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Connection

Wei-Jen Tang to Adenylyl Cyclases

This is a "connection" page, showing publications Wei-Jen Tang has written about Adenylyl Cyclases.
Connection Strength

5.024
  1. Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. Toxins (Basel). 2015 Jul 13; 7(7):2598-614.
    View in: PubMed
    Score: 0.450
  2. The adenylyl cyclase activity of anthrax edema factor. Mol Aspects Med. 2009 Dec; 30(6):423-30.
    View in: PubMed
    Score: 0.296
  3. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2004 Dec 14; 43(49):15463-71.
    View in: PubMed
    Score: 0.216
  4. Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin. Chem Biol. 2004 Aug; 11(8):1139-46.
    View in: PubMed
    Score: 0.211
  5. Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004 Apr 30; 317(2):309-14.
    View in: PubMed
    Score: 0.207
  6. Expression and purification of soluble adenylyl cyclase from Escherichia coli. Methods Mol Biol. 2004; 237:39-53.
    View in: PubMed
    Score: 0.202
  7. Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J Biol Chem. 2003 Jul 11; 278(28):25990-7.
    View in: PubMed
    Score: 0.192
  8. Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. EMBO J. 2002 Dec 16; 21(24):6721-32.
    View in: PubMed
    Score: 0.188
  9. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24; 415(6870):396-402.
    View in: PubMed
    Score: 0.177
  10. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. Methods Enzymol. 2002; 345:231-41.
    View in: PubMed
    Score: 0.176
  11. Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallogr D Biol Crystallogr. 2001 Dec; 57(Pt 12):1881-4.
    View in: PubMed
    Score: 0.175
  12. The regulation of type 7 adenylyl cyclase by its C1b region and Escherichia coli peptidylprolyl isomerase, SlyD. J Biol Chem. 2001 Mar 16; 276(11):8500-6.
    View in: PubMed
    Score: 0.164
  13. An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis. J Biol Chem. 2000 Nov 17; 275(46):36334-40.
    View in: PubMed
    Score: 0.163
  14. Catalytic mechanism and regulation of mammalian adenylyl cyclases. Mol Pharmacol. 1998 Aug; 54(2):231-40.
    View in: PubMed
    Score: 0.139
  15. Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase. Mol Pharmacol. 1998 Feb; 53(2):182-7.
    View in: PubMed
    Score: 0.134
  16. Class III adenylyl cyclases: regulation and underlying mechanisms. Adv Second Messenger Phosphoprotein Res. 1998; 32:137-51.
    View in: PubMed
    Score: 0.133
  17. Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation. J Biol Chem. 1997 Jul 25; 272(30):18849-54.
    View in: PubMed
    Score: 0.129
  18. The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase. J Biol Chem. 1997 May 09; 272(19):12342-9.
    View in: PubMed
    Score: 0.128
  19. Two cytoplasmic domains of mammalian adenylyl cyclase form a Gs alpha- and forskolin-activated enzyme in vitro. J Biol Chem. 1996 May 03; 271(18):10941-5.
    View in: PubMed
    Score: 0.119
  20. Truncation and alanine-scanning mutants of type I adenylyl cyclase. Biochemistry. 1995 Nov 07; 34(44):14563-72.
    View in: PubMed
    Score: 0.115
  21. Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science. 1995 Jun 23; 268(5218):1769-72.
    View in: PubMed
    Score: 0.112
  22. Adenylyl cyclases. Cell. 1992 Sep 18; 70(6):869-72.
    View in: PubMed
    Score: 0.093
  23. Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits. Cold Spring Harb Symp Quant Biol. 1992; 57:135-44.
    View in: PubMed
    Score: 0.088
  24. Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science. 1991 Dec 06; 254(5037):1500-3.
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    Score: 0.088
  25. Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem. 1991 May 05; 266(13):8595-603.
    View in: PubMed
    Score: 0.084
  26. Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. Biochem Pharmacol. 2009 Aug 01; 78(3):224-30.
    View in: PubMed
    Score: 0.074
  27. Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Mol Pharmacol. 2009 Mar; 75(3):693-703.
    View in: PubMed
    Score: 0.071
  28. A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step. J Mol Biol. 2007 Nov 23; 374(2):517-27.
    View in: PubMed
    Score: 0.065
  29. Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem. 2007 Jul 06; 282(27):19781-7.
    View in: PubMed
    Score: 0.064
  30. Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Front Biosci. 2007 May 01; 12:4670-5.
    View in: PubMed
    Score: 0.064
  31. Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin. Infect Immun. 2007 May; 75(5):2120-5.
    View in: PubMed
    Score: 0.063
  32. Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):850-7.
    View in: PubMed
    Score: 0.057
  33. Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells. J Immunol. 2005 Apr 15; 174(8):4934-41.
    View in: PubMed
    Score: 0.055
  34. Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J. 2005 Mar 09; 24(5):929-41.
    View in: PubMed
    Score: 0.055
  35. Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate. J Biol Chem. 2004 Jul 09; 279(28):29427-35.
    View in: PubMed
    Score: 0.052
  36. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3242-7.
    View in: PubMed
    Score: 0.051
  37. Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem. 2003 Aug 01; 278(31):29261-6.
    View in: PubMed
    Score: 0.048
  38. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J Biol Chem. 1994 Feb 25; 269(8):6093-100.
    View in: PubMed
    Score: 0.026
  39. Expression and purification of recombinant adenylyl cyclases in Sf9 cells. Methods Enzymol. 1994; 238:95-108.
    View in: PubMed
    Score: 0.025
  40. Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan; 385(1):57-68.
    View in: PubMed
    Score: 0.022
  41. Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine. J Pharmacol Exp Ther. 2011 Jun; 337(3):724-33.
    View in: PubMed
    Score: 0.021
  42. Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science. 1989 Jun 30; 244(4912):1558-64.
    View in: PubMed
    Score: 0.019
  43. Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Am J Pathol. 2005 Nov; 167(5):1309-20.
    View in: PubMed
    Score: 0.014
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.