2164681Dolan ME, Moschel RC, Pegg AEProceedings of the National Academy of Sciences of the United States of AmericaGuanine; Lomustine; Methyltransferases; Tumor Cells, CulturedAntineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; Humans; Kidney; Kinetics; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesylates; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity RelationshipDepletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5368-72.Proc Natl Acad Sci U S A1990-07-01T00:00:001990Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000970Chemicals & Drugs40723510.435494Antineoplastic AgentsD004357Physiology1533030.932438Drug SynergismD008780Chemicals & Drugs591820.88894MethyltransferasesD008099Anatomy34612290.67236LiverD008130Chemicals & Drugs8260.995344LomustineD008698Chemicals & Drugs7150.995836MesylatesD009682PhenomenaProcedures1353180.894699Magnetic Resonance SpectroscopyD006147Chemicals & Drugs672080.91099GuanineD013058Procedures1191880.929085Mass SpectrometryD006801Living Beings2262862810.130064HumansD007668Anatomy29512400.631829KidneyD014407Anatomy28110400.852692Tumor Cells, CulturedMedicine-Hematology and OncologyD013329Concepts & Ideas1794080.910997Structure-Activity RelationshipD019853Chemicals & Drugs221180.961643O(6)-Methylguanine-DNA MethyltransferaseD002460Anatomy54024660.697119Cell LineD002470Physiology3269660.814133Cell Survivalhttp://www.pgrn.org/pgx-of-chemotherapeutic-toxicities.htmlMy Lab ObjectivesD007700Concepts & Ideas37115130.801696KineticsUniversity of ChicagoMary EileenDolan2mdtBK0UF8zMknJtY0fp/Cv/+94=Mary Eileen Dolan41.78927490000000-87.601250000000002594Dolan, Mary EileenProfessortrue1ProfessorProfessorAuthorship 5059410.09642820.09642821authors10.2517has subject area