smith L, Sun X, Tang C, Eckart H, Moskowitz IP, Basu A, He X, Pott SNature communicationsSingle-cell genomics improves the discovery of risk variants and genes of atrial fibrillation. Nat Commun. 2023 08 17; 14(1):4999.Nat Commun2023-08-17T00:00:002023Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.37693381En A, Bogireddi H, Thomas B, Stutzman A, Ikegami S, LaForest B, Almakki O, Pytel P, Moskowitz IP, Ikegami KbioRxiv : the preprint server for biologyThe cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture. bioRxiv. 2023 Aug 28.bioRxiv2023-08-28T00:00:002023The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture.Authorship 1662869Authorship 166060837772400Yamaguchi N, Chang EW, Lin Z, Shekhar A, Bu L, Khodadadi-Jamayran A, Tsirigos A, Cen Y, Phoon CKL, Moskowitz IP, Park DSCirculationAn Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract. Circulation. 2023 Nov 21; 148(21):1705-1722.Circulation2023-09-29T00:00:002023An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.Authorship 16661310XinanYangXinan Yang41.78927490000000-87.601250000000001429Yang, Xinan0000-0001-8061-8692Research Associate ProfessorDaliaElmoftyDalia Elmofty41.78927490000000-87.601250000000001516Elmofty, DaliaAssociate ProfessorZhong-YuXieZhong-Yu Xie41.78927490000000-87.601250000000002336Xie, Zhong-YuPostdoctoral ScholarRoberto M.LangRoberto M. Lang41.78927490000000-87.601250000000002399Lang, Roberto M.ProfessorFrankZimmermanFrank Zimmerman41.78927490000000-87.601250000000002519Zimmerman, FrankClinical AssociateMarcelo A.Nobrega2W1rGaQSGMzMknJtY0fp/Cv/+94=Marcelo A. Nobrega41.78927490000000-87.601250000000002531Nobrega, Marcelo A.Professor5.386240.00526944394research areas2.389820.021569927coauthor of53.802314.869360similar to1189selected publicationsYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professorhttps://github.com/xyang2uchicagoYangGroup @ Githubhttps://home.uchicago.edu/~xyang2/index.htmlYang Holy Grail http://www.ncbi.nlm.nih.gov/sites/myncbi/1RIUe-yfEE9kx/bibliography/41055186/public/?sort=date&direcBibliography @ National Library of MedicinePaula E.WilliamsPaula E. Williams41.78927490000000-87.60125000000000846Williams, Paula E.Assistant ProfessorOzannaBurnicka-TurekOzanna Burnicka-Turek41.78927490000000-87.60125000000000953Burnicka-Turek, OzannaPostdoctoral ScholarChristopherWeberChristopher Weber41.78927490000000-87.60125000000000975Weber, ChristopherAssociate ProfessorCo-Principal Investigator2024-04-30Washington UniversityMOSKOWITZ, IVAN PAUL2020-07-01High-Throughput Identification of Causal Variants Underlying Cardiac Arrhythmia-Related GWAS HitsR01HL149961Principal IvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator2023-07-31NIH/NHLBIMOSKOWITZ, IVAN PAUL2019-08-17Gene Regulatory Non-Coding RNAs in the Human HeartR01HL1487192023-05-31NIH/NICHDMOSKOWITZ, IVAN PAUL2019-06-01The Molecular Basis of Cardiac Differentiation ControlR01HL1475712026-02-28Additional VenturesMOSKOWITZ, IVAN PAUL2023-03-01Hedgehog Signaling-Dependent Heterochronic Control of Differentiation Timing in Cardiac Development and the Pathogenesis of Single VentriclePending2026-03-31NIHMOSKOWITZ, IVAN PAUL2022-04-01Discovery and interrogation of Genetic Regulatory Variation Impacting Atrial Fibrillation RiskR01HL1635232023-05-31NIHMOSKOWITZ, IVAN PAUL2022-12-26Evaluation of Hedgehog Signaling-Dependent Heart Development in a Mouse Model of Down SyndromeR01HL1475712029-06-30NIHMOSKOWITZ, IVAN PAUL2024-07-01Cardiovascular Sciences Training GrantPending2028-03-31NIHMOSKOWITZ, IVAN PAUL2023-04-01A Heterochronic Model for Birth Defects in Down SyndromePending2026-03-31NIHMOSKOWITZ, IVAN PAUL2023-04-01A heterochronic model for birth defects in Down SyndromeR01HD111938Principal Investigator38189150Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IPCirculationA Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Jan 08.Circulation2024-01-08T00:00:002024A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.Authorship 16936626Authorship 1700702438344303Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, Lu F, Keating EM, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Hill LD, Kyoung Song M, Trembley MA, Wang P, Gianeselli M, Prondzynski M, Bortolin RH, Bezzerides VJ, Chen K, Seidman JG, Seidman CE, Moskowitz IP, Pu WTNature cardiovascular researchTbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898.Nat Cardiovasc Res2023-10-12T00:00:002023Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.true1true1Associate ProfessorAssociate Professortrue1Postdoctoral ScholarPostdoctoral Scholartrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Postdoctoral ScholarPostdoctoral Scholartrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Clinical AssociateClinical Associatetrue1Research Associate ProfessorResearch Associate ProfessorAuthorship 6777617Authorship 6714310Authorship 7296410Authorship 791402125356765Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IPPLoS geneticsFoxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct; 10(10):e1004604.PLoS Genet2014-10-30T00:00:002014Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.25574029Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RLHuman molecular geneticsMATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet. 2015 Apr 15; 24(8):2375-89.Hum Mol Genet2015-01-07T00:00:002015MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.25848000Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li XProceedings of the National Academy of Sciences of the United States of AmericaMaternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):E2020-9.Proc Natl Acad Sci U S A2015-04-06T00:00:002015Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.24642470van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IPThe Journal of clinical investigationA common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest. 2014 Apr; 124(4):1844-52.J Clin Invest2014-03-18T00:00:002014A common genetic variant within SCN10A modulates cardiac SCN5A expression.Authorship 80864526208718Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RHBMC developmental biologyThe pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol. 2015 Jul 25; 15:30.BMC Dev Biol2015-07-25T00:00:002015The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.Authorship 81569226305497Rowton M, Moskowitz IPeLifeMany ways to break a heart. Elife. 2015 Aug 25; 4.Elife2015-08-25T00:00:002015Many ways to break a heart.Medicine-CardiologyChicago60637ILAuthorship 874671226859351Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FLDevelopmental cellThe Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 2016 Feb 08; 36(3):262-75.Dev Cell2016-02-08T00:00:002016The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.Authorship 879571727058611Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EAPLoS geneticsDe Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016 Apr; 12(4):e1005963.PLoS Genet2016-04-08T00:00:002016De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.Pediatrics-CardiologyAuthorship 934701927582060Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IPScience translational medicinePitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm. Sci Transl Med. 2016 08 31; 8(354):354ra115.Sci Transl Med2016-08-31T00:00:002016Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Authorship 504572Authorship 504581Authorship 522592Authorship 533981Authorship 542956Authorship 549332Authorship 562913Authorship 566823Authorship 596076Authorship 5925561885004Heichman KA, Moskowitz IP, Johnson RCGenes & developmentConfiguration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots. Genes Dev. 1991 Sep; 5(9):1622-34.Genes Dev1991-09-01T00:00:001991Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots.1885005Moskowitz IP, Heichman KA, Johnson RCGenes & developmentAlignment of recombination sites in Hin-mediated site-specific DNA recombination. Genes Dev. 1991 Sep; 5(9):1635-45.Genes Dev1991-09-01T00:00:001991Alignment of recombination sites in Hin-mediated site-specific DNA recombination.7813794Gendreau SB, Moskowitz IP, Terns RM, Rothman JHDevelopmental biologyThe potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans. Dev Biol. 1994 Dec; 166(2):770-81.Dev Biol1994-12-01T00:00:001994The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans.13078619FOX MJ, MOSKOWITZ IWisconsin medical journalHysteria in poliomyelitis. Wis Med J. 1953 Jun; 52(6):313-6.Wis Med J1953-06-01T00:00:001953Hysteria in poliomyelitis.11795251Laufs H, Nigrovic PA, Schneider LC, Oettgen H, Del NP, Moskowitz IP, Blume E, Perez-Atayde ARMayo Clinic proceedingsGiant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. Mayo Clin Proc. 2002 Jan; 77(1):92-6.Mayo Clin Proc2002-01-01T00:00:002002Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.22155005Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang JJournal of molecular and cellular cardiologyEnhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012 Mar; 52(3):638-49.J Mol Cell Cardiol2011-12-01T00:00:002011Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.17172441Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CAProceedings of the National Academy of Sciences of the United States of AmericaFilamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19836-41.Proc Natl Acad Sci U S A2006-12-15T00:00:002006Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.10029820Moskowitz IP, Gaynon PS, Shahidi NT, Cripe TPJournal of pediatric hematology/oncologyLow-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura. J Pediatr Hematol Oncol. 1999 Jan-Feb; 21(1):77-9.J Pediatr Hematol Oncol1999-01-01T00:00:001999Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.16565907Aru GM, Juraszek A, Moskowitz I, Van Praagh RPediatric cardiologyTetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship. Pediatr Cardiol. 2006 May-Jun; 27(3):354-9.Pediatr Cardiol2006-05-01T00:00:002006Tetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship.21677783Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang JPloS oneExpression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects. PLoS One. 2011; 6(6):e20803.PLoS One2011-06-03T00:00:002011Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.Authorship 963601327340223Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IPHuman molecular geneticsCilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet. 2016 07 15; 25(14):3011-3028.Hum Mol Genet2016-06-23T00:00:002016Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.Authorship 9903511Authorship 99085228057264Steimle JD, Moskowitz IPCurrent topics in developmental biologyTBX5: A Key Regulator of Heart Development. Curr Top Dev Biol. 2017; 122:195-221.Curr Top Dev Biol2016-09-28T00:00:002016TBX5: A Key Regulator of Heart Development.28033319Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Xie L, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IPPLoS geneticsCorrection: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation. PLoS Genet. 2016 Dec; 12(12):e1006533.PLoS Genet2016-12-29T00:00:002016Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.Authorship 99694728167794Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie LProceedings of the National Academy of Sciences of the United States of AmericaGata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1422-E1431.Proc Natl Acad Sci U S A2017-02-06T00:00:002017Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.