23640485Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa HArteriosclerosis, thrombosis, and vascular biologyCardiomegaly; Coronary Vessels; Guanine Nucleotide Exchange Factors; Human Umbilical Vein Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropeptides; rac GTP-Binding Proteins; rac1 GTP-Binding ProteinAdaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cells, Cultured; Cholesterol; Cholesterol, LDL; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heptanoic Acids; Humans; Japan; Male; Mice; Mice, Knockout; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; RNA Interference; Signal Transduction; TransfectionStatins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1591-600.Arterioscler Thromb Vasc Biol2013-05-02T00:00:002013Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.prns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000804Chemicals & Drugs53940.961098Angiotensin IID000818Living Beings1457265180.249624AnimalsD002784Chemicals & Drugs1203560.84156CholesterolD006332Disorders361110.942598CardiomegalyD004305Concepts & Ideas52019580.724084Dose-Response Relationship, DrugD006538Chemicals & Drugs13720.958765Heptanoic AcidsD005355Disorders1082020.90652FibrosisD011804Chemicals & Drugs60950.926567QuinolinesD007564Geographic Areas793070.9393JapanD006801Living Beings2262862810.130052HumansD015415Concepts & Ideas59717090.619575BiomarkersD008078Chemicals & Drugs502220.890086Cholesterol, LDLD008297Physiology1931408600.201617MaleD020662Chemicals & Drugs40730.953817Guanine Nucleotide Exchange FactorsD020830Chemicals & Drugs30480.981801rac1 GTP-Binding ProteinD009479Chemicals & Drugs631120.946536NeuropeptidesD034622PhenomenaPhysiology1993680.889301RNA InterferenceD018345Living Beings43819180.695188Mice, KnockoutD018384Disorders1874460.783805Oxidative StressD018592Procedures1383990.901207Cross-Over StudiesD019161Chemicals & Drugs893780.727233Hydroxymethylglutaryl-CoA Reductase InhibitorsD020744Chemicals & Drugs18250.987597rac GTP-Binding ProteinsD051379Living Beings980113130.368397MiceD011758Chemicals & Drugs621840.890788PyrrolesD038362Chemicals & Drugs45630.962667Glycogen Synthase Kinase 3D061307Anatomy42630.969734Human Umbilical Vein Endothelial CellsD048868Chemicals & Drugs1653020.849209Adaptor Proteins, Signal TransducingD014162PhysiologyProcedures2878950.851303TransfectionD058539Chemicals & Drugs14140.988833Phosphatidylinositol 3-KinaseD002478Anatomy60328100.667881Cells, CulturedD00007167930370.99106Glycogen Synthase Kinase 3 betaD003331Anatomy801740.872886Coronary VesselsD003598Chemicals & Drugs962220.894713Cytoskeletal ProteinsD004195Disorders59222270.601904Disease Models, AnimalD015398Physiology69932330.460036Signal TransductionD017035Chemicals & Drugs6170.992746PravastatinD051057Chemicals & Drugs1483210.870521Proto-Oncogene Proteins c-aktMedicineUniversity of ChicagoJamesLiaoJames Liao41.78927490000000-87.60125000000000382Liao, JamesProfessortrue1ProfessorProfessorAuthorship 6230090.1174010.1174011authors10.2537has subject area