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One or more keywords matched the following properties of Pincus, David
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overview David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation. David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models. Key project areas: 1) Quantitative cell biology of the heat shock response 2) Single-cell transcriptomics in complex stress environments
One or more keywords matched the following items that are connected to Pincus, David
Item TypeName
Concept Cell Communication
Concept Cell Nucleus
Concept Eukaryotic Cells
Concept Cell Adhesion
Concept Embryonic Stem Cells
Concept Neural Stem Cells
Concept Induced Pluripotent Stem Cells
Concept Cell Line
Concept Cell Nucleolus
Academic Article Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity.
Academic Article Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Academic Article Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.
Academic Article Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
Academic Article tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress.
Academic Article Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Academic Article Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock.
Academic Article Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness.
Academic Article The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
Academic Article Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Academic Article Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Academic Article Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Academic Article Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Academic Article Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.
Grant Regulatory Dynamics of the Proteostasis Network
Grant Quantitative approaches to reveal the homeostatic control mechanisms of stress re
Academic Article Blue light receptor CRY1 regulates HSFA1d nuclear localization to promote plant thermotolerance.
Academic Article Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates.
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