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Barreiro, Luis
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overview Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
One or more keywords matched the following items that are connected to Barreiro, Luis
Item TypeName
Concept Biological Evolution
Concept Evolution, Molecular
Concept Host-Pathogen Interactions
Academic Article Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
Academic Article Social environment is associated with gene regulatory variation in the rhesus macaque immune system.
Academic Article Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Academic Article Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Academic Article Mycobacterial infection induces a specific human innate immune response.
Academic Article Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Academic Article Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.
Academic Article Evolutionary genetic dissection of human interferons.
Academic Article Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.
Academic Article The contribution of admixture to primate evolution.
Academic Article The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.
Academic Article From evolutionary genetics to human immunology: how selection shapes host defence genes.
Academic Article Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Academic Article Reservoir host immune responses to emerging zoonotic viruses.
Academic Article Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis.
Academic Article Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.
Academic Article Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution.
Academic Article Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology.
Academic Article Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.
Academic Article Genetic and evolutionary determinants of human population variation in immune responses.
Academic Article Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.
Academic Article Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.
Academic Article Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.
Academic Article Signatures of purifying and local positive selection in human miRNAs.
Academic Article Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.
Academic Article Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.
Academic Article Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
Academic Article Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Academic Article Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
Academic Article Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.
Academic Article Evolutionary and population (epi)genetics of immunity to infection.
Academic Article Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.
Academic Article Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.
Academic Article A multilayered immune system through the lens of unconventional T cells.
Academic Article Evolution of immune genes is associated with the Black Death.
Grant Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Grant Characterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune system
Academic Article The evolutionary tale of lactase persistence in humans.
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  • pathogen
  • evolution