ChristopherWeberChristopher Weber41.78927490000000-87.60125000000000975Weber, ChristopherGastrointestinal PathologyDr. Weber is an expert in the biophysical properties of the tight junctions and focuses on defining mechanisms of claudin barrier regulation in health and disease.
A second focus of Dr. Weber's lab is cardiac cellular electrophysiology, with an emphasis on mechanisms of abnormal cellular calcium handling in disease.Associate Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1006576Authorship 101671727549371Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HKCancer prevention research (Philadelphia, Pa.)Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. Cancer Prev Res (Phila). 2016 Nov; 9(11):844-854.Cancer Prev Res (Phila)2016-08-22T00:00:002016Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.28248733Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EBInflammatory bowel diseasesEarly Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 Feb 13.Inflamm Bowel Dis2017-02-13T00:00:002017Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.28221248Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EBInflammatory bowel diseasesEarly Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 03; 23(3):366-378.Inflamm Bowel Dis2017-03-01T00:00:002017Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.Authorship 104915128605031Weber CR, Turner JRAnnals of the New York Academy of SciencesDynamic modeling of the tight junction pore pathway. Ann N Y Acad Sci. 2017 06; 1397(1):209-218.Ann N Y Acad Sci2017-06-12T00:00:002017Dynamic modeling of the tight junction pore pathway.29280435Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IPeLifeTranscription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 12 27; 6.Elife2017-12-27T00:00:002017Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.Authorship 10791217Medicine-GastroenterologySurgery-General SurgeryAuthorship 1096269Authorship 1096272Authorship 10962810Authorship 1096296Authorship 10963025Authorship 1096318Authorship 1096327Authorship 1096334Authorship 1096344Authorship 1096358Authorship 1096362Authorship 1096372Authorship 1096383Authorship 1096391Authorship 1096402Authorship 1096413Authorship 1096421Authorship 109643230252535Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen LFASEB journal : official publication of the Federation of American Societies for Experimental BiologyThe cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143.FASEB J2018-09-25T00:00:002018The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation.29796641Sofia MA, Ciorba MA, Meckel K, Lim CK, Guillemin GJ, Weber CR, Bissonnette M, Pekow JRInflammatory bowel diseasesTryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. Inflamm Bowel Dis. 2018 06 08; 24(7):1471-1480.Inflamm Bowel Dis2018-06-08T00:00:002018Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.29751166Christensen B, Gibson PR, Micic D, Colman RJ, Goeppinger SR, Kassim O, Yarur A, Weber CR, Cohen RD, Rubin DTClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationSafety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2019 02; 17(3):486-493.Clin Gastroenterol Hepatol2018-05-08T00:00:002018Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease.28756053Krugliak Cleveland N, Rubin DT, Hart J, Weber CR, Meckel K, Tran AL, Aelvoet AS, Pan I, Gonsalves A, Gaetano JN, Williams KM, Wroblewski K, Jabri B, Pekow JClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationPatients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon. Clin Gastroenterol Hepatol. 2018 Jan; 16(1):68-74.Clin Gastroenterol Hepatol2017-07-26T00:00:002017Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon.23401616Ginsburg KS, Weber CR, Bers DMThe Journal of physiologyCardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes. J Physiol. 2013 Apr 15; 591(8):2067-86.J Physiol2013-02-11T00:00:002013Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes.30171177Romero-Calvo I, Weber CR, Ray M, Brown M, Kirby K, Nandi RK, Long TM, Sparrow SM, Ugolkov A, Qiang W, Zhang Y, Brunetti T, Kindler H, Segal JP, Rzhetsky A, Mazar AP, Buschmann MM, Weichselbaum R, Roggin K, White KPMolecular cancer research : MCRHuman Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors. Mol Cancer Res. 2019 01; 17(1):70-83.Mol Cancer Res2018-08-31T00:00:002018Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors.29988117Overstreet AM, LaTorre DL, Abernathy-Close L, Murphy SF, Rhee L, Boger AM, Adlaka KR, Iverson AM, Bakke DS, Weber CR, Boone DLMucosal immunologyThe JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis. Mucosal Immunol. 2018 09; 11(5):1454-1465.Mucosal Immunol2018-07-09T00:00:002018The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis.12034663Despa S, Islam MA, Weber CR, Pogwizd SM, Bers DMCirculationIntracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 2002 May 28; 105(21):2543-8.Circulation2002-05-28T00:00:002002Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged.29769727Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri BNatureMicrobial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584.Nature2018-05-16T00:00:002018Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.29562271Christensen B, Colman RJ, Micic D, Gibson PR, Goeppinger SR, Yarur A, Weber CR, Cohen RD, Rubin DTInflammatory bowel diseasesVedolizumab as Induction and Maintenance for Inflammatory Bowel Disease: 12-month Effectiveness and Safety. Inflamm Bowel Dis. 2018 03 19; 24(4):849-860.Inflamm Bowel Dis2018-03-19T00:00:002018Vedolizumab as Induction and Maintenance for Inflammatory Bowel Disease: 12-month Effectiveness and Safety.26442383Staruschenko A, Weber CR, Pochynyuk O, McCole DFThe PhysiologistS&R Foundation 15th Anniversary. Physiologist. 2015 Sep; 58(5):241-2.Physiologist2015-09-01T00:00:002015S&R Foundation 15th Anniversary.22491177Frantz AL, Rogier EW, Weber CR, Shen L, Cohen DA, Fenton LA, Bruno ME, Kaetzel CSMucosal immunologyTargeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol. 2012 Sep; 5(5):501-12.Mucosal Immunol2012-04-11T00:00:002012Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides.12600875Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SRCirculation researchCellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res. 2003 Apr 04; 92(6):651-8.Circ Res2003-02-20T00:00:002003Cellular basis of abnormal calcium transients of failing human ventricular myocytes.9524134Ginsburg KS, Weber CR, Bers DMThe Journal of general physiologyControl of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol. J Gen Physiol. 1998 Apr; 111(4):491-504.J Gen Physiol1998-04-01T00:00:001998Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol.29102730Uraizee I, Hart J, Waxman I, Weber CR, Setia NGastrointestinal endoscopyUnusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman. Gastrointest Endosc. 2018 May; 87(5):1355-1356.Gastrointest Endosc2017-11-02T00:00:002017Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman.14557358Weber CR, Piacentino V, Houser SR, Bers DMCirculationDynamic regulation of sodium/calcium exchange function in human heart failure. Circulation. 2003 Nov 04; 108(18):2224-9.Circulation2003-10-13T00:00:002003Dynamic regulation of sodium/calcium exchange function in human heart failure.11158165Weber CR, Ginsburg KS, Philipson KD, Shannon TR, Bers DMThe Journal of general physiologyAllosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes. J Gen Physiol. 2001 Feb; 117(2):119-31.J Gen Physiol2001-02-01T00:00:002001Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes.Authorship 1284891630896405Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CReLifeA calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8.Elife2019-03-21T00:00:002019A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.Authorship 1294791531054900Alpert L, Yassan L, Poon R, Kadri S, Niu N, Patil SA, Mujacic I, Montes D, Galbo F, Wurst MN, Zhen CJ, Cohen RD, Rubin DT, Pekow JR, Weber CR, Xiao SY, Hart J, Segal J, Setia NHuman pathologyTargeted mutational analysis of inflammatory bowel disease-associated colorectal cancers. Hum Pathol. 2019 07; 89:44-50.Hum Pathol2019-05-02T00:00:002019Targeted mutational analysis of inflammatory bowel disease-associated colorectal cancers.2004Loyola University Chicago, Stritch School of MedicineLoyola University Chicago, Stritch School of Medicine, PhysiologyMD, PhDPhysiology2007University of Chicago MedicineUniversity of Chicago Medicine, Anatomic PathologyResidencyAnatomic Pathology2010University of Chicago MedicineUniversity of Chicago Medicine, Gastrointestinal PathologyFellowshipGastrointestinal PathologyAuthorship 31155231609246Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IPThe Journal of clinical investigationAtrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. J Clin Invest. 2019 11 01; 129(11):4937-4950.J Clin Invest2019-11-01T00:00:002019Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.Authorship 350522Authorship 358601Authorship 408954Authorship 1354054Authorship 135339431979311Fuladi S, Jannat RW, Shen L, Weber CR, Khalili-Araghi FInternational journal of molecular sciencesComputational Modeling of Claudin Structure and Function. Int J Mol Sci. 2020 Jan 23; 21(3).Int J Mol Sci2020-01-23T00:00:002020Computational Modeling of Claudin Structure and Function.31968585Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen LInternational journal of molecular sciencesCerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2).Int J Mol Sci2020-01-20T00:00:002020Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation.Authorship 486511Authorship 135510732001212Zou J, Li Y, Yu J, Dong L, Husain AN, Shen L, Weber CRBiochimica et biophysica acta. BiomembranesIdiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr. 2020 05 01; 1862(5):183205.Biochim Biophys Acta Biomembr2020-01-28T00:00:002020Idiopathic pulmonary fibrosis is associated with tight junction protein alterations.Authorship 405891D007413Anatomy1827880.679741Intestinal MucosaAuthorship 1371272232347164Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CRCirculation researchZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43.Circ Res2020-04-29T00:00:002020ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.Authorship 411113Authorship 1381618Authorship 481933Authorship 138772332593688Olivas AD, Setia N, Weber CR, Xiao SY, Villa E, Chapman CG, Siddiqui UD, Waxman I, Hart J, Alpert LGastrointestinal endoscopyHistologic changes caused by injection of a novel submucosal lifting agent for endoscopic resection in GI lesions. Gastrointest Endosc. 2021 02; 93(2):470-476.Gastrointest Endosc2020-06-25T00:00:002020Histologic changes caused by injection of a novel submucosal lifting agent for endoscopic resection in GI lesions.Authorship 140219832844174Manzella CR, Jayawardena D, Pagani W, Li Y, Alrefai WA, Bauer J, Jung B, Weber CR, Gill RKInflammatory bowel diseasesSerum Serotonin Differentiates Between Disease Activity States in Crohn's Patients. Inflamm Bowel Dis. 2020 09 18; 26(10):1607-1618.Inflamm Bowel Dis2020-09-18T00:00:002020Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients.Authorship 427712Authorship 448074Authorship 484755Authorship 141662733077832Schuster B, Junkin M, Kashaf SS, Romero-Calvo I, Kirby K, Matthews J, Weber CR, Rzhetsky A, White KP, Tay SNature communicationsAutomated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020 10 19; 11(1):5271.Nat Commun2020-10-19T00:00:002020Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids.Authorship 143970533534221Boylan KE, Patrey S, McMullen PD, Tesic V, Weber CR, Hart J, Setia NThe American journal of surgical pathologyObjective Visual Analog Scale for Biopsy Diagnosis of Helicobacter pylori Infection in Clinical Practice. Am J Surg Pathol. 2021 05 01; 45(5):672-679.Am J Surg Pathol2021-05-01T00:00:002021Objective Visual Analog Scale for Biopsy Diagnosis of Helicobacter pylori Infection in Clinical Practice.Authorship 1447891533664518Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari FNature immunologyWnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484.Nat Immunol2021-03-04T00:00:002021Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.17513868Sun Q, Weber CR, Sohail A, Bernardo MM, Toth M, Zhao H, Turner JR, Fridman RThe Journal of biological chemistryMMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. J Biol Chem. 2007 Jul 27; 282(30):21998-2010.J Biol Chem2007-05-18T00:00:002007MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.20580720Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TAGastroenterologyPhosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010 Sep; 139(3):869-81, 881.e1-9.Gastroenterology2010-05-24T00:00:002010Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.19636295Snoeks L, Weber CR, Wasland K, Turner JR, Vainder C, Qi W, Savkovic SDLaboratory investigation; a journal of technical methods and pathologyTumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest. 2009 Sep; 89(9):1053-62.Lab Invest2009-07-27T00:00:002009Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation.17172583Weber CR, Turner JRGutInflammatory bowel disease: is it really just another break in the wall? Gut. 2007 Jan; 56(1):6-8.Gut2007-01-01T00:00:002007Inflammatory bowel disease: is it really just another break in the wall?20177070Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JRThe Journal of biological chemistryEpithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010 Apr 16; 285(16):12037-46.J Biol Chem2010-02-22T00:00:002010Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.20351069Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JRThe Journal of cell biologyCaveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010 Apr 05; 189(1):111-26.J Cell Biol2010-03-29T00:00:002010Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.20936941Shen L, Weber CR, Raleigh DR, Yu D, Turner JRAnnual review of physiologyTight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011; 73:283-309.Annu Rev Physiol2011-01-01T00:00:002011Tight junction pore and leak pathways: a dynamic duo.21109589Qi W, Weber CR, Wasland K, Roy H, Wali R, Joshi S, Savkovic SDAmerican journal of physiology. Gastrointestinal and liver physiologyTumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G264-72.Am J Physiol Gastrointest Liver Physiol2010-11-25T00:00:002010Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells.22511722Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JRProceedings of the National Academy of Sciences of the United States of AmericaDynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102.Proc Natl Acad Sci U S A2012-04-17T00:00:002012Dynamic migration of ?d intraepithelial lymphocytes requires occludin.22595989Rhee L, Murphy SF, Kolodziej LE, Grimm WA, Weber CR, Lodolce JP, Chang JE, Bartulis SJ, Messer JS, Schneider JR, Paski S, Nero TM, Boone DLAmerican journal of physiology. Gastrointestinal and liver physiologyExpression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2):G220-7.Am J Physiol Gastrointest Liver Physiol2012-05-17T00:00:002012Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis.22671592Weber CRAnnals of the New York Academy of SciencesDynamic properties of the tight junction barrier. Ann N Y Acad Sci. 2012 Jun; 1257:77-84.Ann N Y Acad Sci2012-06-01T00:00:002012Dynamic properties of the tight junction barrier.18474622Shen L, Weber CR, Turner JRThe Journal of cell biologyThe tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95.J Cell Biol2008-05-12T00:00:002008The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state.22067938Qi W, Joshi S, Weber CR, Wali RK, Roy HK, Savkovic SDGut microbesPolyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia. Gut Microbes. 2011 Sep 01; 2(5):267-73.Gut Microbes2011-09-01T00:00:002011Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia.18711353Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JRLaboratory investigation; a journal of technical methods and pathologyClaudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008 Oct; 88(10):1110-20.Lab Invest2008-08-18T00:00:002008Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.Authorship 1502331634623320Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DFThe Journal of clinical investigationT cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021 09 01; 131(17).J Clin Invest2021-09-01T00:00:002021T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.21536752Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JRThe Journal of cell biologyOccludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82.J Cell Biol2011-05-02T00:00:002011Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.17197450Jacobson DA, Weber CR, Bao S, Turk J, Philipson LHThe Journal of biological chemistryModulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem. 2007 Mar 09; 282(10):7442-9.J Biol Chem2006-12-29T00:00:002006Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.18678662Snoeks L, Weber CR, Turner JR, Bhattacharyya M, Wasland K, Savkovic SDInfection and immunityTumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun. 2008 Oct; 76(10):4677-85.Infect Immun2008-08-04T00:00:002008Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.19122199Mukherjee A, Morosky SA, Shen L, Weber CR, Turner JR, Kim KS, Wang T, Coyne CBThe Journal of biological chemistryRetinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J Biol Chem. 2009 Mar 06; 284(10):6486-94.J Biol Chem2009-01-03T00:00:002009Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions.20404178Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JRProceedings of the National Academy of Sciences of the United States of AmericaMLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8237-41.Proc Natl Acad Sci U S A2010-04-19T00:00:002010MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.22675506Wali RK, Kunte DP, De La Cruz M, Tiwari AK, Brasky J, Weber CR, Gibson TP, Patel A, Savkovic SD, Brockstein BE, Roy HKPloS oneTopical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response. PLoS One. 2012; 7(6):e38047.PLoS One2012-06-04T00:00:002012Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.Authorship 153645935288827Akiyama S, Ollech JE, Traboulsi C, Rai V, Glick LR, Yi Y, Runde J, Olivas AD, Weber CR, Cohen RD, Olortegui KBS, Hurst RD, Umanskiy K, Shogan BD, Rubin MA, Dalal SR, Sakuraba A, Pekow J, Chang EB, Hart J, Hyman NH, Rubin DTDigestive diseases and sciencesHistopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Dig Dis Sci. 2022 08; 67(8):4020-4031.Dig Dis Sci2022-03-14T00:00:002022Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.D019108Anatomy601440.900092Tight JunctionsD019831Chemicals & Drugs7190.989743Sodium-Calcium ExchangerAuthorship 15824212Authorship 1599684Authorship 160111936350878Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay SPLoS computational biologyOrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584.PLoS Comput Biol2022-11-09T00:00:002022OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics.35931701Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko ECell death & diseaseAL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678.Cell Death Dis2022-08-05T00:00:002022AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling.36318156Fuladi S, McGuinness S, Shen L, Weber CR, Khalili-Araghi FThe Journal of general physiologyMolecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12).J Gen Physiol2022-11-01T00:00:002022Molecular mechanism of claudin-15 strand flexibility: A computational study.D002118Chemicals & Drugs28211480.692432CalciumD062826Chemicals & Drugs37660.972238Zonula Occludens-1 Proteinhttp://cweberlab.comChristopher Weber Labhttps://rubinlab.uchicago.edu/Rubin Lab Sitehttps://www.uchicagomedicine.org/conditions-services/inflammatory-bowel-diseaseInflammatory Bowel Disease CenterIBDMD23925821Weber CR, Rubin DTDigestive diseases and sciencesChronic pouchitis versus recurrent Crohn's disease: a diagnostic challenge. Dig Dis Sci. 2013 Oct; 58(10):2748-50.Dig Dis Sci2013-08-08T00:00:002013Chronic pouchitis versus recurrent Crohn's disease: a diagnostic challenge.2011-06-30NIHWEBER, CHRISTOPHER2008-07-01Mechanisms of epithelial barrier dysfunction mediated by inflammatory cytokinesF32DK0821342015-06-30NIHWEBER, CHRISTOPHER2010-07-01Mechanisms and pathways of trans-tight junction conductanceK08DK0889532026-07-31NIHKHALILI-ARAGHI, FATEMEH ;WEBER, CHRISTOPHER2021-09-30Structure, function, and modulation of claudin cation channels in the GI tractR01DK1315422016-04-30NIHWEBER, CHRISTOPHER2014-07-01Mechanisms of tight junction pore and leak pathway regulation in intestinal mucosR03DK103007Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 1638212437322120Shaw DG, Aguirre-Gamboa R, Vieira MC, Gona S, DiNardi N, Wang A, Dumaine A, Gelderloos-Arends J, Earley ZM, Meckel KR, Ciszewski C, Castillo A, Monroe K, Torres J, Shah SC, Colombel JF, Itzkowitz S, Newberry R, Cohen RD, Rubin DT, Quince C, Cobey S, Jonkers IH, Weber CR, Pekow J, Wilson PC, Barreiro LB, Jabri BNature medicineAntigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529.Nat Med2023-06-15T00:00:002023Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.MedicinePathologyUniversity of ChicagoEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorLinLiuLin Liu41.78927490000000-87.601250000000001259Liu, LinClinical Assistant Professor37645840McGuinness S, Li P, Li Y, Fuladi S, Konar S, Sajjadi S, Sidahmed M, Li Y, Shen L, Araghi FK, Weber CRbioRxiv : the preprint server for biologyMolecular dynamics analyses of CLDN15 pore size and charge selectivity. bioRxiv. 2023 Aug 17.bioRxiv2023-08-17T00:00:002023Molecular dynamics analyses of CLDN15 pore size and charge selectivity.37692199Jamil OK, Shaw D, Deng Z, Dinardi N, Fillman N, Khanna S, Krugliak Cleveland N, Sakuraba A, Weber CR, Cohen RD, Dalal S, Jabri B, Rubin DT, Pekow JTherapeutic advances in gastroenterologyInflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis. Therap Adv Gastroenterol. 2023; 16:17562848231184985.Therap Adv Gastroenterol2023-09-07T00:00:002023Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis.Authorship 16616111Authorship 1662759JamesVardimanJames W. Vardiman41.78927490000000-87.601250000000001630Vardiman, JamesEmeritus/EmeritaJoel R.Pekowx2diBLY1DO/RmHllZ0mg9mHvJoel R. Pekow41.78927490000000-87.601250000000001867Pekow, Joel R.Associate ProfessorLorenJosephLoren Joseph41.78927490000000-87.601250000000002234Joseph, LorenAssistant ProfessorTabaKheradmandTaba Kheradmand41.78927490000000-87.601250000000002264Kheradmand, TabaPostdoctoral ScholarSandeepGurbuxaniSandeep Gurbuxani41.78927490000000-87.601250000000002442Gurbuxani, SandeepProfessorDavid T.RubinDavid T. Rubin41.78927490000000-87.60125000000000256Rubin, David T.ProfessorIvanMoskowitz3m9mGKoaDuXNi1pxY07n8GT98IW47aA=Ivan Moskowitz41.78927490000000-87.6012500000000037Moskowitz, IvanProfessorLeShenLe Shen41.78927490000000-87.60125000000000411Shen, LeResearch Associate ProfessorStephenHanauerStephen B. Hanauer41.78927490000000-87.60125000000000660Hanauer, StephenEmeritus/EmeritaAuthorship 167672237879626Cohen NA, Weber CR, Cheng JX, Choi D, Garcia NM, Choi NK, Rubin DTJournal of Crohn's & colitisOzanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes. J Crohns Colitis. 2023 Oct 25.J Crohns Colitis2023-10-25T00:00:002023Ozanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes.4.442520.0124848450research areas1.799090.023685366coauthor of134.8459.7559460similar to1190selected publicationsAuthorship 168477838014192Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott SmedRxiv : the preprint server for health sciencesMultiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients. medRxiv. 2023 Nov 13.medRxiv2023-11-13T00:00:002023Multiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients.Authorship 1687318Authorship 168848738106010Song S, Mohsin E, Zhang R, Kuznetsov A, Shen L, Grossman RL, Weber CR, Khan AAbioRxiv : the preprint server for biologyATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning. bioRxiv. 2023 Dec 10.bioRxiv2023-12-10T00:00:002023ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning.38068838Qazi A, Comiskey S, Calzadilla N, Amin F, Sharma A, Khin E, Holton N, Weber CR, Saksena S, Kumar A, Alrefai WA, Gill RKNutrientsPotential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation. Nutrients. 2023 Nov 30; 15(23).Nutrients2023-11-30T00:00:002023Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation.38189150Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IPCirculationA Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Jan 08.Circulation2024-01-08T00:00:002024A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.Authorship 16936923true1ProfessorProfessortrue1Emeritus/EmeritaEmeritus/Emeritatrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Emeritus/EmeritaEmeritus/Emeritatrue1Assistant ProfessorAssistant Professortrue1Postdoctoral ScholarPostdoctoral Scholartrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate ProfessorAuthorship 659993Authorship 681471Authorship 681934Authorship 695683Authorship 714807Authorship 788786Authorship 6990915Authorship 728912Authorship 78597225128899Liang GH, Weber CRCurrent opinion in pharmacologyMolecular aspects of tight junction barrier function. Curr Opin Pharmacol. 2014 Dec; 19:84-9.Curr Opin Pharmacol2014-08-14T00:00:002014Molecular aspects of tight junction barrier function.25234043Murphy SF, Rhee L, Grimm WA, Weber CR, Messer JS, Lodolce JP, Chang JE, Bartulis SJ, Nero T, Kukla RA, MacDougall G, Binghay C, Kolodziej LE, Boone DLAmerican journal of physiology. Gastrointestinal and liver physiologyIntestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 01; 307(9):G871-82.Am J Physiol Gastrointest Liver Physiol2014-09-18T00:00:002014Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice.23924897Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CRMolecular biology of the cellOccludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68.Mol Biol Cell2013-08-07T00:00:002013Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.24574339Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari FScience translational medicineß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28.Sci Transl Med2014-02-26T00:00:002014ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.21639915Qi W, Weber CR, Wasland K, Savkovic SDBMC cancerGenistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer. 2011 Jun 03; 11:219.BMC Cancer2011-06-03T00:00:002011Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity.24777350Singh P, Bello B, Weber C, Umanskiy KInternational journal of colorectal diseaseRectal leiomyosarcoma in association with ulcerative colitis: a rare condition with an unusual presentation. Int J Colorectal Dis. 2014 Jul; 29(7):887-8.Int J Colorectal Dis2014-04-29T00:00:002014Rectal leiomyosarcoma in association with ulcerative colitis: a rare condition with an unusual presentation.NamrataSetiaNamrata Setia0.000000000000000.000000000000003201Setia, NamrataAssociate ProfessorAuthorship 827591Authorship 82692526197453Chen P, Bakke D, Kolodziej L, Lodolce J, Weber CR, Boone DL, Toback FGInflammatory bowel diseasesAntrum Mucosal Protein-18 Peptide Targets Tight Junctions to Protect and Heal Barrier Structure and Function in Models of Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Oct; 21(10):2393-2402.Inflamm Bowel Dis2015-10-01T00:00:002015Antrum Mucosal Protein-18 Peptide Targets Tight Junctions to Protect and Heal Barrier Structure and Function in Models of Inflammatory Bowel Disease.11834711Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers DMCirculation researchNa(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res. 2002 Feb 08; 90(2):182-9.Circ Res2002-02-08T00:00:002002Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential.Chicago60637ILAuthorship 864746Authorship 862336Authorship 86951126568313Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JReLifeClaudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906.Elife2015-11-14T00:00:002015Claudin-2-dependent paracellular channels are dynamically gated.25645662Grimm WA, Messer JS, Murphy SF, Nero T, Lodolce JP, Weber CR, Logsdon MF, Bartulis S, Sylvester BE, Springer A, Dougherty U, Niewold TB, Kupfer SS, Ellis N, Huo D, Bissonnette M, Boone DLGutThe Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2016 Mar; 65(3):456-64.Gut2015-02-02T00:00:002015The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.Authorship 90285727079612Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EBAmerican journal of physiology. Gastrointestinal and liver physiologyInsights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G973-88.Am J Physiol Gastrointest Liver Physiol2016-04-14T00:00:002016Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.Pediatrics-CardiologyAuthorship 934761827582060Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IPScience translational medicinePitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm. Sci Transl Med. 2016 08 31; 8(354):354ra115.Sci Transl Med2016-08-31T00:00:002016Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Authorship 546501Authorship 581372Authorship 546482Authorship 546492Authorship 546512Authorship 566831Authorship 575772Authorship 578174Authorship 5865111Authorship 589262Authorship 617668Authorship 568862Authorship 60570312502596Piacentino V, Weber CR, Gaughan JP, Margulies KB, Bers DM, Houser SRAnnals of the New York Academy of SciencesModulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Ann N Y Acad Sci. 2002 Nov; 976:466-71.Ann N Y Acad Sci2002-11-01T00:00:002002Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange.12502604Bers DM, Weber CRAnnals of the New York Academy of SciencesNa/Ca exchange function in intact ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:500-12.Ann N Y Acad Sci2002-11-01T00:00:002002Na/Ca exchange function in intact ventricular myocytes.12502599Weber CR, Piacentino V, Margulies KB, Bers DM, Houser SRAnnals of the New York Academy of SciencesCalcium influx via I(NCX) is favored in failing human ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:478-9.Ann N Y Acad Sci2002-11-01T00:00:002002Calcium influx via I(NCX) is favored in failing human ventricular myocytes.23139219Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JBAmerican journal of physiology. Gastrointestinal and liver physiologyCapsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56.Am J Physiol Gastrointest Liver Physiol2012-11-08T00:00:002012Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.12502556Ginsburg KS, Weber CR, Despa S, Bers DMAnnals of the New York Academy of SciencesSimultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes. Ann N Y Acad Sci. 2002 Nov; 976:157-8.Ann N Y Acad Sci2002-11-01T00:00:002002Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes.23470164Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR, De Plaen IGThe American journal of pathologyBifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol. 2013 May; 182(5):1595-606.Am J Pathol2013-03-05T00:00:002013Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis.23603907Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SDThe Journal of biological chemistryFOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013 Jun 07; 288(23):16274-16281.J Biol Chem2013-04-18T00:00:002013FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.Authorship 952811Authorship 956001127648810Meisel M, Mayassi T, Fehlner-Peach H, Koval JC, O'Brien SL, Hinterleitner R, Lesko K, Kim S, Bouziat R, Chen L, Weber CR, Mazmanian SK, Jabri B, Antonopoulos DAThe ISME journalInterleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis. ISME J. 2017 01; 11(1):15-30.ISME J2016-09-20T00:00:002016Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis.12702644Weber CR, Ginsburg KS, Bers DMCirculation researchCardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current. Circ Res. 2003 May 16; 92(9):950-2.Circ Res2003-04-17T00:00:002003Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current.Authorship 963971826503631Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman VGutSpectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 02; 66(2):285-292.Gut2015-10-26T00:00:002015Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin.