Andrzej Joachimiak to Enzyme Inhibitors
This is a "connection" page, showing publications Andrzej Joachimiak has written about Enzyme Inhibitors.
Connection Strength
1.985
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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.
Score: 0.623
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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Sci. 2020 03; 29(3):779-788.
Score: 0.579
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A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity. J Biol Chem. 2015 Feb 27; 290(9):5893-911.
Score: 0.409
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Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10):e0138976.
Score: 0.108
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Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):531-8.
Score: 0.104
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Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry. 2012 Aug 07; 51(31):6148-63.
Score: 0.086
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Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors. Proteins. 2004 Jun 01; 55(4):805-13.
Score: 0.049
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Activation of inhibitors by sortase triggers irreversible modification of the active site. J Biol Chem. 2007 Aug 10; 282(32):23129-39.
Score: 0.015
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The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48. Acta Crystallogr D Biol Crystallogr. 2004 Aug; 60(Pt 8):1347-54.
Score: 0.012