Berg JJ, Harpak A, Sinnott-Armstrong N, Joergensen AM, Mostafavi H, Field Y, Boyle EA, Zhang X, Racimo F, Pritchard JK, Coop G
Reduced signal for polygenic adaptation of height in UK Biobank. Elife. 2019 03 21; 8.
Reduced signal for polygenic adaptation of height in UK Biobank.
Fiziev P, McRae J, Ulirsch JC, Dron JS, Hamp T, Yang Y, Wainschtein P, Ni Z, Schraiber JG, Gao H, Cable D, Field Y, Aguet F, Fasnacht M, Metwally A, Rogers J, Marques-Bonet T, Rehm HL, O'Donnell-Luria A, Khera AV, Kai-How Farh K
medRxiv : the preprint server for health sciences
Rare penetrant mutations confer severe risk of common diseases. medRxiv. 2023 May 08.
Rare penetrant mutations confer severe risk of common diseases.
Gao H, Hamp T, Ede J, Schraiber JG, McRae J, Singer-Berk M, Yang Y, Dietrich A, Fiziev P, Kuderna L, Sundaram L, Wu Y, Adhikari A, Field Y, Chen C, Batzoglou S, Aguet F, Lemire G, Reimers R, Balick D, Janiak MC, Kuhlwilm M, Orkin JD, Manu S, Valenzuela A, Bergman J, Rouselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath J, Hvilsom C, Juan D, Frandsen P, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, do Amaral JV, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Batallion T, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin A, Guschanski K, Schierup MH, Beck RMD, Umapathy G, Roos C, Boubli JP, Lek M, Sunyaev S, O'Donnell A, Rehm H, Xu J, Rogers J, Marques-Bonet T, Kai-How Farh K
bioRxiv : the preprint server for biology
The landscape of tolerated genetic variation in humans and primates. bioRxiv. 2023 May 02.
The landscape of tolerated genetic variation in humans and primates.
Fiziev PP, McRae J, Ulirsch JC, Dron JS, Hamp T, Yang Y, Wainschtein P, Ni Z, Schraiber JG, Gao H, Cable D, Field Y, Aguet F, Fasnacht M, Metwally A, Rogers J, Marques-Bonet T, Rehm HL, O'Donnell-Luria A, Khera AV, Farh KK
Rare penetrant mutations confer severe risk of common diseases. Science. 2023 06 02; 380(6648):eabo1131.
Gao H, Hamp T, Ede J, Schraiber JG, McRae J, Singer-Berk M, Yang Y, Dietrich ASD, Fiziev PP, Kuderna LFK, Sundaram L, Wu Y, Adhikari A, Field Y, Chen C, Batzoglou S, Aguet F, Lemire G, Reimers R, Balick D, Janiak MC, Kuhlwilm M, Orkin JD, Manu S, Valenzuela A, Bergman J, Rousselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath JE, Hvilsom C, Juan D, Frandsen P, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, do Amaral JV, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Bataillon T, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin A, Guschanski K, Schierup MH, Beck RMD, Umapathy G, Roos C, Boubli JP, Lek M, Sunyaev S, O'Donnell-Luria A, Rehm HL, Xu J, Rogers J, Marques-Bonet T, Farh KK
The landscape of tolerated genetic variation in humans and primates. Science. 2023 06 02; 380(6648):eabn8153.
Sinha S, Adler AS, Field Y, Chang HY, Segal E
Systematic functional characterization of cis-regulatory motifs in human core promoters. Genome Res. 2008 Mar; 18(3):477-88.
Systematic functional characterization of cis-regulatory motifs in human core promoters.
Segal E, Fondufe-Mittendorf Y, Chen L, Thåström A, Field Y, Moore IK, Wang JP, Widom J
A genomic code for nucleosome positioning. Nature. 2006 Aug 17; 442(7104):772-8.
A genomic code for nucleosome positioning.
How transcription factors identify regulatory sites in genomic sequence. Subcell Biochem. 2011; 52:193-204.
How transcription factors identify regulatory sites in genomic sequence.
Kaplan N, Moore IK, Fondufe-Mittendorf Y, Gossett AJ, Tillo D, Field Y, LeProust EM, Hughes TR, Lieb JD, Widom J, Segal E
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature. 2009 Mar 19; 458(7236):362-6.
The DNA-encoded nucleosome organization of a eukaryotic genome.
Tillo D, Kaplan N, Moore IK, Fondufe-Mittendorf Y, Gossett AJ, Field Y, Lieb JD, Widom J, Segal E, Hughes TR
High nucleosome occupancy is encoded at human regulatory sequences. PLoS One. 2010 Feb 09; 5(2):e9129.
High nucleosome occupancy is encoded at human regulatory sequences.
Kaplan N, Moore I, Fondufe-Mittendorf Y, Gossett AJ, Tillo D, Field Y, Hughes TR, Lieb JD, Widom J, Segal E
Nucleosome sequence preferences influence in vivo nucleosome organization. Nat Struct Mol Biol. 2010 Aug; 17(8):918-20.
Nucleosome sequence preferences influence in vivo nucleosome organization.
Field Y, Fondufe-Mittendorf Y, Moore IK, Mieczkowski P, Kaplan N, Lubling Y, Lieb JD, Widom J, Segal E
Gene expression divergence in yeast is coupled to evolution of DNA-encoded nucleosome organization. Nat Genet. 2009 Apr; 41(4):438-45.
Gene expression divergence in yeast is coupled to evolution of DNA-encoded nucleosome organization.
Minsky N, Shema E, Field Y, Schuster M, Segal E, Oren M
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol. 2008 Apr; 10(4):483-8.
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells.
Lidor Nili E, Field Y, Lubling Y, Widom J, Oren M, Segal E
p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy. Genome Res. 2010 Oct; 20(10):1361-8.
p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy.
Field Y, Kaplan N, Fondufe-Mittendorf Y, Moore IK, Sharon E, Lubling Y, Widom J, Segal E
Distinct modes of regulation by chromatin encoded through nucleosome positioning signals. PLoS Comput Biol. 2008 Nov; 4(11):e1000216.
Distinct modes of regulation by chromatin encoded through nucleosome positioning signals.
Dadiani M, van Dijk D, Segal B, Field Y, Ben-Artzi G, Raveh-Sadka T, Levo M, Kaplow I, Weinberger A, Segal E
Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise. Genome Res. 2013 Jun; 23(6):966-76.
Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise.
Field Y, Boyle EA, Telis N, Gao Z, Gaulton KJ, Golan D, Yengo L, Rocheleau G, Froguel P, McCarthy MI, Pritchard JK
Detection of human adaptation during the past 2000 years. Science. 2016 11 11; 354(6313):760-764.
Detection of human adaptation during the past 2000 years.