LeShenLe Shen41.78927490000000-87.60125000000000411Shen, LeResearch Associate Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 105279828618266Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JRCell host & microbeIL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe. 2017 Jun 14; 21(6):671-681.e4.Cell Host Microbe2017-06-14T00:00:002017IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.PhysicsMargaretGardelMargaret L. Gardel41.7886000000000087.598699999999993493Gardel, MargaretProfessorD004847Anatomy2496620.724867Epithelial CellsMedicine-GastroenterologySurgery-General Surgery30252535Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen LFASEB journal : official publication of the Federation of American Societies for Experimental BiologyThe cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143.FASEB J2018-09-25T00:00:002018The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation.Authorship 10970311Authorship 1107704Authorship 1191924Authorship 1222032Authorship 1175982Authorship 1229527Authorship 119156629946133Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IALaboratory investigation; a journal of technical methods and pathologyPhenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330.Lab Invest2018-06-26T00:00:002018Phenotypic characterization of murine models of cerebral cavernous malformations.29915162Samanta P, Wang Y, Fuladi S, Zou J, Li Y, Shen L, Weber C, Khalili-Araghi FThe Journal of general physiologyMolecular determination of claudin-15 organization and channel selectivity. J Gen Physiol. 2018 07 02; 150(7):949-968.J Gen Physiol2018-06-18T00:00:002018Molecular determination of claudin-15 organization and channel selectivity.24920678Glotfelty LG, Zahs A, Iancu C, Shen L, Hecht GAAmerican journal of physiology. Cell physiologyMicrotubules are required for efficient epithelial tight junction homeostasis and restoration. Am J Physiol Cell Physiol. 2014 Aug 01; 307(3):C245-54.Am J Physiol Cell Physiol2014-06-11T00:00:002014Microtubules are required for efficient epithelial tight junction homeostasis and restoration.D004848Anatomy1333170.904713EpitheliumAuthorship 1284881330896405Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CReLifeA calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8.Elife2019-03-21T00:00:002019A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.Authorship 243012RomualdGirardRomuald Girard41.7886000000000087.598699999999993817Girard, RomualdResearch Assistant ProfessorAuthorship 268883Authorship 1324851331426861Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IAActa neuropathologica communicationsTranscriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132.Acta Neuropathol Commun2019-08-19T00:00:002019Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.Authorship 273011Authorship 294521Authorship 384163Authorship 291361Authorship 367042Authorship 405334Authorship 411096Authorship 32328331776290Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn MLScience translational medicineDistinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med. 2019 11 27; 11(520).Sci Transl Med2019-11-27T00:00:002019Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.Authorship 135337331979311Fuladi S, Jannat RW, Shen L, Weber CR, Khalili-Araghi FInternational journal of molecular sciencesComputational Modeling of Claudin Structure and Function. Int J Mol Sci. 2020 Jan 23; 21(3).Int J Mol Sci2020-01-23T00:00:002020Computational Modeling of Claudin Structure and Function.31968585Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen LInternational journal of molecular sciencesCerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2).Int J Mol Sci2020-01-20T00:00:002020Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation.32001212Zou J, Li Y, Yu J, Dong L, Husain AN, Shen L, Weber CRBiochimica et biophysica acta. BiomembranesIdiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr. 2020 05 01; 1862(5):183205.Biochim Biophys Acta Biomembr2020-01-28T00:00:002020Idiopathic pulmonary fibrosis is associated with tight junction protein alterations.Authorship 350501Authorship 396911Authorship 405874Authorship 408932D007413Anatomy1827880.679776Intestinal MucosaAuthorship 393931Authorship 1371242132347164Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CRCirculation researchZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43.Circ Res2020-04-29T00:00:002020ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.Authorship 1372341032362501Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IAJournal of autoimmunityAntibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. J Autoimmun. 2020 09; 113:102469.J Autoimmun2020-04-30T00:00:002020Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.Authorship 436442Authorship 4480510Authorship 1378512232461638Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IANature communicationsPermissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nat Commun. 2020 05 27; 11(1):2659.Nat Commun2020-05-27T00:00:002020Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.Authorship 481912Authorship 48808132710309Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DAAngiogenesisNovel Murine Models of Cerebral Cavernous Malformations. Angiogenesis. 2020 11; 23(4):651-666.Angiogenesis2020-07-24T00:00:002020Novel Murine Models of Cerebral Cavernous Malformations.Authorship 198302Authorship 275655Authorship 365781Authorship 427691Authorship 1415668Authorship 1415676Authorship 1415686Authorship 14156915Authorship 1415702Authorship 1415717Authorship 1415728Authorship 1415734Authorship 14157430242130Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JRThe Journal of biological chemistryThe scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 11 09; 293(45):17317-17335.J Biol Chem2018-09-21T00:00:002018The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo.31401143Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JRGastroenterologyInflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Gastroenterology. 2019 11; 157(5):1323-1337.Gastroenterology2019-08-08T00:00:002019Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.32725957Hou Q, Dong Y, Yu Q, Wang B, Le S, Guo Y, Zhang BFASEB journal : official publication of the Federation of American Societies for Experimental BiologyRegulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function. FASEB J. 2020 08; 34(8):10299-10315.FASEB J2020-06-17T00:00:002020Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function.26721332Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao RBiochimica et biophysica actaOccludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochim Biophys Acta. 2016 Apr; 1860(4):765-74.Biochim Biophys Acta2015-12-23T00:00:002015Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice.11739735Algeciras-Schimnich A, Shen L, Barnhart BC, Murmann AE, Burkhardt JK, Peter MEMolecular and cellular biologyMolecular ordering of the initial signaling events of CD95. Mol Cell Biol. 2002 Jan; 22(1):207-20.Mol Cell Biol2002-01-01T00:00:002002Molecular ordering of the initial signaling events of CD95.14767487Clayburgh DR, Shen L, Turner JRLaboratory investigation; a journal of technical methods and pathologyA porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004 Mar; 84(3):282-91.Lab Invest2004-03-01T00:00:002004A porous defense: the leaky epithelial barrier in intestinal disease.33437383Zhao L, Huang L, Zhang J, Fan J, He F, Zhao X, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Pakvasa M, Fu K, Tucker AB, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, Qi H, He TCAmerican journal of translational researchThe inhibition of BRAF activity sensitizes chemoresistant human ovarian cancer cells to paclitaxel-induced cytotoxicity and tumor growth inhibition. Am J Transl Res. 2020; 12(12):8084-8098.Am J Transl Res2020-12-15T00:00:002020The inhibition of BRAF activity sensitizes chemoresistant human ovarian cancer cells to paclitaxel-induced cytotoxicity and tumor growth inhibition.16051797Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JCScience (New York, N.Y.)Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7.Science2005-07-29T00:00:002005Recognition of host immune activation by Pseudomonas aeruginosa.15958494Shen L, Turner JRMolecular biology of the cellActin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell. 2005 Sep; 16(9):3919-36.Mol Biol Cell2005-06-15T00:00:002005Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.Orthopedic Surgery and Rehabilitation Medicine16537969Shen L, Turner JRAmerican journal of physiology. Gastrointestinal and liver physiologyRole of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G577-82.Am J Physiol Gastrointest Liver Physiol2006-04-01T00:00:002006Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed.Authorship 1450091912/2005The University of ChicagoChicagoThe University of Chicago, PathologyPh.D.Pathology07/1998Peking University Health Science CenterBeijing, ChinaPeking University Health Science Center, Basic MedicineM.B. (M.D. equivalent)Basic Medicine03/2011The University of ChicagoChicagoThe University of Chicago, Intestinal PathophysiologyPost-docIntestinal Pathophysiology18669621Gill RK, Shen L, Turner JR, Saksena S, Alrefai WA, Pant N, Esmaili A, Dwivedi A, Ramaswamy K, Dudeja PKAmerican journal of physiology. Gastrointestinal and liver physiologySerotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G700-8.Am J Physiol Gastrointest Liver Physiol2008-07-31T00:00:002008Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.15825080Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JRGastroenterologyDistinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology. 2005 Apr; 128(4):987-1001.Gastroenterology2005-04-01T00:00:002005Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.16638813Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JRJournal of cell scienceMyosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci. 2006 May 15; 119(Pt 10):2095-106.J Cell Sci2006-04-25T00:00:002006Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure.20164257Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JRMolecular biology of the cellTight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010 Apr 01; 21(7):1200-13.Mol Biol Cell2010-02-17T00:00:002010Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.20177070Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JRThe Journal of biological chemistryEpithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010 Apr 16; 285(16):12037-46.J Biol Chem2010-02-22T00:00:002010Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.20351069Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JRThe Journal of cell biologyCaveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010 Apr 05; 189(1):111-26.J Cell Biol2010-03-29T00:00:002010Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.20936941Shen L, Weber CR, Raleigh DR, Yu D, Turner JRAnnual review of physiologyTight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011; 73:283-309.Annu Rev Physiol2011-01-01T00:00:002011Tight junction pore and leak pathways: a dynamic duo.Neurological Surgery22511722Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JRProceedings of the National Academy of Sciences of the United States of AmericaDynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102.Proc Natl Acad Sci U S A2012-04-17T00:00:002012Dynamic migration of ?d intraepithelial lymphocytes requires occludin.18474622Shen L, Weber CR, Turner JRThe Journal of cell biologyThe tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95.J Cell Biol2008-05-12T00:00:002008The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state.Authorship 1478451034232919Huang L, Zhao L, Zhang J, He F, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, He TC, Tang LAgingAntiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways. Aging (Albany NY). 2021 07 07; 13(13):17407-17427.Aging (Albany NY)2021-07-07T00:00:002021Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways.34150011Zhao X, Huang B, Wang H, Ni N, He F, Liu Q, Shi D, Chen C, Zhao P, Wang X, Wagstaff W, Pakvasa M, Tucker AB, Lee MJ, Wolf JM, Reid RR, Hynes K, Strelzow J, Ho SH, Yu T, Yang J, Shen L, He TC, Zhang YAmerican journal of translational researchA functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs). Am J Transl Res. 2021; 13(5):4233-4250.Am J Transl Res2021-05-15T00:00:002021A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs).34179020Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JJK, Wu RFrontiers in cell and developmental biologyEndothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021; 9:691801.Front Cell Dev Biol2021-06-10T00:00:002021Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus.19538322Graham WV, Marchiando AM, Shen L, Turner JRAnnals of the New York Academy of SciencesNo static at all. Ann N Y Acad Sci. 2009 May; 1165:314-22.Ann N Y Acad Sci2009-05-01T00:00:002009No static at all.19812978Shen LCurrent topics in microbiology and immunologyFunctional morphology of the gastrointestinal tract. Curr Top Microbiol Immunol. 2009; 337:1-35.Curr Top Microbiol Immunol2009-01-01T00:00:002009Functional morphology of the gastrointestinal tract.19897958Shen L, Su L, Turner JRDigestive diseases (Basel, Switzerland)Mechanisms and functional implications of intestinal barrier defects. Dig Dis. 2009; 27(4):443-9.Dig Dis2009-11-04T00:00:002009Mechanisms and functional implications of intestinal barrier defects.22731710Shen LAnnals of the New York Academy of SciencesTight junctions on the move: molecular mechanisms for epithelial barrier regulation. Ann N Y Acad Sci. 2012 Jul; 1258:9-18.Ann N Y Acad Sci2012-07-01T00:00:002012Tight junctions on the move: molecular mechanisms for epithelial barrier regulation.34336664Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko EFrontiers in oncologyDoublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2021; 11:677051.Front Oncol2021-07-16T00:00:002021Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma.21237166Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJGastroenterologyThe epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. 2011 Apr; 140(4):1208-1218.e1-2.Gastroenterology2011-01-13T00:00:002011The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding.34522718Mao Y, Ni N, Huang L, Fan J, Wang H, He F, Liu Q, Shi D, Fu K, Pakvasa M, Wagstaff W, Tucker AB, Chen C, Reid RR, Haydon RC, Ho SH, Lee MJ, He TC, Yang J, Shen L, Cai L, Luu HHGenes & diseasesArgonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs). Genes Dis. 2021 Nov; 8(6):918-930.Genes Dis2021-05-13T00:00:002021Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs).17570213Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JRGastroenterologyLIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007 Jun; 132(7):2383-94.Gastroenterology2007-02-27T00:00:002007LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.19000799Shen L, Turner JRCurrent biology : CBIntercellular junctions: actin the PARt. Curr Biol. 2008 Nov 11; 18(21):R1014-7.Curr Biol2008-11-11T00:00:002008Intercellular junctions: actin the PARt.19027740Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JRGastroenterologyTargeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 2009 Feb; 136(2):551-63.Gastroenterology2008-11-06T00:00:002008Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.21536752Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JRThe Journal of cell biologyOccludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82.J Cell Biol2011-05-02T00:00:002011Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.19864322Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JBAmerican journal of physiology. Cell physiologyPhorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C85-97.Am J Physiol Cell Physiol2009-10-28T00:00:002009Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.20404178Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JRProceedings of the National Academy of Sciences of the United States of AmericaMLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8237-41.Proc Natl Acad Sci U S A2010-04-19T00:00:002010MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.34820586Zhong J, Wang H, Yang K, Wang H, Duan C, Ni N, An L, Luo Y, Zhao P, Gou Y, Sheng S, Shi D, Chen C, Wagstaff W, Hendren-Santiago B, Haydon RC, Luu HH, Reid RR, Ho SH, Ameer GA, Shen L, He TC, Fan JBioactive materialsReversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering. Bioact Mater. 2022 Mar; 9:523-540.Bioact Mater2021-07-29T00:00:002021Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering.Authorship 15131118Authorship 15131221Authorship 15131320Authorship 15131410Authorship 15131514Authorship 1513162234850128He F, Ni N, Wang H, Zeng Z, Zhao P, Shi D, Xia Y, Chen C, Hu DA, Qin KH, Wagstaff W, Qin D, Hendren-Santiago B, Ho SH, Haydon RC, Luu HH, Reid RR, Shen L, Gan H, Fan J, He TCNucleic acids researchOUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression. Nucleic Acids Res. 2022 02 28; 50(4):e22.Nucleic Acids Res2022-02-28T00:00:002022OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression.SeanPolsterSean Polster41.7886000000000087.598699999999994144Polster, Sean0000-0002-3229-5021Assistant ProfessorD020786Disorders282230.784958Hemangioma, Cavernous, Central Nervous SystemAuthorship 1553331335715588Romanos SG, Srinath A, Li Y, Xie B, Chen C, Li Y, Moore T, Bi D, Sone JY, Lightle R, Hobson N, Zhang D, Koskimäki J, Shen L, McCurdy S, Lai CC, Stadnik A, Piedad K, Carrión-Penagos J, Shkoukani A, Snellings D, Shenkar R, Sulakhe D, Ji Y, Lopez-Ramirez MA, Kahn ML, Marchuk DA, Ginsberg MH, Girard R, Awad IATranslational stroke researchCirculating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. Transl Stroke Res. 2023 08; 14(4):513-529.Transl Stroke Res2022-06-17T00:00:002022Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.D019108Anatomy601440.900109Tight JunctionsAuthorship 1580945Authorship 15882913Authorship 1599663Authorship 160109836350878Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay SPLoS computational biologyOrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584.PLoS Comput Biol2022-11-09T00:00:002022OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics.26861615Zhang Q, Huang L, Chang Q, Shi W, Shen L, Chen QNanotechnologyGravure-printed interdigital microsupercapacitors on a flexible polyimide substrate using crumpled graphene ink. Nanotechnology. 2016 Mar 11; 27(10):105401.Nanotechnology2016-02-10T00:00:002016Gravure-printed interdigital microsupercapacitors on a flexible polyimide substrate using crumpled graphene ink.36318156Fuladi S, McGuinness S, Shen L, Weber CR, Khalili-Araghi FThe Journal of general physiologyMolecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12).J Gen Physiol2022-11-01T00:00:002022Molecular mechanism of claudin-15 strand flexibility: A computational study.36157497Wagstaff W, Mwamba RN, Grullon K, Armstrong M, Zhao P, Hendren-Santiago B, Qin KH, Li AJ, Hu DA, Youssef A, Reid RR, Luu HH, Shen L, He TC, Haydon RCGenes & diseasesMelanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance. Genes Dis. 2022 Nov; 9(6):1608-1623.Genes Dis2022-04-27T00:00:002022Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance.Authorship 1613302036869161Srinath A, Xie B, Li Y, Sone JY, Romanos S, Chen C, Sharma A, Polster S, Dorrestein PC, Weldon KC, DeBiasse D, Moore T, Lightle R, Koskimäki J, Zhang D, Stadnik A, Piedad K, Hagan M, Shkoukani A, Carrión-Penagos J, Bi D, Shen L, Shenkar R, Ji Y, Sidebottom A, Pamer E, Gilbert JA, Kahn ML, D'Souza M, Sulakhe D, Awad IA, Girard RCommunications medicinePlasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023 Mar 03; 3(1):35.Commun Med (Lond)2023-03-03T00:00:002023Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.http://cweberlab.comChristopher Weber Labhttp://www.boneandcancer.orgLab homepagehttps://scholar.google.com/citations?user=YRifvyAAAAAJ&hl=enGoogle Scholar2017-06-30NIHSHEN, LE2012-07-01Contribution of occludin to intestinal homeostasis and diseaseK01DK092381Principal InvestigatorPathologyUniversity of ChicagoMustafaHussainMustafa Hussain41.78927490000000-87.601250000000001201Hussain, MustafaAssociate ProfessorEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.Professor37748978Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IAJournal of autoimmunityCorrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469]. J Autoimmun. 2023 Sep 23; 103116.J Autoimmun2023-09-23T00:00:002023Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469].Authorship 16659412Olga Y.ZaborinaOlga Y. Zaborina41.78927490000000-87.601250000000001448Zaborina, Olga Y.Research ProfessorEdwin L.KaplanEdwin L. Kaplan41.78927490000000-87.601250000000002046Kaplan, Edwin L.ProfessorPeterAngelosx2NnDKQZFv/5hHlsaUXv9Gq0+s+oPeter Angelos41.78927490000000-87.601250000000002652Angelos, PeterProfessorJohnAlverdy3WNlHaQHHfX5hHlsaUXv9Gq0+s+oJohn Alverdy41.78927490000000-87.601250000000002676Alverdy, JohnProfessor4.341770.00897408340research areas1.798750.017137944coauthor of70.17766.5477260similar to1169selected publicationsNora T.JaskowiakNora T. Jaskowiak41.78927490000000-87.60125000000000487Jaskowiak, Nora T.ProfessorTong-ChuanHew2FhDoEXCuiXhHlsaUXv9Gq0+s+oTong-Chuan He41.78927490000000-87.60125000000000550He, Tong-ChuanAssociate ProfessorIssamAwad3mN+CqU1DO/RmHllZ0mg9mHvIssam Awad41.78927490000000-87.60125000000000867Awad, IssamProfessorChristopherWeberChristopher Weber41.78927490000000-87.60125000000000975Weber, ChristopherAssociate Professor38106010Song S, Mohsin E, Zhang R, Kuznetsov A, Shen L, Grossman RL, Weber CR, Khan AAbioRxiv : the preprint server for biologyATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning. bioRxiv. 2023 Dec 10.bioRxiv2023-12-10T00:00:002023ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning.Authorship 16903552025-07-31NIHIZUMCHENKO, EVGENY (EUGENE) G2023-08-01PDCD10 as a novel driver for head and neck squamous cell carcinoma developmentR21DE032833Co-Principal Investigatortrue1ProfessorProfessortrue1ProfessorProfessortrue1Research Assistant ProfessorResearch Assistant Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Research ProfessorResearch Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 703615Authorship 72105225263012Turner JR, Buschmann MM, Romero-Calvo I, Sailer A, Shen LSeminars in cell & developmental biologyThe role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol. 2014 Dec; 36:204-12.Semin Cell Dev Biol2014-09-28T00:00:002014The role of molecular remodeling in differential regulation of tight junction permeability.23924897Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CRMolecular biology of the cellOccludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68.Mol Biol Cell2013-08-07T00:00:002013Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.25653430Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JMJournal of virologyExpression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. J Virol. 2015 Apr; 89(8):4311-8.J Virol2015-02-04T00:00:002015Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route.24465397Ma K, Malhotra P, Soni V, Hedroug O, Annaba F, Dudeja A, Shen L, Turner JR, Khramtsova EA, Saksena S, Dudeja PK, Gill RK, Alrefai WAPloS oneOveractivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One. 2014; 9(1):e84221.PLoS One2014-01-20T00:00:002014Overactivation of intestinal SREBP2 in mice increases serum cholesterol.Chicago60637ILAuthorship 87483526568313Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JReLifeClaudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906.Elife2015-11-14T00:00:002015Claudin-2-dependent paracellular channels are dynamically gated.Authorship 934041227345427Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IAJournal of neuroscience methodsMicro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. J Neurosci Methods. 2016 09 15; 271:14-24.J Neurosci Methods2016-06-23T00:00:002016Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.Authorship 605684Authorship 622313Authorship 62201423139219Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JBAmerican journal of physiology. Gastrointestinal and liver physiologyCapsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56.Am J Physiol Gastrointest Liver Physiol2012-11-08T00:00:002012Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.23609227Davis JM, Hyjek E, Husain AN, Shen L, Jones J, Schuger LAThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyLymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells. J Histochem Cytochem. 2013 Aug; 61(8):580-90.J Histochem Cytochem2013-04-22T00:00:002013Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells.23619146Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JRGastroenterologyTNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013 Aug; 145(2):407-15.Gastroenterology2013-04-22T00:00:002013TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.