Item Type | Name |
Concept
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Diabetes Mellitus, Experimental
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Concept
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Diabetes Mellitus, Type 1
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Concept
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Diabetes Mellitus, Type 2
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Concept
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Diabetes, Gestational
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Concept
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Diabetes Mellitus
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Academic Article
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Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats.
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Academic Article
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Glucokinase mutations, insulin secretion, and diabetes mellitus.
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Academic Article
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
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Academic Article
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Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance.
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Academic Article
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Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.
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Academic Article
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Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction.
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Academic Article
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Report of the American Diabetes Association's Task Force on standardization of the insulin assay.
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Academic Article
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.
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Academic Article
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Oscillatory insulin secretion after pancreas transplant.
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Academic Article
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
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Academic Article
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Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
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Academic Article
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Basal and glucagon-stimulated plasma C-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism.
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Academic Article
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
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Academic Article
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Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.
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Academic Article
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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
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Academic Article
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Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.
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Academic Article
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Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.
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Academic Article
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Maturity onset diabetes of the young (MODY).
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Academic Article
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Alternative insulin delivery systems: how demanding should the patient be?
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Academic Article
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Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
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Academic Article
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Free fatty acids impair hepatic insulin extraction in vivo.
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Academic Article
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance.
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Academic Article
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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.
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Academic Article
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
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Academic Article
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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes.
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Academic Article
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Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.
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Academic Article
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Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance.
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Academic Article
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Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.
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Academic Article
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Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.
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Academic Article
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Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes.
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Academic Article
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Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients.
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Academic Article
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Dynamics of insulin secretion in obesity and diabetes.
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Academic Article
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Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.
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Academic Article
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Roles of circadian rhythmicity and sleep in human glucose regulation.
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Academic Article
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Insulin production: from gene to granule.
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Academic Article
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
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Academic Article
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Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance.
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Academic Article
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Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes.
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Academic Article
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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
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Academic Article
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Temporal profiles and clinical significance of pulsatile insulin secretion.
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Academic Article
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
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Academic Article
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Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
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Academic Article
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Hypoglycemic thresholds for cognitive dysfunction in IDDM.
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Academic Article
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Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.
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Academic Article
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Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.
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Academic Article
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Calpains play a role in insulin secretion and action.
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Academic Article
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Diabetes mellitus and genetically programmed defects in beta-cell function.
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Academic Article
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Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity.
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Academic Article
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Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
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Academic Article
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Ginseng berry reduces blood glucose and body weight in db/db mice.
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Academic Article
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Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.
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Academic Article
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C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.
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Academic Article
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Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
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Academic Article
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Visualizing superoxide production in normal and diabetic rat islets of Langerhans.
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Academic Article
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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
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Academic Article
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Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes.
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Academic Article
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Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.
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Academic Article
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Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
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Academic Article
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Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus.
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Academic Article
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Effect of temporal distribution of calories on diurnal patterns of glucose levels and insulin secretion in NIDDM.
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Academic Article
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Diabetic pancreatic beta cells ARNT all they should be.
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Academic Article
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Does tight glucose control enhance brain sensitivity to low glucose?
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Academic Article
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Postprandial triglyceride response in type 1 (insulin-dependent) diabetes mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement.
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Academic Article
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Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography.
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Academic Article
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Retinol-binding protein 4, insulin resistance, and type 2 diabetes.
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Academic Article
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Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans.
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Academic Article
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Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
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Academic Article
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Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells.
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Academic Article
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Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
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Academic Article
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A significant role for histocompatibility in human islet transplantation.
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Academic Article
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Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals.
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Academic Article
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
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Academic Article
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Suppressed insulin signaling and increased apoptosis in CD38-null islets.
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Academic Article
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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic ß cell death and diabetes.
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Academic Article
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Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery.
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Academic Article
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Weight loss therapy improves pancreatic endocrine function in obese older adults.
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Academic Article
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Insulin signaling in alpha cells modulates glucagon secretion in vivo.
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Academic Article
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Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus.
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Academic Article
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
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Academic Article
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Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.
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Academic Article
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Introduction of Arthur H. Rubenstein.
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Academic Article
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Reduction in portal vein blood flow by somatostatin.
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Academic Article
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The limitations to and valid use of C-peptide as a marker of the secretion of insulin.
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Academic Article
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Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
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Academic Article
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Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide.
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Academic Article
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Insulin and glucagon breakthrough of somatostatin suppression: importance of portal vein hormone measurements.
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Academic Article
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Evidence for the presence of somatostatin 28 in plasma.
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Academic Article
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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
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Academic Article
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Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
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Academic Article
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Pdx1 and other factors that regulate pancreatic beta-cell survival.
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Academic Article
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Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes.
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Academic Article
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Reevaluation of urine C-peptide as measure of insulin secretion.
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Academic Article
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Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
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Academic Article
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Mutant insulin syndrome: identification of two families with [LeuA3]insulin and determination of its biological activity.
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Academic Article
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Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus.
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Academic Article
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The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
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Academic Article
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The effects of biosynthetic human proinsulin on carbohydrate metabolism.
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Academic Article
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Aldose reductase inhibition improves nerve conduction velocity in diabetic patients.
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Academic Article
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Natural history of multiple intrahepatic canine islet allografts during and following administration of cyclosporine.
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Academic Article
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Defects in insulin secretion and action in women with a history of gestational diabetes.
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Academic Article
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A new method for comparing portal and peripheral venous insulin delivery in humans: tolbutamide versus insulin infusion.
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Academic Article
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Insulin secretion and clearance. Comparison after oral and intravenous glucose.
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Academic Article
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Variable deterioration in cortical function during insulin-induced hypoglycemia.
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Academic Article
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
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Academic Article
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Hepatic extraction of plasma immunoreactive glucagon components. Predilection for 3500-dalton glucagon metabolism by the liver.
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Academic Article
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Alterations in the patterns of insulin secretion before and after diagnosis of IDDM.
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Academic Article
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Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics.
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Academic Article
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Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography.
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Academic Article
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Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat.
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Academic Article
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Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
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Academic Article
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Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited.
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Academic Article
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Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump.
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Academic Article
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Insulin secretion in insulin-resistant women with a history of gestational diabetes.
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Academic Article
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Maturity-onset diabetes of the young.
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Academic Article
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Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.
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Academic Article
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Insulin secretory profiles and C-peptide clearance kinetics at 6 months and 2 years after kidney-pancreas transplantation.
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Academic Article
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Long-term follow-up of canine segmental pancreatic autografts.
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Academic Article
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The past 200 years in diabetes.
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Academic Article
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The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.
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Academic Article
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Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome.
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Academic Article
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Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes.
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Academic Article
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Relation of counterregulatory responses to hypoglycemia in type I diabetics.
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Academic Article
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Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
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Academic Article
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Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
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Academic Article
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Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM.
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Academic Article
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Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat.
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Academic Article
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Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus.
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Academic Article
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Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
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Academic Article
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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
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Academic Article
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Diagnosis of acromegaly in a patient with type 1 diabetes mellitus.
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Academic Article
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Organ alchemy: producing insulin in the liver.
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Academic Article
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Portal vein thrombosis complicating islet transplantation in a recipient with the Factor V Leiden mutation.
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Academic Article
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Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
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Academic Article
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International trial of the Edmonton protocol for islet transplantation.
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Academic Article
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Hypoglycemic thresholds for cognitive dysfunction in humans.
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Academic Article
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Effects of aging on insulin secretion.
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Academic Article
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Ginseng and ginsenoside Re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.
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Academic Article
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Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans.
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Academic Article
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Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
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Academic Article
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Current approaches to measurement of insulin secretion.
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Academic Article
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C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations.
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Academic Article
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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
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Academic Article
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Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
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Academic Article
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Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.
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Award or Honor Receipt
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Outstanding Scientific Achievement Award of the American Diabetes Association (Lilly Award)
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Academic Article
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Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
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Academic Article
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Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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BH3-only molecule Bim mediates ß-cell death in IRS2 deficiency.
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Academic Article
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Donald F. Steiner, MD, 1930-2014: pioneering diabetes researcher.
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Academic Article
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Pancreatic ß-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.
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Academic Article
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35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999.
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