James Liao to rho-Associated Kinases
This is a "connection" page, showing publications James Liao has written about rho-Associated Kinases.
Connection Strength
13.962
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Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms. J Am Heart Assoc. 2021 10 19; 10(20):e022568.
Score: 0.741
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Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening. Expert Opin Ther Targets. 2020 01; 24(1):47-62.
Score: 0.657
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Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ J. 2018 03 23; 82(4):1195-1204.
Score: 0.573
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ROCK as a therapeutic target for ischemic stroke. Expert Rev Neurother. 2017 Dec; 17(12):1167-1177.
Score: 0.564
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Rho Kinases and Cardiac Remodeling. Circ J. 2016 Jun 24; 80(7):1491-8.
Score: 0.511
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The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis. Pharmacol Rev. 2015; 67(1):103-17.
Score: 0.464
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Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors. Int J Cardiol. 2014 Sep; 176(1):250-3.
Score: 0.448
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Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study. Clin Sci (Lond). 2014 Jun; 126(12):829-835.
Score: 0.445
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Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis. Antioxid Redox Signal. 2014 Mar 10; 20(8):1251-67.
Score: 0.425
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FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2. FASEB J. 2013 Apr; 27(4):1439-49.
Score: 0.403
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Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85.
Score: 0.396
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ROCKs as immunomodulators of stroke. Expert Opin Ther Targets. 2012 Oct; 16(10):1013-25.
Score: 0.394
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Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina. Atherosclerosis. 2012 Apr; 221(2):521-6.
Score: 0.377
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Role of Rho kinase isoforms in murine allergic airway responses. Eur Respir J. 2011 Oct; 38(4):841-50.
Score: 0.360
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Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. Trends Pharmacol Sci. 2011 Mar; 32(3):167-73.
Score: 0.352
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Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr Pharm Des. 2009; 15(27):3108-15.
Score: 0.306
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Increased leukocyte ROCK activity in patients after acute ischemic stroke. Brain Res. 2009 Feb 27; 1257:89-93.
Score: 0.306
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Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event. Am J Cardiol. 2009 Feb 15; 103(4):437-41.
Score: 0.306
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Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation. 2009 Jan 06; 119(1):131-8.
Score: 0.305
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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May; 118(5):1632-44.
Score: 0.292
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A method for measuring Rho kinase activity in tissues and cells. Methods Enzymol. 2008; 439:181-9.
Score: 0.285
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Does it matter whether or not a lipid-lowering agent inhibits Rho kinase? Curr Atheroscler Rep. 2007 Nov; 9(5):384-8.
Score: 0.282
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Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol. 2007 Jul; 50(1):17-24.
Score: 0.276
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Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. J Clin Invest. 2020 07 01; 130(7):3654-3670.
Score: 0.170
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 06; 11(3):365-376.
Score: 0.160
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Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. J Hypertens. 2019 05; 37(5):1083-1095.
Score: 0.156
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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744.
Score: 0.155
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The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 04; 58(4):471-481.
Score: 0.145
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Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01; 113(11):1307-1317.
Score: 0.139
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Role of ROCK2 in CD4+ cells in allergic airways responses in mice. Clin Exp Allergy. 2017 Feb; 47(2):224-235.
Score: 0.133
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 01; 48(1):187-194.
Score: 0.132
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Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome. Hypertension. 2015 Oct; 66(4):892-9.
Score: 0.121
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ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 01; 309(7):L736-46.
Score: 0.121
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Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial. Hypertens Res. 2015 Jul; 38(7):485-90.
Score: 0.117
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Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency. Clin Exp Allergy. 2015 Feb; 45(2):457-70.
Score: 0.117
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Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism. Hypertension. 2015 Apr; 65(4):841-8.
Score: 0.116
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Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression. J Mol Cell Cardiol. 2015 Feb; 79:180-6.
Score: 0.115
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Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells. PLoS One. 2014; 9(10):e109017.
Score: 0.114
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Rho-associated kinase activity is a predictor of cardiovascular outcomes. Hypertension. 2014 Apr; 63(4):856-64.
Score: 0.108
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Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation. J Sex Med. 2013 Jun; 10(6):1502-15.
Score: 0.103
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Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease. Clin Cardiol. 2013 Jun; 36(6):347-51.
Score: 0.103
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ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. Curr Mol Med. 2013 Jan; 13(1):205-19.
Score: 0.101
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Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation. 2012 Oct 30; 126(18):2236-47.
Score: 0.099
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A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome. Int J Cardiol. 2013 Sep 10; 167(6):2813-9.
Score: 0.098
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Increased Rho kinase activity in congestive heart failure. Eur J Heart Fail. 2012 Sep; 14(9):965-73.
Score: 0.097
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Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension. Clin Pharmacol Ther. 2012 Feb; 91(2):289-97.
Score: 0.094
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Rho-associated kinase activity, endothelial function, and cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2353-9.
Score: 0.091
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ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery. J Muscle Res Cell Motil. 2011 Sep; 32(2):65-76.
Score: 0.090
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Calcium channel blocker and Rho-associated kinase activity in patients with hypertension. J Hypertens. 2011 Feb; 29(2):373-9.
Score: 0.088
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Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil. Atherosclerosis. 2011 Jan; 214(1):117-21.
Score: 0.087
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest. 2010 Sep; 120(9):3280-95.
Score: 0.085
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Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. Drug Discov Today. 2010 Aug; 15(15-16):622-9.
Score: 0.085
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RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010 Sep; 24(9):3186-95.
Score: 0.084
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Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. Hypertens Res. 2010 Apr; 33(4):354-9.
Score: 0.083
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Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy. Curr Pharm Des. 2009; 15(5):467-78.
Score: 0.076
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Statins inhibit Rho kinase activity in patients with atherosclerosis. Atherosclerosis. 2009 Aug; 205(2):517-21.
Score: 0.076
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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008 Nov 25; 1(47):ra14.
Score: 0.076
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Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice. FASEB J. 2008 Oct; 22(10):3561-70.
Score: 0.074
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Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol. 2007 Apr 17; 49(15):1619-1624.
Score: 0.068
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Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction. Circ Res. 2006 Aug 04; 99(3):238-9.
Score: 0.065
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Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C661-8.
Score: 0.063
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Rho GTPases, statins, and nitric oxide. Circ Res. 2005 Dec 09; 97(12):1232-5.
Score: 0.062
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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation. 2005 Nov 08; 112(19):2959-65.
Score: 0.061
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Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct; 36(10):2251-7.
Score: 0.061
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Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21; 111(24):3261-8.
Score: 0.060
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ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther. 2005 May; 3(3):441-51.
Score: 0.059
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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1842-7.
Score: 0.056
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Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation. 2002 Jul 02; 106(1):57-62.
Score: 0.049
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Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. Biomark Med. 2016; 10(3):255-64.
Score: 0.031
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Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J Am Coll Cardiol. 2007 Feb 13; 49(6):698-705.
Score: 0.017
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Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res. 2006 Dec 08; 99(12):1426-32.
Score: 0.016
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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab. 2007 May; 27(5):998-1009.
Score: 0.016