Hening Lin to Sirtuins
This is a "connection" page, showing publications Hening Lin has written about Sirtuins.
Connection Strength
11.005
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Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities. Curr Opin Chem Biol. 2023 Feb; 72:102231.
Score: 0.696
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Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation. Annu Rev Biochem. 2021 06 20; 90:245-285.
Score: 0.622
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Updates on the epigenetic roles of sirtuins. Curr Opin Chem Biol. 2019 08; 51:18-29.
Score: 0.538
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Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins. Methods Mol Biol. 2019; 2009:129-136.
Score: 0.531
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Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling. Methods Mol Biol. 2019; 2009:137-147.
Score: 0.531
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HPLC-Based Enzyme Assays for Sirtuins. Methods Mol Biol. 2018; 1813:225-234.
Score: 0.495
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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. Elife. 2017 04 13; 6.
Score: 0.471
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SIRT7 Is an RNA-Activated Protein Lysine Deacylase. ACS Chem Biol. 2017 01 20; 12(1):300-310.
Score: 0.461
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Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nat Chem Biol. 2016 08; 12(8):614-20.
Score: 0.445
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The Substrate Specificity of Sirtuins. Annu Rev Biochem. 2016 Jun 02; 85:405-29.
Score: 0.440
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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4320-5.
Score: 0.439
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SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem Biol. 2016 Mar 18; 11(3):742-7.
Score: 0.436
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An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3. Org Biomol Chem. 2016 Feb 21; 14(7):2186-90.
Score: 0.433
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Sirtuins in epigenetic regulation. Chem Rev. 2015 Mar 25; 115(6):2350-75.
Score: 0.404
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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org Biomol Chem. 2014 Oct 14; 12(38):7498-502.
Score: 0.396
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Sirtuin inhibitors as anticancer agents. Future Med Chem. 2014 May; 6(8):945-66.
Score: 0.384
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A fluorogenic assay for screening Sirt6 modulators. Org Biomol Chem. 2013 Aug 28; 11(32):5213-6.
Score: 0.366
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SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013 Apr 04; 496(7443):110-3.
Score: 0.356
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Detecting sirtuin-catalyzed deacylation reactions using ³²P-labeled NAD and thin-layer chromatography. Methods Mol Biol. 2013; 1077:179-89.
Score: 0.350
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Thiosuccinyl peptides as Sirt5-specific inhibitors. J Am Chem Soc. 2012 Feb 01; 134(4):1922-5.
Score: 0.328
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11; 334(6057):806-9.
Score: 0.323
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Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS Chem Biol. 2012 Jan 20; 7(1):155-9.
Score: 0.322
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Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009 Apr 07; 48(13):2878-90.
Score: 0.270
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Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J Am Chem Soc. 2023 03 29; 145(12):6811-6822.
Score: 0.178
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Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase. J Am Chem Soc. 2022 03 02; 144(8):3360-3364.
Score: 0.165
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NAD+-consuming enzymes in immune defense against viral infection. Biochem J. 2021 12 10; 478(23):4071-4092.
Score: 0.163
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Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene. 2021 03; 40(9):1644-1658.
Score: 0.153
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A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7. J Am Chem Soc. 2019 02 13; 141(6):2462-2473.
Score: 0.134
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Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep. 2013 Sep 30; 3:2806.
Score: 0.092
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The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem. 2012 Aug 17; 287(34):28307-14.
Score: 0.085