Hening Lin to Humans
This is a "connection" page, showing publications Hening Lin has written about Humans.
Connection Strength
1.404
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice. Cell Rep. 2025 Aug 26; 44(8):116130.
Score: 0.030
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SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis. Sci Signal. 2025 May 27; 18(888):eadr2008.
Score: 0.030
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SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress. Elife. 2025 May 07; 13.
Score: 0.029
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A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 09 12; 67(17):15428-15437.
Score: 0.028
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MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2403392121.
Score: 0.028
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GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains. ACS Chem Biol. 2024 05 17; 19(5):1093-1105.
Score: 0.027
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Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2319833121.
Score: 0.027
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NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. 2024 04 23; 43(4):114070.
Score: 0.027
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Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets. Nat Rev Cancer. 2024 Apr; 24(4):240-260.
Score: 0.027
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Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism. Mol Cell Proteomics. 2024 Feb; 23(2):100709.
Score: 0.027
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A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain. ACS Chem Biol. 2023 05 19; 18(5):1200-1207.
Score: 0.026
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Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor. ACS Chem Biol. 2023 04 21; 18(4):668-670.
Score: 0.025
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Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. Biochemistry. 2023 01 17; 62(2):543-553.
Score: 0.025
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The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A. Biochemistry. 2022 09 06; 61(17):1874-1882.
Score: 0.024
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A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions. Mol Cell Proteomics. 2022 08; 21(8):100268.
Score: 0.024
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Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2117013119.
Score: 0.024
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NAD+-consuming enzymes in immune defense against viral infection. Biochem J. 2021 12 10; 478(23):4071-4092.
Score: 0.023
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High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases. ACS Chem Biol. 2021 08 20; 16(8):1318-1324.
Score: 0.023
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Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1-3 Inhibitors. ACS Chem Biol. 2021 07 16; 16(7):1266-1275.
Score: 0.023
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Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation. Annu Rev Biochem. 2021 06 20; 90:245-285.
Score: 0.022
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Protein cysteine palmitoylation in immunity and inflammation. FEBS J. 2021 12; 288(24):7043-7059.
Score: 0.022
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Garcinol Is an HDAC11 Inhibitor. ACS Chem Biol. 2020 11 20; 15(11):2866-2871.
Score: 0.021
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A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis. Nature. 2020 10; 586(7829):434-439.
Score: 0.021
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N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections. ACS Chem Biol. 2020 07 17; 15(7):1747-1758.
Score: 0.021
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TiPARP forms nuclear condensates to degrade HIF-1a and suppress tumorigenesis. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13447-13456.
Score: 0.021
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NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 2020 02 26; 11(1):1067.
Score: 0.021
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SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. ACS Chem Biol. 2019 09 20; 14(9):2014-2023.
Score: 0.020
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A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. ACS Chem Biol. 2019 08 16; 14(8):1802-1810.
Score: 0.020
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Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 07 19; 14(7):1393-1397.
Score: 0.020
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Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. J Med Chem. 2019 04 25; 62(8):4131-4141.
Score: 0.019
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Updates on the epigenetic roles of sirtuins. Curr Opin Chem Biol. 2019 08; 51:18-29.
Score: 0.019
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HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5487-5492.
Score: 0.019
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A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation. ChemMedChem. 2019 04 03; 14(7):744-748.
Score: 0.019
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Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins. Methods Mol Biol. 2019; 2009:129-136.
Score: 0.019
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Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling. Methods Mol Biol. 2019; 2009:137-147.
Score: 0.019
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Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities. ChemMedChem. 2018 09 19; 13(18):1890-1894.
Score: 0.018
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Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies. Chem Rev. 2018 02 14; 118(3):919-988.
Score: 0.018
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HPLC-Based Enzyme Assays for Sirtuins. Methods Mol Biol. 2018; 1813:225-234.
Score: 0.018
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SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. Elife. 2017 12 14; 6.
Score: 0.018
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S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. J Biol Chem. 2017 03 31; 292(13):5325-5334.
Score: 0.017
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SIRT7 Is an RNA-Activated Protein Lysine Deacylase. ACS Chem Biol. 2017 01 20; 12(1):300-310.
Score: 0.017
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Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nat Chem Biol. 2016 08; 12(8):614-20.
Score: 0.016
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Lessons learned from a SIRT2-selective inhibitor. Oncotarget. 2016 04 26; 7(17):22971-2.
Score: 0.016
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The Substrate Specificity of Sirtuins. Annu Rev Biochem. 2016 Jun 02; 85:405-29.
Score: 0.016
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Lysine fatty acylation promotes lysosomal targeting of TNF-a. Sci Rep. 2016 Apr 15; 6:24371.
Score: 0.016
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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 2016 Mar 14; 29(3):297-310.
Score: 0.016
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SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem Biol. 2016 Mar 18; 11(3):742-7.
Score: 0.016
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An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3. Org Biomol Chem. 2016 Feb 21; 14(7):2186-90.
Score: 0.015
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Sirtuins in epigenetic regulation. Chem Rev. 2015 Mar 25; 115(6):2350-75.
Score: 0.014
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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org Biomol Chem. 2014 Oct 14; 12(38):7498-502.
Score: 0.014
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Sirtuin inhibitors as anticancer agents. Future Med Chem. 2014 May; 6(8):945-66.
Score: 0.014
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Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. J Am Chem Soc. 2014 Apr 30; 136(17):6179-82.
Score: 0.014
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Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe. J Am Chem Soc. 2014 Apr 16; 136(15):5656-63.
Score: 0.014
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A fluorogenic assay for screening Sirt6 modulators. Org Biomol Chem. 2013 Aug 28; 11(32):5213-6.
Score: 0.013
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SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013 Apr 04; 496(7443):110-3.
Score: 0.013
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Detecting sirtuin-catalyzed deacylation reactions using ³²P-labeled NAD and thin-layer chromatography. Methods Mol Biol. 2013; 1077:179-89.
Score: 0.013
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Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19983-7.
Score: 0.012
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Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Anal Biochem. 2013 Feb 15; 433(2):218-26.
Score: 0.012
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Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS Chem Biol. 2012 Jun 15; 7(6):947-60.
Score: 0.012
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Thiosuccinyl peptides as Sirt5-specific inhibitors. J Am Chem Soc. 2012 Feb 01; 134(4):1922-5.
Score: 0.012
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11; 334(6057):806-9.
Score: 0.012
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Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS Chem Biol. 2012 Jan 20; 7(1):155-9.
Score: 0.012
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Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. J Am Chem Soc. 2010 Jul 14; 132(27):9363-72.
Score: 0.011
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Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009 Apr 07; 48(13):2878-90.
Score: 0.010
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Mechanism-based small molecule probes for labeling CD38 on live cells. J Am Chem Soc. 2009 Feb 11; 131(5):1658-9.
Score: 0.010
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Nicotinamide adenine dinucleotide: beyond a redox coenzyme. Org Biomol Chem. 2007 Aug 21; 5(16):2541-54.
Score: 0.009
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Photoaffinity Labeling Reveals a Role for the Unusual Triply Acylated Phospholipid N-Acylphosphatidylethanolamine in Lactate Homeostasis. J Am Chem Soc. 2025 Sep 17; 147(37):33386-33394.
Score: 0.008
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Biochemistry and regulation of histone lysine L-lactylation. Nat Rev Mol Cell Biol. 2026 Feb; 27(2):95-109.
Score: 0.008
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Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover. J Biol Chem. 2025 07; 301(7):110322.
Score: 0.007
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ATP-release pannexin channels are gated by lysophospholipids. Elife. 2025 May 01; 14.
Score: 0.007
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STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice. Sci Signal. 2023 12 05; 16(814):eadd2282.
Score: 0.007
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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid ß-oxidation and inducing lipotoxicity. Haematologica. 2023 09 01; 108(9):2343-2357.
Score: 0.007
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IGF2BP2 promotes cancer progression by degrading the RNA transcript encoding a v-ATPase subunit. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2200477119.
Score: 0.006
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Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7).
Score: 0.006
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Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nat Commun. 2022 01 10; 13(1):159.
Score: 0.006
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Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6. ACS Chem Biol. 2021 12 17; 16(12):2746-2751.
Score: 0.006
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Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival. Blood Cancer Discov. 2022 01; 3(1):50-65.
Score: 0.006
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Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer. J Med Chem. 2021 10 28; 64(20):15280-15296.
Score: 0.006
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Emerging roles of Sirtuin 2 in cardiovascular diseases. FASEB J. 2021 10; 35(10):e21841.
Score: 0.006
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High-Throughput Screening Identifies Ascorbyl Palmitate as a SIRT2 Deacetylase and Defatty-Acylase Inhibitor. ChemMedChem. 2021 11 19; 16(22):3484-3494.
Score: 0.006
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Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer. Eur J Med Chem. 2021 Dec 05; 225:113799.
Score: 0.006
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Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene. 2021 03; 40(9):1644-1658.
Score: 0.005
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Substrate-Dependent Modulation of SIRT2 by a Fluorescent Probe, 1-Aminoanthracene. Biochemistry. 2020 10 13; 59(40):3869-3878.
Score: 0.005
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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 2019 06 10; 35(6):916-931.e9.
Score: 0.005
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Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell. 2019 05 06; 49(3):393-408.e7.
Score: 0.005
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Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. Sci Rep. 2017 12 12; 7(1):17406.
Score: 0.004
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Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem Biol. 2017 Mar 16; 24(3):339-345.
Score: 0.004
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SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. J Am Chem Soc. 2016 09 28; 138(38):12304-7.
Score: 0.004
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Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 01; 353(6294):45-50.
Score: 0.004
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High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Mol Cell Proteomics. 2015 Jun; 14(6):1489-500.
Score: 0.004
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Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies. Sci Rep. 2015 Feb 23; 5:8529.
Score: 0.004
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The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem. 2012 Aug 17; 287(34):28307-14.
Score: 0.003
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ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Exp Cell Res. 2011 Apr 15; 317(7):910-9.
Score: 0.003
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Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38. Chem Biol. 2008 Oct 20; 15(10):1068-78.
Score: 0.002