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Barreiro, Luis
One or more keywords matched the following properties of Barreiro, Luis
PropertyValue
keywords Functional Genomics, Population Genetics, Natural Selection, Innate Immunity, Population Variation
overview Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
One or more keywords matched the following items that are connected to Barreiro, Luis
Item TypeName
Concept Genetic Vectors
Concept Genetic Engineering
Concept Genetics, Population
Concept Models, Genetic
Concept Selection, Genetic
Concept Polymorphism, Genetic
Concept Genetic Markers
Concept Transcription, Genetic
Concept Genetic Variation
Concept Transduction, Genetic
Concept Genetic Association Studies
Concept Genetic Speciation
Concept Genetic Diseases, Inborn
Concept Databases, Genetic
Concept Promoter Regions, Genetic
Concept Genetic Heterogeneity
Concept Epigenomics
Concept Epistasis, Genetic
Concept Genetic Linkage
Concept Genetic Predisposition to Disease
Concept Epigenesis, Genetic
Concept Genetic Loci
Academic Article Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
Academic Article Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Academic Article Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Academic Article Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Academic Article The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.
Academic Article Mycobacterial infection induces a specific human innate immune response.
Academic Article Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Academic Article The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Academic Article Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Academic Article Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.
Academic Article Evolutionary genetic dissection of human interferons.
Academic Article Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.
Academic Article Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.
Academic Article BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.
Academic Article The contribution of admixture to primate evolution.
Academic Article The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.
Academic Article DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype.
Academic Article The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
Academic Article Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.
Academic Article Natural selection has driven population differentiation in modern humans.
Academic Article Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.
Academic Article From evolutionary genetics to human immunology: how selection shapes host defence genes.
Academic Article Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Academic Article The role played by natural selection on Mendelian traits in humans.
Academic Article Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.
Academic Article The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Academic Article Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.
Academic Article Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.
Academic Article Genetic and evolutionary determinants of human population variation in immune responses.
Academic Article When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection.
Academic Article Genetic and transcriptional analysis of human host response to healthy gut microbiota.
Academic Article Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.
Academic Article Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.
Academic Article Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.
Academic Article A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.
Academic Article Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.
Academic Article High-throughput SNP genotyping: combining tag SNPs and molecular beacons.
Academic Article Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.
Academic Article Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Academic Article Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Academic Article Quantitative trait loci (QTL) study identifies novel genomic regions associated to Chiari-like malformation in Griffon Bruxellois dogs.
Academic Article Signatures of purifying and local positive selection in human miRNAs.
Academic Article Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.
Academic Article Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.
Academic Article Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
Academic Article Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Academic Article Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.
Academic Article Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
Academic Article Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques.
Academic Article Genome-wide quantification of the effects of DNA methylation on human gene regulation.
Academic Article Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-ß Signaling and Epigenomics.
Academic Article Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.
Academic Article Identification of a ?c Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.
Academic Article Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector.
Academic Article Defining trained immunity and its role in health and disease.
Academic Article The epigenetically-encoded memory of the innate immune system.
Academic Article GHRH proliferative action on somatotrophs is cell-type specific and dependent on Pit-1/GHF-1 expression.
Academic Article Evolutionary and population (epi)genetics of immunity to infection.
Academic Article Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.
Academic Article M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity.
Academic Article Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.
Academic Article Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Academic Article Evolution of immune genes is associated with the Black Death.
Academic Article [The Black Death, natural selection and susceptibility to auto-immune disorders].
Academic Article Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity.
Academic Article EpiVar Browser: advanced exploration of epigenomics data under controlled access.
Academic Article The evolutionary tale of lactase persistence in humans.
Academic Article BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow.
Academic Article Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Academic Article EpiVar Browser: advanced exploration of epigenomics data under controlled access.
Search Criteria
  • Genetic
  • Epigenetic