Eric C. Beyer to Cataract
This is a "connection" page, showing publications Eric C. Beyer has written about Cataract.
Connection Strength
9.095
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Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Cells. 2022 09 07; 11(18).
Score: 0.824
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Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens? Biomolecules. 2020 10 07; 10(10).
Score: 0.722
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Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization. Int J Mol Sci. 2020 Aug 13; 21(16).
Score: 0.714
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p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency. Mol Vis. 2020; 26:204-215.
Score: 0.695
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The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):2336-2346.
Score: 0.653
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Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses. Exp Eye Res. 2018 10; 175:192-198.
Score: 0.615
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The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016 08 19; 291(34):17569-78.
Score: 0.536
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Connexin46fs380 causes progressive cataracts. Invest Ophthalmol Vis Sci. 2014 Aug 07; 55(10):6639-48.
Score: 0.471
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Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2013 Nov 19; 54(12):7614-22.
Score: 0.448
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The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation. Mol Vis. 2009 Sep 14; 15:1881-5.
Score: 0.335
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Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal. 2009 Feb; 11(2):339-53.
Score: 0.321
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Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2549-56.
Score: 0.302
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Transgenic overexpression of connexin50 induces cataracts. Exp Eye Res. 2007 Mar; 84(3):513-28.
Score: 0.278
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A crystallin mutant cataract with mineral deposits. J Biol Chem. 2023 08; 299(8):104935.
Score: 0.217
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Loss of function and impaired degradation of a cataract-associated mutant connexin50. Eur J Cell Biol. 2003 May; 82(5):209-21.
Score: 0.216
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Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673.
Score: 0.198
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Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021 12 21; 120(24):5644-5656.
Score: 0.195
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Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C492-C503.
Score: 0.149
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Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract. PLoS One. 2017; 12(8):e0183438.
Score: 0.145
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Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4366–4374.
Score: 0.145
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Connexin23 deletion does not affect lens transparency. Exp Eye Res. 2016 05; 146:283-288.
Score: 0.132
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A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor. J Biol Chem. 2013 Jul 12; 288(28):20427-34.
Score: 0.108
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An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract. Exp Eye Res. 2013 May; 110:136-41.
Score: 0.104
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Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am J Physiol Cell Physiol. 2011 May; 300(5):C1055-64.
Score: 0.092
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A mutant connexin50 with enhanced hemichannel function leads to cell death. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5837-45.
Score: 0.083
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The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum. Exp Eye Res. 2009 Mar; 88(3):600-9.
Score: 0.079
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A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet. 2008 Mar; 45(3):155-60.
Score: 0.074
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A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. J Med Genet. 2006 Jan; 43(1):e2.
Score: 0.065
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An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem. 2005 Dec 09; 280(49):40788-95.
Score: 0.064
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Connexin46 mutations linked to congenital cataract show loss of gap junction channel function. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C596-602.
Score: 0.045
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Molecular mechanism underlying a Cx50-linked congenital cataract. Am J Physiol. 1999 06; 276(6):C1443-6.
Score: 0.041
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The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating. J Membr Biol. 2015 Feb; 248(1):145-55.
Score: 0.030