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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Cross-Sectional Studies
Concept Cohort Studies
Concept Urban Population
Concept Case-Control Studies
Concept Genetic Association Studies
Concept Follow-Up Studies
Concept Prospective Studies
Academic Article Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article Are common disease susceptibility alleles the same in outbred and founder populations?
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals.
Academic Article Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.
Academic Article Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article Evaluating the evidence for transmission distortion in human pedigrees.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Maternal microchimerism protects against the development of asthma.
Academic Article The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Population genetic studies of HLA-E: evidence for selection.
Academic Article Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Academic Article Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.
Academic Article Genome-Wide Association Studies of the Human Gut Microbiota.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Grant Prenatal Origins of Asthma
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Grant Chronic Rhinosinusitis Integrative Studies Program (CRISP)
Academic Article Rare non-coding variants are associated with plasma lipid traits in a founder population.
Academic Article Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study.
Academic Article Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Academic Article Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Academic Article Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Academic Article Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Grant THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
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