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Storb, Ursula

One or more keywords matched the following items that are connected to Storb, Ursula

Item Type	Name
Concept	Mice, Transgenic
Academic Article	Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
Academic Article	The mechanism of somatic hypermutation studied with transgenic and transfected target genes.
Academic Article	Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
Academic Article	N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
Academic Article	Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.
Academic Article	Gamma 2b provides only some of the signals normally given via mu in B cell development.
Academic Article	Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
Academic Article	Immunoglobulin transgenes as targets for somatic hypermutation.
Academic Article	Rearrangement and expression of immunoglobulin genes in transgenic mice.
Academic Article	A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
Academic Article	A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
Academic Article	Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
Academic Article	A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.
Academic Article	Effects of sequence and structure on the hypermutability of immunoglobulin genes.
Academic Article	Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
Academic Article	The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
Academic Article	Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
Academic Article	Immunology. Autoreactive B cells migrate into T cell territory.
Academic Article	Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
Academic Article	Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
Academic Article	The published data.
Academic Article	Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
Academic Article	A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.
Academic Article	Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
Academic Article	Analysis of somatic mutations in kappa transgenes.
Academic Article	Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
Academic Article	Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
Academic Article	Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
Academic Article	Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
Academic Article	Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells.
Academic Article	Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
Academic Article	Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
Academic Article	lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
Academic Article	Transgenic mice with immunoglobulin genes.
Academic Article	Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
Academic Article	Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
Academic Article	Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
Academic Article	The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.
Academic Article	The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
Academic Article	The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
Academic Article	DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.
Academic Article	Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
Academic Article	Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
Academic Article	Expression of immunoglobulin genes in transgenic mice and transfected cells.
Academic Article	Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
Academic Article	B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
Academic Article	Pre-B cells in kappa-transgenic mice.
Academic Article	High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
Grant	CONTROL OF IMMUNOGLOBULIN SYNTHESIS
Grant	EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
Grant	CONTROL OF IMMUNOGLOBULIN SYNTHESIS
Grant	MUTATION OF IG GENES
Grant	Mechanism of Immunoglobulin Hypermutation

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Mice Transgenic