Hening Lin to Mice
This is a "connection" page, showing publications Hening Lin has written about Mice.
Connection Strength
1.468
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice. Cell Rep. 2025 Aug 26; 44(8):116130.
Score: 0.086
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SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis. Sci Signal. 2025 May 27; 18(888):eadr2008.
Score: 0.085
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SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress. Elife. 2025 May 07; 13.
Score: 0.084
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A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 09 12; 67(17):15428-15437.
Score: 0.080
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Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2319833121.
Score: 0.078
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NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. 2024 04 23; 43(4):114070.
Score: 0.078
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Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. Biochemistry. 2023 01 17; 62(2):543-553.
Score: 0.071
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Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation. Nat Commun. 2022 08 02; 13(1):4494.
Score: 0.070
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Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1-3 Inhibitors. ACS Chem Biol. 2021 07 16; 16(7):1266-1275.
Score: 0.064
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A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis. Nature. 2020 10; 586(7829):434-439.
Score: 0.061
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TiPARP forms nuclear condensates to degrade HIF-1a and suppress tumorigenesis. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13447-13456.
Score: 0.060
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Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. J Med Chem. 2019 04 25; 62(8):4131-4141.
Score: 0.055
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HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5487-5492.
Score: 0.055
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SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. Elife. 2017 12 14; 6.
Score: 0.050
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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. Elife. 2017 04 13; 6.
Score: 0.048
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Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nat Chem Biol. 2016 08; 12(8):614-20.
Score: 0.045
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Lessons learned from a SIRT2-selective inhibitor. Oncotarget. 2016 04 26; 7(17):22971-2.
Score: 0.045
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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4320-5.
Score: 0.045
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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 2016 Mar 14; 29(3):297-310.
Score: 0.045
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11; 334(6057):806-9.
Score: 0.033
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Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009 Apr 07; 48(13):2878-90.
Score: 0.028
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ATP-release pannexin channels are gated by lysophospholipids. Elife. 2025 May 01; 14.
Score: 0.021
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STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice. Sci Signal. 2023 12 05; 16(814):eadd2282.
Score: 0.019
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Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice. J Med Chem. 2023 12 14; 66(23):16075-16090.
Score: 0.019
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Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7).
Score: 0.017
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Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nat Commun. 2022 01 10; 13(1):159.
Score: 0.017
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Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6. ACS Chem Biol. 2021 12 17; 16(12):2746-2751.
Score: 0.017
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Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer. Eur J Med Chem. 2021 Dec 05; 225:113799.
Score: 0.016
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Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene. 2021 03; 40(9):1644-1658.
Score: 0.016
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Structural Basis of the Substrate Selectivity of Viperin. Biochemistry. 2020 02 11; 59(5):652-662.
Score: 0.015
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HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models. Antioxid Redox Signal. 2018 05 01; 28(13):1224-1237.
Score: 0.013
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SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. J Am Chem Soc. 2016 09 28; 138(38):12304-7.
Score: 0.012
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Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 01; 353(6294):45-50.
Score: 0.011
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Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep. 2013 Sep 30; 3:2806.
Score: 0.009