MartinFederMartin Feder41.78927490000000-87.60125000000000932Feder, MartinMy research focuses on understanding adaptation to the environment from both a mechanistic and evolutionary perspective; i.e., how organisms function in natural environments, the mechanisms underlying this function, the evolutionary origin, maintenance, and constraint of this function, the evolutionary consequences of variation in function, and how all of these aspects are encoded or reflected in the genome. Thus, my research focuses at the intersection of the four disciplinary domains shown to the left; i.e., evolutionary and ecological functional genomics. My research program addresses this suite of issues through a multidisciplinary, problem-oriented approach.
My present emphasis is on ecological and evolutionary physiology of the stress response [the induction of a specific suite of proteins (stress or heat-shock proteins) by extreme temperatures and other stresses]. Several projects are underway, with a common theme: HEAT-SHOCK PROTEINS AND GENES
Specifically, my laboratory investigates the heat-shock protein Hsp70, its encoding genes, and its regulation in Drosophila as a model system for understanding evolutionary adaptation. Hsp70 is a molecular chaperone that deters stress-induced protein aggregation, but has numerous other functions. Hsp70 is necessary for full-strength tolerance (in terms of survival, normal development, normal function) of high temperature. Such tolerance is critical in nature, where non-adult Drosophila undergo harmful to lethal high temperatures. In nature, Drosophila populations vary in stress tolerance and Hsp70 levels. Our current major focus is on understanding the genomic basis for this variation. The number of hsp70 gene copies and evolution of the hsp70 coding sequence are partial or inadequate explanations. Evidently cis-regulatory regions such as proximal promoters underlie intraspecific variation in Hsp70 levels. Repeated insertion of mobile genetic elements into these promoters is a recurrent mechanism of evolution.Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 100805212770408Krebs RA, Feder MEJournal of insect physiologyHsp70 and larval thermotolerance in Drosophila melanogaster: how much is enough and when is more too much? J Insect Physiol. 1998 Nov; 44(11):1091-1101.J Insect Physiol1998-11-01T00:00:001998Hsp70 and larval thermotolerance in Drosophila melanogaster: how much is enough and when is more too much?Authorship 1017351Authorship 1018761Authorship 1018731Authorship 1019721Authorship 101846228308320Roberts SP, Feder MEOecologiaNatural hyperthermia and expression of the heat shock protein Hsp70 affect developmental abnormalities in Drosophila melanogaster. Oecologia. 1999 Nov; 121(3):323-329.Oecologia1999-11-01T00:00:001999Natural hyperthermia and expression of the heat shock protein Hsp70 affect developmental abnormalities in Drosophila melanogaster.28308753Feder ME, Roberts SP, Bordelon ACOecologiaMolecular thermal telemetry of free-ranging adult Drosophila melanogaster. Oecologia. 2000 Jun; 123(4):460-465.Oecologia2000-06-01T00:00:002000Molecular thermal telemetry of free-ranging adult Drosophila melanogaster.28311459Feder ME, Londos PLOecologiaHydric constraints upon foraging in a terrestrial salamander, Desmognathus ochrophaeus (Amphibia: Plethodontidae). Oecologia. 1984 Nov; 64(3):413-418.Oecologia1984-11-01T00:00:001984Hydric constraints upon foraging in a terrestrial salamander, Desmognathus ochrophaeus (Amphibia: Plethodontidae).28310608Feder ME, Arnold SJOecologiaAnaerobic metabolism and behavior during predatory encounters between snakes (Thamnophis elegans) and salamanders (Plethodon jordani). Oecologia. 1982 Apr; 53(1):93-97.Oecologia1982-04-01T00:00:001982Anaerobic metabolism and behavior during predatory encounters between snakes (Thamnophis elegans) and salamanders (Plethodon jordani).234066Feder ME, Pough FHComparative biochemistry and physiology. A, Comparative physiologyTemperatuer selection by the red-backed salamander, Plethodon c. cinereus (Green) (Caudata: Plethodontidae). Comp Biochem Physiol A Comp Physiol. 1975 Jan 01; 50(1A):91-8.Comp Biochem Physiol A Comp Physiol1975-01-01T00:00:001975Temperatuer selection by the red-backed salamander, Plethodon c. cinereus (Green) (Caudata: Plethodontidae).Authorship 1045572Authorship 1045692Authorship 104534228568793Krebs RA, Feder MEEvolution; international journal of organic evolutionNATURAL VARIATION IN THE EXPRESSION OF THE HEAT-SHOCK PROTEIN HSP70 IN A POPULATION OF DROSOPHILA MELANOGASTER AND ITS CORRELATION WITH TOLERANCE OF ECOLOGICALLY RELEVANT THERMAL STRESS. Evolution. 1997 Feb; 51(1):173-179.Evolution1997-02-01T00:00:001997NATURAL VARIATION IN THE EXPRESSION OF THE HEAT-SHOCK PROTEIN HSP70 IN A POPULATION OF DROSOPHILA MELANOGASTER AND ITS CORRELATION WITH TOLERANCE OF ECOLOGICALLY RELEVANT THERMAL STRESS.28565246Krebs RA, Feder ME, Lee JEvolution; international journal of organic evolutionHERITABILITY OF EXPRESSION OF THE 70KD HEAT-SHOCK PROTEIN IN DROSOPHILA MELANOGASTER AND ITS RELEVANCE TO THE EVOLUTION OF THERMOTOLERANCE. Evolution. 1998 Jun; 52(3):841-847.Evolution1998-06-01T00:00:001998HERITABILITY OF EXPRESSION OF THE 70KD HEAT-SHOCK PROTEIN IN DROSOPHILA MELANOGASTER AND ITS RELEVANCE TO THE EVOLUTION OF THERMOTOLERANCE.28565421Bettencourt BR, Feder ME, Cavicchi SEvolution; international journal of organic evolutionEXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER. Evolution. 1999 Apr; 53(2):484-492.Evolution1999-04-01T00:00:001999EXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER.D004251Chemicals & Drugs631690.916522DNA Transposable ElementsEcology and EvolutionMolecular Genetics and Cell BiologyOrganismal Biology and AnatomyD004331Living Beings1115960.694577Drosophila melanogasterMedicine-GastroenterologyAuthorship 1122474Authorship 1186112Authorship 121455129920826Chen B, Feder ME, Kang LMolecular ecologyEvolution of heat-shock protein expression underlying adaptive responses to environmental stress. Mol Ecol. 2018 08; 27(15):3040-3054.Mol Ecol2018-07-02T00:00:002018Evolution of heat-shock protein expression underlying adaptive responses to environmental stress.29280581Krebs RA, Roberts SP, Bettencourt BR, Feder MEJournal of evolutionary biologyChanges in thermotolerance and Hsp70 expression with domestication in Drosophila melanogaster. J Evol Biol. 2001 Jan 08; 14(1):75-82.J Evol Biol2001-01-08T00:00:002001Changes in thermotolerance and Hsp70 expression with domestication in Drosophila melanogaster.29586709Feder METhe American naturalistEngineering Candidate Genes in Studies of Adaptation: The Heat-Shock Protein Hsp70 in Drosophila melanogaster. Am Nat. 1999 Jul; 154(S1):S55-S66.Am Nat1999-07-01T00:00:001999Engineering Candidate Genes in Studies of Adaptation: The Heat-Shock Protein Hsp70 in Drosophila melanogaster.Authorship 122591Authorship 13162Authorship 137262Authorship 137322Authorship 158201Authorship 144753Authorship 183552Authorship 191292Authorship 205054Authorship 196656Authorship 191887Authorship 192622Authorship 198893Authorship 23853Authorship 212881Authorship 218605Authorship 265351Authorship 239693Authorship 261022D006360Chemicals & Drugs921780.902835Heat-Shock ProteinsAuthorship 257657Authorship 275061Authorship 224185Authorship 291706Authorship 227383Authorship 269403Authorship 230341Authorship 327757Authorship 340832Authorship 277242Authorship 292796Authorship 338601Authorship 319551Authorship 306313Authorship 345455Authorship 404831Authorship 322131Authorship 43541Authorship 471862Authorship 454071Authorship 404841Authorship 61261Authorship 78971Authorship 414503Authorship 54722Authorship 466812Authorship 77752Authorship 113961Authorship 139641Authorship 214178Authorship 217533Authorship 27313Authorship 4014328440967Feder ME, Gonzalez RJ, Robbins T, Talbot CRThe Journal of experimental biologyBulk flow of the medium and cutaneous sodium uptake in frogs: potential significance of sodium and oxygen boundary layers. J Exp Biol. 1993 Jan; 174:235-46.J Exp Biol1993-01-01T00:00:001993Bulk flow of the medium and cutaneous sodium uptake in frogs: potential significance of sodium and oxygen boundary layers.8708583Feder ME, Cartaño NV, Milos L, Krebs RA, Lindquist SLThe Journal of experimental biologyEffect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. J Exp Biol. 1996 Aug; 199(Pt 8):1837-44.J Exp Biol1996-08-01T00:00:001996Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster.9246784Krebs RA, Feder METhe Journal of experimental biologyTissue-specific variation in Hsp70 expression and thermal damage in Drosophila melanogaster larvae. J Exp Biol. 1997 Jul; 200(Pt 14):2007-15.J Exp Biol1997-07-01T00:00:001997Tissue-specific variation in Hsp70 expression and thermal damage in Drosophila melanogaster larvae.9523438Karr TL, Yang W, Feder MEProceedings. Biological sciencesOvercoming cytoplasmic incompatibility in Drosophila. Proc Biol Sci. 1998 Mar 07; 265(1394):391-5.Proc Biol Sci1998-03-07T00:00:001998Overcoming cytoplasmic incompatibility in Drosophila.1469156Clemens DT, Feder MEJournal of comparative physiology. B, Biochemical, systemic, and environmental physiologyDependence of oxygen uptake on ambient PO2 in isolated perfused frog skin. J Comp Physiol B. 1992; 162(7):646-50.J Comp Physiol B1992-01-01T00:00:001992Dependence of oxygen uptake on ambient PO2 in isolated perfused frog skin.10099689Feder ME, Hofmann GEAnnual review of physiologyHeat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol. 1999; 61:243-82.Annu Rev Physiol1999-01-01T00:00:001999Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.9250396Krebs RA, Feder MECell stress & chaperonesDeleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress Chaperones. 1997 Mar; 2(1):60-71.Cell Stress Chaperones1997-03-01T00:00:001997Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae.11136617Lerman DN, Feder METhe Journal of experimental biologyLaboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster. J Exp Biol. 2001 Jan; 204(Pt 2):315-23.J Exp Biol2001-01-01T00:00:002001Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster.11472630Bujnicki JM, Feder M, Radlinska M, Rychlewski LBMC bioinformaticsmRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. BMC Bioinformatics. 2001; 2:2.BMC Bioinformatics2001-06-22T00:00:002001mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships.11441029Zatsepina OG, Velikodvorskaia VV, Molodtsov VB, Garbuz D, Lerman DN, Bettencourt BR, Feder ME, Evgenev MBThe Journal of experimental biologyA Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression. J Exp Biol. 2001 Jun; 204(Pt 11):1869-81.J Exp Biol2001-06-01T00:00:002001A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression.11965431Bettencourt BR, Feder MEJournal of molecular evolutionRapid concerted evolution via gene conversion at the Drosophila hsp70 genes. J Mol Evol. 2002 May; 54(5):569-86.J Mol Evol2002-05-01T00:00:002002Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes.12389724Bettencourt BR, Kim I, Hoffmann AA, Feder MEEvolution; international journal of organic evolutionResponse to natural and laboratory selection at the Drosophila hsp70 genes. Evolution. 2002 Sep; 56(9):1796-801.Evolution2002-09-01T00:00:002002Response to natural and laboratory selection at the Drosophila hsp70 genes.12482205Isaenko OA, Karr TL, Feder MECell stress & chaperonesHsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila. Cell Stress Chaperones. 2002 Jul; 7(3):297-308.Cell Stress Chaperones2002-07-01T00:00:002002Hsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila.12324888Feder ME, Bedford TB, Albright DR, Michalak PPhysiological and biochemical zoology : PBZEvolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster. Physiol Biochem Zool. 2002 Jul-Aug; 75(4):325-34.Physiol Biochem Zool2002-07-01T00:00:002002Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster.12796457Garbuz D, Evgenev MB, Feder ME, Zatsepina OGThe Journal of experimental biologyEvolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype. J Exp Biol. 2003 Jul; 206(Pt 14):2399-408.J Exp Biol2003-07-01T00:00:002003Evolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype.12519916Lerman DN, Michalak P, Helin AB, Bettencourt BR, Feder MEMolecular biology and evolutionModification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements. Mol Biol Evol. 2003 Jan; 20(1):135-44.Mol Biol Evol2003-01-01T00:00:002003Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.12897776Feder ME, Mitchell-Olds TNature reviews. GeneticsEvolutionary and ecological functional genomics. Nat Rev Genet. 2003 Aug; 4(8):651-7.Nat Rev Genet2003-08-01T00:00:002003Evolutionary and ecological functional genomics.12694280Williams KD, Helin AB, Posluszny J, Roberts SP, Feder MEMolecular ecologyEffect of heat shock, pretreatment and hsp70 copy number on wing development in Drosophila melanogaster. Mol Ecol. 2003 May; 12(5):1165-77.Mol Ecol2003-05-01T00:00:002003Effect of heat shock, pretreatment and hsp70 copy number on wing development in Drosophila melanogaster.11420366Bettencourt BR, Feder MEMolecular biology and evolutionHsp70 duplication in the Drosophila melanogaster species group: how and when did two become five? Mol Biol Evol. 2001 Jul; 18(7):1272-82.Mol Biol Evol2001-07-01T00:00:002001Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five?11756523Kelty JD, Noseworthy PA, Feder ME, Robertson RM, Ramirez JMThe Journal of neuroscience : the official journal of the Society for NeuroscienceThermal preconditioning and heat-shock protein 72 preserve synaptic transmission during thermal stress. J Neurosci. 2002 Jan 01; 22(1):RC193.J Neurosci2002-01-01T00:00:002002Thermal preconditioning and heat-shock protein 72 preserve synaptic transmission during thermal stress.15718377Feder MEAdvances in physiology educationAims of undergraduate physiology education: a view from the University of Chicago. Adv Physiol Educ. 2005 Mar; 29(1):3-10.Adv Physiol Educ2005-03-01T00:00:002005Aims of undergraduate physiology education: a view from the University of Chicago.16552433Rashkovetsky E, Iliadi K, Michalak P, Lupu A, Nevo E, Feder ME, Korol AHeredityAdaptive differentiation of thermotolerance in Drosophila along a microclimatic gradient. Heredity (Edinb). 2006 May; 96(5):353-9.Heredity (Edinb)2006-05-01T00:00:002006Adaptive differentiation of thermotolerance in Drosophila along a microclimatic gradient.Ben May Department of Cancer Research17449831Feder METhe Journal of experimental biologyEvolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation. J Exp Biol. 2007 May; 210(Pt 9):1653-60.J Exp Biol2007-05-01T00:00:002007Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation.14671709Roberts SP, Marden JH, Feder MEPhysiological and biochemical zoology : PBZDropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster. Physiol Biochem Zool. 2003 Sep-Oct; 76(5):615-21.Physiol Biochem Zool2003-09-01T00:00:002003Dropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster.17029562Walser JC, Chen B, Feder MEPLoS geneticsHeat-shock promoters: targets for evolution by P transposable elements in Drosophila. PLoS Genet. 2006 Oct 06; 2(10):e165.PLoS Genet2006-08-17T00:00:002006Heat-shock promoters: targets for evolution by P transposable elements in Drosophila.18162758Feder ME, Madara JLAcademic medicine : journal of the Association of American Medical CollegesEvidence-based appointment and promotion of academic faculty at the University of Chicago. Acad Med. 2008 Jan; 83(1):85-95.Acad Med2008-01-01T00:00:002008Evidence-based appointment and promotion of academic faculty at the University of Chicago.1947447Pinder AW, Clemens D, Feder MERespiration physiologyGas exchange in isolated perfused frog skin as a function of perfusion rate. Respir Physiol. 1991 Jul; 85(1):1-14.Respir Physiol1991-07-01T00:00:001991Gas exchange in isolated perfused frog skin as a function of perfusion rate.17714322Chen B, Walser JC, Rodgers TH, Sobota RS, Burke MK, Rose MR, Feder MEJournal of evolutionary biologyAbundant, diverse, and consequential P elements segregate in promoters of small heat-shock genes in Drosophila populations. J Evol Biol. 2007 Sep; 20(5):2056-66.J Evol Biol2007-09-01T00:00:002007Abundant, diverse, and consequential P elements segregate in promoters of small heat-shock genes in Drosophila populations.15480729Evgen'ev MB, Zatsepina OG, Garbuz D, Lerman DN, Velikodvorskaya V, Zelentsova E, Feder MEChromosomaEvolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila. Chromosoma. 2004 Nov; 113(5):223-32.Chromosoma2004-10-05T00:00:002004Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila.15838545Velikodvorskaia VV, Lyozin GT, Feder ME, Evgen'ev MBGenomeUnusual arrangement of the hsp68 locus in the virilis species group of Drosophila implicates evolutionary loss of an hsp68 gene. Genome. 2005 Apr; 48(2):234-40.Genome2005-04-01T00:00:002005Unusual arrangement of the hsp68 locus in the virilis species group of Drosophila implicates evolutionary loss of an hsp68 gene.15574805Lerman DN, Feder MEMolecular biology and evolutionNaturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster. Mol Biol Evol. 2005 Mar; 22(3):776-83.Mol Biol Evol2004-12-01T00:00:002004Naturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster.20148672Feder ME, Garland T, Marden JH, Zera AJAnnual review of physiologyLocomotion in response to shifting climate zones: not so fast. Annu Rev Physiol. 2010; 72:167-90.Annu Rev Physiol2010-01-01T00:00:002010Locomotion in response to shifting climate zones: not so fast.16107220Brown RP, Feder MEBMC genomicsReverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism. BMC Genomics. 2005 Aug 17; 6:110.BMC Genomics2005-08-17T00:00:002005Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism.2096674Pinder A, Clemens D, Feder MAdvances in experimental medicine and biologyAn isolated perfused frog skin preparation for the study of gas exchange. Adv Exp Med Biol. 1990; 277:719-24.Adv Exp Med Biol1990-01-01T00:00:001990An isolated perfused frog skin preparation for the study of gas exchange.20498853Tian S, Haney RA, Feder MEPloS onePhylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila. PLoS One. 2010 May 17; 5(5):e10669.PLoS One2010-05-17T00:00:002010Phylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila.17536162Feder MEJournal of biosciencesKey issues in achieving an integrative perspective on stress. J Biosci. 2007 Apr; 32(3):433-40.J Biosci2007-04-01T00:00:002007Key issues in achieving an integrative perspective on stress.18347937Chen B, Shilova VY, Zatsepina OG, Evgen'ev MB, Feder MECell stress & chaperonesLocation of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster. Cell Stress Chaperones. 2008; 13(1):11-7.Cell Stress Chaperones2008-02-05T00:00:002008Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster.18212796Mitchell-Olds T, Feder M, Wray GHeredityEvolutionary and ecological functional genomics. Heredity (Edinb). 2008 Feb; 100(2):101-2.Heredity (Edinb)2008-02-01T00:00:002008Evolutionary and ecological functional genomics.21708735Feder MEIntegrative and comparative biologyPlant and animal physiological ecology, comparative physiology/biochemistry, and evolutionary physiology: opportunities for synergy: an introduction to the symposium. Integr Comp Biol. 2002 Jul; 42(3):409-14.Integr Comp Biol2002-07-01T00:00:002002Plant and animal physiological ecology, comparative physiology/biochemistry, and evolutionary physiology: opportunities for synergy: an introduction to the symposium.22208704van Straalen NM, Feder ME, Sayler GSEnvironmental science & technologyGuest comment: Environmental genomics focus issue. Environ Sci Technol. 2012 Jan 03; 46(1):1-2.Environ Sci Technol2011-12-12T00:00:002011Guest comment: Environmental genomics focus issue.20041194Haney RA, Feder MEPloS oneContrasting patterns of transposable element insertions in Drosophila heat-shock promoters. PLoS One. 2009 Dec 29; 4(12):e8486.PLoS One2009-12-29T00:00:002009Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters.2863058Feder MEComparative biochemistry and physiology. A, Comparative physiologyAcclimation to constant and variable temperatures in plethodontid salamanders--I. Rates of oxygen consumption. Comp Biochem Physiol A Comp Physiol. 1985; 81(3):673-82.Comp Biochem Physiol A Comp Physiol1985-01-01T00:00:001985Acclimation to constant and variable temperatures in plethodontid salamanders--I. Rates of oxygen consumption.6747542Feder ME, Seale DB, Boraas ME, Wassersug RJ, Gibbs AGThe Journal of experimental biologyFunctional conflicts between feeding and gas exchange in suspension-feeding tadpoles, Xenopus laevis. J Exp Biol. 1984 May; 110:91-8.J Exp Biol1984-05-01T00:00:001984Functional conflicts between feeding and gas exchange in suspension-feeding tadpoles, Xenopus laevis.16033562Feder ME, Walser JCJournal of evolutionary biologyThe biological limitations of transcriptomics in elucidating stress and stress responses. J Evol Biol. 2005 Jul; 18(4):901-10.J Evol Biol2005-07-01T00:00:002005The biological limitations of transcriptomics in elucidating stress and stress responses.20148669Feder MEAnnual review of physiologyPhysiology and global climate change. Annu Rev Physiol. 2010; 72:123-5.Annu Rev Physiol2010-01-01T00:00:002010Physiology and global climate change.D018840Chemicals & Drugs451130.925545HSP70 Heat-Shock Proteins3958678Feder METhe Journal of experimental biologyEffect of thermal acclimation on locomotor energetics and locomotor performance in a lungless salamander, Desmognathus ochrophaeus. J Exp Biol. 1986 Mar; 121:271-83.J Exp Biol1986-03-01T00:00:001986Effect of thermal acclimation on locomotor energetics and locomotor performance in a lungless salamander, Desmognathus ochrophaeus.22043966van Straalen NM, Feder MEEnvironmental science & technologyEcological and evolutionary functional genomics--how can it contribute to the risk assessment of chemicals? Environ Sci Technol. 2012 Jan 03; 46(1):3-9.Environ Sci Technol2011-12-01T00:00:002011Ecological and evolutionary functional genomics--how can it contribute to the risk assessment of chemicals?6619726Wassersug RJ, Feder METhe Journal of experimental biologyThe effects of aquatic oxygen concentration, body size and respiratory behaviour on the stamina of obligate aquatic (Bufo americanus) and facultative air-breathing (Xenopus laevis and Rana berlandieri) anuran larvae. J Exp Biol. 1983 Jul; 105:173-90.J Exp Biol1983-07-01T00:00:001983The effects of aquatic oxygen concentration, body size and respiratory behaviour on the stamina of obligate aquatic (Bufo americanus) and facultative air-breathing (Xenopus laevis and Rana berlandieri) anuran larvae.3485695Burggren WW, Feder METhe Journal of experimental biologyEffect of experimental ventilation of the skin on cutaneous gas exchange in the bullfrog. J Exp Biol. 1986 Mar; 121:445-9.J Exp Biol1986-03-01T00:00:001986Effect of experimental ventilation of the skin on cutaneous gas exchange in the bullfrog.9342848Feder ME, Krebs RAEXSEcological and evolutionary physiology of heat shock proteins and the stress response in Drosophila: complementary insights from genetic engineering and natural variation. EXS. 1997; 83:155-73.EXS1997-01-01T00:00:001997Ecological and evolutionary physiology of heat shock proteins and the stress response in Drosophila: complementary insights from genetic engineering and natural variation.11687637Michalak P, Minkov I, Helin A, Lerman DN, Bettencourt BR, Feder ME, Korol AB, Nevo EProceedings of the National Academy of Sciences of the United States of AmericaGenetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13195-200.Proc Natl Acad Sci U S A2001-10-30T00:00:002001Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel.16582443Shilova VY, Garbuz DG, Myasyankina EN, Chen B, Evgen'ev MB, Feder ME, Zatsepina OGGeneticsRemarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster. Genetics. 2006 Jun; 173(2):809-20.Genetics2006-04-02T00:00:002006Remarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster.D011401Chemicals & Drugs3239370.765551Promoter Regions, Genetichttps://westneatlab.uchicago.edu/Westneat Lab: Biomechanics & Phylogeneticshttps://voices.uchicago.edu/fehonlab/Fehon Labhttps://paulsereno.uchicago.edu/Paul Sereno Paleontologisthttps://hatsopouloslab.uchicago.edu/Hatsopoulos Labhttp://voices.uchicago.edu/rebaylab/Rebay Labhttp://manyuanlonglab.uchicago.edu/Long Lab Websitehttps://bsdacademicaffairs.uchicago.edu/page/martin-e-feder-phdMartin E. Federhttps://scitopiachicago.org/Scitopia Chicagohttps://www.nigerheritage.org/NigerHeritagehttps://news.uchicago.edu/podcasts/big-brains/archaeological-riddle-sahara-paul-serenoBig Discoveries-PodcastHuman GeneticsUniversity of ChicagoRobert K.HoRobert K. Ho41.78927490000000-87.601250000000001089Ho, Robert K.ProfessorPaulSerenoPaul Sereno41.78927490000000-87.601250000000001106Sereno, PaulProfessorEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorDanielMatuteDaniel Matute41.78927490000000-87.601250000000001263Matute, DanielPostdoctoral ScholarRichard G.FehonRichard G. Fehon41.78927490000000-87.601250000000001759Fehon, Richard G.ProfessorJan-MarinoRamirezJan-Marino Ramirez41.78927490000000-87.601250000000002020Ramirez, Jan-MarinoIlariaRebayIlaria Rebay41.78927490000000-87.601250000000002383Rebay, IlariaProfessorRebeccaBrownRebecca P. Brown41.78927490000000-87.601250000000002391Brown, RebeccaManyuanLongManyuan Long41.78927490000000-87.601250000000002617Long, ManyuanProfessorMarkWestneatMark Westneat41.78927490000000-87.601250000000002649Westneat, MarkProfessorCallum F.RossCallum F. Ross41.78927490000000-87.60125000000000347Ross, Callum F.ProfessorNicholas G.HatsopoulosNicholas G. Hatsopoulos41.78927490000000-87.60125000000000709Hatsopoulos, Nicholas G.Professor3.206460.00726736249research areas0.2751970.05351342coauthor of55.6076.6171960similar to1168selected publicationstrue1true1true1ProfessorProfessortrue1ProfessorProfessortrue1Postdoctoral ScholarPostdoctoral Scholartrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 69817225487147Hashimshony T, Feder M, Levin M, Hall BK, Yanai INatureSpatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015 Mar 12; 519(7542):219-22.Nature2014-12-10T00:00:002014Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer.Chicago60637ILAuthorship 876691026886793Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, Senderovich N, Kovalev E, Silver DH, Feder M, Fernandez-Valverde SL, Nakanishi N, Simmons D, Simakov O, Larsson T, Liu SY, Jerafi-Vider A, Yaniv K, Ryan JF, Martindale MQ, Rink JC, Arendt D, Degnan SM, Degnan BM, Hashimshony T, Yanai INatureThe mid-developmental transition and the evolution of animal body plans. Nature. 2016 Mar 31; 531(7596):637-641.Nature2016-02-17T00:00:002016The mid-developmental transition and the evolution of animal body plans.Authorship 539731Authorship 55661211188769Feder M, Liu Z, Apostolou S, Greenberg RE, Testa JRCancer genetics and cytogeneticsLoss of chromosomes 1 and X in a renal oncocytoma: implications for a possible pseudoautosomal tumor suppressor locus. Cancer Genet Cytogenet. 2000 Nov; 123(1):71-2.Cancer Genet Cytogenet2000-11-01T00:00:002000Loss of chromosomes 1 and X in a renal oncocytoma: implications for a possible pseudoautosomal tumor suppressor locus.15664632Kirkwood TB, Feder M, Finch CE, Franceschi C, Globerson A, Klingenberg CP, LaMarco K, Omholt S, Westendorp RGMechanisms of ageing and developmentWhat accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev. 2005 Mar; 126(3):439-43.Mech Ageing Dev2005-03-01T00:00:002005What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?