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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Autoimmune Diseases
Concept Cardiovascular Diseases
Concept Disease
Concept Chronic Disease
Concept Disease Susceptibility
Concept Major Histocompatibility Complex
Concept Disease Progression
Concept Endosomal Sorting Complexes Required for Transport
Concept Genetic Diseases, X-Linked
Concept Genetic Diseases, Inborn
Concept CD3 Complex
Concept National Institute of Allergy and Infectious Diseases (U.S.)
Concept Disease Models, Animal
Concept Virus Diseases
Concept Genetic Predisposition to Disease
Academic Article Broad and narrow heritabilities of quantitative traits in a founder population.
Academic Article Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
Academic Article A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Academic Article Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article Are common disease susceptibility alleles the same in outbred and founder populations?
Academic Article The genetic dissection of complex traits in a founder population.
Academic Article Human body scents: conscious perceptions and biological effects.
Academic Article Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Academic Article ITGB3 shows genetic and expression interaction with SLC6A4.
Academic Article Heritability estimation of sex-specific effects on human quantitative traits.
Academic Article Best linear unbiased allele-frequency estimation in complex pedigrees.
Academic Article Sex-specific genetic architecture of human disease.
Academic Article Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Academic Article Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.
Academic Article Colloquium papers: Heritability of reproductive fitness traits in a human population.
Academic Article Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article The sex-specific genetic architecture of quantitative traits in humans.
Academic Article Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites.
Academic Article Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia.
Academic Article Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Academic Article Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article Genome-wide association study identifies candidate genes for male fertility traits in humans.
Academic Article Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13.
Academic Article A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Academic Article Estimation of variance components of quantitative traits in inbred populations.
Academic Article Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Rethinking genetic models of asthma: the role of environmental modifiers.
Academic Article A genome-wide screen for hyposmia susceptibility Loci.
Academic Article A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Asthma Genetics in the Post-GWAS Era.
Academic Article Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Grant Prenatal Origins of Asthma
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Academic Article Rare non-coding variants are associated with plasma lipid traits in a founder population.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.
Academic Article Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article Advances in asthma and allergic disease genetics: Is bigger always better?
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Academic Article Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk.
Academic Article Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Academic Article New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
Academic Article Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Academic Article Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Academic Article African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Grant Airway inflammation and HLA-G in asthma
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant Training of Junior Faculty for Careers in Omics of Lung Diseases
Grant CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Academic Article Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Academic Article Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.
Search Criteria
  • Complex
  • Traits
  • Diseases