MeganMcnerney2mFnDrMbHPX5hHlsaUXv9Gq0+s+oMegan Mcnerney0.000000000000000.000000000000002681Mcnerney, MeganCancerMyeloid LeukemiaGenomicsTranscription FactorHematopoiesisThe McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities. We focus on myeloid malignancies which are particularly difficult to treat. We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome. Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling. Please visit our webpage for more information https://voices.uchicago.edu/mcnerneylab/+1 (773) 834-8896Associate Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 99974428263985Stricker TP, Brown CD, Bandlamudi C, McNerney M, Kittler R, Montoya V, Peterson A, Grossman R, White KPPLoS geneticsRobust stratification of breast cancer subtypes using differential patterns of transcript isoform expression. PLoS Genet. 2017 03; 13(3):e1006589.PLoS Genet2017-03-06T00:00:002017Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression.Authorship 102276428369554Arthur RK, An N, Khan S, McNerney MENucleic acids researchThe haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters. Nucleic Acids Res. 2017 Jun 20; 45(11):6350-6361.Nucleic Acids Res2017-06-20T00:00:002017The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.2005The University of ChicagoChicagoThe University of Chicago, ImmunologyPhDImmunology2007The University of Chicago ChicagoThe University of Chicago , MedicineMDMedicine1999Northwestern UniversityEvanstonNorthwestern University, Molecular and Cellular BiologyB.A.Molecular and Cellular Biology2010The University of ChicagoChicagoThe University of Chicago, Clinical PathologyResidencyClinical Pathology2014The University of ChicagoChicagoThe University of Chicago, Genomics and Systems BiologyPostdoctoralGenomics and Systems Biology2014“V” Foundation in Cancer Research Scholar Award 2013Leukemia and Lymphoma Society, Illinois Chapter Researcher of the YearAuthorship 10709712013Evans Travel Award, FASEB Hematologic Malignancies Science Research Conference2010Robert W. Wissler Fellowship Award, Department of Pathology2011Leukemia and Lymphoma Society Fellow Award2009Resident Research Grant, College of American Pathologists2007Leon Jacobson Prize for Senior Scientific Presentation, Pritzker School of Medicine2006Honorable Mention Best PhD Dissertation Award, Biological Sciences, University of Chicago2006Committee on Immunology Best PhD Thesis Award, University of Chicago 2005Robert E. Priest Pathology Merit Award, Department of Pathology, University of Chicago2004Doolittle-Harrison Travel Fellowship, University of Chicago2003Elaine Frank Family Fellowship for Medical Research, MSTP, University of Chicago20072000Medical Scientist Training Program, NIH1999Graduation Cum Laude, Northwestern University1999Graduation with Departmental Honors, Biological Sciences, Northwestern University1997Edgar Macey Scholarship for Summer Research, Northwestern University28835720McNerney ME, Godley LA, Le Beau MMNature reviews. CancerTherapy-related myeloid neoplasms: when genetics and environment collide. Nat Rev Cancer. 2017 08 24; 17(9):513-527.Nat Rev Cancer2017-08-24T00:00:002017Therapy-related myeloid neoplasms: when genetics and environment collide.D002897Anatomy38790.962074Chromosomes, Human, Pair 7Molecular Genetics and Cell Biology2017American Society of Hematology Junior Faculty Scholar AwardAuthorship 10797521Authorship 107976729698836Kang W, Kadri S, Puranik R, Wurst MN, Patil SA, Mujacic I, Benhamed S, Niu N, Zhen CJ, Ameti B, Long BC, Galbo F, Montes D, Iracheta C, Gamboa VL, Lopez D, Yourshaw M, Lawrence CA, Aisner DL, Fitzpatrick C, McNerney ME, Wang YL, Andrade J, Volchenboum SL, Furtado LV, Ritterhouse LL, Segal JPThe Journal of molecular diagnostics : JMDSystem for Informatics in the Molecular Pathology Laboratory: An Open-Source End-to-End Solution for Next-Generation Sequencing Clinical Data Management. J Mol Diagn. 2018 07; 20(4):522-532.J Mol Diagn2018-04-24T00:00:002018System for Informatics in the Molecular Pathology Laboratory: An Open-Source End-to-End Solution for Next-Generation Sequencing Clinical Data Management.29592892An N, Khan S, Imgruet MK, Gurbuxani SK, Konecki SN, Burgess MR, McNerney MEBloodGene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood. 2018 06 14; 131(24):2682-2697.Blood2018-03-28T00:00:002018Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.Authorship 123504130388419McNerney ME, Le Beau MMCell stem cellThe Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells. Cell Stem Cell. 2018 11 01; 23(5):634-635.Cell Stem Cell2018-11-01T00:00:002018The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.D006412Anatomy1042920.839093Hematopoietic Stem CellsD012097Chemicals & Drugs1894030.777343Repressor ProteinsAuthorship 1359441432074275Cahill KE, Karimi YH, Karrison TG, Jain N, Green M, Weiner H, Fulton N, Kadri S, Godley LA, Artz AS, Liu H, Thirman MJ, Le Beau MM, McNerney ME, Segal J, Larson RA, Stock W, Odenike OBlood advancesA phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia. Blood Adv. 2020 02 25; 4(4):599-606.Blood Adv2020-02-25T00:00:002020A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.2013Cancer Research Foundation Young Investigator Award2015Nachman Fellow, Dept. of Pediatrics Hematology-Oncology2019American Cancer Society Research Scholar Award2020Faculty Award for Excellence in Graduate Teaching and MentoringAuthorship 140667832924016Stoddart A, Wang J, Fernald AA, Davis EM, Johnson CR, Hu C, Cheng JX, McNerney ME, Le Beau MMBlood cancer discoveryCytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms. Blood Cancer Discov. 2020 07; 1(1):32-47.Blood Cancer Discov2020-07-01T00:00:002020Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms.JeremySegalJeremy Segal0.000000000000000.000000000000002880Segal, JeremyProfessor15905190Lee KM, Forman JP, McNerney ME, Stepp S, Kuppireddi S, Guzior D, Latchman YE, Sayegh MH, Yagita H, Park CK, Oh SB, Wülfing C, Schatzle J, Mathew PA, Sharpe AH, Kumar VBloodRequirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 2006 Apr 15; 107(8):3181-8.Blood2005-05-19T00:00:002005Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.15870174McNerney ME, Guzior D, Kumar VBlood2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. 2005 Aug 15; 106(4):1337-40.Blood2005-05-03T00:00:0020052B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.15841099Kumar V, McNerney MENature reviews. ImmunologyA new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat Rev Immunol. 2005 May; 5(5):363-74.Nat Rev Immunol2005-05-01T00:00:002005A new self: MHC-class-I-independent natural-killer-cell self-tolerance.Medicine-Hematology and Oncology16468959McNerney ME, Lee KM, Zhou P, Molinero L, Mashayekhi M, Guzior D, Sattar H, Kuppireddi S, Wang CR, Kumar V, Alegre MLAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsRole of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006 Mar; 6(3):505-13.Am J Transplant2006-03-01T00:00:002006Role of natural killer cell subsets in cardiac allograft rejection.15607804McNerney ME, Lee KM, Kumar VMolecular immunology2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 2005 Feb; 42(4):489-94.Mol Immunol2005-02-01T00:00:0020052B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells.Authorship 1468051134041524Imgruet MK, Lutze J, An NN, Hu B, Khan S, Kurkewich J, Martinez TC, Wolfgeher DJ, Gurbuxani S, Kron SJ, McNerney MEBloodLoss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 May 26.Blood2021-05-26T00:00:002021Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms.21421111Godley LA, Cunningham J, Dolan ME, Huang RS, Gurbuxani S, McNerney ME, Larson RA, Leong H, Lussier Y, Onel K, Odenike O, Stock W, White KP, Le Beau MMSeminars in oncologyAn integrated genomic approach to the assessment and treatment of acute myeloid leukemia. Semin Oncol. 2011 Apr; 38(2):215-24.Semin Oncol2011-04-01T00:00:002011An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.21713073Stoddart A, McNerney ME, Bartom E, Bergerson R, Young DJ, Qian Z, Wang J, Fernald AA, Davis EM, Larson RA, White KP, Le Beau MMMediterranean journal of hematology and infectious diseasesGenetic pathways leading to therapy-related myeloid neoplasms. Mediterr J Hematol Infect Dis. 2011; 3(1):e2011019.Mediterr J Hematol Infect Dis2011-05-16T00:00:002011Genetic pathways leading to therapy-related myeloid neoplasms.Authorship 1494931134473231Imgruet MK, Lutze J, An N, Hu B, Khan S, Kurkewich J, Martinez TC, Wolfgeher D, Gurbuxani SK, Kron SJ, McNerney MEBloodLoss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 09 02; 138(9):790-805.Blood2021-09-02T00:00:002021Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.Authorship 150744634707089Ludwig LM, Hawley KM, Banks DB, Thomas-Toth AT, Blazar BR, McNerney ME, Leverson JD, LaBelle JLCell death & diseaseVenetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells. Cell Death Dis. 2021 10 27; 12(11):1005.Cell Death Dis2021-10-27T00:00:002021Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.20383307McNerney ME, Baron BW, Volchenboum SL, Papari M, Keith M, Williams K, Richa EBlood transfusion = Trasfusione del sangueDevelopment of warm auto- and allo-antibodies in a 3-year old boy with sickle cell haemoglobinopathy following his first transfusion of a single unit of red blood cells. Blood Transfus. 2010 Apr; 8(2):126-8.Blood Transfus2010-04-01T00:00:002010Development of warm auto- and allo-antibodies in a 3-year old boy with sickle cell haemoglobinopathy following his first transfusion of a single unit of red blood cells.Authorship 151983734997000Krishnan M, Senagolage MD, Baeten JT, Wolfgeher DJ, Khan S, Kron SJ, McNerney MEScientific reportsGenomic studies controvert the existence of the CUX1 p75 isoform. Sci Rep. 2022 01 07; 12(1):151.Sci Rep2022-01-07T00:00:002022Genomic studies controvert the existence of the CUX1 p75 isoform.Authorship 152198535034954Baeten JT, Liu W, Preddy IC, Zhou N, McNerney MELeukemiaCRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. Leukemia. 2022 05; 36(5):1421-1425.Leukemia2022-01-17T00:00:002022CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions.Authorship 152351235084368Jotte MRM, McNerney MECurrent opinion in hematologyThe significance of CUX1 and chromosome 7 in myeloid malignancies. Curr Opin Hematol. 2022 03 01; 29(2):92-102.Curr Opin Hematol2022-03-01T00:00:002022The significance of CUX1 and chromosome 7 in myeloid malignancies.D018398Chemicals & Drugs1905350.737984Homeodomain ProteinsAuthorship 1578137Authorship 15781442022Leukemia and Lymphoma Society Scholar Award36349721Shih AJ, Jun T, Skol AD, Bao R, Huang L, Vora S, McNerney ME, Hungate EA, Le Beau MM, Larson RA, Elliott A, Lu HM, Huether R, Hernandez F, Stölzel F, Allan JM, Onel KBritish journal of haematologyInherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms. Br J Haematol. 2023 02; 200(4):489-493.Br J Haematol2022-11-09T00:00:002022Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.35995095Stoddart A, Fernald AA, Davis EM, McNerney ME, Le Beau MMExperimental hematologyEGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy. Exp Hematol. 2022 11; 115:54-67.Exp Hematol2022-08-20T00:00:002022EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy.24464852Heath AP, Greenway M, Powell R, Spring J, Suarez R, Hanley D, Bandlamudi C, McNerney ME, White KP, Grossman RLJournal of the American Medical Informatics Association : JAMIABionimbus: a cloud for managing, analyzing and sharing large genomics datasets. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):969-75.J Am Med Inform Assoc2014-01-24T00:00:002014Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets.25043302Voce DJ, Schmitt AM, Uppal A, McNerney ME, Bernal GM, Cahill KE, Wahlstrom JS, Nassiri A, Yu X, Crawley CD, White KP, Onel K, Weichselbaum RR, Yamini BOncogeneNfkb1 is a haploinsufficient DNA damage-specific tumor suppressor. Oncogene. 2015 May 21; 34(21):2807-13.Oncogene2014-07-21T00:00:002014Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor.24931631McNerney ME, Brown CD, Peterson AL, Banerjee M, Larson RA, Anastasi J, Le Beau MM, White KPBritish journal of haematologyThe spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q). Br J Haematol. 2014 Aug; 166(4):550-6.Br J Haematol2014-06-13T00:00:002014The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).25407795Wang X, Fu AQ, McNerney ME, White KPNature communicationsWidespread genetic epistasis among cancer genes. Nat Commun. 2014 Nov 19; 5:4828.Nat Commun2014-11-19T00:00:002014Widespread genetic epistasis among cancer genes.Authorship 160642636725889An N, Khan S, Imgruet MK, Jueng L, Gurbuxani S, McNerney MEOncogeneOncogenic RAS promotes leukemic transformation of CUX1-deficient cells. Oncogene. 2023 03; 42(12):881-893.Oncogene2023-02-01T00:00:002023Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://he-group.uchicago.eduMy Lab Sitehttps://imagebank.hematology.org/ASH Image Bankhttps://voices.uchicago.edu/mcnerneylab/McNerney Labhttps://biologicalsciences.uchicago.edu/faculty/stephen-j-kron-md-phdFaculty Profilehttps://mgcb.uchicago.edu/Department of Molecular Genetics & Cell Biologyhttps://voices.uchicago.edu/kronlab/Kron Lab@gvencut12011-06-30NIHMCNERNEY, MEGAN ELIZABETH2010-12-01Next-Generation Sequencing of Therapy-Related Acute Myeloid LeukemiaF32CA1506312023-08-31NIHMCNERNEY, MEGAN2018-09-20The pathogenesis of chromosome 7q deletions in juvenile myelomonocytic leukemiaR01CA2318802019-08-31NIHMCNERNEY, MEGAN ELIZABETH2014-09-16Determining the role of CUX1 in myeloid neoplasiaK08CA1812542023-06-30NIHMCNERNEY, MEGAN2018-07-15Regulation of hematopoiesis by CUX1R01HL142782Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorD009687Chemicals & Drugs2646940.701812Nuclear ProteinsChemistryMedicinePathologyUniversity of ChicagoLucyGodley22VmD60QeczMknJtY0fp/Cv/+94=Lucy Godley41.78927490000000-87.601250000000001017Godley, LucyProfessorRichard A.LarsonRichard A. Larson41.78927490000000-87.601250000000001169Larson, Richard A.ProfessorAngelaStoddartAngela Stoddart41.78927490000000-87.601250000000001586Stoddart, AngelaResearch Associate ProfessorMichelle M.LebeauMichelle M. Lebeau41.78927490000000-87.601250000000002029Lebeau, Michelle M.ProfessorVinayKumarVinay Kumar41.78927490000000-87.601250000000002039Kumar, VinayProfessorSandeepGurbuxaniSandeep Gurbuxani41.78927490000000-87.601250000000002442Gurbuxani, SandeepProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorStephen J.KronxGl7BK81DO/RmHllZ0mg9mHvStephen J. Kron41.78927490000000-87.60125000000000665Kron, Stephen J.ProfessorAuthorship 167810237906947Martinez TC, McNerney MEAnnual review of pathologyHaploinsufficient Transcription Factors in Myeloid Neoplasms. Annu Rev Pathol. 2024 Jan 24; 19:571-598.Annu Rev Pathol2023-10-31T00:00:002023Haploinsufficient Transcription Factors in Myeloid Neoplasms.true1ProfessorProfessortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate ProfessorAuthorship 652241Authorship 702553Authorship 734338Authorship 762324Authorship 76432623733505Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon KCancer discoveryDominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013 Sep; 3(9):993-1001.Cancer Discov2013-06-03T00:00:002013Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.25822087Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SWNature geneticsCooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 2015 May; 47(5):539-43.Nat Genet2015-03-30T00:00:002015Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.Authorship 7945641010NamrataSetiaNamrata Setia0.000000000000000.000000000000003201Setia, NamrataAssociate ProfessorGeoffreyWoolGeoffrey Wool0.000000000000000.000000000000003213Wool, GeoffreyAssociate ProfessorAuthorship 902941026944478Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MMHaematologicaRetroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Haematologica. 2016 06; 101(6):e232-6.Haematologica2016-03-04T00:00:002016Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.Chicago60637IL2.937710.00497154269research areas1.175410.025398534coauthor of57.89549.5688360similar to1141selected publicationsGirishVenkataraman0HRsBaoUDczMknJtY0fp/Cv/+94=Girish Venkataraman0.000000000000000.000000000000002713Venkataraman, GirishProfessorJason X.Cheng3WN6BK9bGuTcn31EdUXm/Hbq9t+85aYQdX1vJason X. Cheng0.000000000000000.000000000000002798Cheng, Jason X.Associate ProfessorAuthorship 556483Authorship 553582Authorship 592832Authorship 562171Authorship 558021Authorship 558353Authorship 539082Authorship 590906Authorship 585441Authorship 561051Authorship 607691Authorship 618448Authorship 556291Authorship 55780211086108Yi Y, McNerney M, Datta SKJournal of immunology (Baltimore, Md. : 1950)Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. J Immunol. 2000 Dec 01; 165(11):6627-34.J Immunol2000-12-01T00:00:002000Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.15123744Lee KM, McNerney ME, Stepp SE, Mathew PA, Schatzle JD, Bennett M, Kumar VThe Journal of experimental medicine2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med. 2004 May 03; 199(9):1245-54.J Exp Med2004-05-03T00:00:0020042B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.15634901Vaidya SV, Stepp SE, McNerney ME, Lee JK, Bennett M, Lee KM, Stewart CL, Kumar V, Mathew PAJournal of immunology (Baltimore, Md. : 1950)Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J Immunol. 2005 Jan 15; 174(2):800-7.J Immunol2005-01-15T00:00:002005Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.16323413McNerney ME, Kumar VCurrent topics in microbiology and immunologyThe CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 2006; 298:91-120.Curr Top Microbiol Immunol2006-01-01T00:00:002006The CD2 family of natural killer cell receptors.23212519McNerney ME, Brown CD, Wang X, Bartom ET, Karmakar S, Bandlamudi C, Yu S, Ko J, Sandall BP, Stricker T, Anastasi J, Grossman RL, Cunningham JM, Le Beau MM, White KPBloodCUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood. 2013 Feb 07; 121(6):975-83.Blood2012-12-03T00:00:002012CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.23490885Brägelmann J, Dagogo-Jack I, El Dinali M, Stricker T, Brown CD, Zuo Z, Khattri A, Keck M, McNerney ME, Longnecker R, Bieging K, Kocherginsky M, Alexander K, Salgia R, Lingen MW, Vokes EE, White KP, Cohen EE, Seiwert TYOral oncologyOral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA. Oral Oncol. 2013 Jun; 49(6):525-33.Oral Oncol2013-03-13T00:00:002013Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA.Authorship 96442227792083Alegre ML, McNerney MECurrent opinion in organ transplantationNatural killer cell subsets in allograft rejection and tolerance. Curr Opin Organ Transplant. 2007 Feb; 12(1):10-16.Curr Opin Organ Transplant2007-02-01T00:00:002007Natural killer cell subsets in allograft rejection and tolerance.Authorship 967551327836695Kadri S, Long BC, Mujacic I, Zhen CJ, Wurst MN, Sharma S, McDonald N, Niu N, Benhamed S, Tuteja JH, Seiwert TY, White KP, McNerney ME, Fitzpatrick C, Wang YL, Furtado LV, Segal JPThe Journal of molecular diagnostics : JMDClinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays. J Mol Diagn. 2017 01; 19(1):43-56.J Mol Diagn2016-11-09T00:00:002016Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays.DanielArberDaniel Arber0.000000000000000.000000000000003406Arber, DanielProfessor