ElizabethHeckscherElizabeth Heckscher0.000000000000000.000000000000003228Heckscher, ElizabethDrosophilaMotor ActivitySensory FunctionNeuronStem CellTranscription FactorLineage, CellEvolution, BiologicalS.My lab studies the assembly, function, and evolution of circuits. Specifically, we focus on sensorimotor circuits, such as those in the spinal cord. These circuits process a variety of stimuli such as heat, light touch, pain, and self-movement. These circuits generate patterned muscle contractions underly animal movement.
Movement control- My lab is interested in understanding how neural circuits implement the motor programs that allow animals to move. Our goal is to understand the functional architecture of a sensorimotor system at the cellular level.
Circuit assembly- We are interested in understanding how circuits self-assemble starting from a small number of stem cells. This should generate developmental insight relevant to stem cell reprogramming that could be used to replace diseased/damaged neural tissue.
Evolution of circuits- We are interested in how sensorimotor circuits change over evolutionary time scales to allow animals to control different body forms and behaviors.+1 (773) 834-1376Associate Professorplugins:TwitterTwitterprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson06/2008Brown UniversityProvidence, RIBrown University, BiologyBSBiology04/2007University of CaliforniaSan Francisco, CAUniversity of California, Cell BiologyPhDCell Biology07/2015University of OregonEugene, ORUniversity of Oregon, Neuronal CircuitsPostdocNeuronal CircuitsAmerican Heart Association20152012Postdoctoral FellowshipHoward Hughes Medical Insitutue20052000Predoctoral FellowshipBrown University Chapter of Sigma Xi1998Sigma Xi MembershipIvy-League1996Academic All-Ivy Selection (fencing)Authorship 1069496Authorship 1069512Authorship 106953127929468Sun X, Heckscher ESJournal of visualized experiments : JoVEUsing Linear Agarose Channels to Study Drosophila Larval Crawling Behavior. J Vis Exp. 2016 11 26; (117).J Vis Exp2016-11-26T00:00:002016Using Linear Agarose Channels to Study Drosophila Larval Crawling Behavior.24917506Heckscher ES, Long F, Layden MJ, Chuang CH, Manning L, Richart J, Pearson JC, Crews ST, Peng H, Myers E, Doe CQDevelopment (Cambridge, England)Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience. Development. 2014 Jun; 141(12):2524-32.Development2014-06-01T00:00:002014Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.28502656Wreden CC, Meng JL, Feng W, Chi W, Marshall ZD, Heckscher ESCurrent biology : CBTemporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits. Curr Biol. 2017 May 22; 27(10):1521-1528.e4.Curr Biol2017-05-11T00:00:002017Temporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits.D004330Living Beings814940.726852DrosophilaEcology and EvolutionMolecular Genetics and Cell BiologyD004331Living Beings1115960.694543Drosophila melanogasterNeurobiologyD009469Anatomy23800.949306Neuromuscular Junction32391795Meng JL, Wang Y, Carrillo RA, Heckscher ESeLifeTemporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships. Elife. 2020 05 11; 9.Elife2020-05-11T00:00:002020Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.D013234Anatomy1793500.817759Stem CellsJothamAustinJotham Austin0.000000000000000.000000000000002979Austin, JothamResearch Associate ProfessorBen May Department of Cancer Research33617535Chi W, Liu W, Fu W, Xia S, Heckscher ES, Zhuang XPLoS geneticsRNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.PLoS Genet2021-02-22T00:00:002021RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila.D029721Chemicals & Drugs894860.698475Drosophila Proteins35723253Wang YW, Wreden CC, Levy M, Meng JL, Marshall ZD, MacLean J, Heckscher EeLifeSequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord. Elife. 2022 06 20; 11.Elife2022-06-20T00:00:002022Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord.Authorship 1578235Authorship 1578244Authorship 1578254Authorship 1578265Authorship 1578272Authorship 1578287Authorship 157829231502540Meng JL, Marshall ZD, Lobb-Rabe M, Heckscher ESeLifeHow prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits. Elife. 2019 09 10; 8.Elife2019-09-10T00:00:002019How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.35031555Marshall ZD, Heckscher ESeNeuroThe Role of Even-Skipped in Drosophila Larval Somatosensory Circuit Assembly. eNeuro. 2022 Jan-Feb; 9(1).eNeuro2022-02-02T00:00:002022The Role of Even-Skipped in Drosophila Larval Somatosensory Circuit Assembly.33706923Meng JL, Heckscher ESCurrent topics in developmental biologyDevelopment of motor circuits: From neuronal stem cells and neuronal diversity to motor circuit assembly. Curr Top Dev Biol. 2021; 142:409-442.Curr Top Dev Biol2020-12-19T00:00:002020Development of motor circuits: From neuronal stem cells and neuronal diversity to motor circuit assembly.30853433He L, Gulyanon S, Mihovilovic Skanata M, Karagyozov D, Heckscher ES, Krieg M, Tsechpenakis G, Gershow M, Tracey WDCurrent biology : CBDirection Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc. Curr Biol. 2019 03 18; 29(6):945-956.e3.Curr Biol2019-03-07T00:00:002019Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc.http://voices.uchicago.edu/heckscherlabHeckscher Lab Websitehttp://shb-lab.orgHorne-Badovinac Lab Websitehttps://voices.uchicago.edu/fehonlab/Fehon Labhttps://cpb-us-w2.wpmucdn.com/voices.uchicago.edu/dist/e/772/files/2019/10/ACFrOgCOWaX1k-0F2phup4Kdbe_UAJxPHs-eXWdz39eZftkvJP7iTAjzrBTAsWiLe56mP9fcDklTlbjhSM51HQSgUi5KmcOHeOnzQgwUSY10fRhBD4-L14dlPBG7hpM.pdfZhuang Labhttps://www.carrillolab.com/Carrillo Labhttps://mgcb.uchicago.edu/faculty/elizabeth-s-heckscher-phdMGCB Heckscher Labhttp://voices.uchicago.edu/rebaylab/Rebay Labhttp://www.hcleelab.orgLee Lab Websitehttps://macleanlab.uchicago.eduMacLean Labhttp://manyuanlonglab.uchicago.edu/Long Lab Websitehttps://mgcb.uchicago.edu/faculty/robert-carrillo-phdMGCB Profileelliehoopla2023-07-31NIHHECKSCHER, ELIZABETH S2018-09-01Development of neuronal circuits for innate behaviorR01NS105748Principal InvestigatorHuman GeneticsMedicinePathologyUniversity of ChicagoDanielMatuteDaniel Matute41.78927490000000-87.601250000000001263Matute, DanielPostdoctoral ScholarJasonMacleanJason Maclean41.78927490000000-87.601250000000001551Maclean, JasonProfessorRichard G.FehonRichard G. Fehon41.78927490000000-87.601250000000001759Fehon, Richard G.ProfessorSallyHorne-BadovinacSally Horne-Badovinac41.78927490000000-87.601250000000002252Horne-Badovinac, SallyProfessorIlariaRebayIlaria Rebay41.78927490000000-87.601250000000002383Rebay, IlariaProfessorManyuanLongManyuan Long41.78927490000000-87.601250000000002617Long, ManyuanProfessorXiaoxiZhuangz3hhHqAbHszMknJtY0fp/Cv/+94=Xiaoxi Zhuang41.78927490000000-87.60125000000000285Zhuang, XiaoxiProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Postdoctoral ScholarPostdoctoral Scholartrue1Clinical AssociateClinical Associatetrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor1010Chicago60637ILGeoffreyWoolGeoffrey Wool0.000000000000000.000000000000003213Wool, GeoffreyAssociate Professor2.490280.010168960research areas0.2211140.1910533coauthor of50.80515.3880160similar to1111selected publicationsAuthorship 83942126439528Heckscher ES, Zarin AA, Faumont S, Clark MQ, Manning L, Fushiki A, Schneider-Mizell CM, Fetter RD, Truman JW, Zwart MF, Landgraf M, Cardona A, Lockery SR, Doe CQNeuronEven-Skipped(+) Interneurons Are Core Components of a Sensorimotor Circuit that Maintains Left-Right Symmetric Muscle Contraction Amplitude. Neuron. 2015 Oct 21; 88(2):314-29.Neuron2015-10-01T00:00:002015Even-Skipped(+) Interneurons Are Core Components of a Sensorimotor Circuit that Maintains Left-Right Symmetric Muscle Contraction Amplitude.Heng-ChiLeeHeng-Chi Lee0.000000000000000.000000000000003275Lee, Heng-ChiAssociate ProfessorJhee UnLeeJhee Un Lee0.000000000000000.000000000000002815Lee, Jhee UnClinical AssociateRobertCarrilloRobert Carrillo0.000000000000000.000000000000003411Carrillo, RobertAssociate Professor